-
1
-
-
77949817711
-
AMPK and SIRT1: a long-standing partnership?
-
Ruderman NB, Xu XJ, Nelson L, Cacicedo JM, Saha AK, Lan F, et al. AMPK and SIRT1: a long-standing partnership? Am J Physiol Endocrinol Metab 2010;298:E751-760.
-
(2010)
Am J Physiol Endocrinol Metab
, vol.298
-
-
Ruderman, N.B.1
Xu, X.J.2
Nelson, L.3
Cacicedo, J.M.4
Saha, A.K.5
Lan, F.6
-
2
-
-
79953898189
-
Sirtuin 1 in lipid metabolism and obesity
-
Schug TT, Li X. Sirtuin 1 in lipid metabolism and obesity. Ann Med 2011;43:198-211.
-
(2011)
Ann Med
, vol.43
, pp. 198-211
-
-
Schug, T.T.1
Li, X.2
-
3
-
-
61949292843
-
Evidence for LKB1/AMP-activated protein kinase/ endothelial nitric oxide synthase cascade regulated by hepatocyte growth factor, S-adenosylmethionine, and nitric oxide in hepatocyte proliferation
-
Vazquez-Chantada M, Ariz U, Varela-Rey M, Embade N, Martinez-Lopez N, Fernandez-Ramos D, et al. Evidence for LKB1/AMP-activated protein kinase/ endothelial nitric oxide synthase cascade regulated by hepatocyte growth factor, S-adenosylmethionine, and nitric oxide in hepatocyte proliferation. Hepatology 2009;49:608-617.
-
(2009)
Hepatology
, vol.49
, pp. 608-617
-
-
Vazquez-Chantada, M.1
Ariz, U.2
Varela-Rey, M.3
Embade, N.4
Martinez-Lopez, N.5
Fernandez-Ramos, D.6
-
4
-
-
78649348967
-
Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress
-
Sengupta S, Peterson TR, Sabatini DM. Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol Cell 2010;40:310-322.
-
(2010)
Mol Cell
, vol.40
, pp. 310-322
-
-
Sengupta, S.1
Peterson, T.R.2
Sabatini, D.M.3
-
5
-
-
79959957224
-
S6 kinase 1 is required for rapamycin-sensitive liver proliferation after mouse hepatectomy
-
Espeillac C, Mitchell C, Celton-Morizur S, Chauvin C, Koka V, Gillet C, et al. S6 kinase 1 is required for rapamycin-sensitive liver proliferation after mouse hepatectomy. J Clin Invest 2011;121:2821-2832.
-
(2011)
J Clin Invest
, vol.121
, pp. 2821-2832
-
-
Espeillac, C.1
Mitchell, C.2
Celton-Morizur, S.3
Chauvin, C.4
Koka, V.5
Gillet, C.6
-
6
-
-
33645821043
-
Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration
-
Huang W, Ma K, Zhang J, Qatanani M, Cuvillier J, Liu J, et al. Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration. Science 2006;312:233-236.
-
(2006)
Science
, vol.312
, pp. 233-236
-
-
Huang, W.1
Ma, K.2
Zhang, J.3
Qatanani, M.4
Cuvillier, J.5
Liu, J.6
-
7
-
-
0035914341
-
The bile acid glycochenodeoxycholate induces trail-receptor 2/DR5 expression and apoptosis
-
Higuchi H, Bronk SF, Takikawa Y, Werneburg N, Takimoto R, El-Deiry W, et al. The bile acid glycochenodeoxycholate induces trail-receptor 2/DR5 expression and apoptosis. J Biol Chem 2001;276:38610-38618.
-
(2001)
J Biol Chem
, vol.276
, pp. 38610-38618
-
-
Higuchi, H.1
Bronk, S.F.2
Takikawa, Y.3
Werneburg, N.4
Takimoto, R.5
El-Deiry, W.6
-
9
-
-
70350606061
-
FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states
-
Kemper JK, Xiao Z, Ponugoti B, Miao J, Fang S, Kanamaluru D, et al. FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states. Cell Metab 2009;10:392-404.
-
(2009)
Cell Metab
, vol.10
, pp. 392-404
-
-
Kemper, J.K.1
Xiao, Z.2
Ponugoti, B.3
Miao, J.4
Fang, S.5
Kanamaluru, D.6
-
10
-
-
58049206267
-
The p300 acetylase is critical for ligand-activated farnesoid X receptor (FXR) induction of SHP
-
Fang S, Tsang S, Jones R, Ponugoti B, Yoon H, Wu SY, et al. The p300 acetylase is critical for ligand-activated farnesoid X receptor (FXR) induction of SHP. J Biol Chem 2008;283:35086-35095.
