Proteins and amino acids are fundamental to optimal nutrition support in critically ill patients

Critical Care

Volumn 18, Issue 6, 2014, Pages

  Weijs, Peter J M ^a,b   Cynober, Luc ^c,d   DeLegge, Mark ^e   Kreymann, Georg ^f   Wernerman, Jan ^g   Wolfe, Robert R ^h  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b AMSTERDAM UNIVERSITY OF APPLIED SCIENCES   (Netherlands)

^c HÔTEL DIEU   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

^e BAXTER HEALTHCARE CORPORATION   (United States)

^f Baxter Healthcare SA Europe   (Switzerland)

^g KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^h TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; MUSCLE PROTEIN; PROTEIN; PROTEIN INTAKE;

ADAPTATION; ADVERSE OUTCOME; AMINO ACID METABOLISM; AMINO ACID TRANSPORT; ANABOLIC RESISTANCE; ARTICLE; CRITICALLY ILL PATIENT; DIET SUPPLEMENTATION; ENTERIC FEEDING; FUNCTIONAL DISEASE; HUMAN; LEAN BODY WEIGHT; METABOLIC STRESS; METABOLISM; MUSCLE ATROPHY; MUSCLE MASS; NITROGEN BALANCE; NUTRITIONAL REQUIREMENT; NUTRITIONAL SUPPORT; PARENTERAL NUTRITION; PHYSICIAN; PRIORITY JOURNAL; PROTEIN INTAKE; PROTEIN INTERACTION; PROTEIN METABOLISM; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; STARVATION; SYNTHESIS; TREATMENT OUTCOME; ADMINISTRATION AND DOSAGE; CRITICAL ILLNESS; PROCEDURES;

AMINO ACIDS; CRITICAL ILLNESS; DIETARY PROTEINS; HUMANS; NUTRITIONAL SUPPORT;

EID: 84920849119     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/s13054-014-0591-0     Document Type: Article

References (136)

1. Plank LD. Protein for the critically ill patient - what and when?. Eur J Clin Nutr 2013, 67:565-568. 23403870.
2. Marik PE, Zaloga GP. Immunonutrition in critically ill patients: a systematic review and analysis of the literature. Intensive Care Med 2008, 34:1980-1990. 18626628.
3. Cynober L, de Bandt JP, Moinard C. Leucine and citrulline: two major regulators of protein turnover. World Rev Nutr Diet 2013, 105:97-105. 23075591.
4. Cynober L, De Bandt JP. Glutamine in the intensive care unit. Curr Opin Clin Nutr Metab Care 2014, 17:98-104. 24281374.
5. Elman R, Weiner DO, Bradley E. Intravenous injections of amino-acids (hydrolyzed casein) in postoperative patients. Ann Surg 1942, 115:1160-1165. 17858044.
6. Shils ME. Guidelines for total parenteral nutrition. JAMA 1972, 220:1721-1729. 4623986.
7. Merrill JP. The Treatment of Renal Failure 1955, Grune & Stratton, New York.
8. Dudrick SJ, Wilmore DW, Vars HM, Rhoads JE. Can intravenous feeding as the sole means of nutrition support growth in the child and restore weight loss in an adult? An affirmative answer. Ann Surg 1969, 169:974-984. 4976960.
9. Wolfe RR, O'Donnell TF, Stone MD, Richmand DA, Burke JF. Investigation of factors determining the optimal glucose infusion rate in total parenteral nutrition. Metabolism 1980, 29:892-900. 6774203.
10. Cerra FB, Benitez MR, Blackburn GL, Irwin RS, Jeejeebhoy K, Katz DP, Pingleton SK, Pomposelli J, Rombeau JL, Shronts E, Wolfe RR, Zaloga GP. Applied nutrition in ICU patients. A consensus statement of the American College of Chest Physicians. Chest 1997, 111:769-778. 9118718.
11. Cerra FB, Siegel JH, Coleman B, Border JR, McMenamy RR. Septic autocannibalism. A failure of exogenous nutritional support. Ann Surg 1980, 192:570-580. 6775605.
12. Hoffer LJ. Clinical nutrition: 1. Protein-energy malnutrition in the inpatient. CMAJ 2001, 165:1345-1349. 11760983.
13. Cahill GF. Starvation in man. Clin Endocrinol Metab 1976, 5:397-415. 182420.
14. Alberda C, Gramlich L, Jones N, Jeejeebhoy K, Day AG, Dhaliwal R, Heyland DK. The relationship between nutritional intake and clinical outcomes in critically ill patients: results of an international multicenter observational study. Intensive Care Med 2009, 35:1728-1737. 19572118.
