Changes of Bcl-2, Bax and Caspase-3 expression in the dermal microvascular endothelial cells and the epidermal layers of the eschar (tache noire) in patients with Mediterranean spotted fever

Folia Histochemica et Cytobiologica

Volumn 51, Issue 2, 2013, Pages 121-126

  Baltadzhiev, Ivan ^a   Delchev, Slavi ^a  

^a MEDICAL UNIVERSITY OF PLOVDIV   (Bulgaria)

Author keywords

Apoptosis; Bax; Bcl 2; Caspase 3; Endothelial cells; Eschar; Immunohistochemistry; Mediterranean spotted fever; Rickettsia conorii

Indexed keywords

CASPASE 3; PROTEIN BAX; PROTEIN BCL 2;

ADULT; AGED; ANTIBODY RESPONSE; ANTIGEN SPECIFICITY; APOPTOSIS; ARTICLE; BOUTONNEUSE FEVER; CLINICAL ARTICLE; CONTROLLED STUDY; ESCHAR; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MICROVASCULAR ENDOTHELIAL CELL; PAPULE; PROTEIN EXPRESSION; PUNCH BIOPSY; RICKETTSIA CONORII; SKIN; UPREGULATION;

RICKETTSIA CONORII;

EID: 84881047536     PISSN: 02398508     EISSN: 18975631     Source Type: Journal    
DOI: 10.5603/FHC.2013.0019     Document Type: Article

References (29)

