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Volumn 36, Issue 1, 2015, Pages 37-43

FXR and liver carcinogenesis

Author keywords

bile acid; carcinogenesis; FXR; inflammation; liver cancer; liver regeneration; nonalcoholic fatty liver disease

Indexed keywords

ACID; BILE ACID; FARNESOID X RECEPTOR; GLUCOSE; LIPID; CELL RECEPTOR;

EID: 84920409241     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2014.117     Document Type: Review
Times cited : (66)

References (92)
  • 1
    • 0028836714 scopus 로고
    • Isolation of proteins that interact specifically with the retinoid X receptor: Two novel orphan receptors
    • Seol W, Choi HS, Moore DD. Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors. Mol Endocrinol 1995; 9: 72-85.
    • (1995) Mol Endocrinol , vol.9 , pp. 72-85
    • Seol, W.1    Choi, H.S.2    Moore, D.D.3
  • 2
    • 0029046931 scopus 로고
    • Identification of a nuclear receptor that is activated by farnesol metabolites
    • Forman BM, Goode E, Chen J, Oro AE, Bradley DJ, Perlmann T, et al. Identification of a nuclear receptor that is activated by farnesol metabolites. Cell 1995; 81: 687-93.
    • (1995) Cell , vol.81 , pp. 687-693
    • Forman, B.M.1    Goode, E.2    Chen, J.3    Oro, A.E.4    Bradley, D.J.5    Perlmann, T.6
  • 5
    • 0033026760 scopus 로고    scopus 로고
    • Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
    • Wang H, Chen J, Hollister K, Sowers LC, Forman BM. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol Cell 1999; 3: 543-53.
    • (1999) Mol Cell , vol.3 , pp. 543-553
    • Wang, H.1    Chen, J.2    Hollister, K.3    Sowers, L.C.4    Forman, B.M.5
  • 6
    • 0033637121 scopus 로고    scopus 로고
    • A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
    • Goodwin B, Jones SA, Price RR, Watson MA, McKee DD, Moore LB, et al. A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol Cell 2000; 6: 517-26.
    • (2000) Mol Cell , vol.6 , pp. 517-526
    • Goodwin, B.1    Jones, S.A.2    Price, R.R.3    Watson, M.A.4    McKee, D.D.5    Moore, L.B.6
  • 7
    • 27844546989 scopus 로고    scopus 로고
    • Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
    • Inagaki T, Choi M, Moschetta A, Peng L, Cummins CL, McDonald JG, et al. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab 2005; 2: 217-25.
    • (2005) Cell Metab , vol.2 , pp. 217-225
    • Inagaki, T.1    Choi, M.2    Moschetta, A.3    Peng, L.4    Cummins, C.L.5    McDonald, J.G.6
  • 8
    • 26244441014 scopus 로고    scopus 로고
    • The Farnesoid X receptor: A molecular link between bile acid and lipid and glucose metabolism
    • Claudel T, Staels B, Kuipers F. The Farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism. Arterioscler Thromb Vasc Biol 2005; 25: 2020-30.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 2020-2030
    • Claudel, T.1    Staels, B.2    Kuipers, F.3
  • 9
    • 33645821043 scopus 로고    scopus 로고
    • Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration
    • Huang W, Ma K, Zhang J, Qatanani M, Cuvillier J, Liu J, et al. Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration. Science 2006; 312: 233-6.
    • (2006) Science , vol.312 , pp. 233-236
    • Huang, W.1    Ma, K.2    Zhang, J.3    Qatanani, M.4    Cuvillier, J.5    Liu, J.6
  • 10
    • 78649759794 scopus 로고    scopus 로고
    • Inhibition of endothelin-1-mediated contraction of hepatic stellate cells by FXR ligand
    • Li J, Kuruba R, Wilson A, Gao X, Zhang Y, Li S. Inhibition of endothelin-1-mediated contraction of hepatic stellate cells by FXR ligand. PLoS One 2010; 5: e13955.
    • (2010) PLoS One , vol.5 , pp. e13955
    • Li, J.1    Kuruba, R.2    Wilson, A.3    Gao, X.4    Zhang, Y.5    Li, S.6
  • 11
    • 7644244675 scopus 로고    scopus 로고
    • The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis
    • Fiorucci S, Antonelli E, Rizzo G, Renga B, Mencarelli A, Riccardi L, et al. The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis. Gastroenterology 2004; 127: 1497-512.
    • (2004) Gastroenterology , vol.127 , pp. 1497-1512
    • Fiorucci, S.1    Antonelli, E.2    Rizzo, G.3    Renga, B.4    Mencarelli, A.5    Riccardi, L.6
  • 12
    • 0346690402 scopus 로고    scopus 로고
    • Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra-and extrahepatic cholestasis
    • Liu Y, Binz J, Numerick MJ, Dennis S, Luo G, Desai B, et al. Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra-and extrahepatic cholestasis. J Clin Invest 2003; 112: 1678-87.
