Biological determinants of depression following bereavement

Neuroscience and Biobehavioral Reviews

Volumn 49, Issue , 2015, Pages 171-181

  Assareh, Amelia A ^a   Sharpley, Christopher F ^a   McFarlane, James R ^a   Sachdev, Perminder S ^b  

^a UNIVERSITY OF NEW ENGLAND   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Bereavement; Depression; Genetic; Grief; Inflammatory; Neuroendocrine immunologic; Neurotransmitters; Neurotropic; Resilience; Stressful event

Indexed keywords

ADRENALIN; BIOLOGICAL MARKER; BRAIN DERIVED NEUROTROPHIC FACTOR; DOPAMINE; FIBROBLAST GROWTH FACTOR 2; NERVE GROWTH FACTOR; NEUROTROPHIN 3; SEROTONIN 1A RECEPTOR; SEROTONIN 1B RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN 2C RECEPTOR; SEROTONIN TRANSPORTER;

ADRENAL CORTEX FUNCTION; ANXIETY DISORDER; BEREAVEMENT; COGNITION; COPING BEHAVIOR; DEPRESSION; ENVIRONMENTAL FACTOR; GABAERGIC TRANSMISSION; GENE IDENTIFICATION; GENETIC POLYMORPHISM; GENETIC REGULATION; GRIEF; HEREDITY; HUMAN; HYPOTHALAMUS HYPOPHYSIS SYSTEM; IMMUNE SYSTEM; IMMUNOPATHOLOGY; MOLECULAR BIOLOGY; NEUROENDOCRINE SYSTEM; NEUROPROTECTION; NEUROSIS; NONHUMAN; PATHOGENESIS; PROTEIN BLOOD LEVEL; PSYCHOTRAUMA; REVIEW; STRESS; SUBSTANCE ABUSE; ANIMAL; GENETIC PREDISPOSITION; GENETICS; PATHOPHYSIOLOGY;

ANIMALS; BEREAVEMENT; DEPRESSIVE DISORDER; GENETIC PREDISPOSITION TO DISEASE; HUMANS; RESILIENCE, PSYCHOLOGICAL;

EID: 84920277592     PISSN: 01497634     EISSN: 18737528     Source Type: Journal    
DOI: 10.1016/j.neubiorev.2014.12.013     Document Type: Review

References (145)

1. Amara S.G., Kuhar M.J. Neurotransmitter transporters: recent progress. Annu. Rev. Neurosci. 1993, 16(1):73-93.
2. Anisman H. Cascading effects of stressors and inflammatory immune system activation: implications for major depressive disorder. J. Psychiatry Neurosci. 2009, 34(1):4.
3. Anisman H., Merali Z., Hayley S. Neurotransmitter, peptide and cytokine processes in relation to depressive disorder: comorbidity between depression and neurodegenerative disorders. Prog. Neurobiol. 2008, 85(1):1-74.
4. ® 2000, American Psychiatric Pub.
5. APA Diagnostic and Statistical Manual of Mental Disorders-5th edition 2013, American Psychiatric Association, Washington, DC.
6. Bagley J., Moghaddam B. Temporal dynamics of glutamate efflux in the prefrontal cortex and in the hippocampus following repeated stress: effects of pretreatment with saline or diazepam. Neuroscience 1997, 77(1):65-73.
7. Baird A. Fibroblast growth factors: activities and significance of non-neurotrophin neurotrophic growth factors. Curr. Opin. Neurobiol. 1994, 4(1):78-86.
8. Bartrop R., Lazarus L., Luckhurst E., Kiloh L.G., Penny R. Depressed lymphocyte function after bereavement. Lancet 1977, 309(8016):834-836.
9. Bayart F., Hayashi K.T., Faull K.F., Barchas J.D., Levine S. Influence of maternal proximity on behavioral and physiological responses to separation in infant rhesus monkeys (Macaca mulatta). Behav. Neurosci. 1990, 104(1):98-107.
10. Beach S.R., Brody G.H., Todorov A.A., Gunter T.D., Philibert R.A. Methylation at SLC6A4 is linked to family history of child abuse: an examination of the Iowa Adoptee sample. Am. J. Med. Genet. B: Neuropsychiatr. Genet. 2010, 153(2):710-713.
