Global liver proteome analysis using iTRAQ labeling quantitative proteomic technology to reveal biomarkers in mice exposed to perfluorooctane sulfonate (PFOS)

Environmental Science and Technology

Volumn 46, Issue 21, 2012, Pages 12170-12177

  Tan, Feng ^a   Jin, Yihe ^a   Liu, Wei ^a   Quan, Xie ^a   Chen, Jingwen ^a   Liang, Zhen ^b  

^a DALIAN UNIVERSITY OF TECHNOLOGY   (China)

^b DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACTION MECHANISMS; ACYL-COA OXIDASE; ALDEHYDE DEHYDROGENASE; APOLIPOPROTEIN A-I; BIFUNCTIONAL ENZYMES; BODY WEIGHT; CONTROL GROUPS; DECARBOXYLASES; DOSE-DEPENDENT; ENVIRONMENTAL POLLUTANTS; EXPRESSION LEVELS; GENE ONTOLOGY; GLUTATHIONE S-TRANSFERASES; LIPID METABOLISMS; LONG-CHAIN ACYL-COA; MOLECULAR MECHANISM; PERFLUOROOCTANE SULFONATES; PROTEOME ANALYSIS; PROTEOMIC ANALYSIS; PROTEOMIC TECHNOLOGIES; SULFINIC ACID; XENOBIOTIC COMPOUNDS;

ALDEHYDES; AMINO ACIDS; ENZYMES; MAMMALS; METABOLISM; PHYSIOLOGY;

PROTEINS;

ACETYL COENZYME A ACYLTRANSFERASE; ACYL COENZYME A OXIDASE; ACYL COENZYME A OXIDASE 1; ALDEHYDE DEHYDROGENASE; APOLIPOPROTEIN A1; CARBOXYLYASE; CYSTEINE SULFINATE DECARBOXYLASE; CYTOCHROME P450; GLUTATHIONE TRANSFERASE; LIPID; LIVER PROTEIN; LONG CHAIN FATTY ACID COENZYME A LIGASE; PERFLUOROOCTANESULFONIC ACID; PROTEOME; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

BIOMARKER; DOSE-RESPONSE RELATIONSHIP; ENVIRONMENTAL FATE; GENE EXPRESSION; GENOME; METABOLISM; POLLUTION EXPOSURE; PROTEIN; QUANTITATIVE ANALYSIS; RODENT;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; FATTY ACID OXIDATION; LIPID METABOLISM; LIPID TRANSPORT; LIPOGENESIS; LIVER LEVEL; LIVER TOXICITY; MALE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PEROXISOME; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEOMICS;

ALKANESULFONIC ACIDS; ANIMALS; BIOLOGICAL MARKERS; ENVIRONMENTAL POLLUTANTS; FLUOROCARBONS; LIVER; MALE; MICE; PROTEOME; PROTEOMICS;

MUS;

EID: 84868527431     PISSN: 0013936X     EISSN: 15205851     Source Type: Journal    
DOI: 10.1021/es3027715     Document Type: Article

References (47)

