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Volumn 74, Issue 12, 2007, Pages 1738-1746

Highly sensitive upregulation of apolipoprotein A-IV by peroxisome proliferator-activated receptor α (PPARα) agonist in human hepatoma cells

Author keywords

Apolipoprotein; HDL; HepaRG; KRP; PPAR ; Triglyceride

Indexed keywords

ACYL COENZYME A DEHYDROGENASE; APOLIPOPROTEIN A1; APOLIPOPROTEIN A2; APOLIPOPROTEIN A4; APOLIPOPROTEIN A5; APOLIPOPROTEIN C3; CARNITINE PALMITOYLTRANSFERASE; ENOYL COENZYME A HYDRATASE; FATTY ACID BINDING PROTEIN; HIGH DENSITY LIPOPROTEIN; KRP 101; LIPID; LIVER FATTY ACID BINDING PROTEIN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PHOSPHOTRANSFERASE; PYRUVATE DEHYDROGENASE KINASE 4; SMALL INTERFERING RNA; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LONG CHAIN ACYL COENZYME A DEHYDROGENASE;

EID: 36048929554     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2007.08.020     Document Type: Article
Times cited : (23)

References (45)
  • 2
    • 0027139820 scopus 로고
    • Peroxisome proliferator-activated receptors
    • Keller H., and Wahli W. Peroxisome proliferator-activated receptors. Trends Endocrinol Metab 4 (1993) 291-296
    • (1993) Trends Endocrinol Metab , vol.4 , pp. 291-296
    • Keller, H.1    Wahli, W.2
  • 3
    • 0033574663 scopus 로고    scopus 로고
    • A unified nomenclature system for the nuclear receptor superfamily
    • A unified nomenclature system for the nuclear receptor superfamily. Cell 97 (1999) 161-163
    • (1999) Cell , vol.97 , pp. 161-163
  • 5
    • 0030047806 scopus 로고    scopus 로고
    • Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-α, -β, and -γ in the adult rat
    • Braissant O., Foufelle F., Scotto C., Dauca M., and Wahli W. Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-α, -β, and -γ in the adult rat. Endocrinology 137 (1996) 354-366
    • (1996) Endocrinology , vol.137 , pp. 354-366
    • Braissant, O.1    Foufelle, F.2    Scotto, C.3    Dauca, M.4    Wahli, W.5
  • 6
    • 0030747895 scopus 로고    scopus 로고
    • Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-α in humans: no alteration in adipose tissue of obese and NIDDM patients
    • Auboeuf D., Rieusset J., Fajas L., Vallier P., Frering V., Riou J.P., et al. Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-α in humans: no alteration in adipose tissue of obese and NIDDM patients. Diabetes 46 (1997) 1319-1327
    • (1997) Diabetes , vol.46 , pp. 1319-1327
    • Auboeuf, D.1    Rieusset, J.2    Fajas, L.3    Vallier, P.4    Frering, V.5    Riou, J.P.6
  • 7
    • 0029994543 scopus 로고    scopus 로고
    • Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression
    • Schoonjans K., Staels B., and Auwerx J. Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J Lipid Res 37 (1996) 907-925
    • (1996) J Lipid Res , vol.37 , pp. 907-925
    • Schoonjans, K.1    Staels, B.2    Auwerx, J.3
  • 9
    • 0027466627 scopus 로고
    • Mechanism of action of fibrates
    • Shepherd J. Mechanism of action of fibrates. Postgrad Med J 69 Suppl 1 (1993) S34-S41
    • (1993) Postgrad Med J , vol.69 , Issue.SUPPL. 1
    • Shepherd, J.1
  • 10
    • 0027092953 scopus 로고
    • Mode of action of fibrates
    • Catapano A.L. Mode of action of fibrates. Pharmacol Res 26 (1992) 331-340
    • (1992) Pharmacol Res , vol.26 , pp. 331-340
    • Catapano, A.L.1
  • 11
    • 33645076793 scopus 로고    scopus 로고
    • Mode of action of fibrates in the regulation of triglyceride and HDL-cholesterol metabolism
    • Fruchart J.C., and Duriez P. Mode of action of fibrates in the regulation of triglyceride and HDL-cholesterol metabolism. Drugs Today (Barc) 42 (2006) 39-64
    • (2006) Drugs Today (Barc) , vol.42 , pp. 39-64