11. Belsky J., Pluess M. Beyond diathesis stress: differential susceptibility to environmental influences. Psychol. Bull. 2009, 135(6):885.
12. Biondi M., Picardi A. Clinical and biological aspects of bereavement and loss-induced depression: a reappraisal. Psychother. Psychosom. 1996, 65(5):229-245.
13. Blugeot A., Rivat C., Bouvier E., Molet J., Mouchard A., Zeau B., Bernard C., Benoliel J.-J., Becker C. Vulnerability to depression: from brain neuroplasticity to identification of biomarkers. J. Neurosci. 2011, 31(36):12889-12899.
14. Bonanno G.A., Kaltman S. The varieties of grief experience. Clin. Psychol. Rev. 2001, 21(5):705-734.
15. Bonanno G.A., Papa A., O'Neill K. Loss and human resilience. Appl. Prev. Psychol. 2001, 10(3):193-206.
16. Bosch O.J., Nair H.P., Ahern T.H., Neumann I.D., Young L.J. The CRF system mediates increased passive stress-coping behavior following the loss of a bonded partner in a monogamous rodent. Neuropsychopharmacology 2008, 34(6):1406-1415.
17. Boulle F., Van den Hove D.L.A., Jakob S.B., Rutten B.P., Hamon M., Van Os J., Lesch K.P., Lanfumey L., Steinbusch H.W., Kenis G. Epigenetic regulation of the BDNF gene: implications for psychiatric disorders. Mol. Psychiatry 2011, 17(6):584-596.
18. Bradley R.G., Binder E.B., Epstein M.P., Tang Y., Nair H.P., Liu W., Gillespie C.F., Berg T., Evces M., Newport D.J. Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene. Arch. Gen. Psychiatry 2008, 65(2):190.
19. Brezo J., Bureau A., Mérette C., Jomphe V., Barker E.D., Vitaro F., Hebert M., Carbonneau R., Tremblay R.E., Turecki G. Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorders: a 22-year longitudinal gene-environment study. Mol. Psychiatry 2009, 15(8):831-843.
20. Buckley T., Sunari D., Marshall A., Bartrop R., McKinley S., Tofler G. Physiological correlates of bereavement and the impact of bereavement interventions. Dialogues Clin. Neurosci. 2012, 14(2):129.
21. Caspi A., Sugden K., Moffitt T.E., Taylor A., Craig I.W., Harrington H., McClay J., Mill J., Martin J., Braithwaite A. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Sci. Signal. 2003, 301(5631):386.
22. Castle J., Phillips W.L. Grief rituals: aspects that facilitate adjustment to bereavement. J. Loss Trauma 2003, 8(1):41-71.
23. Christ G., Bonanno G., Malkinson R., Rubin S. Bereavement experiences after the death of a child. When Children Die: Improving Palliative and End-of-Life Care for Children and their Families 2003, 553-579.
24. Cicchetti D., Rogosch F.A. Gene by environment interaction and resilience: effects of child maltreatment and serotonin, corticotropin releasing hormone, dopamine, and oxytocin genes. Dev. Psychopathol. 2012, 24(2):411.
25. Clarke H., Flint J., Attwood A., Munafo M. Association of the 5-HTTLPR genotype and unipolar depression: a meta-analysis. Psychol. Med. 2010, 40(11):1767.
26. Clayton P., Darvish H. Course of depressive symptoms following the stress of bereavement. Stress Mental Disord. 1979, 121-136.
27. Cole M.G., Dendukuri N. Risk factors for depression among elderly community subjects: a systematic review and meta-analysis. Am. J. Psychiatry 2003, 160(6):1147-1156.
28. Cole S.W., Arevalo J.M., Takahashi R., Sloan E.K., Lutgendorf S.K., Sood A.K., Sheridan J.F., Seeman T.E. Computational identification of gene-social environment interaction at the human IL6 locus. Proc. Natl. Acad. Sci. 2010, 107(12):5681-5686.
29. Connor K.M., Davidson J.R. Development of a new resilience scale: the Connor-Davidson resilience scale (CD-RISC). Depress. Anxiety 2003, 18(2):76-82.
