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Volumn 6, Issue 11, 2014, Pages 931-943

Loss of Nfkb1 leads to early onset aging

Author keywords

Aging; CNS gliosis; Nfkb1; Replicative senescence; H2AX

Indexed keywords

DNA; H2AX PROTEIN, MOUSE; HISTONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NFKB1 PROTEIN, MOUSE;

EID: 84920264332     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100702     Document Type: Article
Times cited : (74)

References (50)
  • 1
    • 0033953142 scopus 로고    scopus 로고
    • Somatic mutations and aging: a re-evaluation
    • Vijg J. Somatic mutations and aging: a re-evaluation. Mutat Res. 2000; 447:117-135.
    • (2000) Mutat Res , vol.447 , pp. 117-135
    • Vijg, J.1
  • 2
    • 33750029285 scopus 로고    scopus 로고
    • Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition
    • Blagosklonny MV. Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition. Cell Cycle. 2006; 5:2087-2102.
    • (2006) Cell Cycle , vol.5 , pp. 2087-2102
    • Blagosklonny, M.V.1
  • 3
    • 84906230064 scopus 로고    scopus 로고
    • Biology of Cancer and Aging: A Complex Association With Cellular Senescence
    • Epub ahead of print
    • Falandry C, Bonnefoy M, Freyer G and Gilson E. Biology of Cancer and Aging: A Complex Association With Cellular Senescence. J Clin Oncol. 2014; Epub ahead of print.
    • (2014) J Clin Oncol
    • Falandry, C.1    Bonnefoy, M.2    Freyer, G.3    Gilson, E.4
  • 4
    • 84873633910 scopus 로고    scopus 로고
    • Genetics of longevity in model organisms: debates and paradigm shifts
    • Gems D and Partridge L. Genetics of longevity in model organisms: debates and paradigm shifts. Annual review of physiology. 2013; 75:621-644.
    • (2013) Annual review of physiology , vol.75 , pp. 621-644
    • Gems, D.1    Partridge, L.2
  • 5
    • 34548186667 scopus 로고    scopus 로고
    • Cellular senescence: when bad things happen to good cells
    • Campisi J and d'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol. 2007; 8:729-740.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 729-740
    • Campisi, J.1    d'Adda di Fagagna, F.2
  • 7
    • 84878118233 scopus 로고    scopus 로고
    • Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan
    • Rana A, Rera M and Walker DW. Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan. Proc Natl Acad Sci U S A. 2013; 110:8638-8643.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 8638-8643
    • Rana, A.1    Rera, M.2    Walker, D.W.3
  • 8
    • 37249009271 scopus 로고    scopus 로고
    • Motif module map reveals enforcement of aging by continual NF-kappaB activity
    • Adler AS, Sinha S, Kawahara TL, Zhang JY, Segal E and Chang HY. Motif module map reveals enforcement of aging by continual NF-kappaB activity. Genes Dev. 2007; 21:3244-3257.
    • (2007) Genes Dev , vol.21 , pp. 3244-3257
    • Adler, A.S.1    Sinha, S.2    Kawahara, T.L.3    Zhang, J.Y.4    Segal, E.5    Chang, H.Y.6
  • 10
    • 81255192180 scopus 로고    scopus 로고
    • The Two Faces of NF-kappaB Signaling in Cancer Development and Therapy
    • Klein U and Ghosh S. The Two Faces of NF-kappaB Signaling in Cancer Development and Therapy. Cancer Cell. 2011; 20:556-558.
    • (2011) Cancer Cell , vol.20 , pp. 556-558
    • Klein, U.1    Ghosh, S.2
  • 11
    • 35448960010 scopus 로고    scopus 로고
    • Many faces of NF-kappaB signaling induced by genotoxic stress
    • Wu ZH and Miyamoto S. Many faces of NF-kappaB signaling induced by genotoxic stress. J Mol Med. 2007; 85:1187-1202.
    • (2007) J Mol Med , vol.85 , pp. 1187-1202
    • Wu, Z.H.1    Miyamoto, S.2
  • 12
    • 84856641109 scopus 로고    scopus 로고
    • NF-kappaB, the first quartercentury: remarkable progress and outstanding questions
    • Hayden MS and Ghosh S. NF-kappaB, the first quartercentury: remarkable progress and outstanding questions. Genes Dev. 2012; 26:203-234.
    • (2012) Genes Dev , vol.26 , pp. 203-234
    • Hayden, M.S.1    Ghosh, S.2
  • 13
    • 33750467991 scopus 로고    scopus 로고
    • Unravelling the complexities of the NFkappaB signalling pathway using mouse knockout and transgenic models
    • Gerondakis S, Grumont R, Gugasyan R, Wong L, Isomura I, Ho W and Banerjee A. Unravelling the complexities of the NFkappaB signalling pathway using mouse knockout and transgenic models. Oncogene. 2006; 25:6781-6799.