    • Fruchart, J.C.1    Duriez, P.2
  • 12
    • 0029791412 scopus 로고    scopus 로고
    • PPARα and PPARγ activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene
    • Schoonjans K., Peinado-Onsurbe J., Lefebvre A.M., Heyman R.A., Briggs M., Deeb S., et al. PPARα and PPARγ activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene. Eur Mol Biol Org J 15 (1996) 5336-5348
    • (1996) Eur Mol Biol Org J , vol.15 , pp. 5336-5348
    • Schoonjans, K.1    Peinado-Onsurbe, J.2    Lefebvre, A.M.3    Heyman, R.A.4    Briggs, M.5    Deeb, S.6
  • 13
    • 0038043229 scopus 로고    scopus 로고
    • Apolipoprotein A5, a crucial determinant of plasma triglyceride levels, is highly responsive to peroxisome proliferator-activated receptor alpha activators
    • Vu-Dac N., Gervois P., Jakel H., Nowak M., Bauge E., Dehondt H., et al. Apolipoprotein A5, a crucial determinant of plasma triglyceride levels, is highly responsive to peroxisome proliferator-activated receptor alpha activators. J Biol Chem 278 (2003) 17982-17985
    • (2003) J Biol Chem , vol.278 , pp. 17982-17985
    • Vu-Dac, N.1    Gervois, P.2    Jakel, H.3    Nowak, M.4    Bauge, E.5    Dehondt, H.6
  • 14
    • 0028998129 scopus 로고
    • Mode of action of peroxisome proliferators as hypolipidemic drugs. Suppression of apolipoprotein C-III
    • Hertz R., Bishara-Shieban J., and Bar-Tana J. Mode of action of peroxisome proliferators as hypolipidemic drugs. Suppression of apolipoprotein C-III. J Biol Chem 270 (1995) 13470-13475
    • (1995) J Biol Chem , vol.270 , pp. 13470-13475
    • Hertz, R.1    Bishara-Shieban, J.2    Bar-Tana, J.3
  • 15
    • 0028817459 scopus 로고
    • Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates
    • Staels B., Vu-Dac N., Kosykh V.A., Saladin R., Fruchart J.C., Dallongeville J., et al. Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates. J Clin Invest 95 (1995) 705-712
    • (1995) J Clin Invest , vol.95 , pp. 705-712
    • Staels, B.1    Vu-Dac, N.2    Kosykh, V.A.3    Saladin, R.4    Fruchart, J.C.5    Dallongeville, J.6
  • 16
    • 0024474642 scopus 로고
    • Apolipoproteins C-II and C-III metabolism in hypertriglyceridemic patients. Effect of a drastic triglyceride reduction by combined diet restriction and fenofibrate administration
    • Malmendier C.L., Lontie J.F., Delcroix C., Dubois D.Y., Magot T., and De Roy L. Apolipoproteins C-II and C-III metabolism in hypertriglyceridemic patients. Effect of a drastic triglyceride reduction by combined diet restriction and fenofibrate administration. Atherosclerosis 77 (1989) 139-149
    • (1989) Atherosclerosis , vol.77 , pp. 139-149
    • Malmendier, C.L.1    Lontie, J.F.2    Delcroix, C.3    Dubois, D.Y.4    Magot, T.5    De Roy, L.6
  • 17
    • 8944252340 scopus 로고    scopus 로고
    • Opposite regulation of human versus mouse apolipoprotein A-I by fibrates in human apolipoprotein A-I transgenic mice
    • Berthou L., Duverger N., Emmanuel F., Langouet S., Auwerx J., Guillouzo A., et al. Opposite regulation of human versus mouse apolipoprotein A-I by fibrates in human apolipoprotein A-I transgenic mice. J Clin Invest 97 (1996) 2408-2416
    • (1996) J Clin Invest , vol.97 , pp. 2408-2416
    • Berthou, L.1    Duverger, N.2    Emmanuel, F.3    Langouet, S.4    Auwerx, J.5    Guillouzo, A.6
  • 18
    • 0031748864 scopus 로고    scopus 로고
    • Regulation of apoA-I gene expression by fibrates
    • Staels B., and Auwerx J. Regulation of apoA-I gene expression by fibrates. Atherosclerosis 137 Suppl (1998) S19-S23
    • (1998) Atherosclerosis , vol.137 , Issue.SUPPL
    • Staels, B.1    Auwerx, J.2
  • 19
    • 0032475854 scopus 로고    scopus 로고