1. Mak, Y. L.; Taniyasu, S.; Yeung, L. W. Y.; Lu, G. H.; Jin, L.; Yang, Y. L.; Lam, P. K. S.; Kannan, K.; Yamashita, N. Perfluorinated compounds in tap water from china and several other countries Environ. Sci. Technol. 2009, 43 (13) 4824-4829
2. Apelberg, B. J.; Witter, F. R.; Herbstman, J. B.; Calafat, A. M.; Halden, R. U.; Needham, L. L.; Goldman, L. R. Cord serum concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in relation to weight and size at birth Environ. Health Perspect. 2007, 115 (11) 1670-1676
3. Hoffman, K.; Webster, T. F.; Weisskopf, M. G.; Weinberg, J.; Vieira, V. M. Exposure to polyfluoroalkyl chemicals and attention deficit/hyperactivity disorder in U.S. children 12-15 years of age Environ. Health Perspect. 2010, 118 (12) 1762-1767
4. Wang, F. Q.; Liu, W.; Jin, Y. H.; Dai, J. Y.; Yu, W. G.; Liu, X. H.; Liu, L. Transcriptional effects of prenatal and neonatal exposure to PFOS in developing rat brain Environ. Sci. Technol. 2010, 44 (5) 1847-1853
5. Lantz, R. C.; Lynch, B. J.; Boitano, S.; Poplin, G. S.; Littau, S.; Tsaprailis, G.; Burgess, J. L. Pulmonary biomarkers based on alterations in protein expression after exposure to arsenic Environ. Health Perspect. 2007, 115 (4) 586-591
6. Benninghoff, A. D. Toxicoproteomics-The next step in the evolution of environmental biomarkers? Toxicol. Sci. 2007, 95 (1) 1-4
7. Colquhoun, D. R.; Goldman, L. R.; Cole, R. N.; Gucek, M.; Mansharamani, M.; Witter, F. R.; Apelberg, B. J.; Halden, R. U. Global Screening of human cord blood proteomes for biomarkers of toxic exposure and effect Environ. Health Perspect. 2009, 117 (5) 832-838
8. Merrick, B. A. The Human Proteome Organization (HUPO) and environmental health Environ. Health Perspect. 2003, 111 (6) 797-801
9. Zhao, Y. Y.; Xie, P.; Fan, H. H. Genomic profiling of MicroRNAs and proteomics reveals an early molecular alteration associated with tumorigenesis induced by MC-LR in mice Environ. Sci. Technol. 2012, 46 (1) 34-41
10. Klubicova, K.; Danchenko, M.; Skultety, L.; Miernyk, J. A.; Rashydov, N. M.; Berezhna, V. V.; PretOva, A.; Hajduch, M. Proteomics analysis of flax grown in chernobyl area suggests limited effect of contaminated environment on seed proteome Environ. Sci. Technol. 2010, 44 (18) 6940-6946
11. Pollack, K.; Balazs, K.; Ogunseitan, O. Proteomic assessment of caffeine effects on coral symbionts Environ. Sci. Technol. 2009, 43 (6) 2085-2091
12. Dorts, J.; Kestemont, P.; Marchand, P. A.; DHollander, W.; Thezenas, M. L.; Raes, M.; Silvestre, F. Ecotoxicoproteomics in gills of the sentinel fish species, cottus gobio, exposed to perfluorooctane sulfonate (PFOS) Aquat. Toxicol. 2011, 103 (1-2) 1-8
13. Shi, X. J.; Yeung, L. W. Y.; Lam, P. K. S.; Wu, R. S. S.; Zhou, B. S. Protein profiles in zebrafish (Danio rerio) embryos exposed to perfluorooctane sulfonate Toxicol. Sci. 2009, 110 (2) 334-340
14. Nesatyy, V. J.; Suter, M. J. F. Proteomics for the analysis of environmental stress responses in organisms Environ. Sci. Technol. 2007, 41 (20) 6891-6900
15. Ross, P. L.; Huang, Y. L. N.; Marchese, J. N.; Williamson, B.; Parker, K.; Hattan, S.; Khainovski, N.; Pillai, S.; Dey, S.; Daniels, S.; Purkayastha, S.; Juhasz, P.; Martin, S.; Bartlet-Jones, M.; He, F.; Jacobson, A.; Pappin, D. J. Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents Mol. Cell. Proteomics 2004, 3 (12) 1154-1169
16. Shipley, J. M.; Hurst, C. H.; Tanaka, S. S.; DeRoos, F. L.; Butenhoff, J. L.; Seacat, A. M.; Waxman, D. J. Trans-activation of PPAR alpha and induction of PPAR alpha target genes by perfluorooctane-based chemicals Toxicol. Sci. 2004, 80 (1) 151-160