-
(2008)
J Biol Chem
, vol.283
, pp. 35086-35095
-
-
Fang, S.1
Tsang, S.2
Jones, R.3
Ponugoti, B.4
Yoon, H.5
Wu, S.Y.6
-
11
-
-
0028076991
-
Serum bile acids and cholestasis in alcoholic hepatitis. Relationship with usual liver tests and histological features
-
Trinchet JC, Gerhardt MF, Balkau B, Munz C, Poupon RE. Serum bile acids and cholestasis in alcoholic hepatitis. Relationship with usual liver tests and histological features. J Hepatol 1994;21:235-240.
-
(1994)
J Hepatol
, vol.21
, pp. 235-240
-
-
Trinchet, J.C.1
Gerhardt, M.F.2
Balkau, B.3
Munz, C.4
Poupon, R.E.5
-
12
-
-
84872142834
-
Serum bile acid levels as a predictor for the severity of liver fibrosis in patients with chronic hepatitis C
-
Shlomai A, Halfon P, Goldiner I, Zelber-Sagi S, Halpern Z, Oren R, et al. Serum bile acid levels as a predictor for the severity of liver fibrosis in patients with chronic hepatitis C. J Viral Hepat 2013;20:95-102.
-
(2013)
J Viral Hepat
, vol.20
, pp. 95-102
-
-
Shlomai, A.1
Halfon, P.2
Goldiner, I.3
Zelber-Sagi, S.4
Halpern, Z.5
Oren, R.6
-
13
-
-
84866386083
-
SIRT1 and c-Myc promote liver tumor cell survival and predict poor survival of human hepatocellular carcinomas
-
Jang KY, Noh SJ, Lehwald N, Tao GZ, Bellovin DI, Park HS, et al. SIRT1 and c-Myc promote liver tumor cell survival and predict poor survival of human hepatocellular carcinomas. PloS One 2012;7:e45119.
-
(2012)
PloS One
, vol.7
-
-
Jang, K.Y.1
Noh, S.J.2
Lehwald, N.3
Tao, G.Z.4
Bellovin, D.I.5
Park, H.S.6
-
14
-
-
78650758398
-
Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer
-
Herranz D, Munoz-Martin M, Canamero M, Mulero F, Martinez-Pastor B, Fernandez-Capetillo O, et al. Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer. Nat Commun 2010;1:3.
-
(2010)
Nat Commun
, vol.1
, pp. 3
-
-
Herranz, D.1
Munoz-Martin, M.2
Canamero, M.3
Mulero, F.4
Martinez-Pastor, B.5
Fernandez-Capetillo, O.6
-
15
-
-
32044467118
-
24-NorUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice
-
Fickert P, Wagner M, Marschall HU, Fuchsbichler A, Zollner G, Tsybrovskyy O, et al. 24-NorUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice. Gastroenterology 2006;130:465-481.
-
(2006)
Gastroenterology
, vol.130
, pp. 465-481
-
-
Fickert, P.1
Wagner, M.2
Marschall, H.U.3
Fuchsbichler, A.4
Zollner, G.5
Tsybrovskyy, O.6
-
16
-
-
42549144094
-
Pharmacological IKK2 inhibition blocks liver steatosis and initiation of non-alcoholic steatohepatitis
-
Beraza N, Malato Y, Vander Borght S, Liedtke C, Wasmuth HE, Dreano M, et al. Pharmacological IKK2 inhibition blocks liver steatosis and initiation of non-alcoholic steatohepatitis. Gut 2008;57:655-663.
-
(2008)
Gut
, vol.57
, pp. 655-663
-
-
Beraza, N.1
Malato, Y.2
Vander Borght, S.3
Liedtke, C.4
Wasmuth, H.E.5
Dreano, M.6
-
17
-
-
79953728734
-
A homozygous nonsense mutation (c.214C->A) in the biliverdin reductase alpha gene (BLVRA) results in accumulation of biliverdin during episodes of cholestasis
-
Nytofte NS, Serrano MA, Monte MJ, Gonzalez-Sanchez E, Tumer Z, Ladefoged K, et al. A homozygous nonsense mutation (c.214C->A) in the biliverdin reductase alpha gene (BLVRA) results in accumulation of biliverdin during episodes of cholestasis. J Med Genet 2011;48:219-225.