1. Alexandrov E, Kazar J, Hechemy K, Kantardjiev T, eds. Contemporary state of the rickettsioses in the world and in Bulgaria. Sofia: Prof. Marin Drinov Acad. Publish. House; 2007.
2. Popivanova N, Baltadzhiev 1, Zaprianov Z. Mediterranean spotted fever in the Plovdiv region of Bulgaria. In: Alexandrov E, Kazar J, Hechemy K, Kantardjiev T, eds. Contemporary state of the rickettsioses in the world and in Bulgaria. Sofia: Prof. Marin Drinov Acad. Publish. House; 2007:116-130.
3. Walker DH, Ismail N. Emerging and re-emerging rickettsioses: endothelial cell infection and early disease events. Nat Rev Microbiol. 2008;6:375-386.
4. Sahni S, Rydkina E. Host-cell interactions with pathogenic Rickettsia species. Future Microbiol. 2009;4:323-339.
5. Walker DH. Rickettsiae and rickettsial infections: the current state of knowledge. Clin Infect Dis. 2007;45 (Suppl. 1):S39-44.
6. Mansueto P, Vitale G, Cascio A et al. New insight into immunity and immunopathology of Rickettsial diseases. Clin Dev Immunol. 2012;2012:967852.
7. Faherty C., Maureli A. Staying alive: bacterial inhibition of apoptosis during infection. Trends Microbiol. 2008;16:173-180.
8. Bortner CD, Cidlowski JA. Cellular mechanisms for the repression of apoptosis. Annu Rev Pharmacol Toxicol. 2002;42:259-281.
9. Walker DH, Valbuena GA, Olano JP. Pathogenic mechanisms of diseases caused by Rickettsia. Ann N Y Acad Sci. 2003;990:1-11.
10. Joshi SG, Francis CW, Silvermann DJ, Sahni SK. NF-kB activation suppresses host cell apoptosis during Rickettsia rickettsii infection via regulatory effects on intracellular localization or levels of apoptogenic and anti-apoptotic proteins. EMS Microbiol Lett. 2004;234:333-341.
11. Bechelli JB, Rydkina E, Colonne PM, Sahni SK. Rickettsia rickettsii infection protects human microvascular endothelial cells against staurosporine-induced apoptosis by a cIAP2-independent mechanisms. J Infect Dis. 2009;199:1389-1398.
12. Radulovic S, Price PW, Beier MS, Gaywee J, Macaluso JA, Azad A. Rickettsia-macrophage interactions: host cell responses to Rickettsia akari and Rickettsia typhi. Infect Immun. 2002;70:2576-2582.
13. Clifton DR, Goss RA, Sahni SK et al. NF-kB-dependent inhibition of apoptosis is essential for host cell survival during Rickettsia rickettsii infection. Proc Natl Acad Sci USA 1998;95:4646-4651.
14. Hsia JY, Chen CY, Hsu CP, et al. Expression of apoptosis-regulating proteins p53, Bcl-2, and Bax in primary resected esophageal squamous cell carcinoma. Neoplasma. 2001;48:483-488.
15. de Haas ER, de Bruijn HS, Sterenborg HJ, Neumann HA, Robinson DJ. Apoptosis markers in ALA-PDT treated superficial basal cell carcinomas using a single and a two fold illumination scheme. In: Ellen RM de Haas: ALA-PDT; the treatment of non melanoma skin-cancer re-illuminated. Thesis: Erasmus University, Rotterdam 2007:89-107.
16. Vassilev V, Baltadjiev G, Baltadjiev A. Human Anatomy. Plovdiv: IK-VAP Publish. House; 2009.
17. Gross A, McDonnell JM, Korsmeyer SJ. BCL-2 family members and the mitochondria in apoptosis. Genes Dev. 1999;13:1899-1911.
18. Harris MH, Thompson CB. The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability. Cell Death Differ. 2000;7:1182-1191.
19. Kroemer G. The mitochondrion as an integrator/coordinator of cell death pathways. Cell Death Differ.1998;5:547.
20. Scorrano L, Korsmeyer SJ. Mechanisms of cytochrome c release by proapoptotic Bcl-2 family members. Biochem Biophys Res Commun, 2003;304:437-444.
21. Smaili SS, Hsu YT, Carvalho AC, Rosenstock TR, Sharpe JC, Youle RJ. Mitochondria, calcium and pro-apoptotic proteins as mediators in cell death signaling. Braz J Med Biol Res. 2003;36:183-190.
22. Joshi SG, Francis CW, Silverman DJ, Sahni SK. Nuclear factor kappa B protects against host cell apoptosis during Rickettsia rickettsii infection by inhibiting activation of apical and effector caspases and maintaining mitochondrial integrity. Infect Immun. 2003;71:4127-4136.
23. Clifton DR, Rydkina E. Freeman RS, Sahni SK. NF-kB activation during Rickettsia rickettsii infection of endothelial cells involves the activation of catalytic IkB kinases IKKa and IKKb and phosphorilation-proteolysis of the inhibitor protein IkBa. Infect Immun. 2005;73:155-165.
24. Clifton DR, Rydkina E, Huyck H, et al. Expression and secretion of chemotactic cytokines IL-8 and MCP-1 by human endothelial cells after R. rickettsii infection: regulation by nuclear transcription factor NF-kB. Int J Med Microbiol 2005;295:267-278.
25. Walker DH, Olano JP, Feng HM. Critical role of cytotoxic T lymphocytes in immune clearance of rickettsial infection. Infect Immun. 2001;69:1841-1846.
26. Chiu SM, Xue LY, Usuda J, Azizuddin K, Oleinick NL. Bax is essential for mitochondrion-mediated apoptosis but not for cell death caused by photodynamic therapy. Br J Cancer. 2003;89:1590-1597.
27. Finucane DM, Bossy-Wetzel E, Waterhouse NJ, Cotter TG, Green DR. Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL. J Biol Chem. 1999;274:2225-2233.
28. Mazumder S, Plesca D, Almasan A. Caspase-3 activation is a critical determinant of genotoxic stress-induced apoptosis. Methods Mol Biol. 2007;414:13-22.
29. Riedl SJ, Shi Y. Molecular mechanisms of caspase regulation during apoptosis. Nat Rev Mol Cell Biol. 2004;5:897-907.