DR4-selective tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) variants obtained by structure-based design

Journal of Biological Chemistry

Volumn 283, Issue 29, 2008, Pages 20560-20568

  Tur, Vicente ^a   Van Der Sloot, Almer M ^a   Reis, Carlos R ^e   Szegezdi, Eva ^b   Cool, Robbert H ^c,e   Samali, Afshin ^b   Serrano, Luis ^d   Quax, Wim J ^e  

^a CENTRE FOR GENOMIC REGULATION CRG   (Spain)

^b NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^c Triskel Therapeutics BV   (Netherlands)

^d UNIVERSITAT POMPEU FABRA   (Spain)

^e UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; AMINO ACIDS; CELL CULTURE; CRYSTAL STRUCTURE; GLYCOPROTEINS; LIGANDS; MACROPHAGES; ORGANIC ACIDS; SURFACE PLASMON RESONANCE; TUMORS;

AMINO ACID SUBSTITUTIONS; ANTI CANCER AGENTS; APOPTOSIS; BINDING SPECIFICITIES; CANCER CELLS; CELL LINES; CHEMOTHERAPEUTIC DRUGS; DEATH RECEPTORS; OSTEOPROTEGERIN; PROTEIN DESIGNS; RECEPTOR BINDINGS; SURFACE PLASMONS; TUMOR NECROSIS FACTORS;

CELL DEATH;

ASPARTIC ACID; CYTOKINE RECEPTOR; DEATH RECEPTOR 4; DEATH RECEPTOR 5; HISTIDINE; MUTANT PROTEIN; OSTEOPROTEGERIN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR 3; TYROSINE; RECOMBINANT PROTEIN; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR;

AMINO ACID SUBSTITUTION; APOPTOSIS; ARTICLE; BINDING AFFINITY; CANCER CELL; CELL LINE; CELL STRAIN; CELL STRAIN A2780; COMPUTER AIDED DESIGN; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG TARGETING; GENETIC VARIABILITY; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STRUCTURE; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION; SURFACE PLASMON RESONANCE; CHEMICAL STRUCTURE; CHEMISTRY; ELECTRICITY; GENETICS; HUMAN; METABOLISM; MUTATION; PROTEIN TERTIARY STRUCTURE; TUMOR CELL LINE; X RAY CRYSTALLOGRAPHY;

CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; ELECTROSTATICS; HUMANS; MODELS, MOLECULAR; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; RECOMBINANT PROTEINS; SURFACE PLASMON RESONANCE; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR NECROSIS FACTORS;

EID: 50649111704     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M800457200     Document Type: Article

References (38)

