Plumbagin induces apoptosis in lymphoma cells via oxidative stress mediated glutathionylation and inhibition of mitogen-activated protein kinase phosphatases (MKP1/2)

Cancer Letters

Volumn 357, Issue 1, 2015, Pages 265-278

  Checker, Rahul ^a   Gambhir, Lokesh ^a   Sharma, Deepak ^a   Kumar, Mukesh ^a   Sandur, Santosh K ^a  

^a BHABHA ATOMIC RESEARCH CENTRE   (India)

Author keywords

Caspase; GSH GSSG; JNK; ROS; Vitamin K3

Indexed keywords

CASPASE; CYTOCHROME C; FAS LIGAND; GLUTATHIONE; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 2; PLUMBAGIN; PROTEIN BAX; SHORT HAIRPIN RNA; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; DUAL SPECIFICITY PHOSPHATASE; DUSP1 PROTEIN, HUMAN; DUSP4 PROTEIN, HUMAN; NAPHTHOQUINONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DRUG CYTOTOXICITY; DRUG EFFICACY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; ENZYME RELEASE; GENE SILENCING; GLUTATHIONYLATION; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; OVERALL SURVIVAL; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN MODIFICATION; T CELL LYMPHOMA; T-CELL LYMPHOMA CELL LINE; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CHEMICAL STRUCTURE; DRUG EFFECTS; ENZYMOLOGY; JURKAT CELL LINE; LYMPHOMA, T-CELL; METABOLISM; PHOSPHORYLATION; RANDOMIZATION; SIGNAL TRANSDUCTION;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; DISEASE MODELS, ANIMAL; DUAL SPECIFICITY PHOSPHATASE 1; DUAL-SPECIFICITY PHOSPHATASES; ENZYME ACTIVATION; GLUTATHIONE; HUMANS; JURKAT CELLS; LYMPHOMA, T-CELL; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASE PHOSPHATASES; MODELS, MOLECULAR; NAPHTHOQUINONES; OXIDATIVE STRESS; PHOSPHORYLATION; RANDOM ALLOCATION;

EID: 84920406338     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2014.11.031     Document Type: Article

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