15. Ishibashi N, Plank LD, Sando K, Hill GL. Optimal protein requirements during the first 2 weeks after the onset of critical illness. Crit Care Med 1998, 26:1529-1535. 9751589.
16. Souba WW. Glutamine: a key substrate for the splanchnic bed. Annu Rev Nutr 1991, 11:285-308. 1892702.
17. Felig P. Amino acid metabolism in man. Annu Rev Biochem 1975, 44:933-955. 1094924.
18. De Bandt JP, Lim SK, Plassart F, Lucas CC, Rey C, Poupon R, Giboudeau J, Cynober L. Independent and combined actions of interleukin-1 beta, tumor necrosis factor alpha, and glucagon on amino acid metabolism in the isolated perfused rat liver. Metabolism 1994, 43:822-829. 8028504.
19. Lang CH, Frost RA. Glucocorticoids and TNFα interact cooperatively to mediate sepsis-induced leucine resistance in skeletal muscle. Mol Med 2006, 12:291-299. 17380194.
20. van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R. Intensive insulin therapy in critically ill patients. N Engl J Med 2001, 345:1359-1367. 11794168.
21. Brosnan JT. Interorgan amino acid transport and its regulation. J Nutr 2003, 133:2068S-2072S. 12771367.
22. Essen P, McNurlan MA, Gamrin L, Hunter K, Calder G, Garlick PJ, Wernerman J. Tissue protein synthesis rates in critically ill patients. Crit Care Med 1998, 26:92-100. 9428549.
23. Barle H, Gamrin L, Essen P, McNurlan MA, Garlick PJ, Wernerman J. Growth hormone does not affect albumin synthesis in the critically ill. Intensive Care Med 2001, 27:836-843. 11430539.
24. Roth E. Nonnutritive effects of glutamine. J Nutr 2008, 138:2025S-2031S. 18806119.
25. Gamrin L, Essen P, Forsberg AM, Hultman E, Wernerman J. A descriptive study of skeletal muscle metabolism in critically ill patients: free amino acids, energy-rich phosphates, protein, nucleic acids, fat, water, and electrolytes. Crit Care Med 1996, 24:575-583. 8612406.
26. Vesali RF, Klaude M, Rooyackers OE, Jäder I.T., Barle H, Wernerman J. Longitudinal pattern of glutamine/glutamate balance across the leg in long-stay intensive care unit patients. Clin Nutr 2002, 21:505-514. 12468371.
27. Gielen M, Vanhorebeek I, Wouters PJ, Mesotten D, Wernerman J, Van den Berghe G, Rooyackers O. Amino acid concentrations in critically ill children following cardiac surgery. Pediatr Crit Care Med 2014, 15:314-328. 24472873.
28. Oudemans-van Straaten HM, Bosman RJ, Treskes M, van der Spoel HJ, Zandstra DF. Plasma glutamine depletion and patient outcome in acute ICU admissions. Intensive Care Med 2001, 27:84-90. 11280678.
29. Rodas PC, Rooyackers O, Hebert C, Norberg A, Wernerman J. Glutamine and glutathione at ICU admission in relation to outcome. Clin Sci (Lond) 2012, 122:591-597.
30. Jahoor F, Desai M, Herndon DN, Wolfe RR. Dynamics of the protein metabolic response to burn injury. Metabolism 1988, 37:330-337. 3282147.
31. Berg A, Rooyackers O, Bellander BM, Wernerman J. Whole body protein kinetics during hypocaloric and normocaloric feeding in critically ill patients. Crit Care 2013, 17:R158. 23883571.
32. Wolfe RR. Regulation of skeletal muscle protein metabolism in catabolic states. Curr Opin Clin Nutr Met Care 2005, 8:61-65.
33. Wolfe RR, Miller SL. Amino acid availability controls muscle protein metabolism. Diabetes Nutr Metab 1999, 12:322-328. 10741346.
34. Puthucheary ZA, Rawal J, McPhail M, Connolly B, Ratnayake G, Chan P, Hopkinson NS, Padhke R, Dew T, Sidhu PS, Velloso C, Seymour J, Agley CC, Selby A, Limb M, Edwards LM, Smith K, Rowlerson A, Rennie MJ, Moxham J, Harridge SD, Hart N, Montgomery HE. Acute skeletal muscle wasting in critical illness. JAMA 2013, 310:1591-1600. 24108501.