1. Shifman, J. M., and Mayo, S. L. (2002) J. Mol. Biol. 323, 417-423
2. Reina, J., Lacroix, E., Hobson, S. D., Fernandez-Ballester, G., Rybin, V., Schwab, M. S., Serrano, L., and Gonzalez, C. (2002) Nat. Struct. Biol. 9, 621-627
3. Havranek, J. J., and Harbury, P. B. (2003) Nat. Struct. Biol. 10, 45-52
4. Kortemme, T., Joachimiak, L. A., Bullock, A. N., Schuler, A. D., Stoddard, B. L., and Baker, D. (2004) Nat. Struct. Mol. Biol. 11, 371-379
5. Ashkenazi, A., Pai, R. C., Fong, S., Leung, S., Lawrence, D. A., Marsters, S. A., Blackie, C., Chang, L., McMurtrey, A. E., Hebert, A., Deforge, L., Koumenis, I. L., Lewis, D., Harris, L., Bussiere, J., Koeppen, H., Shahrokh, Z., and Schwall, R. H. (1999) J. Clin. Invest. 104, 155-162
6. LeBlanc, H. N., and Ashkenazi, A. (2003) Cell Death. Differ. 10, 66-75
7. Chaudhary, P. M., Eby, M., Jasmin, A., Bookwalter, A., Murray, J., and Hood, L. (1997) Immunity 7, 821-830
8. Schneider, P., Thome, M., Burns, K., Bodmer, J. L., Hofmann, K., Kataoka, T., Holler, N., and Tschopp, J. (1997) Immunity 7, 831-836
9. Kuang, A. A., Diehl, G. E., Zhang, J., and Winoto, A. (2000) J. Biol. Chem. 275, 25065-25068
10. Kischkel, F. C., Lawrence, D. A., Chuntharapai, A., Schow, P., Kim, K. J., and Ashkenazi, A. (2000) Immunity 12, 611-620
11. Sprick, M. R., Weigand, M. A., Rieser, E., Rauch, C. T., Juo, P., Blenis, J., Krammer, P. H., and Walczak, H. (2000) Immunity 12, 599-609
12. Bodmer, J. L., Holler, N., Reynard, S., Vinciguerra, P., Schneider, P., Juo, P., Blenis, J., and Tschopp, J. (2000) Nat. Cell Biol. 2, 241-243
13. Kischkel, F. C., Lawrence, D. A., Tinel, A., LeBlanc, H., Virmani, A., Schow, P., Gazdar, A., Blenis, J., Arnott, D., and Ashkenazi, A. (2001) J. Biol. Chem. 276, 46639-46646
14. Kimberley, F. C., and Screaton, G. R. (2004) Cell Res. 14, 359-372
15. Griffith, T. S., Rauch, C. T., Smolak, P. J., Waugh, J. Y., Boiani, N., Lynch, D. H., Smith, C. A., Goodwin, R. G., and Kubin, M. Z. (1999) J. Immunol. 162, 2597-2605
16. Ichikawa, K., Liu, W., Zhao, L., Wang, Z., Liu, D., Ohtsuka, T., Zhang, H., Mountz, J. D., Koopman, W. J., Kimberly, R. P., and Zhou, T. (2001) Nat. Med. 7, 954-960
17. Chuntharapai, A., Dodge, K., Grimmer, K., Schroeder, K., Marsters, S. A., Koeppen, H., Ashkenazi, A., and Kim, K. J. (2001) J. Immunol. 166, 4891-4898
18. Bin, L., Thorburn, J., Thomas, L. R., Clark, P. E., Humphreys, R., and Thorburn, A. (2007) J. Biol. Chem. 282, 28189-28194
19. Wen, J., Ramadevi, N., Nguyen, D., Perkins, C., Worthington, E., and Bhalla, K. (2000) Blood 96, 3900-3906
20. van der Sloot, A. M., Tur, V., Szegezdi, E., Mullally, M. M., Cool, R. H., Samali, A., Serrano, L., and Quax, W. J. (2006) Proc. Natl. Acad. Sci. U. S. A. 103, 8634-8639
21. MacFarlane, M., Inoue, S., Kohlhaas, S. L., Majid, A., Harper, N., Kennedy, D. B., Dyer, M. J., and Cohen, G. M. (2005) Cell Death. Differ. 12, 773-782
22. MacFarlane, M., Kohlhaas, S. L., Sutcliffe, M. J., Dyer, M. J., and Cohen, G. M. (2005) Cancer Res. 65, 11265-11270
23. Yagita, H., Takeda, K., Hayakawa, Y., Smyth, M. J., and Okumura, K. (2004) Cancer Sci. 95, 777-783
24. Truneh, A., Sharma, S., Silverman, C., Khandekar, S., Reddy, M. P., Deen, K. C., McLaughlin, M. M., Srinivasula, S. M., Livi, G. P., Marshall, L. A., Alnemri, E. S., Williams, W. V., and Doyle, M. L. (2000) J. Biol. Chem. 275, 23319-23325
