Insulin therapy in burn patients does not contribute to hepatic triglyceride production

Journal of Clinical Investigation

Volumn 101, Issue 10, 1998, Pages 2233-2239

  Aarsland, Asle ^b   Chinkes, David L ^a   Sakurai, Yoichi ^a   Nguyen, Thuan T ^a   Herndon, David N ^a   Wolfe, Robert R ^a,b  

^a SHRINERS HOSPITALS FOR CHILDREN   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Carbohydrate; Fat synthesis; Lipogenesis; Lipolysis; Liver

Indexed keywords

CARBOHYDRATE; FATTY ACID; GLUCAGON; GLUCOSE; ISOPHANE INSULIN; LACTIC ACID; LINOLEIC ACID; LIPID; OLEIC ACID; PALMITIC ACID; PROTEIN; STEARIC ACID; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ADOLESCENT; ADULT; ARTICLE; BODY WEIGHT; BURN; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; FATTY ACID SYNTHESIS; FEMALE; GLUCAGON BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN TREATMENT; INTRAVENOUS DRUG ADMINISTRATION; LACTATE BLOOD LEVEL; LIPID BLOOD LEVEL; LIPID METABOLISM; LIPID STORAGE; LIPOGENESIS; LIPOLYSIS; LIPOPROTEIN BLOOD LEVEL; MALE; PRIORITY JOURNAL; PROTEIN METABOLISM; RANDOMIZED CONTROLLED TRIAL; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0032524027     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200     Document Type: Article

References (32)

