DR4 specific TRAIL variants are more efficacious than wild-type TRAIL in pancreatic cancer

Cancer Biology and Therapy

Volumn 15, Issue 12, 2014, Pages 1658-1666

  Yu, Rui ^a   Albarenque, Stella Maris ^a   Cool, Robbert H ^b,c   Quax, Wim J ^b   Mohr, Andrea ^d   Zwacka, Ralf M ^a,d  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

^c Triskel Therapeutics BV   (Netherlands)

^d UNIVERSITY OF ESSEX   (United Kingdom)

Author keywords

Apoptosis; Dr4 specific trail variant; Pancreatic cancer; TRAIL; Trail receptor; XIAP

Indexed keywords

AMINO ACID; DEATH RECEPTOR 4; DEATH RECEPTOR 5; RECOMBINANT TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; SOLUBLE TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; RECOMBINANT PROTEIN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; DRUG EFFICACY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PANCREAS CARCINOMA; PANCREATIC CANCER CELL LINE; SUPERNATANT; TUMOR XENOGRAFT; ANIMAL; DISEASE MODEL; DRUG EFFECTS; DRUG SCREENING; FEMALE; GENE EXPRESSION; GENETIC TRANSFECTION; GENETIC VARIABILITY; GENETICS; METABOLISM; MUTATION; PANCREAS TUMOR; PATHOLOGY; SECRETION (PROCESS); TUMOR CELL LINE; TUMOR VOLUME;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION; GENETIC VARIATION; HUMANS; MICE; MUTATION; PANCREATIC NEOPLASMS; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; RECOMBINANT PROTEINS; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TRANSFECTION; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84920169131     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/15384047.2014.972183     Document Type: Article

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