-
(2011)
J Med Genet
, vol.48
, pp. 219-225
-
-
Nytofte, N.S.1
Serrano, M.A.2
Monte, M.J.3
Gonzalez-Sanchez, E.4
Tumer, Z.5
Ladefoged, K.6
-
19
-
-
77950127881
-
SIRT1 negatively regulates the mammalian target of rapamycin
-
Ghosh HS, McBurney M, Robbins PD. SIRT1 negatively regulates the mammalian target of rapamycin. PloS One 2010;5:e9199.
-
(2010)
PloS One
, vol.5
-
-
Ghosh, H.S.1
McBurney, M.2
Robbins, P.D.3
-
20
-
-
79958862979
-
Role of AMP-activated protein kinase in the control of hepatocyte priming and proliferation during liver regeneration
-
Varela-Rey M, Beraza N, Lu SC, Mato JM, Martinez-Chantar ML. Role of AMP-activated protein kinase in the control of hepatocyte priming and proliferation during liver regeneration. Exp Biol Med 2011;236:402-408.
-
(2011)
Exp Biol Med
, vol.236
, pp. 402-408
-
-
Varela-Rey, M.1
Beraza, N.2
Lu, S.C.3
Mato, J.M.4
Martinez-Chantar, M.L.5
-
21
-
-
14544282413
-
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
-
Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 2005;434:113-118.
-
(2005)
Nature
, vol.434
, pp. 113-118
-
-
Rodgers, J.T.1
Lerin, C.2
Haas, W.3
Gygi, S.P.4
Spiegelman, B.M.5
Puigserver, P.6
-
22
-
-
78650037609
-
Ubiquitin proteasome-dependent degradation of the transcriptional coactivator PGC-1{alpha} via the N-terminal pathway
-
Trausch-Azar J, Leone TC, Kelly DP, Schwartz AL. Ubiquitin proteasome-dependent degradation of the transcriptional coactivator PGC-1{alpha} via the N-terminal pathway. J Biol Chem 2010;285:40192-40200.
-
(2010)
J Biol Chem
, vol.285
, pp. 40192-40200
-
-
Trausch-Azar, J.1
Leone, T.C.2
Kelly, D.P.3
Schwartz, A.L.4
-
23
-
-
70350418625
-
mTOR signaling at a glance
-
Laplante M, Sabatini DM. mTOR signaling at a glance. J Cell Sci 2009;122:3589-3594.
-
(2009)
J Cell Sci
, vol.122
, pp. 3589-3594
-
-
Laplante, M.1
Sabatini, D.M.2
-
24
-
-
80052022281
-
The reduction of SIRT1 in livers of old mice leads to impaired body homeostasis and to inhibition of liver proliferation
-
Jin J, Iakova P, Jiang Y, Medrano EE, Timchenko NA. The reduction of SIRT1 in livers of old mice leads to impaired body homeostasis and to inhibition of liver proliferation. Hepatology 2011;54:989-998.
-
(2011)
Hepatology
, vol.54
, pp. 989-998
-
-
Jin, J.1
Iakova, P.2
Jiang, Y.3
Medrano, E.E.4
Timchenko, N.A.5
-
25
-
-
79958285869
-
Regulation of FXR transcriptional activity in health and disease: emerging roles of FXR cofactors and post-translational modifications
-
Kemper JK. Regulation of FXR transcriptional activity in health and disease: emerging roles of FXR cofactors and post-translational modifications. Biochim Biophys Acta 2011;1812:842-850.
-
(2011)
Biochim Biophys Acta
, vol.1812
, pp. 842-850
-
-
Kemper, J.K.1
-
26
-
-
79953760389
-
H3 lysine 4 is acetylated at active gene promoters and is regulated by H3 lysine 4 methylation
-
Guillemette B, Drogaris P, Lin HH, Armstrong H, Hiragami-Hamada K, Imhof A, et al. H3 lysine 4 is acetylated at active gene promoters and is regulated by H3 lysine 4 methylation. PLoS Genet 2011;7:e1001354.
-
(2011)
PLoS Genet
, vol.7
-
-
Guillemette, B.1
Drogaris, P.2
Lin, H.H.3
Armstrong, H.4
Hiragami-Hamada, K.5
Imhof, A.6
-
27
-
-
0034677535
-
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
-
Imai S, Armstrong CM, Kaeberlein M, Guarente L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 2000;403:795-800.