35. Hammarqvist F, Petersson B, Ali MR, Wernerman J. Glutamine in postoperative parenteral nutrition has a positive effect on nitrogen balance. Lakartidningen 1989, 86:229-231. 2492361.
36. Essen P, McNurlan MA, Wernerman J, Vinnars E, Garlick PJ. Uncomplicated surgery, but not general anesthesia, decreases muscle protein synthesis. Am J Physiol 1992, 262:E253-E260. 1550218.
37. Frontera WR, Hughes VA, Fielding RA, Fiatarone MA, Evans WJ, Roubenoff R. Aging of skeletal muscle: a 12-yr longitudinal study. J Appl Physiol 2000, 88:1321-1326. 10749826.
38. Rennie MJ. Anabolic resistance in critically ill patients. Crit Care Med 2009, 37:S398-S399. 20046126.
39. Biolo G, Ciocchi B, Lebenstedt M, Barazzoni R, Zanetti M, Platen P, Heer M, Guarnieri G. Short-term bed rest impairs amino acid-induced protein anabolism in humans. J Physiol 2004, 558:381-388. 15131238.
40. Jourdan M, Deutz NE, Cynober L, Aussel C. Features, causes and consequences of splanchnic sequestration of amino acid in old rats. PLoS One 2011, 6:e27002. 22087243.
41. Boirie Y, Gachon P, Beaufrere B. Splanchnic and whole-body leucine kinetics in young and elderly men. Am J Clin Nutr 1997, 65:489-495. 9022534.
42. Paddon-Jones D, Sheffield-Moore M, Zhang XJ, Volpi E, Wolf SE, Aarsland A, Ferrando AA, Wolfe RR. Amino acid ingestion improves muscle protein synthesis in the young and elderly. Am J Physiol Endocrinol Metab 2004, 286:E321-E328. 14583440.
43. Dardevet D, Remond D, Peyron MA, Papet I, Savary-Auzeloux I, Mosoni L. Muscle wasting and resistance of muscle anabolism: the 'anabolic threshold concept' for adapted nutritional strategies during sarcopenia. Scientific World Journal 2012, 2012:269531. 23326214.
44. Prod'homme M, Rieu I, Balage M, Dardevet D, Grizard J. Insulin and amino acids both strongly participate to the regulation of protein metabolism. Curr Opin Clin Nutr Metab Care 2004, 7:71-77. 15090906.
45. Chua HR, Baldwin I, Fealy N, Naka T, Bellomo R. Amino acid balance with extended daily diafiltration in acute kidney injury. Blood Purif 2012, 33:292-299. 22652535.
46. Hammarqvist F, Wernerman J, Ali R, von der Decken A, Vinnars E. Addition of glutamine to total parenteral nutrition after elective abdominal surgery spares free glutamine in muscle, counteracts the fall in muscle protein synthesis, and improves nitrogen balance. Ann Surg 1989, 209:455-461. 2494960.
47. Vary TC. Acute oral leucine administration stimulates protein synthesis during chronic sepsis through enhanced association of eukaryotic initiation factor 4G with eukaryotic initiation factor 4E in rats. J Nutr 2007, 137:2074-2079. 17709445.
48. Van Loon LJ. Leucine as a pharmaconutrient in health and disease. Curr Opin Clin Nutr Metab Care 2012, 15:71-77. 22037013.
49. Sherman HC. The protein requirement of maintenance in man. Proc Natl Acad Sci U S A 1920, 6:38-40. 16576450.
50. Hart DW, Wolf SE, Chinkes DL, Beauford RB, Mlcak RP, Heggers JP, Wolfe RR, Herndon DN. Effects of early excision and aggressive enteral feeding on hypermetabolism, catabolism, and sepsis after severe burn. J Trauma 2003, 54:755-761. discussion 761-764, 12707540.
51. Aarsland A, Chinkes DL, Sakurai Y, Nguyen TT, Herndon DN, Wolfe RR. Insulin therapy in burn patients does not contribute to hepatic triglyceride production. J Clin Invest 1998, 101:2233-2239. 9593779.