1. Wolfe, R.R. 1996. Herman Award Lecture, 1996: relation of metabolic studies to clinical nutrition - the example of burn injury. Am. J. Clin. Nutr. 64: 800-808.
2. Aarsland, A., D. Chinkes, R.R. Wolfe, R.E. Barrow, S.O. Nelson, E. Pierre, and D.H. Herndon. 1996. Beta-blockade lowers peripheral lipolysis in burn patients receiving growth hormone. Rate of hepatic very low density lipoprotein triglyceride secretion remains unchanged. Ann. Surg. 223:777-789.
3. Herndon, D.H., M.D. Stein, T.C. Rutan, S. Abston, and H. Linares. 1987. Failure of TPN supplementation to improve liver function, immunity, and mortality in thermally injured patients. J. Trauma. 27:195-204.
4. Talaat, S.M., G.E. Beheri, M.S. Zaki, and N. El-Bolkainy. 1973. Prevention of early histopathological changes in the liver in extensive burns. Br. J. Plast. Surg. 26:132-139.
5. Wolfe, W.A., J.R. Elkinton, and J.E. Rhoads. 1940. Liver damage and dextrose tolerance in severe burns. Ann. Surg. 112:158-160.
6. James, G.W., O. Purnell, and E.I. Evans. 1951. The anemia of the thermal injury: II. Studies of liver function. J. Clin. Invest. 30:191-199.
7. Burke, J.F., R.R. Wolfe, C.J. Mullany, D.E. Mathews, and D.M. Bier. 1979. Glucose requirements following burn injury. Parameters of optimal glucose infusion and possible hepatic and respiratory abnormalities following excessive glucose intake. Ann. Surg. 190:274-285.
8. Wilmore, D.W., J.A. Moylan, Jr., B.F. Bristow, A.D. Mason, Jr., and B.A. Pruitt. 1974. Anabolic effects of human growth hormone and high caloric feedings following thermal injury. Surg. Gynecol. Obstet. 133:875-884.
9. Revhaug, A. and M. Mjaaland. 1993. Growth hormone and surgery. Horm. Res. 40:99-101.
10. Sakurai, Y., A. Aarsland, D.N. Herndon, D.L. Chinkes, E. Pierre, T.T. Nguyen, B.W. Patterson, and R.R. Wolfe. 1995. Stimulation of muscle protein synthesis by long-term insulin infusion in severely burned patients. Ann. Surg. 222:283-297.
11. Chascione, C., D.H. Elwyn, M. Davila, K.M. Gil, J. Askanazi, and J.M. Kinney. 1987. Effect of carbohydrate intake on de novo lipogenesis in human adipose tissue. Am. J. Physiol. 253:E664-E669.
12. Guenst, J.M., and L.D. Nelson. 1994. Predictors of total parenteral nutrition-induced lipogenesis. Chest. 105:553-559.
13. Hill, J.O., and A.M. Prentice. 1995. Sugar and body weight regulation. Am. J. Clin. Nutr. 62(Suppl.):S264-S274.
14. Aarsland, A., D. Chinkes, and R.R. Wolfe. 1997. Hepatic and whole-body fat synthesis in humans during carbohydrate overfeeding. Am. J. Clin. Nutr. 65:1774-1782.
15. Coppack, S.W., M.D. Jensen, and J.M. Miles. 1994. In vivo regulation of lipolysis in humans. J. Lipid Res. 35:177-193.
16. Woodside, W.F., and M. Heimberg. 1976. Effects of anti-insulin serum, insulin, and glucose on output of triglycerides and ketogenesis by the perfused rat liver. J. Biol. Chem. 251:13-23.
17. Fukuda, N., and J.A. Ontko. 1984. Interactions between fatty acid synthesis, oxidation, and esterification in the production of triglyceride-rich lipoproteins by the liver. J. Lipid Res. 25:831-842.
18. Aarsland, A., D. Chinkes, and R.R. Wolfe. 1996. Contributions of de novo synthesis of fatty acids to total VLDL-triglyceride secretion during prolonged hyperglycemia/hyperinsulinemia in normal man. J. Clin. Invest. 98:2008-2017.
19. Lewis, G.F., K.D. Uffelman, L. Szeto, B. Weller, and G. Steiner. 1995. Interaction between free fatty acids and insulin in the acute control of very low density lipoprotein production in humans. J. Clin. Invest. 95:158-166.
20. Gibbons, G.F. 1989. Insulin, diabetes and hepatic very-low-density lipoprotein metabolism. Biochem. Soc. Trans. 17:49-51.
21. Grundy, S.M., H.Y.I. Mok, L. Zech, and D. Steinberg. 1979. Transport of very low density lipoprolein triglycerides in varying degrees of obesity and hypertriglyceridemia. J. Clin. Invest. 63:1274-1283.
22. McGowman, M.W., J.D. Artiss, D.R. Strandbergh, and B. Zak. 1983. A peroxidase-coupled method for the colorimetric determination of serum triglycerides. Clin. Chem. 29:538-542.
23. Wolfe, R.R. 1992. Radioactive and Stable Isotope Tracers in Biomedicine: Principles and Practice of Kinetic Analysis. Wiley-Liss, New York. 317-340.
24. Armitage, P., and G. Berry. 1994. Statistical Methods in Medical Research. Blackwell Scientific Publications, Oxford. 112-120.
25. Hellerstein, M.K., C. Kletke, S. Kaempfer, K. Wu, and C.H. Shackleton. 1991. Use of mass isotopomer distributions in secreted lipids to sample lipogenic acetyl-CoA pool in vivo in humans. Am. J. Physiol. 261:E479-E486.
26. Hellerstein, M.K., and R.K. Neese. 1992. Mass isotopomer distribution analysis: a technique for measuring biosynthesis and turnover of polymers. Am. J. Physiol. 263:E988-E1001.
27. Chinkes, D., A. Aarsland, J. Rosenblatt, and R.R. Wolfe. 1996. A comparison of mass isotopomer dilution methods used to compute production of VLDL fatty acids in vivo in human subjects. Am. J. Physiol. 271:E373-E383.
28. Glickman, R.M., and S.M. Sabesin. 1994. Lipoprotein metabolism. In The Liver, Biology and Pathobiology. I.M. Arias, J.L. Boyer, N. Fausto, W.B. Jakoby, D. Schachter, and D.A. Shafritz, editors. Raven Press, New York. 391-414.
29. Ferrannini, E. 1988. The theoretical bases of indirect calorimetry: a review. Metabolism. 37:287-301.
30. DeFronzo, R.A. 1988. The triumvirate: b-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes. 37:667-687.
31. Newton, R.S., and R.A. Freedland. 1980. The effects of specific lipogenic substrates and metabolic inhibitors on de novo fatty acid synthesis in isolated hepatocytes from chow-fed female rats. Arch. Biochem. Biophys. 204: 379-386.
32. Wolfe, B.M., S. Klein, E.J. Peters, B.F. Schmidt, and R.R. Wolfe. 1988. Effect of elevated free fatty acids on glucose oxidation in normal humans. Metabolism. 37:323-329.