    • (2006) Oncogene , vol.25 , pp. 6781-6799
    • Gerondakis, S.1    Grumont, R.2    Gugasyan, R.3    Wong, L.4    Isomura, I.5    Ho, W.6    Banerjee, A.7
  • 14
    • 0028804551 scopus 로고
    • Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses
    • Sha WC, Liou HC, Tuomanen EI and Baltimore D. Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses. Cell. 1995; 80:321-330.
    • (1995) Cell , vol.80 , pp. 321-330
    • Sha, W.C.1    Liou, H.C.2    Tuomanen, E.I.3    Baltimore, D.4
  • 16
    • 36849088515 scopus 로고    scopus 로고
    • Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer
    • Li H, Vogel H, Holcomb VB, Gu Y and Hasty P. Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer. Mol Cell Biol. 2007; 27:8205-8214.
    • (2007) Mol Cell Biol , vol.27 , pp. 8205-8214
    • Li, H.1    Vogel, H.2    Holcomb, V.B.3    Gu, Y.4    Hasty, P.5
  • 20
    • 0027156673 scopus 로고
    • Age-related gliosis in the white matter of mice
    • Bronson RT, Lipman RD and Harrison DE. Age-related gliosis in the white matter of mice. Brain Res. 1993; 609:124-128.
    • (1993) Brain Res , vol.609 , pp. 124-128
    • Bronson, R.T.1    Lipman, R.D.2    Harrison, D.E.3
  • 22
    • 79953677172 scopus 로고    scopus 로고
    • Apoptosis and aging: increased resistance to apoptosis enhances the aging process
    • Salminen A, Ojala J and Kaarniranta K. Apoptosis and aging: increased resistance to apoptosis enhances the aging process. Cell Mol Life Sci. 2011; 68:1021-1031.
    • (2011) Cell Mol Life Sci , vol.68 , pp. 1021-1031
    • Salminen, A.1    Ojala, J.2    Kaarniranta, K.3
  • 23
    • 0033535375 scopus 로고    scopus 로고
    • DNA adduct formation from tobacco-specific Nnitrosamines
    • Hecht SS. DNA adduct formation from tobacco-specific Nnitrosamines. Mutat Res. 1999; 424:127-142.
    • (1999) Mutat Res , vol.424 , pp. 127-142
    • Hecht, S.S.1
  • 24
    • 0027477075 scopus 로고
    • In vivo evidence for endogenous DNA alkylation damage as a source of spontaneous mutation in eukaryotic cells
    • Xiao W and Samson L. In vivo evidence for endogenous DNA alkylation damage as a source of spontaneous mutation in eukaryotic cells. Proc Natl Acad Sci U S A. 1993; 90:2117-2121.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 2117-2121
    • Xiao, W.1    Samson, L.2
  • 28
    • 0029834145 scopus 로고    scopus 로고
    • Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-kappa B
    • Helenius M, Hanninen M, Lehtinen SK and Salminen A. Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-kappa B. Biochem J. 1996; 318:603-608.
    • (1996) Biochem J , vol.318 , pp. 603-608
    • Helenius, M.1    Hanninen, M.2    Lehtinen, S.K.3    Salminen, A.4
  • 30
    • 48549099463 scopus 로고    scopus 로고
    • Cell autonomous expression of inflammatory genes in biologically aged fibroblasts associated with elevated NF-kappaB activity
    • Kriete A, Mayo KL, Yalamanchili N, Beggs W, Bender P, Kari C and Rodeck U. Cell autonomous expression of inflammatory genes in biologically aged fibroblasts associated with elevated NF-kappaB activity. Immunity & ageing: I & A. 2008; 5:5.
    • (2008) Immunity & ageing: I & A , vol.5 , pp. 5
    • Kriete, A.1    Mayo, K.L.2    Yalamanchili, N.3    Beggs, W.4    Bender, P.5    Kari, C.6    Rodeck, U.7
  • 31
    • 0142105387 scopus 로고    scopus 로고
    • Genetic analysis of NF-kappaB/Rel transcription factors defines functional specificities
    • Hoffmann A, Leung TH and Baltimore D. Genetic analysis of NF-kappaB/Rel transcription factors defines functional specificities. Embo J. 2003; 22:5530-5539.
    • (2003) Embo J , vol.22 , pp. 5530-5539
    • Hoffmann, A.1    Leung, T.H.2    Baltimore, D.3
  • 34
    • 33646156398 scopus 로고    scopus 로고
    • Age-related neural degeneration in nuclear-factor kappaB p50 knockout mice
    • Lu ZY, Yu SP, Wei JF and Wei L. Age-related neural degeneration in nuclear-factor kappaB p50 knockout mice. Neuroscience. 2006; 139:965-978.
    • (2006) Neuroscience , vol.139 , pp. 965-978
    • Lu, Z.Y.1    Yu, S.P.2    Wei, J.F.3    Wei, L.4
  • 36
    • 35948990508 scopus 로고    scopus 로고
    • Development of spontaneous optic neuropathy in NFkappaBetap50-deficient mice: requirement for NFkappaBetap50 in ganglion cell survival