52. Evans WJ, Morley JE, Argilés J, Bales C, Baracos V, Guttridge D, Jatoi A, Kalantar-Zadeh K, Lochs H, Mantovani G, Marks D, Mitch WE, Muscaritoli M, Najand A, Ponikowski P, Rossi Fanelli F, Schambelan M, Schols A, Schuster M, Thomas D, Wolfe R, Anker SD. Cachexia: a new definition. Clin Nutr 2008, 27:793-799. 18718696.
53. Katsanos CS, Aarsland A, Cree MG, Wolfe RR. Muscle protein synthesis and balance responsiveness to essential amino acids ingestion in the presence of elevated plasma free fatty acid concentrations. J Clin Endocrinol Metab 2009, 94:2984-2990. 19454587.
54. Cynober LA. Plasma amino acid levels with a note on membrane transport: characteristics, regulation, and metabolic significance. Nutrition 2002, 18:761-766. 12297216.
55. Meijer AJ, Lamers WH, Chamuleau RA. Nitrogen metabolism and ornithine cycle function. Physiol Rev 1990, 70:701-748. 2194222.
56. Yudkoff M, Daikhin Y, Nissim I, Horyn O, Luhovyy B, Lazarow A, Nissim I. Brain amino acid requirements and toxicity: the example of leucine. J Nutr 2005, 135:1531S-1538S. 15930465.
57. Cynober L. Introduction to the 5th Amino Acid Assessment Workshop. J Nutr 2006, 136:1633S-1635S. 16702332.
58. Cynober L, Bier DM, Kadowaki M, Morris SM, Renwick AG. A proposal for an upper limit of leucine safe intake in healthy adults. J Nutr 2012, 142:2249S-2250S. 23096009.
59. Garlick PJ. The nature of human hazards associated with excessive intake of amino acids. J Nutr 2004, 134:1633S-1639S. discussion 1664S-1666S, 1667S-1672S, 15173443.
60. Holecek M. Side effects of long-term glutamine supplementation. JPEN J Parenter Enteral Nutr 2013, 37:607-616. 22990615.
61. Garlick PJ. Toxicity of methionine in humans. J Nutr 2006, 136:1722S-1725S. 16702346.
62. Manzanares W, Heyland DK. Pharmaconutrition with arginine decreases bacterial translocation in an animal model of severe trauma. Is a clinical studied justified?... The time is now!. Crit Care Med 2012, 40:350-352. 22179379.
63. Cynober L, Moinard C, Charrueau C. If the soup tastes bad, it doesn't mean the potatoes are the culprit. Crit Care Med 2012, 40:2540-2541. author reply 2541-2542, 22809953.
64. Energy and protein requirements. Report of a joint FAO/WHO/UNU Expert Consultation.World Health Organ Tech Rep Ser 1985, 724:1-206.
65. Scientific opinion on dietary reference values for protein. EFSA J 2012, 10:2557.
66. Scheinkestel CD, Adams F, Mahony L, Bailey M, Davies AR, Nyulasi I, Tuxen DV. Impact of increasing parenteral protein loads on amino acid levels and balance in critically ill anuric patients on continuous renal replacement therapy. Nutrition 2003, 19:733-740. 12921882.
67. Singer P. High-dose amino acid infusion preserves diuresis and improves nitrogen balance in non-oliguric acute renal failure. Wien Klin Wochenschr 2007, 119:218-222. 17492348.
68. Hoffer LJ, Bistrian BR. Appropriate protein provision in critical illness: a systematic and narrative review. Am J Clin Nutr 2012, 96:591-600. 22811443.
69. Waterlow JC. The nature and significance of nutritional adaptation. Eur J Clin Nutr 1999, 53:S2-S5. 10365976.
70. Furst P, Stehle P. What are the essential elements needed for the determination of amino acid requirements in humans?. J Nutr 2004, 134:1558S-1565S. 15173430.
71. Wierdsma NJ, Peters JH, Weijs PJ, Keur MB, Girbes AR, van Bodegraven AA, Beishuizen A. Malabsorption and nutritional balance in the ICU: fecal weight as a biomarker: a prospective observational pilot study. Crit Care 2011, 15:R264. 22071233.
72. Milner EA, Cioffi WG, Mason AD, McManus WF, Pruitt BA. Accuracy of urinary urea nitrogen for predicting total urinary nitrogen in thermally injured patients. JPEN J Parenter Enteral Nutr 1993, 17:414-416. 8289405.
73. Cynober L, Coudray-Lucas C. Urinary urea nitrogen prediction of total urinary nitrogen. JPEN J Parenter Enteral Nutr 1995, 19:174. 7609285.