25. Mongkolsapaya, J., Grimes, J. M., Chen, N., Xu, X. N., Stuart, D. I., Jones, E. Y., and Screaton, G. R. (1999) Nat. Struct. Biol. 6, 1048-1053
26. Strausberg, R. L., Feingold, E. A., Grouse, L. H., Derge, J. G., Klausner, R. D., Collins, F. S., Wagner, L., Shenmen, C. M., Schuler, G. D., Altschul, S. F., Zeeberg, B., Buetow, K. H., Schaefer, C. F., Bhat, N. K., Hopkins, R. F., Jordan, H., Moore, T., Max, S. I., Wang, J., Hsieh, F., Diatchenko, L., Marusina, K., Farmer, A. A., Rubin, G. M., Hong, L., Stapleton, M., Soares, M. B., Bonaldo, M. F., Casavant, T. L., Scheetz, T. E., Brownstein, M. J., Usdin, T. B., Toshiyuki, S., Carninci, P., Prange, C., Raha, S. S., Loquellano, N. A., Peters, G. J., Abramson, R. D., Mullahy, S. J., Bosak, S. A., McEwan, P. J., McKernan, K. J., Malek, J. A., Gunaratne, P. H., Richards, S., Worley, K. C., Hale, S., Garcia, A. M., Gay, L. J., Hulyk, S. W., Villalon, D. K., Muzny, D. M., Sodergren, E. J., Lu, X., Gibbs, R. A., Fahey, J., Helton, E., Ketteman, M., Madan, A., Rodrigues, S., Sanchez, A., Whiting, M., Madan, A., Young, A. C., Shevchenko, Y., Bouffard, G. G., Blakesley, R. W., Touchman, J. W., Green, E. D., Dickson, M. C., Rodriguez, A. C., Grimwood, J., Schmutz, J., Myers, R. M., Butterfield, Y. S., Krzywinski, M. I., Skalska, U., Smailus, D. E., Schnerch, A., Schein, J. E., Jones, S. J., and Marra, M. A. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 16899-16903
27. Guerois, R., Nielsen, J. E., and Serrano, L. (2002) J. Mol. Biol. 320, 369 -387
28. Schymkowitz, J. W., Rousseau, F., Martins, I. C., Ferkinghoff-Borg, J., Stricher, F., and Serrano, L. (2005) Proc. Natl. Acad. Sci. U. S. A. 102, 10147-10152
29. Kiel, C., Serrano, L., and Herrmann, C. (2004) J. Mol. Biol. 340, 1039-1058
30. van der Sloot, A. M., Mullally, M. M., Fernandez-Ballester, G., Serrano, L., and Quax, W. J. (2004) Protein Eng. Des. Sel. 17, 673-680
31. Hymowitz, S. G., O'Connell, M. P., Ultsch, M. H., Hurst, A., Totpal, K., Ashkenazi, A., de Vos, A. M., and Kelley, R. F. (2000) Biochemistry 39, 633-640
32. Kelley, R. F., Totpal, K., Lindstrom, S. H., Mathieu, M., Billeci, K., Deforge, L., Pai, R., Hymowitz, S. G., and Ashkenazi, A. (2005) J. Biol. Chem. 280, 2205-2212
33. Wiley, S. R., Schooley, K., Smolak, P. J., Din, W. S., Huang, C. P., Nicholl, J. K., Sutherland, G. R., Smith, T. D., Rauch, C., Smith, C. A., and Goodwin, R. G. (1995) Immunity 3, 673-682
34. Steed, P. M., Tansey, M. G., Zalevsky, J., Zhukovsky, E. A., Desjarlais, J. R., Szymkowski, D. E., Abbott, C., Carmichael, D., Chan, C., Cherry, L., Cheung, P., Chirino, A. J., Chung, H. H., Doberstein, S. K., Eivazi, A., Filikov, A. V., Gao, S. X., Hubert, R. S., Hwang, M., Hyun, L., Kashi, S., Kim, A., Kim, E., Kung, J., Martinez, S. P., Muchhal, U. S., Nguyen, D. H., O'Brien, C., O'Keefe, D., Singer, K., Vafa, O., Vielmetter, J., Yoder, S. C., and Dahiyat, B. I. (2003) Science 301, 1895-1898
35. Wohlgemuth, S., Kiel, C., Kramer, A., Serrano, L., Wittinghofer, F., and Herrmann, C. (2005) J. Mol. Biol. 348, 741-758
36. Kiel, C., Wohlgemuth, S., Rousseau, F., Schymkowitz, J., Ferkinghoff-Borg, J., Wittinghofer, F., and Serrano, L. (2005) J. Mol. Biol. 348, 759-775
37. Kempkens, O., Medina, E., Fernandez-Ballester, G., Ozuyaman, S., Le Bivic, A., Serrano, L., and Knust, E. (2006) Eur. J. Cell Biol. 85, 753-767
38. Szczepek, M., Brondani, V., Buchel, J., Serrano, L., Segal, D. J., and Cathomen, T. (2007) Nat. Biotechnol. 25, 786-793