    • The nuclear receptors peroxisome proliferator-activated receptor α and Rev-erbα mediate the species-specific regulation of apolipoprotein A-I expression by fibrates
    • Vu-Dac N., Chopin-Delannoy S., Gervois P., Bonnelye E., Martin G., Fruchart J.C., et al. The nuclear receptors peroxisome proliferator-activated receptor α and Rev-erbα mediate the species-specific regulation of apolipoprotein A-I expression by fibrates. J Biol Chem 273 (1998) 25713-25720
    • (1998) J Biol Chem , vol.273 , pp. 25713-25720
    • Vu-Dac, N.1    Chopin-Delannoy, S.2    Gervois, P.3    Bonnelye, E.4    Martin, G.5    Fruchart, J.C.6
  • 20
    • 0029119082 scopus 로고
    • Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor
    • Vu-Dac N., Schoonjans K., Kosykh V., Dallongeville J., Fruchart J.C., Staels B., et al. Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor. J Clin Invest 96 (1995) 741-750
    • (1995) J Clin Invest , vol.96 , pp. 741-750
    • Vu-Dac, N.1    Schoonjans, K.2    Kosykh, V.3    Dallongeville, J.4    Fruchart, J.C.5    Staels, B.6
  • 21
    • 0033025523 scopus 로고    scopus 로고
    • Absence of spontaneous peroxisome proliferation in enoyl-CoA hydratase/L-3-hydroxyacyl-CoA dehydrogenase-deficient mouse liver. Further support for the role of fatty acyl CoA oxidase in PPARalpha ligand metabolism
    • Qi C., Zhu Y., Pan J., Usuda N., Maeda N., Yeldandi A.V., et al. Absence of spontaneous peroxisome proliferation in enoyl-CoA hydratase/L-3-hydroxyacyl-CoA dehydrogenase-deficient mouse liver. Further support for the role of fatty acyl CoA oxidase in PPARalpha ligand metabolism. J Biol Chem 274 (1999) 15775-15780
    • (1999) J Biol Chem , vol.274 , pp. 15775-15780
    • Qi, C.1    Zhu, Y.2    Pan, J.3    Usuda, N.4    Maeda, N.5    Yeldandi, A.V.6
  • 22
    • 0032957086 scopus 로고    scopus 로고
    • Phytanic acid is ligand and transcriptional activator of murine liver fatty acid binding protein
    • Wolfrum C., Ellinghaus P., Fobker M., Seedorf U., Assmann G., Borchers T., et al. Phytanic acid is ligand and transcriptional activator of murine liver fatty acid binding protein. J Lipid Res 40 (1999) 708-714
    • (1999) J Lipid Res , vol.40 , pp. 708-714
    • Wolfrum, C.1    Ellinghaus, P.2    Fobker, M.3    Seedorf, U.4    Assmann, G.5    Borchers, T.6
  • 23
    • 0035865496 scopus 로고    scopus 로고
    • Long-chain fatty acids regulate liver carnitine palmitoyltransferase I gene (L-CPT I) expression through a peroxisome-proliferator-activated receptor alpha (PPARalpha)-independent pathway
    • Louet J.F., Chatelain F., Decaux J.F., Park E.A., Kohl C., Pineau T., et al. Long-chain fatty acids regulate liver carnitine palmitoyltransferase I gene (L-CPT I) expression through a peroxisome-proliferator-activated receptor alpha (PPARalpha)-independent pathway. Biochem J 354 (2001) 189-197
    • (2001) Biochem J , vol.354 , pp. 189-197
    • Louet, J.F.1    Chatelain, F.2    Decaux, J.F.3    Park, E.A.4    Kohl, C.5    Pineau, T.6
  • 24
    • 0028229531 scopus 로고
    • Rat very-long-chain acyl-CoA dehydrogenase, a novel mitochondrial acyl-CoA dehydrogenase gene product, is a rate-limiting enzyme in long-chain fatty acid beta-oxidation system. cDNA and deduced amino acid sequence and distinct specificities of the cDNA-expressed protein
    • Aoyama T., Ueno I., Kamijo T., and Hashimoto T. Rat very-long-chain acyl-CoA dehydrogenase, a novel mitochondrial acyl-CoA dehydrogenase gene product, is a rate-limiting enzyme in long-chain fatty acid beta-oxidation system. cDNA and deduced amino acid sequence and distinct specificities of the cDNA-expressed protein. J Biol Chem 269 (1994) 19088-19094
    • (1994) J Biol Chem , vol.269 , pp. 19088-19094
    • Aoyama, T.1    Ueno, I.2    Kamijo, T.3    Hashimoto, T.4
  • 25
