-
1
-
-
0036162436
-
The molecular architecture of the TNF superfamily
-
DOI 10.1016/S0968-0004(01)01995-8, PII S0968000401019958
-
Bodmer, J. L., Schneider, P., and Tschopp, J. (2002) The molecular architecture of the TNF superfamily. Trends Biochem. Sci. 27, 19-26 (Pubitemid 34131621)
-
(2002)
Trends in Biochemical Sciences
, vol.27
, Issue.1
, pp. 19-26
-
-
Bodmer, J.-L.1
Schneider, P.2
Tschopp, J.3
-
2
-
-
18144383021
-
Cellular signaling by fibroblast growth factor receptors
-
DOI 10.1016/j.cytogfr.2005.01.001
-
Eswarakumar, V. P., Lax, I., and Schlessinger, J. (2005) Cellular signaling by fibroblast growth factor receptors. Cytokine Growth Factor Rev. 16, 139-149 (Pubitemid 40616112)
-
(2005)
Cytokine and Growth Factor Reviews
, vol.16
, Issue.2 SPEC. ISS.
, pp. 139-149
-
-
Eswarakumar, V.P.1
Lax, I.2
Schlessinger, J.3
-
3
-
-
48249158391
-
Structure-based view of epidermal growth factor receptor regulation
-
Ferguson, K. M. (2008) Structure-based view of epidermal growth factor receptor regulation. Annu. Rev. Biophys. 37, 353-373
-
(2008)
Annu. Rev. Biophys.
, vol.37
, pp. 353-373
-
-
Ferguson, K.M.1
-
4
-
-
33344474964
-
Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis
-
DOI 10.1016/j.yexcr.2005.11.012, PII S0014482705005215
-
Shibuya, M., and Claesson-Welsh, L. (2006) Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis. Exp. Cell Res. 312, 549-560 (Pubitemid 43290332)
-
(2006)
Experimental Cell Research
, vol.312
, Issue.5
, pp. 549-560
-
-
Shibuya, M.1
Claesson-Welsh, L.2
-
5
-
-
56949098506
-
Molecular titration and ultrasensitivity in regulatory networks
-
Buchler, N. E., and Louis, M. (2008) Molecular titration and ultrasensitivity in regulatory networks. J. Mol. Biol. 384, 1106-1119
-
(2008)
J. Mol. Biol.
, vol.384
, pp. 1106-1119
-
-
Buchler, N.E.1
Louis, M.2
-
6
-
-
70350452750
-
Cell type-specific importance of Ras-c-Raf complex association rate constants for MAPK signaling
-
Kiel, C., and Serrano, L. (2009) Cell type-specific importance of Ras-c-Raf complex association rate constants for MAPK signaling. Sci. Signal. 2, ra38
-
(2009)
Sci. Signal.
, vol.2
-
-
Kiel, C.1
Serrano, L.2
-
7
-
-
79958750290
-
Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL variants
-
Reis, C. R., van der Sloot, A. M., Natoni, A., Szegezdi, E., Setroikromo, R., Meijer, M., Sjollema, K., Stricher, F., Cool, R. H., Samali, A., Serrano, L., and Quax, W. J. (2010) Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL variants. Cell Death Dis. 1, e83
-
(2010)
Cell Death Dis.
, vol.1
-
-
Reis, C.R.1
Van Der Sloot, A.M.2
Natoni, A.3
Szegezdi, E.4
Setroikromo, R.5
Meijer, M.6
Sjollema, K.7
Stricher, F.8
Cool, R.H.9
Samali, A.10
Serrano, L.11
Quax, W.J.12
-
8
-
-
0032575714
-
Death receptors: Signaling and modulation
-
Ashkenazi, A., and Dixit, V. M. (1998) Death receptors: Signaling and modulation. Science 281, 1305-1308 (Pubitemid 28406815)
-
(1998)
Science
, vol.281
, Issue.5381
, pp. 1305-1308
-
-
Ashkenazi, A.1
Dixit, V.M.2
-
9
-
-
0032713075
-
Safety and antitumor activity of recombinant soluble Apo2 ligand
-
Ashkenazi, A., Pai, R. C., Fong, S., Leung, S., Lawrence, D. A., Marsters, S. A., Blackie, C., Chang, L., McMurtrey, A. E., Hebert, A., DeForge, L., Koumenis, I. L., Lewis, D., Harris, L., Bussiere, J., Koeppen, H., Shahrokh, Z., and Schwall, R. H. (1999) Safety and antitumor activity of recombinant soluble Apo2 ligand. J. Clin. Invest. 104, 155-162
-
(1999)