74. Walser M. Misinterpretation of nitrogen balances when glutamine stores fall or are replenished. Am J Clin Nutr 1991, 53:1337-1338. 2035459.
75. Potter MA, Luxton G. Transthyretin measurement as a screening tool for protein calorie malnutrition in emergency hospital admissions. Clin Chem Lab Med 2002, 40:1-6.
76. McClave SA, Mitoraj TE, Thielmeier KA, Greenburg RA. Differentiating subtypes (hypoalbuminemic vs marasmic) of protein-calorie malnutrition: incidence and clinical significance in a university hospital setting. JPEN J Parenter Enteral Nutr 1992, 16:337-342. 1640631.
77. Buzby GP, Williford WO, Peterson OL, Crosby LO, Page CP, Reinhardt GF, Mullen JL. A randomized clinical trial of total parenteral nutrition in malnourished surgical patients: the rationale and impact of previous clinical trials and pilot study on protocol design. Am J Clin Nutr 1988, 47:357-365. 3124597.
78. Bouillanne O, Morineau G, Dupont C, Coulombel I, Vincent JP, Nicolis I, Benazeth S, Cynober L, Aussel C. Geriatric nutritional risk index: a new index for evaluating at-risk elderly medical patients. Am J Clin Nutr 2005, 82:777-783. 16210706.
79. Sjolin J, Stjernstrom H, Arturson G, Andersson E, Friman G, Larsson J. Exchange of 3-methylhistidine in the splanchnic region in human infection. Am J Clin Nutr 1989, 50:1407-1414. 2596430.
80. Coudray-Lucas C, Cynober L, Lioret N, Saizy R, Baux S, Giboudeau J. Origins of hyperphenylalaninemia in burn patients. Clin Nutr 1985, 4:179-183. 16831729.
81. Curis E, Nicolis I, Moinard C, Osowska S, Zerrouk N, Bénazeth S, Cynober L. Almost all about citrulline in mammals. Amino Acids 2005, 29:177-205. 16082501.
82. van de Poll MC, Siroen MP, van Leeuwen PA, Soeters PB, Melis GC, Boelens PG, Deutz NE, Dejong CH. Interorgan amino acid exchange in humans: consequences for arginine and citrulline metabolism. Am J Clin Nutr 2007, 85:167-172. 17209193.
83. Crenn P, Coudray-Lucas C, Thuillier F, Cynober L, Messing B. Postabsorptive plasma citrulline concentration is a marker of absorptive enterocyte mass and intestinal failure in humans. Gastroenterology 2000, 119:1496-1505. 11113071.
84. Crenn P, Hanachi M, Neveux N, Cynober L. Circulating citrulline levels: a biomarker for intestinal functionality assessment. Ann Biol Clin (Paris) 2011, 69:513-521.
85. Cynober L. Lessons from pharmacokinetics in the design of new nutrition formulas for critically ill patients. Nestle Nutr Workshop Ser Clin Perform Programme 2003, 8:265-272. discussion 272-277, 12968459.
86. Abumrad N, Darmaun D, Cynober L. Approaches to studying amino acid metabolism: from quantitative assays to flux assessment using stable isotopes. Amino Acid Metabolism in Health and Nutritional Disease 1995, 15-30. CRC Press, Boca Raton, FL, Cynober L.
87. Berard MP, Pelletier A, Ollivier JM, Gentil B, Cynober L. Qualitative manipulation of amino acid supply during total parenteral nutrition in surgical patients. JPEN J Parenter Enteral Nutr 2002, 26:136-143. 11871738.
88. Wolfe RR, Chinkes DL. Isotope Tracers in Metabolic Research: Principles and Practice of Kinetic Analysis 2004, John Wiley & Sons, Hoboken, New Jersey, USA.
89. Zhang XJ, Chinkes DL, Wolfe RR. Measurement of muscle protein fractional synthesis and breakdown rates from a pulse tracer injection. Am J Physiol Endocrinol Metab 2002, 283:E753-E764. 12217893.
90. Biolo G, Fleming RY, Maggi SP, Wolfe RR. Transmembrane transport and intracellular kinetics of amino acids in human skeletal muscle. Am J Physiology 1995, 268:E75-E84.
