Resilience to chronic stress is mediated by hippocampal brain-derived neurotrophic factor

Journal of Neuroscience

Volumn 31, Issue 12, 2011, Pages 4475-4483

  Taliaz, Dekel ^a   Loya, Assaf ^a   Gersner, Roman ^a   Haramati, Sharon ^a   Chen, Alon ^a   Zangen, Abraham ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CORTICOSTERONE; HYDROCORTISONE;

ADAPTIVE BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC STRESS; CONTROLLED STUDY; COPING BEHAVIOR; CORTICOSTERONE BLOOD LEVEL; CORTICOSTERONE RELEASE; DEPRESSION; EMBRYO; HIPPOCAMPUS; HUMAN; HUMAN CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; AGING; ANIMAL; BLOOD; CHRONIC DISEASE; ENVIRONMENT; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPLORATORY BEHAVIOR; GENE SILENCING; GENETICS; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; LOCOMOTION; MENTAL STRESS; METABOLISM; MICROINJECTION; MOLECULAR GENETICS; PHYSIOLOGY; PSYCHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT; SWIMMING;

AGING; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHRONIC DISEASE; CORTICOSTERONE; ENVIRONMENT; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXPLORATORY BEHAVIOR; GENE KNOCKDOWN TECHNIQUES; HIPPOCAMPUS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; LOCOMOTION; MALE; MICROINJECTIONS; MOLECULAR SEQUENCE DATA; PITUITARY-ADRENAL SYSTEM; RATS; RATS, SPRAGUE-DAWLEY; RESILIENCE, PSYCHOLOGICAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STRESS, PSYCHOLOGICAL; SWIMMING;

EID: 79953008100     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5725-10.2011     Document Type: Article

References (29)

