Unfolded protein response-induced ERdj3 secretion links ER stress to extracellular proteostasis

EMBO Journal

Volumn 34, Issue 1, 2015, Pages 4-19

  Genereux, Joseph C ^a   Qu, Song ^a   Zhou, Minghai ^b   Ryno, Lisa M ^a   Wang, Shiyu ^c   Shoulders, Matthew D ^a,d   Kaufman, Randal J ^c   Lasmézas, Corinne I ^b   Kelly, Jeffery W ^a   Wiseman, R Luke ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c BURNHAM INSTITUTE   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

ER stress; ERdj3; extracellular proteostasis; molecular chaperones; unfolded protein response

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; ERDJ3 PROTEIN; HEAT SHOCK PROTEIN 40; MUTANT PROTEIN; PRION PROTEIN; PROTEIN; RIBONUCLEASE A; UNCLASSIFIED DRUG; DNAJB11 PROTEIN, HUMAN; PRION; PROTEIN AGGREGATE;

ARTICLE; CELL VIABILITY; CHO CELL LINE; CIRCULAR DICHROISM; COMPLEX FORMATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; EXTRACELLULAR PROTEOSTASIS; EXTRACELLULAR SPACE; FEMALE; HEK293 CELL LINE; HELA CELL LINE; HEPG2 CELL LINE; HUMAN; HUMAN CELL; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN HOMEOSTASIS; PROTEIN LOCALIZATION; PROTEIN SECRETION; PROTEIN SYNTHESIS; SECRETORY PATHWAY; UNFOLDED PROTEIN RESPONSE; UPREGULATION; ANIMAL; CRICETULUS; GENETICS; HAMSTER; HEP-G2 CELL LINE; METABOLISM; PATHOLOGY; PRION; PROTEINOSIS; SECRETION (PROCESS);

METAZOA;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; ENDOPLASMIC RETICULUM STRESS; HELA CELLS; HEP G2 CELLS; HSP40 HEAT-SHOCK PROTEINS; HUMANS; PRIONS; PROTEIN AGGREGATES; PROTEIN AGGREGATION, PATHOLOGICAL; UNFOLDED PROTEIN RESPONSE;

EID: 84920480039     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201488896     Document Type: Article

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