17. Rosen, M. B.;; Schmid, J. R.;; Corton, J. C.;; Zehr, R. D.;; Das, K. P.;; Abbott, B. D.;; Lau, C. Gene expression profiling in wild-type and PPAR alpha-null mice exposed to perfluorooctane sulfonate reveals ppar alpha-independent effects. PPAR Res. 2010, 2010.
18. Hansen, K. J.; Clemen, L. A.; Ellefson, M. E.; Johnson, H. O. Compound-specific, quantitative characterization of organic: Fluorochemicals in biological matrices Environ. Sci. Technol. 2001, 35 (4) 766-770
19. Austin, M. E.; Kasturi, B. S.; Barber, M.; Kannan, K.; MohanKumar, P. S.; MohanKumar, S. M. J. Neuroendocrine effects of perfluorooctane sulfonate in rats Environ. Health Perspect. 2003, 111 (12) 1485-1489
20. Jain, S.; Graham, C.; Graham, R. L. J.; McMullan, G.; Ternan, N. G. Quantitative proteomic analysis of the heat stress response in clostridium difficile strain 630 J. Proteome Res. 2011, 10 (9) 3880-3890
21. Williamson, A. J. K.; Smith, D. L.; Blinco, D.; Unwin, R. D.; Pearson, S.; Wilson, C.; Miller, C.; Lancashire, L.; Lacaud, G.; Kouskoff, V.; Whetton, A. D. Quantitative proteomics analysis demonstrates post-transcriptional regulation of embryonic stem cell differentiation to hematopoiesis Mol. Cell. Proteomics 2008, 7 (3) 459-472
22. Li, D.; Li, J. Q.; Ouyang, S. G.; Wu, S. F.; Wang, J.; Xu, X. J.; Zhu, Y. P.; He, F. C. An integrated strategy for functional analysis in large-scale proteomic research by gene ontology Prog. Biochem. Biophys. 2005, 32 (11) 1026-1029
23. Mandard, S.; Muller, M.; Kersten, S. Peroxisome proliferator-activated receptor alpha target genes Cell. Mol. Life Sci. 2004, 61 (4) 393-416
24. Hu, W. Y.; Jones, P. D.; Celius, T.; Giesy, J. P. Identification of genes responsive to PFOS using gene expression profiling Environ. Toxicol. Pharmacol. 2005, 19 (1) 57-70
25. Hu, X.-Z.; Hu, D.-C. Effects of perfluorooctanoate and perfluorooctane sulfonate exposure on hepatoma Hep G2 cells Arch. Toxicol. 2009, 83 (9) 851-861
26. Liu, C.; Yu, K.; Shi, X.; Wang, J.; Lam, P. K. S.; Wu, R. S. S.; Zhou, B. Induction of oxidative stress and apoptosis by PFOS and PFOA in primary cultured hepatocytes of freshwater tilapia (Oreochromis niloticus) Aquat. Toxicol. 2007, 82 (2) 135-143
27. Shi, X.; Zhou, B. The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos Toxicol. Sci. 2010, 115 (2) 391-400
28. Qiao, S. J.; Tuohimaa, P. Vitamin D-3 inhibits fatty acid synthase expression by stimulating the expression of long-chain fatty-acid-CoA ligase 3 in prostate cancer cells FEBS Lett. 2004, 577 (3) 451-454
29. Dongol, B.; Shah, Y.; Kim, I.; Gonzalez, F. J.; Hunt, M. C. The acyl-CoA thioesterase I is regulated by PPAR alpha and HNF4 alpha via a distal response element in the promoter J. Lipid Res. 2007, 48 (8) 1781-1791
30. Seacat, A. M.; Thomford, P. J.; Hansen, K. J.; Olsen, G. W.; Case, M. T.; Butenhoff, J. L. Subchronic toxicity studies on perfluorooctanesulfonate potassium salt in cynomolgus monkeys Toxicol. Sci. 2002, 68 (1) 249-264
31. Kliewer, S. A.; Moore, J. T.; Wade, L.; Staudinger, J. L.; Watson, M. A.; Jones, S. A.; McKee, D. D.; Oliver, B. B.; Willson, T. M.; Zetterstrom, R. H.; Perlmann, T.; Lehmann, J. M. An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway Cell 1998, 92 (1) 73-82
32. Bijland, S.; Rensen, P. C. N.; Pieterman, E. J.; Maas, A. C. E.; van der Hoorn, J. W.; van Erk, M. J.; Havekes, L. M.; van Dijk, K. W.; Chang, S.-C.; Ehresman, D. J.; Butenhoff, J. L.; Princen, H. M. G. Perfluoroalkyl sulfonates cause alkyl chain length-dependent hepatic steatosis and hypolipidemia mainly by impairing lipoprotein production in APOE*3-leiden CETP mice Toxicol. Sci. 2011, 123 (1) 290-303