    • 0344082370 scopus 로고    scopus 로고
    • A metabolic switching hypothesis for the first step in the hypolipidemic effects of fibrates
    • Motojima K. A metabolic switching hypothesis for the first step in the hypolipidemic effects of fibrates. Biol Pharm Bull 25 (2002) 1509-1511
    • (2002) Biol Pharm Bull , vol.25 , pp. 1509-1511
    • Motojima, K.1
  • 26
    • 0025248437 scopus 로고
    • Lipoprotein ApoC-II activation of lipoprotein lipase. Modulation by apolipoprotein A-IV
    • Goldberg I.J., Scheraldi C.A., Yacoub L.K., Saxena U., and Bisgaier C.L. Lipoprotein ApoC-II activation of lipoprotein lipase. Modulation by apolipoprotein A-IV. J Biol Chem 265 (1990) 4266-4272
    • (1990) J Biol Chem , vol.265 , pp. 4266-4272
    • Goldberg, I.J.1    Scheraldi, C.A.2    Yacoub, L.K.3    Saxena, U.4    Bisgaier, C.L.5
  • 27
    • 0034749662 scopus 로고    scopus 로고
    • Apolipoprotein C-III deficiency accelerates triglyceride hydrolysis by lipoprotein lipase in wild-type and apoE knockout mice
    • Jong M.C., Rensen P.C., Dahlmans V.E., van der Boom H., van Berkel T.J., and Havekes L.M. Apolipoprotein C-III deficiency accelerates triglyceride hydrolysis by lipoprotein lipase in wild-type and apoE knockout mice. J Lipid Res 42 (2001) 1578-1585
    • (2001) J Lipid Res , vol.42 , pp. 1578-1585
    • Jong, M.C.1    Rensen, P.C.2    Dahlmans, V.E.3    van der Boom, H.4    van Berkel, T.J.5    Havekes, L.M.6
  • 28
    • 0033554001 scopus 로고    scopus 로고
    • Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor α
    • Murakami K., Ide T., Suzuki M., Mochizuki T., and Kadowaki T. Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor α. Biochem Biophys Res Commun 260 (1999) 609-613
    • (1999) Biochem Biophys Res Commun , vol.260 , pp. 609-613
    • Murakami, K.1    Ide, T.2    Suzuki, M.3    Mochizuki, T.4    Kadowaki, T.5
  • 29
    • 0031793850 scopus 로고    scopus 로고
    • A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-α (PPAR-α) and PPAR-γ: effect of PPAR-α activation on abnormal lipid metabolism in liver of Zucker fatty rats
    • Murakami K., Tobe K., Ide T., Mochizuki T., Ohashi M., Akanuma Y., et al. A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-α (PPAR-α) and PPAR-γ: effect of PPAR-α activation on abnormal lipid metabolism in liver of Zucker fatty rats. Diabetes 47 (1998) 1841-1847
    • (1998) Diabetes , vol.47 , pp. 1841-1847
    • Murakami, K.1    Tobe, K.2    Ide, T.3    Mochizuki, T.4    Ohashi, M.5    Akanuma, Y.6
  • 30
    • 2342475664 scopus 로고    scopus 로고
    • Pharmacological characterization of a human-specific peroxisome proliferater-activated receptor alpha (PPARalpha) agonist in dogs
    • Nagasawa M., Ide T., Suzuki M., Tsunoda M., Akasaka Y., Okazaki T., et al. Pharmacological characterization of a human-specific peroxisome proliferater-activated receptor alpha (PPARalpha) agonist in dogs. Biochem Pharmacol 67 (2004) 2057-2069
    • (2004) Biochem Pharmacol , vol.67 , pp. 2057-2069
    • Nagasawa, M.1    Ide, T.2    Suzuki, M.3    Tsunoda, M.4    Akasaka, Y.5    Okazaki, T.6
  • 31
    • 0026577411 scopus 로고
    • Fibrates influence the expression of genes involved in lipoprotein metabolism in a tissue-selective manner in the rat
    • Staels B., van Tol A., Andreu T., and Auwerx J. Fibrates influence the expression of genes involved in lipoprotein metabolism in a tissue-selective manner in the rat. Arterioscler Thromb 12 (1992) 286-294
    • (1992) Arterioscler Thromb , vol.12 , pp. 286-294
    • Staels, B.1    van Tol, A.2    Andreu, T.3    Auwerx, J.4
  • 32
    • 9444234519 scopus 로고    scopus 로고
    • Overlapping transcriptional programs regulated by the nuclear receptors peroxisome proliferator-activated receptor alpha, retinoid X receptor, and liver X receptor in mouse liver