30. Corruble E., Pies R., Zisook S. Grief in health care professionals: when screening for major depression is needed. Arch. Intern. Med. 2012, 172(22):1768-1769.
31. Duman R.S., Monteggia L.M. A neurotrophic model for stress-related mood disorders. Biol. Psychiatry 2006, 59(12):1116-1127.
32. Eley T.C., Sugden K., Corsico A., Gregory A.M., Sham P., McGuffin P., Plomin R., Craig I.W. Gene-environment interaction analysis of serotonin system markers with adolescent depression. Mol. Psychiatry 2004, 9(10):908-915.
33. Elovainio M., Jokela M., Kivimäki M., Pulkki-Råback L., Lehtimäki T., Airla N., Keltikangas-Järvinen L. Genetic variants in the DRD2 gene moderate the relationship between stressful life events and depressive symptoms in adults: cardiovascular risk in young Finns study. Psychosom. Med. 2007, 69(5):391-395.
34. Fatemi S.H. Reelin, a marker of stress resilience in depression and psychosis. Neuropsychopharmacology 2011, 36(12):2371-2372.
35. Feder A., Nestler E.J., Charney D.S. Psychobiology and molecular genetics of resilience. Nat. Rev. Neurosci. 2009, 10(6):446-457.
36. Feenstra M., Botterblom M., Van Uum J. Novelty-induced increase in dopamine release in the rat prefrontal cortex in vivo: inhibition by diazepam. Neurosci. Lett. 1995, 189(2):81-84.
37. Feinberg A.P. Phenotypic plasticity and the epigenetics of human disease. Nature 2007, 447(7143):433-440.
38. Ferster C.B. A functional analysis of depression. Am. Psychol. 1973, 28(10):857.
39. Folsom T.D., Fatemi S.H. The involvement of reelin in neurodevelopmental disorders. Neuropharmacology 2013, 68:122-135.
40. Gail I., Wynings C., Schneiderman N., Baum A., Rodriguez M., Greenwood D., Benight C., et al. Posttraumatic stress symptoms, intrusive thoughts, loss, and immune function after Hurricane Andrew. Psychosom. Med. 1997, 59(2):128-141.
41. Galatzer-Levy I.R., Bonanno G.A. Beyond normality in the study of bereavement: heterogeneity in depression outcomes following loss in older adults. Soc. Sci. Med. 2012, 74(12):1987-1994.
42. Gatt J., Nemeroff C., Dobson-Stone C., Paul R., Bryant R., Schofield P., Gordon E., Kemp A., Williams L. Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety. Mol. Psychiatry 2009, 14(7):681-695.
43. Gerra G., Monti D., Panerai A.E., Sacerdote P., Anderlini R., Avanzini P., Zaimovic A., Brambilla F., Franceschi C. Long-term immune-endocrine effects of bereavement: relationships with anxiety levels and mood. Psychiatry Res. 2003, 121(2):145-158.
44. Goldberger C., Gourion D., Leroy S., Schürhoff F., Bourdel M.C., Leboyer M., Krebs M.O. Population-based and family-based association study of 5' UTR polymorphism of the reelin gene and schizophrenia. Am. J. Med. Genet. B: Neuropsychiatr. Genet. 2005, 137(1):51-55.
45. Gräff J., Kim D., Dobbin M.M., Tsai L.-H. Epigenetic regulation of gene expression in physiological and pathological brain processes. Physiol. Rev. 2011, 91(2):603-649.
46. Harro J., Kiive E. Droplets of black bile? Development of vulnerability and resilience to depression in young age. Psychoneuroendocrinology 2011, 36(3):380-392.
47. Higley J.D., Suomi S.J., Linnoila M. CSF monoamine metabolite concentrations vary according to age, rearing, and sex, and are influenced by the stressor of social separation in rhesus monkeys. Psychopharmacology (Berl) 1991, 103(4):551-556.
48. Hsieh J., Eisch A.J. Epigenetics, hippocampal neurogenesis, and neuropsychiatric disorders: unraveling the genome to understand the mind. Neurobiol. Dis. 2010, 39(1):73-84.