J. Clin. Invest.
, vol.104
, pp. 155-162
-
-
Ashkenazi, A.1
Pai, R.C.2
Fong, S.3
Leung, S.4
Lawrence, D.A.5
Marsters, S.A.6
Blackie, C.7
Chang, L.8
McMurtrey, A.E.9
Hebert, A.10
DeForge, L.11
Koumenis, I.L.12
Lewis, D.13
Harris, L.14
Bussiere, J.15
Koeppen, H.16
Shahrokh, Z.17
Schwall, R.H.18
-
10
-
-
34447094000
-
TRAIL signalling: Decisions between life and death
-
DOI 10.1016/j.biocel.2007.02.007, PII S1357272507000520
-
Falschlehner, C., Emmerich, C. H., Gerlach, B., and Walczak, H. (2007) TRAIL signalling: Decisions between life and death. Int. J. Biochem. Cell Biol. 39, 1462-1475 (Pubitemid 47031030)
-
(2007)
International Journal of Biochemistry and Cell Biology
, vol.39
, Issue.7-8
, pp. 1462-1475
-
-
Falschlehner, C.1
Emmerich, C.H.2
Gerlach, B.3
Walczak, H.4
-
11
-
-
0033605722
-
Caspase-9 can be activated without proteolytic processing
-
DOI 10.1074/jbc.274.13.8359
-
Stennicke, H. R., Deveraux, Q. L., Humke, E. W., Reed, J. C., Dixit, V. M., and Salvesen, G. S. (1999) Caspase-9 can be activated without proteolytic processing. J. Biol. Chem. 274, 8359-8362 (Pubitemid 29164620)
-
(1999)
Journal of Biological Chemistry
, vol.274
, Issue.13
, pp. 8359-8362
-
-
Stennicke, H.R.1
Deveraux, Q.L.2
Humke, E.W.3
Reed, J.C.4
Dixit, V.M.5
Salvesen, G.S.6
-
12
-
-
0032555697
-
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
-
Li, H., Zhu, H., Xu, C. J., and Yuan, J. (1998) Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94, 491-501 (Pubitemid 28391865)
-
(1998)
Cell
, vol.94
, Issue.4
, pp. 491-501
-
-
Li, H.1
Zhu, H.2
Xu, C.-J.3
Yuan, J.4
-
13
-
-
0036133127
-
Molecular ordering of the initial signaling events of CD95
-
DOI 10.1128/MCB.22.1.207-220.2002
-
Algeciras-Schimnich, A., Shen, L., Barnhart, B. C., Murmann, A. E., Burkhardt, J. K., and Peter, M. E. (2002) Molecular ordering of the initial signaling events of CD95. Mol. Cell. Biol. 22, 207-220 (Pubitemid 33144269)
-
(2002)
Molecular and Cellular Biology
, vol.22
, Issue.1
, pp. 207-220
-
-
Algeciras-Schimnich, A.1
Shen, L.2
Barnhart, B.C.3
Murmann, A.E.4
Burkhardt, J.K.5
Peter, M.E.6
-
14
-
-
84883829346
-
Modeling a snap-action, variable-delay switch controlling extrinsic cell death
-
Albeck, J. G., Burke, J. M., Spencer, S. L., Lauffenburger, D. A., and Sorger, P. K. (2008) Modeling a snap-action, variable-delay switch controlling extrinsic cell death. PLoS Biol. 6, 2831-2852
-
(2008)
PLoS Biol.