    • (2003) J Clin Invest , vol.112 , pp. 1678-1687
    • Liu, Y.1    Binz, J.2    Numerick, M.J.3    Dennis, S.4    Luo, G.5    Desai, B.6
  • 13
    • 56149085041 scopus 로고    scopus 로고
    • Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response
    • Wang YD, Chen WD, Wang M, Yu D, Forman BM, Huang W. Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response. Hepatology 2008; 48: 1632-43.
    • (2008) Hepatology , vol.48 , pp. 1632-1643
    • Wang, Y.D.1    Chen, W.D.2    Wang, M.3    Yu, D.4    Forman, B.M.5    Huang, W.6
  • 15
    • 77149159568 scopus 로고    scopus 로고
    • The bile acid receptor FXR is a modulator of intestinal innate immunity
    • Vavassori P, Mencarelli A, Renga B, Distrutti E, Fiorucci S. The bile acid receptor FXR is a modulator of intestinal innate immunity. J Immunol 2009; 183: 6251-61.
    • (2009) J Immunol , vol.183 , pp. 6251-6261
    • Vavassori, P.1    Mencarelli, A.2    Renga, B.3    Distrutti, E.4    Fiorucci, S.5
  • 16
    • 77952674868 scopus 로고    scopus 로고
    • The bile acid sensor farnesoid X receptor is a modulator of liver immunity in a rodent model of acute hepatitis
    • Mencarelli A, Renga B, Migliorati M, Cipriani S, Distrutti E, Santucci L, et al. The bile acid sensor farnesoid X receptor is a modulator of liver immunity in a rodent model of acute hepatitis. J Immunol 2009; 183: 6657-66.
    • (2009) J Immunol , vol.183 , pp. 6657-6666
    • Mencarelli, A.1    Renga, B.2    Migliorati, M.3    Cipriani, S.4    Distrutti, E.5    Santucci, L.6
  • 17
    • 77954837070 scopus 로고    scopus 로고
    • FXR regulates liver repair after CCl4-induced toxic injury
    • Meng Z, Wang Y, Wang L, Jin W, Liu N, Pan H, et al. FXR regulates liver repair after CCl4-induced toxic injury. Mol Endocrinol 2010; 24: 886-97.
    • (2010) Mol Endocrinol , vol.24 , pp. 886-897
    • Meng, Z.1    Wang, Y.2    Wang, L.3    Jin, W.4    Liu, N.5    Pan, H.6
  • 18
    • 33644867569 scopus 로고    scopus 로고
    • Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
    • Inagaki T, Moschetta A, Lee YK, Peng L, Zhao G, Downes M, et al. Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. Proc Natl Acad Sci USA 2006; 103: 3920-5.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 3920-3925
    • Inagaki, T.1    Moschetta, A.2    Lee, Y.K.3    Peng, L.4    Zhao, G.5    Downes, M.6
  • 19
    • 33847044019 scopus 로고    scopus 로고
    • Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor
    • Yang F, Huang X, Yi T, Yen Y, Moore DD, Huang W. Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor. Cancer Res 2007; 67: 863-7.
    • (2007) Cancer Res , vol.67 , pp. 863-867
    • Yang, F.1    Huang, X.2    Yi, T.3    Yen, Y.4    Moore, D.D.5    Huang, W.6
  • 22
    • 84876371590 scopus 로고    scopus 로고
    • Farnesoid X receptor expression is decreased in colonic mucosa of patients with primary sclerosing cholangitis and colitis-associated neoplasia
    • Torres J, Bao X, Iuga AC, Chen A, Harpaz N, Ullman T, et al. Farnesoid X receptor expression is decreased in colonic mucosa of patients with primary sclerosing cholangitis and colitis-associated neoplasia. Inflamm Bowel Dis 2013; 19: 275-82.
    • (2013) Inflamm Bowel Dis , vol.19 , pp. 275-282
    • Torres, J.1    Bao, X.2    Iuga, A.C.3    Chen, A.4    Harpaz, N.5    Ullman, T.6
  • 23
    • 84870481778 scopus 로고    scopus 로고
    • Downregulation of nuclear receptor FXR is associated with multiple malignant clinicopathological characteristics in human hepatocellular carcinoma
    • Su H, Ma C, Liu J, Li N, Gao M, Huang A, et al. Downregulation of nuclear receptor FXR is associated with multiple malignant clinicopathological characteristics in human hepatocellular carcinoma. Am J Physiol Gastrointest Liver Physiol 2012; 303: G1245-53.
    • (2012) Am J Physiol Gastrointest Liver Physiol , vol.303 , pp. G1245-G1253
    • Su, H.1    Ma, C.2    Liu, J.3    Li, N.4    Gao, M.5    Huang, A.6
  • 24
    • 84874503997 scopus 로고    scopus 로고
    • Farnesoid X receptor inhibits gankyrin in mouse livers and prevents development of liver cancer
    • Jiang Y, Iakova P, Jin J, Sullivan E, Sharin V, Hong IH, et al. Farnesoid X receptor inhibits gankyrin in mouse livers and prevents development of liver cancer. Hepatology 2013; 57: 1098-106.