91. McClave SA, Kushner R, Van Way CW, Cave M, DeLegge M, Dibaise J, Dickerson R, Drover J, Frazier TH, Fujioka K, Gallagher D, Hurt RT, Kaplan L, Kiraly L, Martindale R, McClain C, Ochoa J. Nutrition therapy of the severely obese, critically ill patient: summation of conclusions and recommendations. JPEN J Parenter Enteral Nutr 2011, 35:88S-96S. 21881019.
92. Kyle UG, Bosaeus I, De Lorenzo AD, Deurenberg P, Elia M, Gómez JM, Heitmann BL, Kent-Smith L, Melchior JC, Pirlich M, Scharfetter H, Schols AM, Pichard C. Bioelectrical impedance analysis - part I: review of principles and methods. Clin Nutr 2004, 23:1226-1243. 15380917.
93. Kyle UG, Bosaeus I, De Lorenzo AD, Deurenberg P, Elia M, Manuel Gómez J, Lilienthal Heitmann B, Kent-Smith L, Melchior JC, Pirlich M, Scharfetter H, MWJ Schols A, Pichard C. Bioelectrical impedance analysis - part II: utilization in clinical practice. Clin Nutr 2004, 23:1430-1453. 15556267.
94. Heymsfield SB, Smith R, Aulet M, Bensen B, Lichtman S, Wang J, Pierson RN. Appendicular skeletal muscle mass: measurement by dual-photon absorptiometry. Am J Clin Nutr 1990, 52:214-218. 2375286.
95. Mourtzakis M, Prado CM, Lieffers JR, Reiman T, McCargar LJ, Baracos VE. A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care. Appl Physiol Nutr Metab 2008, 33:997-1006. 18923576.
96. Tan BH, Birdsell LA, Martin L, Baracos VE, Fearon KC. Sarcopenia in an overweight or obese patient is an adverse prognostic factor in pancreatic cancer. Clin Cancer Res 2009, 15:6973-6979. 19887488.
97. Moisey LL, Mourtzakis M, Cotton BA, Premji T, Heyland DK, Wade CE, Bulger E, Kozar RA. Skeletal muscle predicts ventilator-free days, ICU-free days, and mortality in elderly ICU patients. Crit Care 2013, 17:R206. 24050662.
98. Weijs PJ, Looijaard WG, Dekker IM, Stapel SN, Girbes AR, Oudemans-van Straaten HM, Beishuizen A. Low skeletal muscle area is a risk factor for mortality in mechanically ventilated critically ill patients. Crit Care 2014, 18:R12. 24410863.
99. Campbell IT, Watt T, Withers D, England R, Sukumar S, Keegan MA, Faragher B, Martin DF. Muscle thickness, measured with ultrasound, may be an indicator of lean tissue wasting in multiple organ failure in the presence of edema. Am J Clin Nutr 1995, 62:533-539. 7661114.
100. Braunschweig CA, Sheean PM, Peterson SJ, Perez SG, Freels S, Troy KL, Ajanaku FC, Patel A, Sclamberg JS, Wang Z. Exploitation of diagnostic computed tomography scans to assess the impact of nutritional support on body composition changes in respiratory failure patients. JPEN J Parenter Enteral Nutr 2014, 38:880-885. 23976767.
101. Casaer MP, Wilmer A, Hermans G, Wouters PJ, Mesotten D, Van den Berghe G. Role of disease and macronutrient dose in the randomized controlled EPaNIC trial: a post hoc analysis. Am J Respir Crit Care Med 2013, 187:247-255. 23204255.
102. Herridge MS, Tansey CM, Matté A, Tomlinson G, Diaz-Granados N, Cooper A, Guest CB, Mazer CD, Mehta S, Stewart TE, Kudlow P, Cook D, Slutsky AS, Cheung AM. Functional disability 5 years after acute respiratory distress syndrome. N Engl J Med 2011, 364:1293-1304. 21470008.
103. Herridge MS, Cheung AM, Tansey CM, Matte-Martyn A, Diaz-Granados N, Al-Saidi F, Cooper AB, Guest CB, Mazer CD, Mehta S, Stewart TE, Barr A, Cook D, Slutsky AS. One-year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med 2003, 348:683-693. 12594312.
104. Rosenblatt S, Clowes GH, George BC, Hirsch E, Lindberg B. Exchange of amino acids by muscle and liver in sepsis. Arch Surg 1983, 118:167-175. 6849634.
105. Pearl RH, Clowes GH, Hirsch EF, Loda M, Grindlinger GA, Wolfort S. Prognosis and survival as determined by visceral amino acid clearance in severe trauma. J Trauma 1985, 25:777-783. 4020912.