, vol.6
, pp. 2831-2852
-
-
Albeck, J.G.1
Burke, J.M.2
Spencer, S.L.3
Lauffenburger, D.A.4
Sorger, P.K.5
-
15
-
-
38749133727
-
Proteasome inhibition blocks caspase-8 degradation and sensitizes prostate cancer cells to death receptor-mediated apoptosis
-
DOI 10.1002/pros.20706
-
Thorpe, J. A., Christian, P. A., and Schwarze, S. R. (2008) Proteasome inhibition blocks caspase-8 degradation and sensitizes prostate cancer cells to death receptor-mediated apoptosis. Prostate 68, 200-209 (Pubitemid 351186232)
-
(2008)
Prostate
, vol.68
, Issue.2
, pp. 200-209
-
-
Thorpe, J.A.1
Christian, P.A.2
Schwarze, S.R.3
-
16
-
-
41549132691
-
Quantitative Analysis of Pathways Controlling Extrinsic Apoptosis in Single Cells
-
DOI 10.1016/j.molcel.2008.02.012, PII S1097276508001317
-
Albeck, J. G., Burke, J. M., Aldridge, B. B., Zhang, M., Lauffenburger, D. A., and Sorger, P. K. (2008) Quantitative analysis of pathways controlling extrinsic apoptosis in single cells. Mol. Cell 30, 11-25 (Pubitemid 351470145)
-
(2008)
Molecular Cell
, vol.30
, Issue.1
, pp. 11-25
-
-
Albeck, J.G.1
Burke, J.M.2
Aldridge, B.B.3
Zhang, M.4
Lauffenburger, D.A.5
Sorger, P.K.6
-
17
-
-
1942533472
-
Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth
-
McDonald, E. R., 3rd, and El-Deiry, W. S. (2004) Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth. Proc. Natl. Acad. Sci. U.S.A. 101, 6170-6175
-
(2004)
Proc. Natl. Acad. Sci. U.S.A.
, vol.101
, pp. 6170-6175
-
-
McDonald III, E.R.1
El-Deiry, W.S.2
-
18
-
-
0037273848
-
Apo2L/TRAIL and its death and decoy receptors
-
DOI 10.1038/sj.cdd.4401187
-
LeBlanc, H. N., and Ashkenazi, A. (2003) Apo2L/TRAIL and its death and decoy receptors. Cell Death Differ. 10, 66-75 (Pubitemid 36511833)
-
(2003)
Cell Death and Differentiation
, vol.10
, Issue.1
, pp. 66-75
-
-
LeBlanc, H.N.1
Ashkenazi, A.2
-
19
-
-
13144265771
-
A novel receptor for Apo2L/TRAIL contains a truncated death domain
-
Marsters, S. A., Sheridan, J. P., Pitti, R. M., Huang, A., Skubatch, M., Baldwin, D., Yuan, J., Gurney, A., Goddard, A. D., Godowski, P., and Ashkenazi, A. (1997) A novel receptor for Apo2L/TRAIL contains a truncated death domain. Curr. Biol. 7, 1003-1006 (Pubitemid 28017080)
-
(1997)
Current Biology
, vol.7
, Issue.12
, pp. 1003-1006
-
-
Marsters, S.A.1
Sheridan, J.P.2
Pitti, R.M.3
Huang, A.4
Skubatch, M.5
Baldwin, D.6
Yuan, J.7
Gurney, A.8
Goddard, A.D.9
Godowski, P.10
Ashkenazi, A.11
-
20
-
-
33749164762
-
Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2
-
DOI 10.1128/MCB.00520-06
-
Mérino, D., Lalaoui, N., Morizot, A., Schneider, P., Solary, E., and Micheau, O. (2006) Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2. Mol. Cell. Biol. 26, 7046-7055 (Pubitemid 44477684)
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.19
, pp. 7046-7055
-
-
Merino, D.1
Lalaoui, N.2
Morizot, A.3
Schneider, P.4
Solary, E.5
Micheau, O.6
-
21
-
-
0030762815
-
An antagonist decoy receptor and a death domain-containing receptor for TRAIL
-
DOI 10.1126/science.277.5327.815
-
Pan, G., Ni, J., Wei, Y. F., Yu, G., Gentz, R., and Dixit, V. M. (1997) An antagonist decoy receptor and a death domain-Containing receptor for TRAIL. Science 277, 815-818 (Pubitemid 27366732)
-
(1997)
Science
, vol.277
, Issue.5327
, pp. 815-818