    • (2013) Hepatology , vol.57 , pp. 1098-1106
    • Jiang, Y.1    Iakova, P.2    Jin, J.3    Sullivan, E.4    Sharin, V.5    Hong, I.H.6
  • 25
    • 84860330199 scopus 로고    scopus 로고
    • Hepatocarcinogenesis in FXR-/-mice mimics human HCC progression that operates through HNF1alpha regulation of FXR expression
    • Liu N, Meng Z, Lou G, Zhou W, Wang X, Zhang Y, et al. Hepatocarcinogenesis in FXR-/-mice mimics human HCC progression that operates through HNF1alpha regulation of FXR expression. Mol Endocrinol 2012; 26: 775-85.
    • (2012) Mol Endocrinol , vol.26 , pp. 775-785
    • Liu, N.1    Meng, Z.2    Lou, G.3    Zhou, W.4    Wang, X.5    Zhang, Y.6
  • 26
    • 84859101637 scopus 로고    scopus 로고
    • Expression of the nuclear bile acid receptor/farnesoid X receptor is reduced in human colon carcinoma compared to nonneoplastic mucosa independent from site and may be associated with adverse prognosis
    • Lax S, Schauer G, Prein K, Kapitan M, Silbert D, Berghold A, et al. Expression of the nuclear bile acid receptor/farnesoid X receptor is reduced in human colon carcinoma compared to nonneoplastic mucosa independent from site and may be associated with adverse prognosis. Int J Cancer 2012; 130: 2232-9.
    • (2012) Int J Cancer , vol.130 , pp. 2232-2239
    • Lax, S.1    Schauer, G.2    Prein, K.3    Kapitan, M.4    Silbert, D.5    Berghold, A.6
  • 27
    • 57149118460 scopus 로고    scopus 로고
    • Nuclear bile acid receptor FXR protects against intestinal tumorigenesis
    • Modica S, Murzilli S, Salvatore L, Schmidt DR, Moschetta A. Nuclear bile acid receptor FXR protects against intestinal tumorigenesis. Cancer Res 2008; 68: 9589-94.
    • (2008) Cancer Res , vol.68 , pp. 9589-9594
    • Modica, S.1    Murzilli, S.2    Salvatore, L.3    Schmidt, D.R.4    Moschetta, A.5
  • 28
    • 59649084903 scopus 로고    scopus 로고
    • Farnesoid X receptor deficiency in mice leads to increased intestinal epithelial cell proliferation and tumor development
    • Maran RR, Thomas A, Roth M, Sheng Z, Esterly N, Pinson D, et al. Farnesoid X receptor deficiency in mice leads to increased intestinal epithelial cell proliferation and tumor development. J Pharmacol Exp Ther 2009; 328: 469-77.
    • (2009) J Pharmacol Exp Ther , vol.328 , pp. 469-477
    • Maran, R.R.1    Thomas, A.2    Roth, M.3    Sheng, Z.4    Esterly, N.5    Pinson, D.6
  • 29
    • 84867305638 scopus 로고    scopus 로고
    • FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model
    • Deuschle U, Schuler J, Schulz A, Schluter T, Kinzel O, Abel U, et al. FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model. PLoS One 2012; 7: e43044.
    • (2012) PLoS One , vol.7 , pp. e43044
    • Deuschle, U.1    Schuler, J.2    Schulz, A.3    Schluter, T.4    Kinzel, O.5    Abel, U.6
  • 30
    • 33645738747 scopus 로고    scopus 로고
    • Endocrine functions of bile acids
    • Houten SM, Watanabe M, Auwerx J. Endocrine functions of bile acids. EMBO J 2006; 25: 1419-25.
    • (2006) EMBO J , vol.25 , pp. 1419-1425
    • Houten, S.M.1    Watanabe, M.2    Auwerx, J.3
  • 32
    • 55549144718 scopus 로고    scopus 로고
    • FXR: A metabolic regulator and cell protector
    • Wang YD, Chen WD, Moore DD, Huang W. FXR: a metabolic regulator and cell protector. Cell Res 2008; 18: 1087-95.
    • (2008) Cell Res , vol.18 , pp. 1087-1095
    • Wang, Y.D.1    Chen, W.D.2    Moore, D.D.3    Huang, W.4
  • 33
    • 58249110568 scopus 로고    scopus 로고
    • Role of bile acids and bile acid receptors in metabolic regulation
    • Lefebvre P, Cariou B, Lien F, Kuipers F, Staels B. Role of bile acids and bile acid receptors in metabolic regulation. Physiol Rev 2009; 89: 147-91.
    • (2009) Physiol Rev , vol.89 , pp. 147-191
    • Lefebvre, P.1    Cariou, B.2    Lien, F.3    Kuipers, F.4    Staels, B.5
  • 36
    • 33645983221 scopus 로고    scopus 로고
    • LXRS and FXR: The yin and yang of cholesterol and fat metabolism
    • Kalaany NY, Mangelsdorf DJ. LXRS and FXR: the yin and yang of cholesterol and fat metabolism. Annu Rev Physiol 2006; 68: 159-91.
    • (2006) Annu Rev Physiol , vol.68 , pp. 159-191
    • Kalaany, N.Y.1    Mangelsdorf, D.J.2
  • 37
    • 78650953014 scopus 로고    scopus 로고
    • Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis
    • Anakk S, Watanabe M, Ochsner SA, McKenna NJ, Finegold MJ, Moore DD. Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis. J Clin Invest 2011; 121: 86-95.
