Mycophenolic acid inhibits replication of Japanese encephalitis virus

Chemotherapy

Volumn 57, Issue 1, 2011, Pages 56-61

  Sebastian, Liba ^a   Madhusudana, Shampur Narayan ^a   Ravi, Vasanthapuram ^a   Desai, Anita ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH AND NEUROSCIENCES   (India)

Author keywords

Antiviral agents; Flaviviruses; Mycophenolic acid

Indexed keywords

MYCOPHENOLIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DOSE RESPONSE; DRUG EFFECT; IC 50; IN VITRO STUDY; IN VIVO STUDY; JAPANESE ENCEPHALITIS VIRUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; VIRUS INHIBITION; VIRUS PLAQUE; VIRUS REPLICATION;

ANIMALS; ANTIVIRAL AGENTS; ENCEPHALITIS VIRUS, JAPANESE; ENCEPHALITIS, JAPANESE; MICE; MYCOPHENOLIC ACID; VIRUS REPLICATION;

EID: 79251536544     PISSN: 00093157     EISSN: None     Source Type: Journal    
DOI: 10.1159/000321483     Document Type: Article

References (22)

1. Chen CJ, Raung SL, Kuo MD, Wang YM: Suppression of Japanese encephalitis virus infection by non-steroidal anti-inflammatory drugs. J Gen Virol 2002;83:1897-1905.
2. Morrey JD, Smee DF, Sidwell RW, Tseng C: Identification of active antiviral compounds against a New York isolate of West Nile virus. Antivir Res 2002;55:107-116. (Pubitemid 34655646)
3. Markland W, McQuaid TJ, Jain J, Kwong AD: Broad spectrum antiviral activity of the IMP dehydrogenase inhibitor VX-497: a comparison with ribavirin and demonstration of antiviral activity with alpha interferon. Antimicrob Agents Chemother 2000;44:859-866. (Pubitemid 30165261)
4. De Clercq E: Virus replication: target functions and events for virus-specific inhibitors; in Antiviral Agents and Human Viral Diseases, ed 4. Philadelphia, Lippincott-Raven, 1997, pp 1-42.
5. Neyts J, Meerbach A, McKenna P, De Clercq E: Use of the yellow fever virus vaccine strain-17D for the study of strategies for the treatment of yellow fever virus infections. Antiviral Res 1996;30:125-132. (Pubitemid 26178132)
6. Diamond MS, Zachariah M, Harris E: Mycophenolic acid inhibits Dengue virus infection by preventing replication of viral RNA. Virology 2002;304:211-221.
7. Crance JM, Scarmozzino N, Jouan A, Garin D: Interferon, ribavirin, 6-azauridine and glycyrrhizin: antiviral compounds active against pathogenic flavivirus. Antivir Res 2003;58:73-79. (Pubitemid 36507224)
8. Sebastian L, Desai A, Madhusudana SN, Yogeeswari Y, Sriram D, Ravi V: N-methylisatin- beta-t thiosemicarbazone derivative (SCH 16) is an inhibitor of Japanese encephalitis virus infection in vitro and in vivo. Virol J 2008;5:64.
9. Sebastian L, Desai A, Madhusudana SN, Yogeeswari Y, Sriram D, Ravi V: Pentoxifylline inhibits replication of Japanese encephalitis virus: a comparative study with ribavirin. Int J Antimicrob Agents 2009;33:168-173.
10. Kumar R, Mathur A, Kumar A, Sethi GD, Sharma S, Chaturvedi UC: Virological investigations of acute encephalopathy in India. Arch Dis Child 1990;65:1227-1230. (Pubitemid 20356890)
11. Monath TP: Flaviviruses;in Field BN, Knipe DM (eds): Virology. New York, Raven, 1990, pp 763-814.
12. Leyssen P, Balzarini J, De Clercq E, Neyts J: The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase. J Virol 2005;79:1943-1947. (Pubitemid 40459141)
13. Takhampunya R, Ubol S, Houng H, Cameron CE, Padmanabhan R: Inhibition of dengue virus replication by mycophenolic acid and ribavirin. J Gen Virology 2006;87:1947-1952. (Pubitemid 43985877)
14. Sintchak MD, Fleming MA, Futer O, et al: Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid. Cell 1996;85:921-930. (Pubitemid 26192142)
15. Durez P, Appelboom T, Pira C, Stordeur P, Vray B, Goldman M: Anti-inflammatory properties of mycophenolate mofetil in murine endotoxemia: inhibition of TNF-alpha and upregulation of IL-10 release. Int J Immunopharmacol 1999;21:581-587. (Pubitemid 29364265)
16. Baer PC, Wegner B, Geiger H: Effects of mycophenolic acid on IL-6 expression of human renal proximal and distal tubular cells in vitro. Nephrol Dial Transplant 2004;19:47-52. (Pubitemid 38072614)
17. Ravi V, Parida S, Desai A, Chandramukhi A, Gourie-Devi M, Grau GE: Correlation of tumor necrosis factor levels in the serum and cerebrospinal fluid with clinical outcome in Japanese encephalitis patients, J Med Virology 1997;51:132-136. (Pubitemid 27101284)
18. Winter PM, Dung NM, Loan HT, Kneen R, Wills B, Thu LT, House D, White N, Jeremy J, Farra JJ, Hart CA, Solomon T: Pro-inflammatory cytokines and chemokines in humans with Japanese encephalitis. J Infect Diseases 2004;190:1618-1626. (Pubitemid 39411011)
19. Subramanian GM, Moore PA, Gowen BB, Olsen Al, Barnard DL, Paragas J, Hogan RJ, Sidwell RW: Potent in vitro activity of the albumin fusion type 1 interferons (albumin-interferon-alpha and albumin-interferonbeta) against RNA viral agents of bioterrorism and the severe acute respiratory syndrome (SARS) virus. Chemotherapy 2008;54:176-180. (Pubitemid 351929267)
20. Harinasatu C, Nimmanitya S, Titsyakorn U: The effect of interferon on two cases of Japanese encephalitis in Thailand. Southeast Asian J Trop Med Public Health 1985;16:332-336. (Pubitemid 16226897)
21. Schäfer A, Scheurlen M, Weissbrich B, Schöttker K, Kraus MR: Sustained virological response in the antiviral therapy of chronic hepatitis virus C: is there a predictive value of interferon-induced depression? Chemotherapy 2007;53:292-299.
22. Vanrenterghem Y: The use of mycophenolate mofetil (Cellcept) in renal transplantation. Nephron 1997;76:392-399.