-
-
Pan, G.1
Ni, J.2
Wei, Y.-F.3
Yu, G.-I.4
Gentz, R.5
Dixit, V.M.6
-
22
-
-
34247899117
-
Three is better than one: Pre-ligand receptor assembly in the regulation of TNF receptor signaling
-
Chan, F. K. (2007) Three is better than one: Pre-ligand receptor assembly in the regulation of TNF receptor signaling. Cytokine 37, 101-107
-
(2007)
Cytokine
, vol.37
, pp. 101-107
-
-
Chan, F.K.1
-
23
-
-
0034733682
-
A domain in TNF receptors that mediates ligand-independent receptor assembty and signaling
-
DOI 10.1126/science.288.5475.2351
-
Chan, F. K., Chun, H. J., Zheng, L., Siegel, R. M., Bui, K. L., and Lenardo, M. J. (2000) A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. Science 288, 2351-2354 (Pubitemid 30448156)
-
(2000)
Science
, vol.288
, Issue.5475
, pp. 2351-2354
-
-
Chan, F.K.-M.1
Chun, H.J.2
Zheng, L.3
Siegel, R.M.4
Bui, K.L.5
Lenardo, M.J.6
-
24
-
-
29144496895
-
Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis
-
DOI 10.1073/pnas.0507329102
-
Clancy, L., Mruk, K., Archer, K., Woelfel, M., Mongkolsapaya, J., Screaton, G., Lenardo, M. J., and Chan, F. K. (2005) Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis. Proc. Natl. Acad. Sci. U.S.A. 102, 18099-18104 (Pubitemid 41798508)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.50
, pp. 18099-18104
-
-
Clancy, L.1
Mruk, K.2
Archer, K.3
Woelfel, M.4
Mongkolsapaya, J.5
Screaton, G.6
Lenardo, M.J.7
Chan, F.K.-M.8
-
25
-
-
17044382532
-
Homomeric and heteromeric interactions of the extracellular domains of death receptors and death decoy receptors
-
Lee, H. W., Lee, S. H., Lee, H. W., Ryu, Y. W., Kwon, M. H., and Kim, Y. S. (2005) Homomeric and heteromeric interactions of the extracellular domains of death receptors and death decoy receptors. Biochem. Biophys. Res. Commun. 330, 1205-1212
-
(2005)
Biochem. Biophys. Res. Commun.
, vol.330
, pp. 1205-1212
-
-
Lee, H.W.1
Lee, S.H.2
Lee, H.W.3
Ryu, Y.W.4
Kwon, M.H.5
Kim, Y.S.6
-
26
-
-
0034725664
-
Temperature-sensitive differential affinity of TRAIL for its receptors: DR5 is the highest affinity receptor
-
DOI 10.1074/jbc.M910438199
-
Truneh, A., Sharma, S., Silverman, C., Khandekar, S., Reddy, M. P., Deen, K. C., McLaughlin, M. M., Srinivasula, S. M., Livi, G. P., Marshall, L. A., Alnemri, E. S., Williams, W. V., and Doyle, M. L. (2000) Temperature-sensitive differential affinity of TRAIL for its receptors: DR5 is the highest affinity receptor. J. Biol. Chem. 275, 23319-23325 (Pubitemid 30646233)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.30
, pp. 23319-23325
-
-
Truneh, A.1
Sharma, S.2
Silverman, C.3
Khandekar, S.4
Reddy, M.P.5
Deen, K.C.6
Mclaughlin, M.M.7
Srinivasula, S.M.8
Livi, G.P.9
Marshall, L.A.10
Alnemri, E.S.11
Williams, W.V.12
Doyle, M.L.13
-
27
-
-
14844328879
-
Smart-Cell, a framework to simulate cellular processes that combines stochastic approximation with diffusion and localisation: Analysis of simple networks
-
Ander, M., Beltrao, P., Di Ventura, B., Ferkinghoff-Borg, J., Foglierini, M., Kaplan, A., Lemerle, C., Tomas-Oliveira, I., and Serrano, L. (2004) Smart-Cell, a framework to simulate cellular processes that combines stochastic approximation with diffusion and localisation: Analysis of simple networks. Syst. Biol. 1, 129-138
-
(2004)
Syst. Biol.
