The Natural Anticancer Agent Plumbagin Induces Potent Cytotoxicity in MCF-7 Human Breast Cancer Cells by Inhibiting a PI-5 Kinase for ROS Generation

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Lee, Ju Hee ^a   Yeon, Ji Hyun ^a   Kim, Hanna ^a   Roh, Whijae ^a   Chae, Jeiwook ^a   Park, Han Oh ^a   Kim, Dong Myung ^a  

^a Bioneer Corporation   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 PHOSPHATIDYLINOSITOL 5 KINASE; ACETYLCYSTEINE; PHOSPHOTRANSFERASE; PLUMBAGIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL ELONGATION; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG STRUCTURE; DRUG TARGETING; ENZYME INHIBITION; GENE DELETION; GENE SILENCING; GROWTH INHIBITION; HETEROZYGOSITY; HUMAN; HUMAN CELL; INHIBITION KINETICS; NONHUMAN; ORTHOLOGY; SCHIZOSACCHAROMYCES POMBE; WILD TYPE;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; DOWN-REGULATION; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; GENE KNOCKDOWN TECHNIQUES; HAPLOINSUFFICIENCY; HETEROZYGOTE; HUMANS; MCF-7 CELLS; MODELS, BIOLOGICAL; MUTATION; NAPHTHOQUINONES; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SCHIZOSACCHAROMYCES;

SCHIZOSACCHAROMYCES POMBE; SCHIZOSACCHAROMYCETACEAE;

EID: 84866419791     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0045023     Document Type: Article

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