    • Anderson S.P., Dunn C., Laughter A., Yoon L., Swanson C., Stulnig T.M., et al. Overlapping transcriptional programs regulated by the nuclear receptors peroxisome proliferator-activated receptor alpha, retinoid X receptor, and liver X receptor in mouse liver. Mol Pharmacol 66 (2004) 1440-1452
    • (2004) Mol Pharmacol , vol.66 , pp. 1440-1452
    • Anderson, S.P.1    Dunn, C.2    Laughter, A.3    Yoon, L.4    Swanson, C.5    Stulnig, T.M.6
  • 33
    • 0018689153 scopus 로고
    • Apolipoprotein A-IV: a protein occurring in human mesenteric lymph chylomicrons and free in plasma. Isolation and quantification
    • Utermann G., and Beisiegel U. Apolipoprotein A-IV: a protein occurring in human mesenteric lymph chylomicrons and free in plasma. Isolation and quantification. Eur J Biochem 99 (1979) 333-343
    • (1979) Eur J Biochem , vol.99 , pp. 333-343
    • Utermann, G.1    Beisiegel, U.2
  • 34
    • 0021715084 scopus 로고
    • Metabolism of apolipoprotein A-IV
    • Lefevre M., and Roheim P.S. Metabolism of apolipoprotein A-IV. J Lipid Res 25 (1984) 1603-1610
    • (1984) J Lipid Res , vol.25 , pp. 1603-1610
    • Lefevre, M.1    Roheim, P.S.2
  • 35
    • 0008138455 scopus 로고
    • Expression of rat apolipoprotein A-IV and A-I genes: mRNA induction during development and in response to glucocorticoids and insulin
    • Elshourbagy N.A., Boguski M.S., Liao W.S., Jefferson L.S., Gordon J.I., and Taylor J.M. Expression of rat apolipoprotein A-IV and A-I genes: mRNA induction during development and in response to glucocorticoids and insulin. Proc Natl Acad Sci USA 82 (1985) 8242-8246
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 8242-8246
    • Elshourbagy, N.A.1    Boguski, M.S.2    Liao, W.S.3    Jefferson, L.S.4    Gordon, J.I.5    Taylor, J.M.6
  • 37
    • 0030944085 scopus 로고    scopus 로고
    • Reduced aortic lesions and elevated high density lipoprotein levels in transgenic mice overexpressing mouse apolipoprotein A-IV
    • Cohen R.D., Castellani L.W., Qiao J.H., Van Lenten B.J., Lusis A.J., and Reue K. Reduced aortic lesions and elevated high density lipoprotein levels in transgenic mice overexpressing mouse apolipoprotein A-IV. J Clin Invest 99 (1997) 1906-1916
    • (1997) J Clin Invest , vol.99 , pp. 1906-1916
    • Cohen, R.D.1    Castellani, L.W.2    Qiao, J.H.3    Van Lenten, B.J.4    Lusis, A.J.5    Reue, K.6
  • 38
    • 15644365767 scopus 로고    scopus 로고
    • Decreased HDL cholesterol levels but normal lipid absorption, growth, and feeding behavior in apolipoprotein A-IV knockout mice
    • Weinstock P.H., Bisgaier C.L., Hayek T., Aalto-Setala K., Sehayek E., Wu L., et al. Decreased HDL cholesterol levels but normal lipid absorption, growth, and feeding behavior in apolipoprotein A-IV knockout mice. J Lipid Res 38 (1997) 1782-1794
    • (1997) J Lipid Res , vol.38 , pp. 1782-1794
    • Weinstock, P.H.1    Bisgaier, C.L.2    Hayek, T.3    Aalto-Setala, K.4    Sehayek, E.5    Wu, L.6
  • 39
    • 0026696728 scopus 로고
    • Increased apolipoprotein A-IV in rat mesenteric lymph after lipid meal acts as a physiological signal for satiation
    • Fujimoto K., Cardelli J.A., and Tso P. Increased apolipoprotein A-IV in rat mesenteric lymph after lipid meal acts as a physiological signal for satiation. Am J Physiol 262 (1992) G1002-G1006
    • (1992) Am J Physiol , vol.262
    • Fujimoto, K.1    Cardelli, J.A.2    Tso, P.3
  • 40
    • 0027175434 scopus 로고
    • Suppression of food intake by apolipoprotein A-IV is mediated through the central nervous system in rats
    • Fujimoto K., Fukagawa K., Sakata T., and Tso P. Suppression of food intake by apolipoprotein A-IV is mediated through the central nervous system in rats. J Clin Invest 91 (1993) 1830-1833