33. Lamsa, V.; Levonen, A.-L.; Leinonen, H.; Yla-Herttuala, S.; Yamamoto, M.; Hakkola, J. Cytochrome P450 2A5 Constitutive expression and induction by heavy metals is dependent on redox-sensitive transcription factor Nrf2 in liver Chem. Res. Toxicol. 2010, 23 (5) 977-985
34. Barclay, T. B.; Peters, J. M.; Sewer, M. B.; Ferrari, L.; Gonzalez, F. J.; Morgan, E. T. Modulation of cytochrome P-450 gene expression in endotoxemic mice is tissue specific and peroxisome proliferator-activated receptor-alpha dependent J. Pharmacol. Exp. Ther. 1999, 290 (3) 1250-1257
35. Mortensen, A. S.; Letcher, R. J.; Cangialosi, M. V.; Chu, S. G.; Arukwe, A. Tissue bioaccumulation patterns, xenobiotic biotransformation and steroid hormone levels in Atlantic salmon (Salmo salar) fed a diet containing perfluoroactane sulfonic or perfluorooctane carboxylic acids Chemosphere 2011, 83 (8) 1035-1044
36. Petit, E.; Michelet, X.; Rauch, C.; Bertrand-Michel, J.; Terce, F.; Legouis, R.; Morel, F. Glutathione transferases kappa 1 and kappa 2 localize in peroxisomes and mitochondria, respectively, and are involved in lipid metabolism and respiration in Caenorhabditis elegans FEBS J. 2009, 276 (18) 5030-5040
37. Yang, Y.; Parsons, K. K.; Chi, L.; Malakauskas, S. M.; Le, T. H. Glutathione S-transferase-μ1 regulates vascular smooth muscle cell proliferation, migration, and oxidative stress Hypertension 2009, 54 (6) 1360-1368
38. Cui, J. Y.; Choudhuri, S.; Knight, T. R.; Klaassen, C. D. Genetic and epigenetic regulation and expression signatures of glutathione s-transferases in developing mouse liver Toxicol. Sci. 2010, 116 (1) 32-43
39. Knight, T. R.; Choudhuri, S.; Klaassen, C. D. Induction of Hepatic glutathione S-transferases in male mice by prototypes of various classes of microsomal enzyme inducers Toxicol. Sci. 2008, 106 (2) 329-338
40. Devi, S. L.; Viswanathan, P.; Anuradha, C. V. Taurine enhances the metabolism and detoxification of ethanol and prevents hepatic fibrosis in rats treated with iron and alcohol Environ. Toxicol. Pharmacol. 2009, 27 (1) 120-126
41. Kishimoto, T.; Kokura, K.; Nakadai, T.; Miyazawa, Y.; Wakamatsu, T.; Makino, Y.; Nakamura, T.; Hara, E.; Oda, K.; Muramatsu, M.; Tamura, T. Overexpression of cysteine sulfinic acid decarboxylase stimulated by hepatocarcinogenesis results in autoantibody production in rats Cancer Res. 1996, 56 (22) 5230-5237
42. Li, S. Y.; Gomelsky, M.; Duan, J. H.; Zhang, Z. J.; Gomelsky, L.; Zhang, X. C.; Epstein, P. N.; Ren, J. Overexpression of aldehyde dehydrogenase-2 (ALDH2) transgene prevents acetaldehyde-induced cell injury in human umbilical vein endothelial cells-Role of ERK and p38 mitogen-activated protein kinase J. Biol. Chem. 2004, 279 (12) 11244-11252
43. Frederiksen, K. S.; Wulff, E. M.; Sauerberg, P.; Mogensen, J. P.; Jeppesen, L.; Fleckner, J. Prediction of PPAR-alpha ligand-mediated physiological changes using gene expression profiles J. Lipid Res. 2004, 45 (3) 592-601
44. Lau, C.; Butenhoff, J. L.; Rogers, J. M. The developmental toxicity of perfluoroalkyl acids and their derivatives Toxicol. Appl. Pharmacol. 2004, 198 (2) 231-241
45. Seacat, A. M.; Thomford, P. J.; Hansen, K. J.; Clemen, L. A.; Eldridge, S. R.; Elcombe, C. R.; Butenhoff, J. L. Sub-chronic dietary toxicity of potassium perfluorooctanesulfonate in rats Toxicology 2003, 192 (2-3) 263-264
46. Hu, J.; Zhang, Z.; Shen, W.-J.; Azhar, S. Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones Nutr. Metab. 2010, 7
47. Hu, W. Y.; Jones, P. D.; Upham, B. L.; Trosko, J. E.; Lau, C.; Giesy, J. P. Inhibition of gap junctional intercellular communication by perfluorinated compounds in rat liver and dolphin kidney epithelial cell lines in vitro and sprague-dawley rats in vivo Toxicol. Sci. 2002, 68 (2) 429-436