, vol.1
, pp. 129-138
-
-
Ander, M.1
Beltrao, P.2
Di Ventura, B.3
Ferkinghoff-Borg, J.4
Foglierini, M.5
Kaplan, A.6
Lemerle, C.7
Tomas-Oliveira, I.8
Serrano, L.9
-
28
-
-
33745056174
-
Designed tumor necrosis factor-related apoptosis-inducing ligand variants initiating apoptosis exclusively via the DR5 receptor
-
DOI 10.1073/pnas.0510187103
-
van der Sloot, A. M., Tur, V., Szegezdi, E., Mullally, M. M., Cool, R. H., Samali, A., Serrano, L., and Quax, W. J. (2006) Designed tumor necrosis factor-related apoptosis-inducing ligand variants initiating apoptosis exclusively via the DR5 receptor. Proc. Natl. Acad. Sci. U.S.A. 103, 8634-8639 (Pubitemid 43878072)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.23
, pp. 8634-8639
-
-
Van Der, S.A.M.1
Tur, V.2
Szegezdi, E.3
Mullally, M.M.4
Cool, R.H.5
Samali, A.6
Serrano, L.7
Quax, W.J.8
-
29
-
-
63449085835
-
Enhanced antitumor efficacy of a DR5-specific TRAIL variant over recombinant human TRAIL in a bioluminescent ovarian cancer xenograft model
-
Duiker, E. W., de Vries, E. G., Mahalingam, D., Meersma, G. J., Boersmavan Ek, W., Hollema, H., Lub-de Hooge, M. N., van Dam, G. M., Cool, R. H., Quax, W. J., Samali, A., van der Zee, A. G., and de Jong, S. (2009) Enhanced antitumor efficacy of a DR5-specific TRAIL variant over recombinant human TRAIL in a bioluminescent ovarian cancer xenograft model. Clin. Cancer Res. 15, 2048-2057
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 2048-2057
-
-
Duiker, E.W.1
De Vries, E.G.2
Mahalingam, D.3
Meersma, G.J.4
Boersmavan Ek, W.5
Hollema, H.6
Lub-de Hooge, M.N.7
Van Dam, G.M.8
Cool, R.H.9
Quax, W.J.10
Samali, A.11
Van Der Zee, A.G.12
De Jong, S.13
-
30
-
-
18044387255
-
Stabilization of TRAIL, an all-β-sheet multimeric protein, using computational redesign
-
DOI 10.1093/protein/gzh079
-
van der Sloot, A. M., Mullally, M. M., Fernandez-Ballester, G., Serrano, L., and Quax, W. J. (2004) Stabilization of TRAIL, an all-β-sheet multimeric protein, using computational redesign. Protein Eng. Des. Sel. 17, 673-680 (Pubitemid 40601887)
-
(2004)
Protein Engineering, Design and Selection
, vol.17
, Issue.9
, pp. 673-680
-
-
Van Der, S.A.M.1
Mullally, M.M.2
Fernandez-Ballester, G.3
Serrano, L.4
Quax, W.J.5
-
31
-
-
33748100542
-
The clinical trail of TRAIL
-
DOI 10.1016/j.ejca.2006.03.018, PII S0959804906004813
-
Duiker, E. W., Mom, C. H., de Jong, S., Willemse, P. H., Gietema, J. A., van der Zee, A. G., and de Vries, E. G. (2006) The clinical trail of TRAIL. Eur. J. Cancer 42, 2233-2240 (Pubitemid 44307615)
-
(2006)
European Journal of Cancer
, vol.42
, Issue.14
, pp. 2233-2240
-
-
Duiker, E.W.1
Mom, C.H.2
De Jong, S.3
Willemse, P.H.B.4
Gietema, J.A.5
Van Der Zee, A.G.J.6
De Vries, E.G.E.7
-
32
-
-
32544435965
-
TRAIL sensitisation by arsenic trioxide is caspase-8 dependent and involves modulation of death receptor components and Akt
-
DOI 10.1038/sj.bjc.6602954, PII 6602954
-
Szegezdi, E., Cahill, S., Meyer, M., O'Dwyer, M., and Samali, A. (2006) TRAIL sensitisation by arsenic trioxide is caspase-8 dependent and involves modulation of death receptor components and Akt. Br. J. Cancer 94, 398-406 (Pubitemid 43237564)
