Investigating the interactions of the 18 kDa translocator protein and its ligand PK11195 in planar lipid bilayers

Biochimica et Biophysica Acta - Biomembranes

Volumn 1838, Issue 3, 2014, Pages 1019-1030

  Hatty, Claire R ^a   Le Brun, Anton P ^b   Lake, Vanessa ^b   Clifton, Luke A ^c   Liu, Guo Jun ^a,b   James, Michael ^b,d   Banati, Richard B ^a,b  

^a UNIVERSITY OF SYDNEY   (Australia)

^b AUSTRALIAN NUCLEAR SCIENCE AND TECHNOLOGY ORGANISATION   (Australia)

^c RUTHERFORD APPLETON LABORATORY   (United Kingdom)

^d UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Lipid bilayer; Membrane protein; Neutron reflectometry; PK11195; QCM D; TSPO

Indexed keywords

CARRIER PROTEIN; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; POLYHISTIDINE TAG; PROTEIN TSPO; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID RECEPTOR; BZRP PROTEIN, MOUSE; DITHIOTHREITOL; DODECYL SULFATE SODIUM; ISOQUINOLINE DERIVATIVE; LIPOSOME; MEMBRANE LIPID; MEMBRANE PROTEIN; NITRILOTRIACETIC ACID; NSAIDS; PHOSPHATE BUFFERED SALINE; PHOSPHATIDYLCHOLINE; TRANSLOCATOR PROTEIN;

ARTICLE; CONFORMATIONAL TRANSITION; DRUG PROTEIN BINDING; DRUG STRUCTURE; LIGAND BINDING; LIPID BILAYER; LIPID MONOLAYER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ISOLATION; PROTEIN TARGETING; QUARTZ CRYSTAL MICROBALANCE; REFLECTOMETRY; RIGIDITY; STRUCTURE ANALYSIS; SURFACE PROPERTY; THICKNESS; 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE; 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE; 1-(2-CHLOROPHENYL)-N-METHYL-N-(1-METHYLPROPYL)-3-ISOQUINOLINECARBOXAMIDE; AFFINITY OR EQUILIBRIUM DISSOCIATION CONSTANT; ANIMAL; ANTA; BMAX; CM4; CMAU; CMSI; DDM; DITHIOBIS(SUCCINIMIDYL PROPIONATE); DMPC; DMPE; DTSP; ESCHERICHIA COLI; GOLD CONTRAST MATCHED WATER; IPTG; ISOPROPYL Β-D-1-THIOGALACTOPYRANOSIDE; KD; MAXIMAL NUMBER OF RECEPTOR BINDING SITES; METABOLISM; N-DODECYL-Β-D-MALTOPYRANOSIDE; NEUTRON REFLECTOMETRY; NITRILOTRIACETIC ACID GROUP WITH A TERMINAL AMINO GROUP; NON-STEROIDAL ANTI-INFLAMMATORY DRUGS; NR; OD; OPTICAL DENSITY; PBS; PC; PROTEIN TRANSPORT; QCM-D; QUARTZ CRYSTAL MICROBALANCE WITH DISSIPATION MONITORING; SCATTERING LENGTH DENSITY; SCATTERING LENGTH DENSITY 4 CONTRAST MATCHED WATER; SDS; SILICON CONTRAST MATCHED WATER; SLD; SMALL UNILAMELLAR VESICLE; SPR; SURFACE PLASMON RESONANCE; SUV; TEV; TOBACCO VIRUS; TRYPTOPHAN RICH SENSORY PROTEIN; TSPO;

1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE; 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE; 1-(2-CHLOROPHENYL)-N-METHYL-N-(1-METHYLPROPYL)-3-ISOQUINOLINECARBOXAMIDE; AFFINITY OR EQUILIBRIUM DISSOCIATION CONSTANT; ANTA; BMAX; CM4; CMAU; CMSI; DDM; DITHIOBIS(SUCCINIMIDYL PROPIONATE); DITHIOTHREITOL; DMPC; DMPE; DTSP; DTT; E. COLI; ESCHERICHIA COLI; GOLD CONTRAST MATCHED WATER; IPTG; ISOPROPYL Β-D-1-THIOGALACTOPYRANOSIDE; KD; LIPID BILAYER; MAXIMAL NUMBER OF RECEPTOR BINDING SITES; MEMBRANE PROTEIN; N-DODECYL-Β-D-MALTOPYRANOSIDE; NEUTRON REFLECTOMETRY; NITRILOTRIACETIC ACID; NITRILOTRIACETIC ACID GROUP WITH A TERMINAL AMINO GROUP; NON-STEROIDAL ANTI-INFLAMMATORY DRUGS; NR; NSAIDS; NTA; OD; OPTICAL DENSITY; PBS; PC; PHOSPHATE BUFFERED SALINE; PHOSPHATIDYLCHOLINE; PK11195; QCM-D; QUARTZ CRYSTAL MICROBALANCE WITH DISSIPATION MONITORING; SCATTERING LENGTH DENSITY; SCATTERING LENGTH DENSITY 4 CONTRAST MATCHED WATER; SDS; SILICON CONTRAST MATCHED WATER; SLD; SMALL UNILAMELLAR VESICLE; SODIUM DODECYL SULPHATE; SPR; SURFACE PLASMON RESONANCE; SUV; TEV; TOBACCO ETCH VIRUS; TRANSLOCATOR PROTEIN; TRYPTOPHAN RICH SENSORY PROTEIN; TSPO;

ANIMALS; ISOQUINOLINES; LIPID BILAYERS; LIPOSOMES; MEMBRANE LIPIDS; MICE; PROTEIN TRANSPORT; QUARTZ CRYSTAL MICROBALANCE TECHNIQUES; RECEPTORS, GABA;

EID: 84892410771     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2013.12.013     Document Type: Article

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