Heart rate reduction by ivabradine reduces oxidative stress, improves endothelial function, and prevents atherosclerosis in apolipoprotein E-deficient mice

Circulation

Volumn 117, Issue 18, 2008, Pages 2377-2387

  Custodis, Florian ^a   Baumhäkel, Magnus ^a   Schlimmer, Nils ^a   List, Franka ^a   Gensch, Christoph ^a   Böhm, Michael ^a   Laufs, Ulrich ^a,b  

^a SAARLAND UNIVERSITY   (Germany)

^b Klinik fur Innere Medizin III   (Germany)

Author keywords

Atherosclerosis; Endothelium; Heart rate; Pharmacology; Tachycardia

Indexed keywords

APOLIPOPROTEIN E; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HYDRALAZINE; INTERCELLULAR ADHESION MOLECULE 1; IVABRADINE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; N(G) NITROARGININE METHYL ESTER; PROTEIN KINASE B; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; AORTA ROOT; AORTA WALL; ARTICLE; ASCENDING AORTA; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BLOOD PRESSURE; CHOLESTEROL DIET; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; HEART RATE; LIPID BLOOD LEVEL; LIPID PEROXIDATION; MALE; MONOTHERAPY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; VASCULAR ENDOTHELIUM; VASCULAR RING; VASODILATATION;

ANIMALS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; BENZAZEPINES; CELLS, CULTURED; CHOLESTEROL, DIETARY; ENDOTHELIUM, VASCULAR; HEART RATE; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; OXIDATIVE STRESS; TACHYCARDIA;

EID: 43249091146     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.107.746537     Document Type: Article

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