-
(2006)
British Journal of Cancer
, vol.94
, Issue.3
, pp. 398-406
-
-
Szegezdi, E.1
Cahill, S.2
Meyer, M.3
O'Dwyer, M.4
Samali, A.5
-
33
-
-
42349110538
-
L: Apoptosis
-
DOI 10.1111/j.1582-4934.2007.00191.x
-
Holohan, C., Szegezdi, E., Ritter, T., O'Brien, T., and Samali, A. (2008) Cytokine-induced β-cell apoptosis is NO-dependent, mitochondria-mediated and inhibited by BCL-XL. J. Cell Mol. Med. 12, 591-606 (Pubitemid 351555138)
-
(2008)
Journal of Cellular and Molecular Medicine
, vol.12
, Issue.2
, pp. 591-606
-
-
Holohan, C.1
Szegezdi, E.2
Ritter, T.3
O'Brien, T.4
Samali, A.5
-
34
-
-
54949142920
-
Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion via regulation of Bim
-
Szegezdi, E., Herbert, K. R., Kavanagh, E. T., Samali, A., and Gorman, A. M. (2008) Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion via regulation of Bim. J. Cell Mol. Med. 12, 2482-2496
-
(2008)
J. Cell Mol. Med.
, vol.12
, pp. 2482-2496
-
-
Szegezdi, E.1
Herbert, K.R.2
Kavanagh, E.T.3
Samali, A.4
Gorman, A.M.5
-
35
-
-
0031567782
-
The entropy cost of protein association
-
DOI 10.1006/jmbi.1997.1368
-
Tamura, A., and Privalov, P. L. (1997) The entropy cost of protein association. J. Mol. Biol. 273, 1048-1060 (Pubitemid 27501159)
-
(1997)
Journal of Molecular Biology
, vol.273
, Issue.5
, pp. 1048-1060
-
-
Tamura, A.1
Privalov, P.L.2
-
36
-
-
0033860639
-
Association entropy in adsorption processes
-
Ben-Tal, N., Honig, B., Bagdassarian, C. K., and Ben-Shaul, A. (2000) Association entropy in adsorption processes. Biophys. J. 79, 1180-1187
-
(2000)
Biophys. J.
, vol.79
, pp. 1180-1187
-
-
Ben-Tal, N.1
Honig, B.2
Bagdassarian, C.K.3
Ben-Shaul, A.4
-
37
-
-
78549236456
-
The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations
-
Wang, L., Yang, J. K., Kabaleeswaran, V., Rice, A. J., Cruz, A. C., Park, A. Y., Yin, Q., Damko, E., Jang, S. B., Raunser, S., Robinson, C. V., Siegel, R. M., Walz, T., and Wu, H. (2010) The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations. Nat. Struct. Mol. Biol. 17, 1324-1329
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 1324-1329
-
-
Wang, L.1
Yang, J.K.2
Kabaleeswaran, V.3
Rice, A.J.4
Cruz, A.C.5
Park, A.Y.6
Yin, Q.7
Damko, E.8
Jang, S.B.9
Raunser, S.10
Robinson, C.V.11
Siegel, R.M.12
Walz, T.13
Wu, H.14
-
38
-
-
66149132686
-
Examination of the contributions of size and avidity to the neutralization mechanisms of the anti-HIV antibodies b12 and 4E10
-
Klein, J. S., Gnanapragasam, P. N., Galimidi, R. P., Foglesong, C. P., West, A. P., Jr., and Bjorkman, P. J. (2009) Examination of the contributions of size and avidity to the neutralization mechanisms of the anti-HIV antibodies b12 and 4E10. Proc. Natl. Acad. Sci. U.S.A. 106, 7385-7390
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 7385-7390
-
-
Klein, J.S.1
Gnanapragasam, P.N.2
Galimidi, R.P.3
Foglesong, C.P.4
West Jr., A.P.5
Bjorkman, P.J.6
-
39
-
-
0035937833
-