49. Insel T. Transforming Diagnosis 2013, Retrieved May 27, 2013 from: www.nimh.nih.gov/about/director/2013/transforming-diagnosis-shtml.
50. Insel T. The NIMH Research Domain Criteria (RDoC) Project: precision medicine for psychiatry. Am. J. Psychiatry 2014, 171:395-397.
51. Irwin M., Daniels M., Bloom E.T., Smith T.L. Life events, depressive symptoms, and immune function. Am. J. Psychiatry 1987, 144(4):437-441.
52. Irwin M., Daniels M., Craig Risch S., Bloom E., Weiner H. Plasma cortisol and natural killer cell activity during bereavement. Biol. Psychiatry 1988, 24(2):173-178.
53. Isovich E., Engelmann M., Landgraf R., Fuchs E. Social isolation after a single defeat reduces striatal dopamine transporter binding in rats. Eur. J. Neurosci. 2001, 13(6):1254-1256.
54. Jacobs S.C., Mason J., Kosten T.R., Kasl S.V., Ostfeld A.M., Wahby V. Urinary free cortisol and separation anxiety early in the course of bereavement and threatened loss. Biol. Psychiatry 1987, 22(2):148-152.
55. Karg K., Burmeister M., Shedden K., Sen S. The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation. Arch. Gen. Psychiatry 2011, 68(5):444.
56. Kauer-Sant'Anna M., Tramontina J., Andreazza A.C., Cereser K., Costa S.D., Santin A., Yatham L.N., Kapczinski F. Traumatic life events in bipolar disorder: impact on BDNF levels and psychopathology. Bipolar Disord. 2007, 9(s1):128-135.
57. Kendler K.S., Gatz M., Gardner C.O., Pedersen N.L. A Swedish national twin study of lifetime major depression. Am. J. Psychiatry 2006, 163(1):109-114.
58. Kendler K.S., Karkowski L.M., Prescott C.A. Causal relationship between stressful life events and the onset of major depression. Am. J. Psychiatry 1999, 156(6):837-841.
59. Kendler K.S., Kessler R.C., Walters E.E., MacLean C., Neale M.C., Heath A.C., Eaves L.J. Stressful life events, genetic liability, and onset of an episode of major depression in women. Am. J. Psychiatry 1995, 152(6):833-842.
60. Kendler K., Myers J., Zisook S. Does bereavement-related major depression differ from major depression associated with other stressful life events?. Am. J. Psychiatry 2008, 165(11):1449-1455.
61. Kersting A., Kroker K., Horstmann J., Baune B.T., Hohoff C., Mortensen L.S., Neumann L.C., Arolt V., Domschke K. Association of MAO-A variant with complicated grief in major depression. Neuropsychobiology 2008, 56(4):191-196.
62. Kessler R.C. The Effects of Stressful Life Events on Depression 1997.
63. Khanfer R., Lord J.M., Phillips A.C. Neutrophil function and cortisol: DHEAS ratio in bereaved older adults. Brain Behav. Immun. 2011, 25(6):1182-1186.
64. Kim-Cohen J., Turkewitz R. Resilience and measured gene-environment interactions. Dev. Psychopathol. 2012, 24(04):1297-1306.
65. Kinnally E.L., Capitanio J.P., Leibel R., Deng L., LeDuc C., Haghighi F., Mann J.J. Epigenetic regulation of serotonin transporter expression and behavior in infant rhesus macaques. Genes Brain Behav. 2010, 9(6):575-582.
66. Koolhaas J., De Boer S., De Rutter A., Meerlo P., Sgoifo A. Social stress in rats and mice. Acta Physiol. Scand. Suppl. 1997, 640:69.
67. Kosten T.R., Jacobs S., Mason J., Wahby V., Atkins S. Psychological correlates of growth hormone response to stress. Psychosom. Med. 1984, 46(1):49-58.
68. Kunugi H., Ishida S., Kato T., Tatsumi M., Sakai T., Hattori M., Hirose T., Nanko S. A functional polymorphism in the promoter region of monoamine oxidase-A gene and mood disorders. Mol. Psychiatry 1999, 4(4):393-395.
