I(f) current channel inhibitor (ivabradine) deserves cardioprotective effect via down-regulating the expression of matrix metalloproteinase (MMP)-2 and attenuating apoptosis in diabetic mice

BMC Cardiovascular Disorders

Volumn 14, Issue 1, 2014, Pages

  Chen, Shao Liang ^a   Hu, Zuo Ying ^b   Zuo, Guang Feng ^a   Li, Ming Hui ^c   Li, Bin ^c  

^a NANJING MEDICAL UNIVERSITY   (China)

^b Nanjing Heart Center   (China)

^c NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Diabetes; Gene; Immunohistochemistry; Microarray; Signal pathway

Indexed keywords

CASPASE 3; GELATINASE A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IVABRADINE; PROTEIN BAX; BAX PROTEIN, MOUSE; BENZAZEPINE DERIVATIVE; CARDIOTONIC AGENT; CASP3 PROTEIN, MOUSE; MMP2 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DIABETIC PATIENT; DOWN REGULATION; ECHOCARDIOGRAPHY; GENE EXPRESSION; HEART FUNCTION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART PROTECTION; IMMUNOHISTOCHEMISTRY; MALE; MICROARRAY ANALYSIS; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SCORING SYSTEM; TRANSTHORACIC ECHOCARDIOGRAPHY; WESTERN BLOTTING; ANIMAL; CELL CULTURE; CONVALESCENCE; DIABETES MELLITUS; DIABETIC CARDIOMYOPATHIES; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; GENETICS; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CELL; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BENZAZEPINES; CARDIOTONIC AGENTS; CASPASE 3; CELLS, CULTURED; DIABETES MELLITUS; DIABETIC CARDIOMYOPATHIES; DISEASE MODELS, ANIMAL; DOWN-REGULATION; MALE; MATRIX METALLOPROTEINASE 2; MICE; MYOCYTES, CARDIAC; NF-KAPPA B; PHOSPHORYLATION; RECOVERY OF FUNCTION; SIGNAL TRANSDUCTION; VENTRICULAR FUNCTION, LEFT;

EID: 84920808610     PISSN: None     EISSN: 14712261     Source Type: Journal    
DOI: 10.1186/1471-2261-14-150     Document Type: Article

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