    • (2011) J Clin Invest , vol.121 , pp. 86-95
    • Anakk, S.1    Watanabe, M.2    Ochsner, S.A.3    McKenna, N.J.4    Finegold, M.J.5    Moore, D.D.6
  • 38
    • 18444377348 scopus 로고    scopus 로고
    • Redundant pathways for negative feedback regulation of bile acid production
    • Wang L, Lee YK, Bundman D, Han Y, Thevananther S, Kim CS, et al. Redundant pathways for negative feedback regulation of bile acid production. Dev Cell 2002; 2: 721-31.
    • (2002) Dev Cell , vol.2 , pp. 721-731
    • Wang, L.1    Lee, Y.K.2    Bundman, D.3    Han, Y.4    Thevananther, S.5    Kim, C.S.6
  • 39
    • 0036086509 scopus 로고    scopus 로고
    • Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis
    • Kerr TA, Saeki S, Schneider M, Schaefer K, Berdy S, Redder T, et al. Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis. Dev Cell 2002; 2: 713-20.
    • (2002) Dev Cell , vol.2 , pp. 713-720
    • Kerr, T.A.1    Saeki, S.2    Schneider, M.3    Schaefer, K.4    Berdy, S.5    Redder, T.6
  • 40
    • 79959491395 scopus 로고    scopus 로고
    • Increased activation of the Wnt/beta-catenin pathway in spontaneous hepatocellular carcinoma observed in farnesoid X receptor knockout mice
    • Wolfe A, Thomas A, Edwards G, Jaseja R, Guo GL, Apte U. Increased activation of the Wnt/beta-catenin pathway in spontaneous hepatocellular carcinoma observed in farnesoid X receptor knockout mice. J Pharmacol Exp Ther 2011; 338: 12-21.
    • (2011) J Pharmacol Exp Ther , vol.338 , pp. 12-21
    • Wolfe, A.1    Thomas, A.2    Edwards, G.3    Jaseja, R.4    Guo, G.L.5    Apte, U.6
  • 42
    • 76549124517 scopus 로고    scopus 로고
    • Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver
    • Lu L, Li Y, Kim SM, Bossuyt W, Liu P, Qiu Q, et al. Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci USA 2010; 107: 1437-42.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 1437-1442
    • Lu, L.1    Li, Y.2    Kim, S.M.3    Bossuyt, W.4    Liu, P.5    Qiu, Q.6
  • 43
    • 78049451932 scopus 로고    scopus 로고
    • The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program
    • Cai J, Zhang N, Zheng Y, de Wilde RF, Maitra A, Pan D. The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program. Genes Dev 2010; 24: 2383-8.
    • (2010) Genes Dev , vol.24 , pp. 2383-2388
    • Cai, J.1    Zhang, N.2    Zheng, Y.3    De Wilde, R.F.4    Maitra, A.5    Pan, D.6
  • 44
    • 70350502865 scopus 로고    scopus 로고
    • Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene
    • Zhou D, Conrad C, Xia F, Park JS, Payer B, Yin Y, et al. Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell 2009; 16: 425-38.
    • (2009) Cancer Cell , vol.16 , pp. 425-438
    • Zhou, D.1    Conrad, C.2    Xia, F.3    Park, J.S.4    Payer, B.5    Yin, Y.6
  • 45
    • 84893131910 scopus 로고    scopus 로고
    • Cocarcinogenic effects of intrahepatic bile acid accumulation in cholangiocarcinoma development
    • Lozano E, Sanchez-Vicente L, Monte MJ, Herraez E, Briz O, Banales JM, et al. Cocarcinogenic effects of intrahepatic bile acid accumulation in cholangiocarcinoma development. Mol Cancer Res 2014; 12: 91-100.
    • (2014) Mol Cancer Res , vol.12 , pp. 91-100
    • Lozano, E.1    Sanchez-Vicente, L.2    Monte, M.J.3    Herraez, E.4    Briz, O.5    Banales, J.M.6
  • 46
    • 80053927730 scopus 로고    scopus 로고
    • Impact of bile acids on the growth of human cholangiocarcinoma via FXR
    • Dai J, Wang H, Shi Y, Dong Y, Zhang Y, Wang J. Impact of bile acids on the growth of human cholangiocarcinoma via FXR. J Hematol Oncol 2011; 4: 41.
    • (2011) J Hematol Oncol , vol.4 , pp. 41
    • Dai, J.1    Wang, H.2    Shi, Y.3    Dong, Y.4    Zhang, Y.5    Wang, J.6
  • 48
    • 84896731603 scopus 로고    scopus 로고
    • From nonalcoholic Fatty liver disease to hepatocellular carcinoma: A systems understanding
    • Rozman D. From nonalcoholic Fatty liver disease to hepatocellular carcinoma: a systems understanding. Dig Dis Sci 2014; 59: 238-41.
    • (2014) Dig Dis Sci , vol.59 , pp. 238-241
    • Rozman, D.1
  • 49
    • 84865499656 scopus 로고    scopus 로고
    • Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis
    • Adorini L, Pruzanski M, Shapiro D. Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis. Drug Discov Today 2012; 17: 988-97.