69. Lesch K.-P. When the serotonin transporter gene meets adversity: the contribution of animal models to understanding epigenetic mechanisms in affective disorders and resilience. Molecular and Functional Models in Neuropsychiatry 2011, 251-280. Springer.
70. Lesch K.-P., Bengel D., Heils A., Sabol S.Z., Greenberg B.D., Petri S., Benjamin J., Müller C.R., Hamer D.H., Murphy D.L. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996, 274(5292):1527-1531.
71. Lindstrøm T.C. Immunity and health after bereavement in relation to coping. Scand. J. Psychol. 1997, 38(3):235-259.
72. Linn M.W., Linn B.S., Jensen J. Stressful events, dysphoric mood, and immune responsiveness. Psychol. Rep. 1984, 54(1):219-222.
73. Lobb E.A., Kristjanson L.J., Aoun S.M., Monterosso L., Halkett G.K., Davies A. Predictors of complicated grief: a systematic review of empirical studies. Death Stud. 2010, 34(8):673-698.
74. Lopez-Leon S., Janssens A., Ladd A.G.-Z., Del-Favero J., Claes S., Oostra B., Van Duijn C. Meta-analyses of genetic studies on major depressive disorder. Mol. Psychiatry 2007, 13(8):772-785.
75. Marais L., Stein D.J., Daniels W.M. Exercise increases BDNF levels in the striatum and decreases depressive-like behavior in chronically stressed rats. Metab. Brain Dis. 2009, 24(4):587-597.
76. Marais L., Van Rensburg S.J., Van Zyl J.M., Stein D.J., Daniels W.M. Maternal separation of rat pups increases the risk of developing depressive-like behavior after subsequent chronic stress by altering corticosterone and neurotrophin levels in the hippocampus. Neurosci. Res. 2008, 61(1):106-112.
77. Martinowich K., Manji H., Lu B. New insights into BDNF function in depression and anxiety. Nat. Neurosci. 2007, 10(9):1089-1093.
78. McEwen B.S., Milner T.A. Hippocampal formation: shedding light on the influence of sex and stress on the brain. Brain Res. Rev. 2007, 55(2):343-355.
79. McGowan P.O., Sasaki A., D'Alessio A.C., Dymov S., Labonté B., Szyf M., Turecki G., Meaney M.J. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat. Neurosci. 2009, 12(3):342-348.
80. Meyer J.H., Ginovart N., Boovariwala A., Sagrati S., Hussey D., Garcia A., Young T., Praschak-Rieder N., Wilson A.A., Houle S. Elevated monoamine oxidase a levels in the brain: an explanation for the monoamine imbalance of major depression. Arch. Gen. Psychiatry 2006, 63(11):1209.
81. Middleton W., Burnett P., Raphael B., Martinek N. The bereavement response: a cluster analysis. Br. J. Psychiatry 1996, 169(2):167-171.
82. Molteni R., Lipska B., Weinberger D., Racagni G., Riva M. Developmental and stress-related changes of neurotrophic factor gene expression in an animal model of schizophrenia. Mol. Psychiatry 2001, 6(3):285-292.
83. Moussavi S., Chatterji S., Verdes E., Tandon A., Patel V., Ustun B. Depression, chronic diseases, and decrements in health: results from the World Health Surveys. Lancet 2007, 370(9590):851-858.
84. Munafò M.R., Durrant C., Lewis G., Flint J. Gene×environment interactions at the serotonin transporter locus. Biol. Psychiatry 2009, 65(3):211-219.
85. Mykletun A., Bjerkeset O., Øverland S., Prince M., Dewey M., Stewart R. Levels of anxiety and depression as predictors of mortality: the HUNT study. Br. J. Psychiatry 2009, 195(2):118-125.
86. Ostergaard S., Jensen S., Bech P. The heterogeneity of the depressive syndrome: when numbers get serious. Acta Psychiatr. Scand. 2011, 124:495-496.
87. Parker G. Opening Pandora's box: how DSM-5 is coming to grief. Acta Psychiatr. Scand. 2013, 128(1):88-91.
88. Parkes C.M., Brown R.J. Health after bereavement. A controlled study of young Boston widows and widowers. Psychosom. Med. 1972, 34(5):449-461.