Kinetic analysis of adenovirus fiber binding to its receptor reveals an avidity mechanism for trimeric receptor-ligand interactions
-
Lortat-Jacob, H., Chouin, E., Cusack, S., and van Raaij, M. J. (2001) Kinetic analysis of adenovirus fiber binding to its receptor reveals an avidity mechanism for trimeric receptor-ligand interactions. J. Biol. Chem. 276, 9009-9015
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 9009-9015
-
-
Lortat-Jacob, H.1
Chouin, E.2
Cusack, S.3
Van Raaij, M.J.4
-
40
-
-
4544242734
-
Death induction by recombinant native TRAIL and its prevention by a caspase 9 inhibitor in primary human esophageal epithelial cells
-
DOI 10.1074/jbc.M404541200
-
Kim, S. H., Kim, K., Kwagh, J. G., Dicker, D. T., Herlyn, M., Rustgi, A. K., Chen, Y., and El-Deiry, W. S. (2004) Death induction by recombinant native TRAIL and its prevention by a caspase 9 inhibitor in primary human esophageal epithelial cells. J. Biol. Chem. 279, 40044-40052 (Pubitemid 39258279)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.38
, pp. 40044-40052
-
-
Kim, S.-H.1
Kim, K.2
Kwagh, J.G.3
Dicker, D.T.4
Herlyn, M.5
Rustgi, A.K.6
Chen, Y.7
El-Deiry, W.S.8
-
41
-
-
20844455677
-
Spontaneous separation of bi-stable biochemical systems into spatial domains of opposite phases
-
Elf, J., and Ehrenberg, M. (2004) Spontaneous separation of bi-stable biochemical systems into spatial domains of opposite phases. Syst. Biol. 1, 230-236
-
(2004)
Syst. Biol.
, vol.1
, pp. 230-236
-
-
Elf, J.1
Ehrenberg, M.2
-
42
-
-
0041324718
-
Mesoscopic reaction-diffusion in intracellular signaling
-
(Bezrukov, S. M., Frauenfelder, H., and Moss, F., eds), Bellingham WA98227-0010 USA
-
Elf, J., Doncic, A., and Ehrenberg, M. (2003) Mesoscopic reaction-diffusion in intracellular signaling. In Fluctuations and Noise in Biological, Biophysical, and Biomedical Systems (Bezrukov, S. M., Frauenfelder, H., and Moss, F., eds), pp. 114-124, Bellingham WA98227-0010 USA; volume 5110
-
(2003)
Fluctuations and Noise in Biological, Biophysical, and Biomedical Systems
, vol.5110
, pp. 114-124
-
-
Elf, J.1
Doncic, A.2
Ehrenberg, M.3
-
43
-
-
33846108256
-
Noise in transcription negative feedback loops: Simulation and experimental analysis
-
Dublanche, Y., Michalodimitrakis, K., Kummerer, N., Foglierini, M., and Serrano, L. (2006) Noise in transcription negative feedback loops: Simulation and experimental analysis. Mol. Syst. Biol. 2, 41
-
(2006)
Mol. Syst. Biol.
, vol.2
, pp. 41
-
-
Dublanche, Y.1
Michalodimitrakis, K.2
Kummerer, N.3
Foglierini, M.4
Serrano, L.5
-
44
-
-
77952290633
-
Single chain TNF derivatives with individually mutated receptor binding sites reveal differential stoichiometry of ligand receptor complex formation for TNFR1 and TNFR2
-
Boschert, V., Krippner-Heidenreich, A., Branschädel, M., Tepperink, J., Aird, A., and Scheurich, P. (2010) Single chain TNF derivatives with individually mutated receptor binding sites reveal differential stoichiometry of ligand receptor complex formation for TNFR1 and TNFR2. Cell Signal. 22, 1088-1096
-
(2010)
Cell Signal.