    • Takahashi Y, Katai N, Murata T, Taniguchi SI and Hayashi T. Development of spontaneous optic neuropathy in NFkappaBetap50-deficient mice: requirement for NFkappaBetap50 in ganglion cell survival. Neuropathology and applied neurobiology. 2007; 33:692-705.
    • (2007) Neuropathology and applied neurobiology , vol.33 , pp. 692-705
    • Takahashi, Y.1    Katai, N.2    Murata, T.3    Taniguchi, S.I.4    Hayashi, T.5
  • 39
    • 0038198881 scopus 로고    scopus 로고
    • Neurons, glia, and plasticity in normal brain aging
    • discussion S131
    • Finch CE. Neurons, glia, and plasticity in normal brain aging. Neurobiol Aging. 2003; 24 Suppl 1:S123-127; discussion S131.
    • (2003) Neurobiol Aging , vol.24 , pp. S123-S127
    • Finch, C.E.1
  • 41
    • 74949088495 scopus 로고    scopus 로고
    • Targeted disruption of NF-{kappa}B1 (p50) augments cigarette smoke-induced lung inflammation and emphysema in mice: a critical role of p50 in chromatin remodeling
    • Rajendrasozhan S, Chung S, Sundar IK, Yao H and Rahman I. Targeted disruption of NF-{kappa}B1 (p50) augments cigarette smoke-induced lung inflammation and emphysema in mice: a critical role of p50 in chromatin remodeling. Am J Physiol Lung Cell Mol Physiol. 2010; 298:L197-209.
    • (2010) Am J Physiol Lung Cell Mol Physiol , vol.298 , pp. L197-L209
    • Rajendrasozhan, S.1    Chung, S.2    Sundar, I.K.3    Yao, H.4    Rahman, I.5
  • 43
    • 13944270339 scopus 로고    scopus 로고
    • Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
    • Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell. 2005; 120:513-522.
    • (2005) Cell , vol.120 , pp. 513-522
    • Campisi, J.1
  • 44
    • 0029023626 scopus 로고
    • Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved
    • Wang E. Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved. Cancer Res. 1995; 55:2284-2292.
    • (1995) Cancer Res , vol.55 , pp. 2284-2292
    • Wang, E.1
  • 46
    • 0030960606 scopus 로고    scopus 로고
    • Age-related changes in the regulation of transcription factor NF-kappa B in rat brain
    • Korhonen P, Helenius M and Salminen A. Age-related changes in the regulation of transcription factor NF-kappa B in rat brain. Neurosci Lett. 1997; 225:61-64.
    • (1997) Neurosci Lett , vol.225 , pp. 61-64
    • Korhonen, P.1    Helenius, M.2    Salminen, A.3
  • 47
    • 0033921321 scopus 로고    scopus 로고
    • Induction of transcriptional activity of AP-1 and NF-kappaB in the gastric mucosa during aging
    • Xiao ZQ and Majumdar AP. Induction of transcriptional activity of AP-1 and NF-kappaB in the gastric mucosa during aging. Am J Physiol Gastrointest Liver Physiol. 2000; 278:G855-865.
    • (2000) Am J Physiol Gastrointest Liver Physiol , vol.278 , pp. G855-G865
    • Xiao, Z.Q.1    Majumdar, A.P.2
  • 48
    • 3042738400 scopus 로고    scopus 로고
    • Age-associated increase in oxidative stress and nuclear factor kappaB activation are attenuated in rat liver by regular exercise
    • Radak Z, Chung HY, Naito H, Takahashi R, Jung KJ, Kim HJ and Goto S. Age-associated increase in oxidative stress and nuclear factor kappaB activation are attenuated in rat liver by regular exercise. Faseb J. 2004; 18:749-750.
    • (2004) Faseb J , vol.18 , pp. 749-750
    • Radak, Z.1    Chung, H.Y.2    Naito, H.3    Takahashi, R.4    Jung, K.J.5    Kim, H.J.6    Goto, S.7
  • 49
    • 0034102203 scopus 로고    scopus 로고
    • The effect of age on cyclooxygenase-2 gene expression: NF-kappaB activation and IkappaBalpha degradation
    • Kim HJ, Kim KW, Yu BP and Chung HY. The effect of age on cyclooxygenase-2 gene expression: NF-kappaB activation and IkappaBalpha degradation. Free Radic Biol Med. 2000; 28:683-692.
    • (2000) Free Radic Biol Med , vol.28 , pp. 683-692
    • Kim, H.J.1    Kim, K.W.2    Yu, B.P.3    Chung, H.Y.4
  • 50
    • 0035082777 scopus 로고    scopus 로고
    • Characterization of aging-associated up-regulation of constitutive nuclear factor-kappa B binding activity
    • Helenius M, Kyrylenko S, Vehvilainen P and Salminen A. Characterization of aging-associated up-regulation of constitutive nuclear factor-kappa B binding activity. Antioxid Redox Signal. 2001; 3:147-156.
    • (2001) Antioxid Redox Signal , vol.3 , pp. 147-156
    • Helenius, M.1    Kyrylenko, S.2    Vehvilainen, P.3    Salminen, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.