89. Paykel E. Life events and affective disorders. Acta Psychiatr. Scand. 2003, 108(s418):61-66.
90. Persico A., D'agruma L., Maiorano N., Totaro A., Militerni R., Bravaccio C., Wassink T., Schneider C., Melmed R., Trillo S. Reelin gene alleles and haplotypes as a factor predisposing to autistic disorder. Mol. Psychiatry 2001, 6(2):150.
91. Philibert R., Madan A., Andersen A., Cadoret R., Packer H., Sandhu H. Serotonin transporter mRNA levels are associated with the methylation of an upstream CpG island. Am. J. Med. Genet. B: Neuropsychiatr. Genet. 2007, 144(1):101-105.
92. Pies R.W. The Bereavement Exclusion and DSM-5: an Update and Commentary. Innovat. Clin. Neurosci. 2014, 11.
93. Pittenger C., Duman R.S. Stress, depression, and neuroplasticity: a convergence of mechanisms. Neuropsychopharmacology 2008, 33(1):88-109.
94. Prigerson H.G., Frank E., Kasl S.V., Reynolds C.F., Anderson B., Zubenko G.S., Houck P.R., George C.J., Kupfer D.J. Complicated grief and bereavement-related depression as distinct disorders: preliminary empirical validation in elderly bereaved spouses. Am. J. Psychiatry 1995, 152(1):22-30.
95. Rice D.S., Curran T. Role of the reelin signaling pathway in central nervous system development. Annu. Rev. Neurosci. 2001, 24(1):1005-1039.
96. Risch N., Herrell R., Lehner T., Liang K.-Y., Eaves L., Hoh J., Griem A., Kovacs M., Ott J., Merikangas K.R. Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression. JAMA: J. Am. Med. Assoc. 2009, 301(23):2462-2471.
97. Riso L.P., Miyatake R.K., Thase M.E. The search for determinants of chronic depression: a review of six factors. J. Affect. Disord. 2002, 70(2):103-115.
98. Riva M., Fumagalli F., Racagni G. Opposite regulation of basic fibroblast growth factor and nerve growth factor gene expression in rat cortical astrocytes following dexamethasone treatment. J. Neurochem. 1995, 64(6):2526-2533.
99. Roceri M., Hendriks W., Racagni G., Ellenbroek B., Riva M. Early maternal deprivation reduces the expression of BDNF and NMDA receptor subunits in rat hippocampus. Mol. Psychiatry 2001, 7(6):609-616.
100. Roth T.L., Lubin F.D., Funk A.J., Sweatt J.D. Lasting epigenetic influence of early-life adversity on the BDNF gene. Biol. Psychiatry 2009, 65(9):760-769.
101. Rush A., Trivedi M., Wisniewski S., Nierenberg A., Stewart J., Warden D. Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR* report. Am. J. Psychiatry 2006, 163:1905-1917.
102. Russo S.J., Murrough J.W., Han M.-H., Charney D.S., Nestler E.J. Neurobiology of resilience. Nat. Neurosci. 2012.
103. Rutten B., Hammels C., Geschwind N., Menne-Lothmann C., Pishva E., Schruers K., den Hove D., Kenis G., Os J., Wichers M. Resilience in mental health: linking psychological and neurobiological perspectives. Acta Psychiatr. Scand. 2013, 128(1):3-20.
104. Rutter M. Resilience in the face of adversity: protective factors and resistance to psychiatric disorder. Br. J. Psychiatry 1985, 147:598-611.
105. Rutter M. The Promotion of Resilience in the Face of Adversity 2006.
106. Sabol S.Z., Hu S., Hamer D. A functional polymorphism in the monoamine oxidase A gene promoter. Hum. Genet. 1998, 103(3):273-279.
107. Schleifer S.J., Keller S.E., Camerino M., Thornton J.C., Stein M. Suppression of lymphocyte stimulation following bereavement. JAMA: J. Am. Med. Assoc. 1983, 250(3):374-377.
108. Schmidt H.D., Duman R.S. Peripheral BDNF produces antidepressant-like effects in cellular and behavioral models. Neuropsychopharmacology 2010, 35(12):2378-2391.