    • (1993) J Clin Invest , vol.91 , pp. 1830-1833
    • Fujimoto, K.1    Fukagawa, K.2    Sakata, T.3    Tso, P.4
  • 41
    • 34247104590 scopus 로고    scopus 로고
    • Associations of the apolipoprotein A1/C3/A4/A5 gene cluster with triglyceride and HDL cholesterol levels in women with type 2 diabetes
    • Qi L., Liu S., Rifai N., Hunter D., and Hu F.B. Associations of the apolipoprotein A1/C3/A4/A5 gene cluster with triglyceride and HDL cholesterol levels in women with type 2 diabetes. Atherosclerosis 192 (2007) 204-210
    • (2007) Atherosclerosis , vol.192 , pp. 204-210
    • Qi, L.1    Liu, S.2    Rifai, N.3    Hunter, D.4    Hu, F.B.5
  • 42
    • 0035715730 scopus 로고    scopus 로고
    • Antioxidative and antiatherosclerotic effects of human apolipoprotein A-IV in apolipoprotein E-deficient mice
    • Ostos M.A., Conconi M., Vergnes L., Baroukh N., Ribalta J., Girona J., et al. Antioxidative and antiatherosclerotic effects of human apolipoprotein A-IV in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 21 (2001) 1023-1028
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 1023-1028
    • Ostos, M.A.1    Conconi, M.2    Vergnes, L.3    Baroukh, N.4    Ribalta, J.5    Girona, J.6
  • 43
    • 0035914298 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-alpha regulates lipid homeostasis, but is not associated with obesity: studies with congenic mouse lines
    • Akiyama T.E., Nicol C.J., Fievet C., Staels B., Ward J.M., Auwerx J., et al. Peroxisome proliferator-activated receptor-alpha regulates lipid homeostasis, but is not associated with obesity: studies with congenic mouse lines. J Biol Chem 276 (2001) 39088-39093
    • (2001) J Biol Chem , vol.276 , pp. 39088-39093
    • Akiyama, T.E.1    Nicol, C.J.2    Fievet, C.3    Staels, B.4    Ward, J.M.5    Auwerx, J.6
  • 44
    • 0035943681 scopus 로고    scopus 로고
    • Differential gene regulation in human versus rodent hepatocytes by peroxisome proliferator-activated receptor (PPAR) alpha. PPAR alpha fails to induce peroxisome proliferation-associated genes in human cells independently of the level of receptor expresson
    • Lawrence J.W., Li Y., Chen S., DeLuca J.G., Berger J.P., Umbenhauer D.R., et al. Differential gene regulation in human versus rodent hepatocytes by peroxisome proliferator-activated receptor (PPAR) alpha. PPAR alpha fails to induce peroxisome proliferation-associated genes in human cells independently of the level of receptor expresson. J Biol Chem 276 (2001) 31521-31527
    • (2001) J Biol Chem , vol.276 , pp. 31521-31527
    • Lawrence, J.W.1    Li, Y.2    Chen, S.3    DeLuca, J.G.4    Berger, J.P.5    Umbenhauer, D.R.6
  • 45
    • 23944482211 scopus 로고    scopus 로고
    • Identification of a novel selective peroxisome proliferator-activated receptor alpha agonist, 2-methyl-2-(4-{3-[1-(4-methylbenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl]propyl}phenoxy)propanoic acid (LY518674), that produces marked changes in serum lipids and apolipoprotein A-1 expression
    • Singh J.P., Kauffman R., Bensch W., Wang G., McClelland P., Bean J., et al. Identification of a novel selective peroxisome proliferator-activated receptor alpha agonist, 2-methyl-2-(4-{3-[1-(4-methylbenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl]propyl}phenoxy)propanoic acid (LY518674), that produces marked changes in serum lipids and apolipoprotein A-1 expression. Mol Pharmacol 68 (2005) 763-768
    • (2005) Mol Pharmacol , vol.68 , pp. 763-768
    • Singh, J.P.1    Kauffman, R.2    Bensch, W.3    Wang, G.4    McClelland, P.5    Bean, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.