106. Sakurai Y, Aarsland A, Herndon DN, Chinkes DL, Pierre E, Nguyen TT, Patterson BW, Wolfe RR. Stimulation of muscle protein synthesis by long-term insulin infusion in severely burned patients. Ann Surg 1995, 222:283-294. 294-297, 7677459.
107. Herndon DN, Hart DW, Wolf SE, Chinkes DL, Wolfe RR. Reversal of catabolism by beta-blockade after severe burns. N Engl J Med 2001, 345:1223-1229. 11680441.
108. Ferrando AA, Sheffield-Moore M, Wolf SE, Herndon DN, Wolfe RR. Testosterone administration in severe burns ameliorates muscle catabolism. Crit Care Med 2001, 29:1936-1942. 11588456.
109. Gamrin L, Essen P, Hultman E, McNurlan MA, Garlick PJ, Wernerman J. Protein-sparing effect in skeletal muscle of growth hormone treatment in critically ill patients. Ann Surg 2000, 231:577-586. 10749620.
110. Takala J, Ruokonen E, Webster NR, Nielsen MS, Zandstra DF, Vundelinckx G, Hinds CJ. Increased mortality associated with growth hormone treatment in critically ill adults. N Engl J Med 1999, 341:785-792. 10477776.
111. Kreymann KG, Berger MM, Deutz NE, Hiesmayr M, Jolliet P, Kazandjiev G, Nitenberg G, van den Berghe G, Wernerman J, Ebner C, Hartl W, Heymann C, Spies C. ESPEN guidelines on enteral nutrition: intensive care. Clin Nutr 2006, 25:210-223. 16697087.
112. Singer P, Berger MM, Van den Berghe G, Biolo G, Calder P, Forbes A, Griffiths R, Kreyman G, Leverve X, Pichard C. ESPEN guidelines on parenteral nutrition: intensive care. Clin Nutr 2009, 28:387-400. 19505748.
113. McClave SA, Martindale RG, Vanek VW, McCarthy M, Roberts P, Taylor B, Ochoa JB, Napolitano L, Cresci G. Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.). JPEN J Parenter Enteral Nutr 2009, 33:277-316. 19398613.
114. Larsson J, Lennmarken C, Martensson J, Sandstedt S, Vinnars E. Nitrogen requirements in severely injured patients. Br J Surg 1990, 77:413-416. 2111195.
115. Dickerson RN, Pitts SL, Maish GO, Schroeppel TJ, Magnotti LJ, Croce MA, Minard G, Brown RO. A reappraisal of nitrogen requirements for patients with critical illness and trauma. J Trauma Acute Care Surg 2012, 73:549-557. 23007014.
116. Verbruggen SC, Coss-Bu J, Wu M, Schierbeek H, Joosten KF, Dhar A, van Goudoever JB, Castillo L. Current recommended parenteral protein intakes do not support protein synthesis in critically ill septic, insulin-resistant adolescents with tight glucose control. Crit Care Med 2011, 39:2518-2525. 21765361.
117. Doig GS, Simpson F, Finfer S, Delaney A, Davies AR, Mitchell I, Dobb G. Effect of evidence-based feeding guidelines on mortality of critically ill adults: a cluster randomized controlled trial. JAMA 2008, 300:2731-2741. 19088351.
118. Barr J, Hecht M, Flavin KE, Khorana A, Gould MK. Outcomes in critically ill patients before and after the implementation of an evidence-based nutritional management protocol. Chest 2004, 125:1446-1457. 15078758.
119. Martin CM, Doig GS, Heyland DK, Morrison T, Sibbald WJ. Multicentre, cluster-randomized clinical trial of algorithms for critical-care enteral and parenteral therapy (ACCEPT). CMAJ 2004, 170:197-204. 14734433.
120. van Schijndel RJ S, Weijs PJ, Koopmans RH, Sauerwein HP, Beishuizen A, Girbes AR. Optimal nutrition during the period of mechanical ventilation decreases mortality in critically ill, long-term acute female patients: a prospective observational cohort study. Crit Care 2009, 13:R132.
121. Weijs PJ, Stapel SN, de Groot SD, Driessen RH, de Jong E, Girbes AR, van Schijndel RJ S, Beishuizen A. Optimal protein and energy nutrition decreases mortality in mechanically ventilated, critically ill patients: a prospective observational cohort study. JPEN J Parenter Enteral Nutr 2012, 36:60-68. 22167076.