    • (2012) Drug Discov Today , vol.17 , pp. 988-997
    • Adorini, L.1    Pruzanski, M.2    Shapiro, D.3
  • 50
    • 84863427742 scopus 로고    scopus 로고
    • Non-alcoholic Fatty liver disease: The bile Acid-activated farnesoid x receptor as an emerging treatment target
    • Fuchs M. Non-alcoholic Fatty liver disease: the bile Acid-activated farnesoid x receptor as an emerging treatment target. J Lipids 2012; 2012: 934396.
    • (2012) J Lipids , vol.2012 , pp. 934396
    • Fuchs, M.1
  • 51
    • 84880664792 scopus 로고    scopus 로고
    • Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease
    • Mudaliar S, Henry RR, Sanyal AJ, Morrow L, Marschall HU, Kipnes M, et al. Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease. Gastroenterology 2013; 145: 574-82.
    • (2013) Gastroenterology , vol.145 , pp. 574-582
    • Mudaliar, S.1    Henry, R.R.2    Sanyal, A.J.3    Morrow, L.4    Marschall, H.U.5    Kipnes, M.6
  • 52
    • 84875463056 scopus 로고    scopus 로고
    • Diabetes mellitus and risk of hepatocellular carcinoma: Findings from the Singapore Chinese Health Study
    • Koh WP, Wang R, Jin A, Yu MC, Yuan JM. Diabetes mellitus and risk of hepatocellular carcinoma: findings from the Singapore Chinese Health Study. Br J Cancer 2013; 108: 1182-8.
    • (2013) Br J Cancer , vol.108 , pp. 1182-1188
    • Koh, W.P.1    Wang, R.2    Jin, A.3    Yu, M.C.4    Yuan, J.M.5
  • 53
    • 32244447570 scopus 로고    scopus 로고
    • Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice
    • Zhang Y, Lee FY, Barrera G, Lee H, Vales C, Gonzalez FJ, et al. Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. Proc Natl Acad Sci USA 2006; 103: 1006-11.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 1006-1011
    • Zhang, Y.1    Lee, F.Y.2    Barrera, G.3    Lee, H.4    Vales, C.5    Gonzalez, F.J.6
  • 55
    • 59149106502 scopus 로고    scopus 로고
    • Farnesoid X receptor deficiency induces nonalcoholic steatohepatitis in low-density lipoprotein receptor-knockout mice fed a high-fat diet
    • Kong B, Luyendyk JP, Tawfik O, Guo GL. Farnesoid X receptor deficiency induces nonalcoholic steatohepatitis in low-density lipoprotein receptor-knockout mice fed a high-fat diet. J Pharmacol Exp Ther 2009; 328: 116-22.
    • (2009) J Pharmacol Exp Ther , vol.328 , pp. 116-122
    • Kong, B.1    Luyendyk, J.P.2    Tawfik, O.3    Guo, G.L.4
  • 56
    • 67649210759 scopus 로고    scopus 로고
    • Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis
    • Zhang S, Wang J, Liu Q, Harnish DC. Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis. J Hepatol 2009; 51: 380-8.
    • (2009) J Hepatol , vol.51 , pp. 380-388
    • Zhang, S.1    Wang, J.2    Liu, Q.3    Harnish, D.C.4
  • 57
    • 33644547706 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: From steatosis to cirrhosis
    • Farrell GC, Larter CZ. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology 2006; 43: S99-S112.
    • (2006) Hepatology , vol.43 , pp. S99-S112
    • Farrell, G.C.1    Larter, C.Z.2
  • 58
    • 77950613528 scopus 로고    scopus 로고
    • FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats
    • Cipriani S, Mencarelli A, Palladino G, Fiorucci S. FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats. J Lipid Res 2010; 51: 771-84.
    • (2010) J Lipid Res , vol.51 , pp. 771-784
    • Cipriani, S.1    Mencarelli, A.2    Palladino, G.3    Fiorucci, S.4
  • 59
    • 78649475438 scopus 로고    scopus 로고
    • Effects of nuclear receptor FXR on the regulation of liver lipid metabolism in patients with non-alcoholic fatty liver disease
    • Yang ZX, Shen W, Sun H. Effects of nuclear receptor FXR on the regulation of liver lipid metabolism in patients with non-alcoholic fatty liver disease. Hepatol Int 2010; 4: 741-8.
    • (2010) Hepatol Int , vol.4 , pp. 741-748
    • Yang, Z.X.1    Shen, W.2    Sun, H.3
  • 61
    • 58849138857 scopus 로고    scopus 로고
    • Significance and mechanism of CYP7a1 gene regulation during the acute phase of liver regeneration
    • Zhang L, Huang X, Meng Z, Dong B, Shiah S, Moore DD, et al. Significance and mechanism of CYP7a1 gene regulation during the acute phase of liver regeneration. Mol Endocrinol 2009; 23: 137-45.