1. Altholtz LY, Fowler KA, Badura LL, Kovacs MS (2006) Comparison of the stress response in rats to repeated isoflurane or CO2:O2 anesthesia used for restraint during serial blood collection via the jugular vein. J Am Assoc Lab Anim Sci 45:17-22. (Pubitemid 43828864)
2. Charney DS (2004) Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress. Am J Psychiatry 161:195-216.
3. de Kloet ER, Joëls M, Holsboer F (2005) Stress and the brain: from adaptation to disease. Nat Rev Neurosci 6:463-475. (Pubitemid 40769171)
4. de Kloet ER, Derijk RH, Meijer OC (2007) Therapy insight: is there an imbalanced response of mineralocorticoid and glucocorticoid receptors in depression? Nat Clin Pract Endocrinol Metab 3:168-179.
5. Dhabhar FS, McEwen BS, Spencer RL (1993) Stress response, adrenal steroid receptor levels and corticosteroid-binding globulin levels: a comparison between Sprague-Dawley, Fischer 344 and Lewis rats. Brain Res 616:89-98.
6. Feder A, Nestler EJ, Charney DS (2009) Psychobiology and molecular genetics of resilience. Nat Rev Neurosci 10:446-457.
7. Fomby LM, Wheat TM, Hatter DE, Tuttle RL, Black CA (2004) Use of CO2/O2 anesthesia in the collection of samples for serum corticosterone analysis from Fischer 344 rats. Contemp Top Lab Anim Sci 43:8-12.
8. Francis DD, Diorio J, Plotsky PM, Meaney MJ (2002) Environmental enrichment reverses the effects of maternal separation on stress reactivity. J Neurosci 22:7840-7843. (Pubitemid 35379088)
9. Gersner R, Dar DE, Shabat-Simon M, Zangen A (2005) Behavioral analysis during the forced swimming test using a joystick device. J Neurosci Methods 143:117-121. (Pubitemid 40462256)
10. Gersner R, Gordon-Kiwkowitz M, Zangen A (2009) Automated behavioral analysis of limbs' activity in the forced swim test. J Neurosci Methods 180:82-86.
11. Gersner R, Toth E, Isserles M, Zangen A (2010) Site-specific antidepressant effects of repeated subconvulsive electrical stimulation: potential role of brain-derived neurotrophic factor. Biol Psychiatry 67:125-132.
12. Grønli J, Bramham C, Murison R, Kanhema T, Fiske E, Bjorvatn B, Ursin R, Portas CM (2006) Chronic mild stress inhibits BDNF protein expression and CREB activation in the dentate gyrus but not in the hippocampus proper. Pharmacol Biochem Behav 85:842-849. (Pubitemid 46149013)
13. Heim C, Newport DJ, Mletzko T, Miller AH, Nemeroff CB (2008) The link between childhood trauma and depression: insights from HPA axis studies in humans. Psychoneuroendocrinology 33:693-710.
14. Kendler KS, Karkowski LM, Prescott CA (1999) Causal relationship between stressful life events and the onset of major depression. Am J Psychiatry 156:837-841. (Pubitemid 29260336)
15. Krishnan V, Han MH, Graham DL, Berton O, Renthal W, Russo SJ, Laplant Q, Graham A, Lutter M, Lagace DC, Ghose S, Reister R, Tannous P, Green TA, Neve RL, Chakravarty S, Kumar A, Eisch AJ, Self DW, Lee FS, et al. (2007) Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell 131:391-404. (Pubitemid 47576141)
16. Lippmann M, Bress A, Nemeroff CB, Plotsky PM, Monteggia LM (2007) Long-term behavioural and molecular alterations associated with maternal separation in rats. Eur J Neurosci 25:3091-3098. (Pubitemid 46888796)
17. McEwen BS, Wingfield JC (2003) The concept of allostasis in biology and biomedicine. Horm Behav 43:2-15. (Pubitemid 36293268)
18. McGowan PO, Sasaki A, D'Alessio AC, Dymov S, Labonté B, Szyf M, Turecki G, Meaney MJ (2009) Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci 12:342-348.
19. Muscat R, Willner P (1992) Suppression of sucrose drinking by chronic mild unpredictable stress: a methodological analysis. Neurosci Biobehav Rev 16:507-517.
20. Nestler EJ, Carlezon WA Jr (2006) The mesolimbic dopamine reward circuit in depression. Biol Psychiatry 59:1151-1159. (Pubitemid 44192421)
21. Nestler EJ, Barrot M, DiLeone RJ, Eisch AJ, Gold SJ, Monteggia LM (2002) Neurobiology of depression. Neuron 34:13-25. (Pubitemid 34270695)
22. Numakawa T, Kumamaru E, Adachi N, Yagasaki Y, Izumi A, Kunugi H (2009) Glucocorticoid receptor interaction with TrkB promotes BDNF-triggered PLC-gamma signaling for glutamate release via a glutamate transporter. Proc Natl Acad Sci U S A 106:647-652.
23. Ridder S, Chourbaji S, Hellweg R, Urani A, Zacher C, Schmid W, Zink M, Hörtnagl H, Flor H, Henn FA, Schütz G, Gass P (2005) Mice with genetically altered glucocorticoid receptor expression show altered sensitivity for stress-induced depressive reactions. J Neurosci 25:6243-6250. (Pubitemid 40923491)
24. Sapolsky RM, Krey LC, McEwen BS (1984) Glucocorticoid-sensitive hippocampal neurons are involved in terminating the adrenocortical stress response. Proc Natl Acad Sci U S A 81:6174-6177. (Pubitemid 15220802)
25. Sapolsky RM, Zola-Morgan S, Squire LR (1991) Inhibition of glucocorticoid secretion by the hippocampal formation in the primate. J Neurosci 11:3695-3704.
26. Smith MA, Makino S, Kvetnansky R, Post RM (1995) Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. J Neurosci 15:1768-1777.
27. Taliaz D, Stall N, Dar DE, Zangen A (2010) Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis. Mol Psychiatry 15:80-92.
28. Toth E, Gersner R, Wilf-Yarkoni A, Raizel H, Dar DE, Richter-Levin G, Levit O, Zangen A (2008) Age-dependent effects of chronic stress on brain plasticity and depressive behavior. J Neurochem 107:522-532.
29. Xu L, Holscher C, Anwyl R, Rowan MJ (1998) Glucocorticoid receptor and protein/RNA synthesis-dependent mechanisms underlie the control of synaptic plasticity by stress. Proc Natl Acad Sci U S A 95:3204-3208. (Pubitemid 28135880)