Integrated proteomic and miRNA transcriptional analysis reveals the hepatotoxicity mechanism of PFNA exposure in mice

Journal of Proteome Research

Volumn 14, Issue 1, 2015, Pages 330-341

  Wang, Jianshe ^a   Yan, Shengmin ^a   Zhang, Wei ^a   Zhang, Hongxia ^a   Dai, Jiayin ^a  

^a INSTITUTE OF ZOOLOGY   (China)

Author keywords

hepatotoxicity; iTRAQ; miRNAs; PFNA

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; FUCOSYLTRANSFERASE; LACTATE DEHYDROGENASE; LIVER PROTEIN; MESSENGER RNA; MICRORNA; MICRORNA 100; MICRORNA 107; MICRORNA 200A; MICRORNA 200C; MICRORNA 31; MICRORNA 34A; PERFLUORONONANOIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; STEROL REGULATORY ELEMENT BINDING PROTEIN; TRIACYLGLYCEROL; AMINOTRANSFERASE; FLUOROCARBON; LUCIFERASE; PROTEOME;

AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; FATTY ACID OXIDATION; HEPATOMEGALY; HEPG2 CELL LINE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIPID LIVER LEVEL; LIVER TOXICITY; LIVER WEIGHT; MOUSE; NONHUMAN; PH; PROTEIN PROCESSING; PROTEOMICS; RNA TRANSCRIPTION; TANDEM MASS SPECTROMETRY; TRIACYLGLYCEROL BLOOD LEVEL; WESTERN BLOTTING; ANIMAL; BLOOD; CHEMICALLY INDUCED; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; LIVER; MALE; METABOLISM; PROCEDURES;

MUS;

ANIMALS; BLOTTING, WESTERN; CHOLESTEROL; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUOROCARBONS; GENE EXPRESSION REGULATION; HEPATOMEGALY; LIVER; LUCIFERASES; MALE; MICE; MICRORNAS; PROTEOME; PROTEOMICS; TRANSAMINASES; TRIGLYCERIDES;

EID: 84920272204     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr500641b     Document Type: Article

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