    • (2009) Mol Endocrinol , vol.23 , pp. 137-145
    • Zhang, L.1    Huang, X.2    Meng, Z.3    Dong, B.4    Shiah, S.5    Moore, D.D.6
  • 62
    • 84870489524 scopus 로고    scopus 로고
    • Promotion of liver regeneration/repair by farnesoid X receptor in both liver and intestine in mice
    • Zhang L, Wang YD, Chen WD, Wang X, Lou G, Liu N, et al. Promotion of liver regeneration/repair by farnesoid X receptor in both liver and intestine in mice. Hepatology 2012; 56: 2336-43.
    • (2012) Hepatology , vol.56 , pp. 2336-2343
    • Zhang, L.1    Wang, Y.D.2    Chen, W.D.3    Wang, X.4    Lou, G.5    Liu, N.6
  • 63
    • 0346100571 scopus 로고    scopus 로고
    • Enterohepatic bile salt transporters in normal physiology and liver disease
    • Kullak-Ublick GA, Stieger B, Meier PJ. Enterohepatic bile salt transporters in normal physiology and liver disease. Gastroenterology 2004; 126: 322-42.
    • (2004) Gastroenterology , vol.126 , pp. 322-342
    • Kullak-Ublick, G.A.1    Stieger, B.2    Meier, P.J.3
  • 64
    • 77950616155 scopus 로고    scopus 로고
    • Farnesoid X receptor alleviates age-related proliferation defects in regenerating mouse livers by activating forkhead box m1b transcription
    • Chen WD, Wang YD, Zhang L, Shiah S, Wang M, Yang F, et al. Farnesoid X receptor alleviates age-related proliferation defects in regenerating mouse livers by activating forkhead box m1b transcription. Hepatology 2010; 51: 953-62.
    • (2010) Hepatology , vol.51 , pp. 953-962
    • Chen, W.D.1    Wang, Y.D.2    Zhang, L.3    Shiah, S.4    Wang, M.5    Yang, F.6
  • 65
    • 84899099870 scopus 로고    scopus 로고
    • SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling
    • Garcia-Rodriguez JL, Barbier-Torres L, Fernandez-Alvarez S, Gutierrezde Juan V, Monte MJ, Halilbasic E, et al. SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling. Hepatology 2014; 59: 1972-83.
    • (2014) Hepatology , vol.59 , pp. 1972-1983
    • Garcia-Rodriguez, J.L.1    Barbier-Torres, L.2    Fernandez-Alvarez, S.3    Gutierrezde Juan, V.4    Monte, M.J.5    Halilbasic, E.6
  • 66
    • 84870568672 scopus 로고    scopus 로고
    • Hepatocytespecific deletion of farnesoid X receptor delays but does not inhibit liver regeneration after partial hepatectomy in mice
    • Borude P, Edwards G, Walesky C, Li F, Ma X, Kong B, et al. Hepatocytespecific deletion of farnesoid X receptor delays but does not inhibit liver regeneration after partial hepatectomy in mice. Hepatology 2012; 56: 2344-52.
    • (2012) Hepatology , vol.56 , pp. 2344-2352
    • Borude, P.1    Edwards, G.2    Walesky, C.3    Li, F.4    Ma, X.5    Kong, B.6
  • 67
    • 46349098249 scopus 로고    scopus 로고
    • Farnesoid X receptor protects liver cells from apoptosis induced by serum deprivation in vitro and fasting in vivo
    • Wang YD, Yang F, Chen WD, Huang X, Lai L, Forman BM, et al. Farnesoid X receptor protects liver cells from apoptosis induced by serum deprivation in vitro and fasting in vivo. Mol Endocrinol 2008; 22: 1622-32.
    • (2008) Mol Endocrinol , vol.22 , pp. 1622-1632
    • Wang, Y.D.1    Yang, F.2    Chen, W.D.3    Huang, X.4    Lai, L.5    Forman, B.M.6
  • 68
    • 80052960387 scopus 로고    scopus 로고
    • Insufficient bile acid signaling impairs liver repair in CYP27-/-mice
    • Meng Z, Liu N, Fu X, Wang X, Wang YD, Chen WD, et al. Insufficient bile acid signaling impairs liver repair in CYP27-/-mice. J Hepatol 2011; 55: 885-95.
    • (2011) J Hepatol , vol.55 , pp. 885-895
    • Meng, Z.1    Liu, N.2    Fu, X.3    Wang, X.4    Wang, Y.D.5    Chen, W.D.6
  • 69
    • 0035147365 scopus 로고    scopus 로고
    • Irregular regeneration of hepatocytes is an important factor in the hepatocarcinogenesis of liver disease
    • Ueno Y, Moriyama M, Uchida T, Arakawa Y. Irregular regeneration of hepatocytes is an important factor in the hepatocarcinogenesis of liver disease. Hepatology 2001; 33: 357-62.
    • (2001) Hepatology , vol.33 , pp. 357-362
    • Ueno, Y.1    Moriyama, M.2    Uchida, T.3    Arakawa, Y.4
  • 70
    • 34548321204 scopus 로고    scopus 로고
    • Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis
    • Elsharkawy AM, Mann DA. Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis. Hepatology 2007; 46: 590-7.