109. Schmidt H.D., Shelton R.C., Duman R.S. Functional biomarkers of depression: diagnosis, treatment, and pathophysiology. Neuropsychopharmacology 2011, 36(12):2375-2394.
110. Schultze-Florey C.R., Martínez-Maza O., Magpantay L., Breen E.C., Irwin M.R., Gündel H., O'Connor M.-F. When grief makes you sick: bereavement induced systemic inflammation is a question of genotype. Brain Behav. Immun. 2012, 26(7):1066-1071.
111. Schulze T.G., Müller D.J., Krauss H., Scherk H., Ohlraun S., Syagailo Y.V., Windemuth C., Neidt H., Grässle M., Papassotiropoulos A. Association between a functional polymorphism in the monoamine oxidase A gene promoter and major depressive disorder. Am. J. Med. Genet. 2000, 96(6):801-803.
112. Sharpley C., Bitsika V. Differences in neurobiological pathways of four clinical content subtypes of depression. Behav. Brain Res. 2013, 256:368-376.
113. Sharpley C., Bitsika V. Validity, reliability and prevalence of four 'Clinical Content' subtypes of depression. Behav. Brain Res. 2014, 259:9-15.
114. Sharpley C., Bitsika V., Christie D. The incidence and causes of different subtypes of depression in prostate cancer patients: implications for cancer care. Eur. J. Cancer Care 2013, 22:815-823.
115. Sharpley C., Palanisamy S., Glyde N., Dillingham P., Agnew L. An update of the interaction between the serotonic transporter promoter variant (5-HTTLPR), stress and depression, plus an exploration of non-confirming findings. Behav. Brain Res. 2014, 273:89-105.
116. Sharpley C.F. Understanding and Treating Depression: Biological, Psychological and Behavioural Perspectives 2013, Tilde Publishing and Distribution.
117. Sharpley C.F., Bitsika V. Joining the dots: neurobiological links in a functional analysis of depression. Behav. Brain Funct. 2010, 6:73.
118. Shear K., Shair H. Attachment, loss, and complicated grief. Dev. Psychobiol. 2005, 47(3):253-267.
119. Shear M.K., Ghesquiere A., Glickman K. Bereavement and complicated grief. Curr. Psychiatry Rep. 2013, 15(11):1-7.
120. Shear M.K., Simon N., Wall M., Zisook S., Neimeyer R., Duan N., Reynolds C., Lebowitz B., Sung S., Ghesquiere A. Complicated grief and related bereavement issues for DSM-5. Depress. Anxiety 2011, 28(2):103-117.
121. Shih J., Thompson R. Monoamine oxidase in neuropsychiatry and behavior. Am. J. Hum. Genet. 1999, 65(3):593.
122. Shimizu E., Hashimoto K., Okamura N., Koike K., Komatsu N., Kumakiri C., Nakazato M., Watanabe H., Shinoda N., Okada S.-I. Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol. Psychiatry 2003, 54(1):70-75.
123. Simon N.M., Shear K.M., Thompson E.H., Zalta A.K., Perlman C., Reynolds C.F., Frank E., Melhem N.M., Silowash R. The prevalence and correlates of psychiatric comorbidity in individuals with complicated grief. Compr. Psychiatry 2007, 48(5):395-399.
124. Stroebe M.S., Folkman S., Hansson R.O., Schut H. The prediction of bereavement outcome: Development of an integrative risk factor framework. Soc. Sci. Med. 2006, 63(9):2440-2451.
125. Sullivan P.F., Neale M.C., Kendler K.S. Genetic epidemiology of major depression: review and meta-analysis. Am. J. Psychiatry 2000, 157(10):1552-1562.
126. Syagailo Y.V., Stöber G., Gräßle M., Reimer E., Knapp M., Jungkunz G., Okladnova O., Meyer J., Lesch K.P. Association analysis of the functional monoamine oxidase A gene promoter polymorphism in psychiatric disorders. Am. J. Med. Genet. 2001, 105(2):168-171.
127. Taliaz D., Loya A., Gersner R., Haramati S., Chen A., Zangen A. Resilience to chronic stress is mediated by hippocampal brain-derived neurotrophic factor. J. Neurosci. 2011, 31(12):4475-4483.