-
(2000)
Nature
, vol.403
, pp. 795-800
-
-
Imai, S.1
Armstrong, C.M.2
Kaeberlein, M.3
Guarente, L.4
-
28
-
-
79955551251
-
Histone H3K4 trimethylation by MLL3 as part of ASCOM complex is critical for NR activation of bile acid transporter genes and is downregulated in cholestasis
-
Ananthanarayanan M, Li Y, Surapureddi S, Balasubramaniyan N, Ahn J, Goldstein JA, et al. Histone H3K4 trimethylation by MLL3 as part of ASCOM complex is critical for NR activation of bile acid transporter genes and is downregulated in cholestasis. Am J Physiol Gastrointest Liver Physiol 2011;300:G771-G781.
-
(2011)
Am J Physiol Gastrointest Liver Physiol
, vol.300
-
-
Ananthanarayanan, M.1
Li, Y.2
Surapureddi, S.3
Balasubramaniyan, N.4
Ahn, J.5
Goldstein, J.A.6
-
29
-
-
84888131014
-
Elevated microRNA-34a in obesity reduces NAD levels and SIRT1 activity by directly targeting NAMPT
-
Choi SE, Fu T, Seok S, Kim DH, Yu E, Lee KW, et al. Elevated microRNA-34a in obesity reduces NAD levels and SIRT1 activity by directly targeting NAMPT. Aging Cell 2013;12:1062-1072.
-
(2013)
Aging Cell
, vol.12
, pp. 1062-1072
-
-
Choi, S.E.1
Fu, T.2
Seok, S.3
Kim, D.H.4
Yu, E.5
Lee, K.W.6
-
30
-
-
38349130508
-
Dynamic regulation of PGC-1alpha localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response
-
Anderson RM, Barger JL, Edwards MG, Braun KH, O'Connor CE, Prolla TA, et al. Dynamic regulation of PGC-1alpha localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response. Aging Cell 2008;7:101-111.
-
(2008)
Aging Cell
, vol.7
, pp. 101-111
-
-
Anderson, R.M.1
Barger, J.L.2
Edwards, M.G.3
Braun, K.H.4
O'Connor, C.E.5
Prolla, T.A.6
-
31
-
-
79956331962
-
Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1
-
Back JH, Rezvani HR, Zhu Y, Guyonnet-Duperat V, Athar M, Ratner D, et al. Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1. J Biol Chem 2011;286:19100-19108.
-
(2011)
J Biol Chem
, vol.286
, pp. 19100-19108
-
-
Back, J.H.1
Rezvani, H.R.2
Zhu, Y.3
Guyonnet-Duperat, V.4
Athar, M.5
Ratner, D.6
-
32
-
-
79959355078
-
Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity
-
Gao Z, Zhang J, Kheterpal I, Kennedy N, Davis RJ, Ye J. Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity. J Biol Chem 2011;286:22227-22234.
-
(2011)
J Biol Chem
, vol.286
, pp. 22227-22234
-
-
Gao, Z.1
Zhang, J.2
Kheterpal, I.3
Kennedy, N.4
Davis, R.J.5
Ye, J.6
-
33
-
-
84864941013
-
The histone H3 lysine 56 acetylation pathway is regulated by target of rapamycin (TOR) signaling and functions directly in ribosomal RNA biogenesis
-
Chen H, Fan M, Pfeffer LM, Laribee RN. The histone H3 lysine 56 acetylation pathway is regulated by target of rapamycin (TOR) signaling and functions directly in ribosomal RNA biogenesis. Nucleic Acids Res 2012;40:6534-6546.
-
(2012)
Nucleic Acids Res
, vol.40
, pp. 6534-6546
-
-
Chen, H.1
Fan, M.2
Pfeffer, L.M.3
Laribee, R.N.4
-
34
-
-
84867380741
-
Janus-faced role of SIRT1 in tumorigenesis
-
Song NY, Surh YJ. Janus-faced role of SIRT1 in tumorigenesis. Ann N Y Acad Sci 2012;1271:10-19.
-
(2012)
Ann N Y Acad Sci
, vol.1271
, pp. 10-19
-
-
Song, N.Y.1
Surh, Y.J.2
-
35
-
-
33847044019
-
Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor
-
Yang F, Huang X, Yi T, Yen Y, Moore DD, Huang W. Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor. Cancer Res 2007;67:863-867.
-
(2007)
Cancer Res
, vol.67
, pp. 863-867
-
-
Yang, F.1
Huang, X.2
Yi, T.3
Yen, Y.4
Moore, D.D.5
Huang, W.6
|