    • (2007) Hepatology , vol.46 , pp. 590-597
    • Elsharkawy, A.M.1    Mann, D.A.2
  • 71
    • 84883770766 scopus 로고    scopus 로고
    • Small heterodimer partner overexpression partially protects against liver tumor development in farnesoid X receptor knockout mice
    • Li G, Kong B, Zhu Y, Zhan L, Williams JA, Tawfik O, et al. Small heterodimer partner overexpression partially protects against liver tumor development in farnesoid X receptor knockout mice. Toxicol Appl Pharmacol 2013; 272: 299-305.
    • (2013) Toxicol Appl Pharmacol , vol.272 , pp. 299-305
    • Li, G.1    Kong, B.2    Zhu, Y.3    Zhan, L.4    Williams, J.A.5    Tawfik, O.6
  • 73
    • 84867581829 scopus 로고    scopus 로고
    • Deletion of IFNgamma enhances hepatocarcinogenesis in FXR knockout mice
    • Meng Z, Wang X, Gan Y, Zhang Y, Zhou H, Ness CV, et al. Deletion of IFNgamma enhances hepatocarcinogenesis in FXR knockout mice. J Hepatol 2012; 57: 1004-12.
    • (2012) J Hepatol , vol.57 , pp. 1004-1012
    • Meng, Z.1    Wang, X.2    Gan, Y.3    Zhang, Y.4    Zhou, H.5    Ness, C.V.6
  • 74
    • 77549083560 scopus 로고    scopus 로고
    • Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer
    • Grivennikov SI, Karin M. Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer. Cytokine Growth Factor Rev 2010; 21: 11-9.
    • (2010) Cytokine Growth Factor Rev , vol.21 , pp. 11-19
    • Grivennikov, S.I.1    Karin, M.2
  • 75
    • 1042302005 scopus 로고    scopus 로고
    • The STATs of cancer-new molecular targets come of age
    • Yu H, Jove R. The STATs of cancer-new molecular targets come of age. Nat Rev Cancer 2004; 4: 97-105.
    • (2004) Nat Rev Cancer , vol.4 , pp. 97-105
    • Yu, H.1    Jove, R.2
  • 76
    • 74549217325 scopus 로고    scopus 로고
    • Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation
    • He G, Yu GY, Temkin V, Ogata H, Kuntzen C, Sakurai T, et al. Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation. Cancer Cell 2010; 17: 286-97.
    • (2010) Cancer Cell , vol.17 , pp. 286-297
    • He, G.1    Yu, G.Y.2    Temkin, V.3    Ogata, H.4    Kuntzen, C.5    Sakurai, T.6
  • 77
    • 4644324186 scopus 로고    scopus 로고
    • NF-kappaB functions as a tumour promoter in inflammationassociated cancer
    • Pikarsky E, Porat RM, Stein I, Abramovitch R, Amit S, Kasem S, et al. NF-kappaB functions as a tumour promoter in inflammationassociated cancer. Nature 2004; 431: 461-6.
    • (2004) Nature , vol.431 , pp. 461-466
    • Pikarsky, E.1    Porat, R.M.2    Stein, I.3    Abramovitch, R.4    Amit, S.5    Kasem, S.6
  • 78
    • 79751492851 scopus 로고    scopus 로고
    • NF-kappaB in the liver-linking injury, fibrosis and hepatocellular carcinoma
    • Luedde T, Schwabe RF. NF-kappaB in the liver-linking injury, fibrosis and hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol 2011; 8: 108-18.
    • (2011) Nat Rev Gastroenterol Hepatol , vol.8 , pp. 108-118
    • Luedde, T.1    Schwabe, R.F.2
  • 79
    • 0030001371 scopus 로고    scopus 로고
    • An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors
    • Seol W, Choi HS, Moore DD. An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors. Science 1996; 272: 1336-9.
    • (1996) Science , vol.272 , pp. 1336-1339
    • Seol, W.1    Choi, H.S.2    Moore, D.D.3
  • 80
    • 79958243702 scopus 로고    scopus 로고
    • Role of nuclear receptor SHP in metabolism and cancer
    • Zhang Y, Hagedorn CH, Wang L. Role of nuclear receptor SHP in metabolism and cancer. Biochim Biophys Acta 2011; 1812: 893-908.
    • (2011) Biochim Biophys Acta , vol.1812 , pp. 893-908
    • Zhang, Y.1    Hagedorn, C.H.2    Wang, L.3
  • 82
    • 47149095737 scopus 로고    scopus 로고
    • Orphan receptor small heterodimer partner suppresses tumorigenesis by modulating cyclin D1 expression and cellular proliferation
    • Zhang Y, Xu P, Park K, Choi Y, Moore DD, Wang L. Orphan receptor small heterodimer partner suppresses tumorigenesis by modulating cyclin D1 expression and cellular proliferation. Hepatology 2008; 48: 289-98.
    • (2008) Hepatology , vol.48 , pp. 289-298
    • Zhang, Y.1    Xu, P.2    Park, K.3    Choi, Y.4    Moore, D.D.5    Wang, L.6
  • 83
    • 39749198581 scopus 로고    scopus 로고
    • Epigenetic inhibition of nuclear receptor small heterodimer partner is associated with and regulates hepatocellular carcinoma growth
    • He N, Park K, Zhang Y, Huang J, Lu S, Wang L. Epigenetic inhibition of nuclear receptor small heterodimer partner is associated with and regulates hepatocellular carcinoma growth. Gastroenterology 2008; 134: 793-802.