122. Allingstrup MJ, Esmailzadeh N, Wilkens Knudsen A, Espersen K, Hartvig Jensen T, Wiis J, Perner A, Kondrup J. Provision of protein and energy in relation to measured requirements in intensive care patients. Clin Nutr 2012, 31:462-468. 22209678.
123. Casaer MP, Mesotten D, Hermans G, Wouters PJ, Schetz M, Meyfroidt G, Van Cromphaut S, Ingels C, Meersseman P, Muller J, Vlasselaers D, Debaveye Y, Desmet L, Dubois J, Van Assche A, Vanderheyden S, Wilmer A, Van den Berghe G. Early versus late parenteral nutrition in critically ill adults. N Engl J Med 2011, 365:1-17.
124. Arabi YM, Tamim HM, Dhar GS, Al-Dawood A, Al-Sultan M, Sakkijha MH, Kahoul SH, Brits R. Permissive underfeeding and intensive insulin therapy in critically ill patients: a randomized controlled trial. Am J Clin Nutr 2011, 93:569-577. 21270385.
125. Rice TW, Mogan S, Hays MA, Bernard GR, Jensen GL, Wheeler AP. Randomized trial of initial trophic versus full-energy enteral nutrition in mechanically ventilated patients with acute respiratory failure. Crit Care Med 2011, 39:967-974. 21242788.
126. Singer P, Anbar R, Cohen J, Shapiro H, Shalita-Chesner M, Lev S, Grozovski E, Theilla M, Frishman S, Madar Z. The tight calorie control study (TICACOS): a prospective, randomized, controlled pilot study of nutritional support in critically ill patients. Intensive Care Med 2011, 37:601-609. 21340655.
127. Heart N, Rice TW, Wheeler AP, Thompson BT, Steingrub J, Hite RD, Moss M, Morris A, Dong N, Rock P. Initial trophic vs full enteral feeding in patients with acute lung injury: the EDEN randomized trial. JAMA 2012, 307:795-803.
128. Heidegger CP, Berger MM, Graf S, Zingg W, Darmon P, Costanza MC, Thibault R, Pichard C. Optimisation of energy provision with supplemental parenteral nutrition in critically ill patients: a randomised controlled clinical trial. Lancet 2013, 381:385-393. 23218813.
129. Doig GS, Simpson F, Sweetman EA, Finfer SR, Cooper DJ, Heighes PT, Davies AR, O'Leary M, Solano T, Peake S. Early parenteral nutrition in critically ill patients with short-term relative contraindications to early enteral nutrition: a randomized controlled trial. JAMA 2013, 309:2130-2138. 23689848.
130. Weijs PJ, Wischmeyer PE. Optimizing energy and protein balance in the ICU. Curr Opin Clin Nutr Metab Care 2013, 16:194-201. 23334173.
131. Vanhorebeek I, Gunst J, Derde S, Derese I, Boussemaere M, Güiza F, Martinet W, Timmermans JP, D'Hoore A, Wouters PJ, Van den Berghe G. Insufficient activation of autophagy allows cellular damage to accumulate in critically ill patients. J Clin Endocrinol Metab 2011, 96:E633-E645. 21270330.
132. Heyland DK, MacDonald S, Keefe L, Drover JW. Total parenteral nutrition in the critically ill patient: a meta-analysis. JAMA 1998, 280:2013-2019. 9863853.
133. Doig GS, Heighes PT, Simpson F, Sweetman EA. Early enteral nutrition reduces mortality in trauma patients requiring intensive care: a meta-analysis of randomised controlled trials. Injury 2011, 42:50-56. 20619408.
134. Rooyakers O, Koucheck-Zadeh R, Tjader I, Norberg A, Klaude M, Wernerman J. Whole body protein turnover in mechanically ventilated ICU patients. Intensive Care Med 2012, 38:S130.
135. van Schijndel RJM S, Weijs PJM, Sauerwein HP, de Grootb SDW, Beishuizena A, Girbesa ARJ. An algorithm for balanced protein/energy provision in critically ill mechanically ventilated patients. e-SPEN J 2007, 2:69-74.
136. van Schijndel RJ, de Groot SD, Driessen RH, Ligthart-Melis G, Girbes AR, Beishuizen A, Weijs PJ. Computer-aided support improves early and adequate delivery of nutrients in the ICU. Neth J Med 2009, 67:388-393. 20009115.