CCL19-induced chemokine receptor 7 activates the phosphoinositide-3 kinase-mediated invasive pathway through Cdc42 in metastatic squamous cell carcinoma of the head and neck

Oncology Reports

Volumn 25, Issue 3, 2011, Pages 729-737

  Zhao, Zhen Jin ^a   Liu, Fa Yu ^a   Li, Peng ^a   Ding, Xue ^a   Zong, Zhi Hong ^a   Sun, Chang Fu ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Actin cytoskeleton; Cdc42; Chemokine receptor 7; Invasion; Migration; Phosphoinositide 3 kinase; Signal transduction; Squamous cell carcinoma of head and neck

Indexed keywords

CHEMOKINE RECEPTOR CCR7; F ACTIN; GUANOSINE TRIPHOSPHATASE; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN CDC42; RAC PROTEIN; SMALL INTERFERING RNA;

ADULT; ARTICLE; CANCER INVASION; CELL ADHESION; CELL MIGRATION; CELL SURVIVAL; CELLULAR DISTRIBUTION; ENZYME ACTIVITY; FEMALE; HEAD AND NECK CARCINOMA; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; METASTASIS; PRIORITY JOURNAL; PROTEIN FUNCTION; SQUAMOUS CELL CARCINOMA; WESTERN BLOTTING;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA; CDC42 GTP-BINDING PROTEIN; CELL MOVEMENT; CHEMOKINE CCL19; DRUG EVALUATION, PRECLINICAL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEAD AND NECK NEOPLASMS; HUMANS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASMS, SQUAMOUS CELL; PHOSPHATIDYLINOSITOL 3-KINASES; RECEPTORS, CCR7; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 79551609975     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2010.1109     Document Type: Article

References (27)

1. Greenlee RT, Hill-Harmon MB, Murray T and Thun M: Cancer Statistics, 2001. CA Cancer J Clin 51: 15-36, 2001.
2. Eccles SA: Targeting key steps in metastatic tumour progression. Curr Opin Genet Dev 15: 77-86, 2005.
3. Zlotnik A and Yoshie O: Chemokines: a new classification system and their role in immunity. Immunity 12: 121-127, 2000.
4. Zlotnik A: Chemokines in neoplastic progression. Semin Cancer Biol 14: 181-185, 2004.
5. Wang J, Xi L, Hunt JL, et al: Expression pattern of chemokine receptor 6 (CCR6) and CCR7 in squamous cell carcinoma of the head and neck identifies a novel metastatic phenotype. Cancer Res 64: 1861-1866, 2004.
6. Wang J, Zhang X, Thomas SM, et al: Chemokine receptor 7 activates phosphoinositide-3 kinase-mediated invasive and prosurvival pathways in head and neck cancer cells independent of EGFR. Oncogene 24: 5897-5904, 2005.
7. Wang J, Seethala RR, Zhang Q, et al: Autocrine and paracrine chemokine receptor 7 activation in head and neck cancer: implications for therapy. J Nat Cancer Inst 100: 502-512, 2008.
8. Liu F, Zhao Z, Li P, Ding X, Zong Z and Sun C: Mammalian target of rapamycin (mTOR) is involved in the survival of cells mediated by chemokine receptor 7 through PI3K/Akt in metastatic squamous cell carcinoma of the head and neck. Br J Oral Maxillofac Surg 48: 291-296, 2010.
9. Zhao Z, Liu F and Sun C: Effect of chemokine reportor 7 small interfering RNA on proliferation and invation of squamous cell carcinoma of head and neck. Zhonghua Kou Qiang Yi Xue Za Zhi 44: 5-10, 2009.
10. Janetopoulos C, Ma L, Devreotes PN and Iglesias PA: Chemoattractant- induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton. Proc Natl Acad Sci USA 101: 8951-8956, 2004.
11. Xu J, Wang F, Keymeulen AV, et al: Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils. Cell 114: 201-214, 2003.
12. Hall A: Rho GTPases and the actin cytoskeleton. Science 279: 509-514, 1998.
13. Yanagawa Y and Onoé K: CCL19 induces rapid dendritic extension of murine dendritic cells. Blood 100: 1948-1956, 2002.
14. Etienne-Manneville S and Hall A: Rho GTPases in cell biology. Nature 420: 629-635, 2002.
15. Yanagawa Y and Onoé K: CCR7 ligands induce rapid endocytosis in mature dendritic cells with concomitant up-regulation of Cdc42 and Rac activities. Blood 101: 4923-4929, 2003.
16. Ueda H, Morishita R, Yamauchi J, Itoh H, Kato K and Asano T: Regulation of Rac and Cdc42 pathways by Gi during lysophosphatidic acid-induced cell spreading. J Biol Chem 276: 6846-6852, 2001.
17. Del Pozo MA, Price LS, Alderson NB, Ren XD and Schwartz MA: Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK. EMBO J 19: 2008-2014, 2000.
18. Buchsbaum RJ: Rho activation at a glance. J Cell Sci 120: 1149-1152, 2007.
19. Muller A, Homey B, Soto H, et al: Involvement of chemokine receptors in breast cancer metastasis. Nature 410: 50-56, 2001.
20. Evers EE, Zondag GC, Malliri A, et al: Rho family proteins in cell adhesion and cell migration. Eur J Cancer 36: 1269-1274, 2000.
21. Ridley AJ: Rho GTPases and cell migration. J Cell Sci 114: 2713-2722, 2001.
22. Wennerberg K and Der CJ: Rho-family GTPases: it's not only Rac and Rho (and I like it). J Cell Sci 117: 1301-1312, 2004.
23. Nikolic DL, Boettiger AN, Bar-Sagi D, Carbeck JD and Shvartsman SY: Role of boundary conditions in an experimental model of epithelial wound healing. Am J Physiol Cell Physiol 291: C68-C75, 2006.
24. Keese CR, Wegener J, Walker SR and Giaever I: Electrical wound-healing assay for cells in vitro. Proc Natl Acad Sci USA 101: 1554-1559, 2004.
25. Mackay DJG and Hall A: Rho GTPases. J Biol Chem 273: 20685-20688, 1998.
26. Hirsch DS, Shen Y and Wu WJ: Growth and motility inhibition of breast cancer cells by epidermal growth factor receptor degradation is correlated with inactivation of Cdc42. Cancer Res 66: 3523-3530, 2006.
27. Schwartz M: Rho signalling at a glance. J Cell Sci 117: 5457-5458, 2004.