    • (2008) Gastroenterology , vol.134 , pp. 793-802
    • He, N.1    Park, K.2    Zhang, Y.3    Huang, J.4    Lu, S.5    Wang, L.6
  • 84
    • 77749330820 scopus 로고    scopus 로고
    • Nuclear receptor SHP, a death receptor that targets mitochondria, induces apoptosis and inhibits tumor growth
    • Zhang Y, Soto J, Park K, Viswanath G, Kuwada S, Abel ED, et al. Nuclear receptor SHP, a death receptor that targets mitochondria, induces apoptosis and inhibits tumor growth. Mol Cell Biol 2010; 30: 1341-56.
    • (2010) Mol Cell Biol , vol.30 , pp. 1341-1356
    • Zhang, Y.1    Soto, J.2    Park, K.3    Viswanath, G.4    Kuwada, S.5    Abel, E.D.6
  • 85
    • 79953702566 scopus 로고    scopus 로고
    • Nuclear receptor small heterodimer partner in apoptosis signaling and liver cancer
    • Zhang Y, Wang L. Nuclear receptor small heterodimer partner in apoptosis signaling and liver cancer. Cancers (Basel) 2011; 3: 198-212.
    • (2011) Cancers (Basel) , vol.3 , pp. 198-212
    • Zhang, Y.1    Wang, L.2
  • 86
    • 33747032310 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in ten children under five years of age with bile salt export pump deficiency
    • Knisely AS, Strautnieks SS, Meier Y, Stieger B, Byrne JA, Portmann BC, et al. Hepatocellular carcinoma in ten children under five years of age with bile salt export pump deficiency. Hepatology 2006; 44: 478-86.
    • (2006) Hepatology , vol.44 , pp. 478-486
    • Knisely, A.S.1    Strautnieks, S.S.2    Meier, Y.3    Stieger, B.4    Byrne, J.A.5    Portmann, B.C.6
  • 88
    • 84876116381 scopus 로고    scopus 로고
    • Bile salt export pump is dysregulated with altered farnesoid X receptor isoform expression in patients with hepatocellular carcinoma
    • Chen Y, Song X, Valanejad L, Vasilenko A, More V, Qiu X, et al. Bile salt export pump is dysregulated with altered farnesoid X receptor isoform expression in patients with hepatocellular carcinoma. Hepatology 2013; 57: 1530-41.
    • (2013) Hepatology , vol.57 , pp. 1530-1541
    • Chen, Y.1    Song, X.2    Valanejad, L.3    Vasilenko, A.4    More, V.5    Qiu, X.6
  • 89
    • 0037414757 scopus 로고    scopus 로고
    • Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation
    • Zhang Y, Kast-Woelbern HR, Edwards PA. Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation. J Biol Chem 2003; 278: 104-10.
    • (2003) J Biol Chem , vol.278 , pp. 104-110
    • Zhang, Y.1    Kast-Woelbern, H.R.2    Edwards, P.A.3
  • 90
    • 79958278121 scopus 로고    scopus 로고
    • Activation of bile salt nuclear receptor FXR is repressed by pro-inflammatory cytokines activating NF-kappaB signaling in the intestine
    • Gadaleta RM, Oldenburg B, Willemsen EC, Spit M, Murzilli S, Salvatore L, et al. Activation of bile salt nuclear receptor FXR is repressed by pro-inflammatory cytokines activating NF-kappaB signaling in the intestine. Biochim Biophys Acta 2011; 1812: 851-8.
    • (2011) Biochim Biophys Acta , vol.1812 , pp. 851-858
    • Gadaleta, R.M.1    Oldenburg, B.2    Willemsen, E.C.3    Spit, M.4    Murzilli, S.5    Salvatore, L.6
  • 91
    • 84859874520 scopus 로고    scopus 로고
    • Downregulation of human farnesoid X receptor by miR-421 promotes proliferation and migration of hepatocellular carcinoma cells
    • Zhang Y, Gong W, Dai S, Huang G, Shen X, Gao M, et al. Downregulation of human farnesoid X receptor by miR-421 promotes proliferation and migration of hepatocellular carcinoma cells. Mol Cancer Res 2012; 10: 516-22.
    • (2012) Mol Cancer Res , vol.10 , pp. 516-522
    • Zhang, Y.1    Gong, W.2    Dai, S.3    Huang, G.4    Shen, X.5    Gao, M.6
  • 92
    • 84655169703 scopus 로고    scopus 로고
    • MicroRNA-421 functions as an oncogenic miRNA in biliary tract cancer through down-regulating farnesoid X receptor expression
    • Zhong XY, Yu JH, Zhang WG, Wang ZD, Dong Q, Tai S, et al. MicroRNA-421 functions as an oncogenic miRNA in biliary tract cancer through down-regulating farnesoid X receptor expression. Gene 2012; 493: 44-51.
    • (2012) Gene , vol.493 , pp. 44-51
    • Zhong, X.Y.1    Yu, J.H.2    Zhang, W.G.3    Wang, Z.D.4    Dong, Q.5    Tai, S.6


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