128. Teixeira C.M., Martín E.D., Sahún I., Masachs N., Pujadas L., Corvelo A., Bosch C., Rossi D., Martinez A., Maldonado R. Overexpression of reelin prevents the manifestation of behavioral phenotypes related to schizophrenia and bipolar disorder. Neuropsychopharmacology 2011, 36(12):2395-2405.
129. Tomita T., Kitamura T. Clinical and research measures of grief: a reconsideration. Compr. Psychiatry 2002, 43(2):95-102.
130. Trajkovska V., Vinberg M., Aznar S., Knudsen G.M., Kessing L.V. Whole blood BDNF levels in healthy twins discordant for affective disorder: association to life events and neuroticism. J. Affect. Disord. 2008, 108(1):165-169.
131. Üstün T., Ayuso-Mateos J.L., Chatterji S., Mathers C., Murray C.J. Global burden of depressive disorders in the year 2000. Br. J. Psychiatry 2004, 184(5):386-392.
132. Ustun T., Chatterji S. Global Burden of Depressive Disorders and Future Projections. Depression: Social and Economic Timebomb 2001, BMJ Books, London.
133. van IJzendoorn M.H., Caspers K., Bakermans-Kranenburg M.J., Beach S.R., Philibert R. Methylation matters: interaction between methylation density and serotonin transporter genotype predicts unresolved loss or trauma. Biol. Psychiatry 2010, 68(5):405-407.
134. Vos T., Flaxman A.D., Naghavi M., Lozano R., Michaud C., Ezzati M., Shibuya K., Salomon J.A., Abdalla S., Aboyans V. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2013, 380(9859):2163-2196.
135. Wakefield J.C., First B.M. Validity of the bereavement exclusion to major depression: does the empirical evidence support the proposal to eliminate the exclusion in DSM-5?. World Psychiatry. 2012, 11(1):3-10.
136. Weller E.B., Weller R.A., Fristad M.A., Bowes J.M. Dexamethasone suppression test and depressive symptoms in bereaved children: a preliminary report. J. Neuropsychiatry Clin. Neurosci. 1990, 2(4):418-421.
137. Wijngaards-de Meij L., Stroebe M., Schut H., Stroebe W., van den Bout J., van der Heijden P., Dijkstra I. Neuroticism and attachment insecurity as predictors of bereavement outcome. J. Res. Personal. 2007, 41(2):498-505.
138. Yu Y.W., Tsai S.-J., Hong C.-J., Chen T.-J., Chen M.-C., Yang C.-W. Association study of a monoamine oxidase a gene promoter polymorphism with major depressive disorder and antidepressant response. Neuropsychopharmacology 2005, 30(9):1719-1723.
139. Zisook S., Corruble E., Duan N., Iglewicz A., Karam E.G., Lanuoette N., Lebowitz B., Pies R., Reynolds C., Seay K. The bereavement exclusion and DSM-5. Depress. Anxiety 2012, 29(5):425-443.
140. Zisook S., Kendler K.S. Is bereavement-related depression different than non-bereavement-related depression?. Psychol. Med. 2007, 37(06):779-794.
141. Zisook S., Pies R., Corruble E. When is grief a disease?. Lancet 2012, 379(9826):1590.
142. Zisook S., Reynolds C.F., Pies R., Simon N., Lebowitz B., Madowitz J., Tal-Young I., Katherine Shear M. Bereavement, complicated grief, and DSM, part 1: depression. J. Clin. Psychiatry 2010, 71(7):955-956.
143. Zisook S., Shuchter S.R. Depression through the first year after the death of a spouse. Am. J. Psychiatry 1991, 148(10):1346-1352.
144. Zisook S., Shuchter S.R., Irwin M., Darko D.F., Sledge P., Resovsky K. Bereavement, depression, and immune function. Psychiatry Res. 1994, 52(1):1-10.
145. Zisook S., Shuchter S.R., Sledge P.A., Paulus M.P. The spectrum of depressive phenomena after spousal bereavement. J. Clin. Psychiatry 1994, 55(Suppl):29-36.