, vol.22
, pp. 1088-1096
-
-
Boschert, V.1
Krippner-Heidenreich, A.2
Branschädel, M.3
Tepperink, J.4
Aird, A.5
Scheurich, P.6
-
45
-
-
0029069758
-
Crystallographic evidence for dimerization of unliganded tumor necrosis factor receptor
-
Naismith, J. H., Devine, T. Q., Brandhuber, B. J., and Sprang, S. R. (1995) Crystallographic evidence for dimerization of unliganded tumor necrosis factor receptor. J. Biol. Chem. 270, 13303-13307
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 13303-13307
-
-
Naismith, J.H.1
Devine, T.Q.2
Brandhuber, B.J.3
Sprang, S.R.4
-
46
-
-
0027301244
-
Ligand passing: The 75-kDa tumor necrosis factor (TNF) receptor recruits TNF for signaling by the 55-kDa TNF receptor
-
Tartaglia, L. A., Pennica, D., and Goeddel, D. V. (1993) Ligand passing: The 75-kDa tumor necrosis factor (TNF) receptor recruits TNF for signaling by the 55-kDa TNF receptor. J. Biol. Chem. 268, 18542-18548 (Pubitemid 23273787)
-
(1993)
Journal of Biological Chemistry
, vol.268
, Issue.25
, pp. 18542-18548
-
-
Tartaglia, L.A.1
Pennica, D.2
Goeddel, D.V.3
-
47
-
-
0033662433
-
Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5
-
Kischkel, F. C., Lawrence, D. A., Chuntharapai, A., Schow, P., Kim, K. J., and Ashkenazi, A. (2000) Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5. Immunity 12, 611-620
-
(2000)
Immunity
, vol.12
, pp. 611-620
-
-
Kischkel, F.C.1
Lawrence, D.A.2
Chuntharapai, A.3
Schow, P.4
Kim, K.J.5
Ashkenazi, A.6
-
48
-
-
0032750511
-
Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation
-
DOI 10.1038/14935
-
Mongkolsapaya, J., Grimes, J. M., Chen, N., Xu, X. N., Stuart, D. I., Jones, E. Y., and Screaton, G. R. (1999) Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation. Nat. Struct. Biol. 6, 1048-1053 (Pubitemid 29519600)
-
(1999)
Nature Structural Biology
, vol.6
, Issue.11
, pp. 1048-1053
-
-
Mongkolsapaya, J.1
Grimes, J.M.2
Chen, N.3
Xu, X.-N.4
Stuart, D.I.5
Jones, E.Y.6
Screaton, G.R.7
-
49
-
-
0033212968
-
Triggering cell death: The crystal structure of Apo2L/TRAIL in a complex with death receptor 5
-
DOI 10.1016/S1097-2765(00)80207-5
-
Hymowitz, S. G., Christinger, H. W., Fuh, G., Ultsch, M., O'Connell, M., Kelley, R. F., Ashkenazi, A., and de Vos, A. M. (1999) Triggering cell death: The crystal structure of Apo2L/TRAIL in a complex with death receptor 5. Mol. Cell 4, 563-571 (Pubitemid 29531136)
-
(1999)
Molecular Cell
, vol.4
, Issue.4
, pp. 563-571
-
-
Hymowitz, S.G.1
Christinger, H.W.2
Fuh, G.3
Ultsch, M.4
O'Connell, M.5
Kelley, R.F.6
Ashkenazi, A.7
De Vos, A.M.8
-
50
-
-
78651088886
-
Unraveling the binding mechanism of trivalent tumor necrosis factor ligands and their receptors
-
M110.002808
-
Reis, C. R., van Assen, A. H., Quax, W. J., and Cool, R. H. (2012) Unraveling the binding mechanism of trivalent tumor necrosis factor ligands and their receptors. Mol. Cell. Proteomics 10, M110.002808
-
(2012)
Mol. Cell. Proteomics
, vol.10
-
-
Reis, C.R.1
Van Assen, A.H.2
Quax, W.J.3
Cool, R.H.4
-
51
-
-
64049103030
-
TRAIL receptor signalling and modulation: Are we on the right TRAIL?
-
Mahalingam, D., Szegezdi, E., Keane, M., de Jong, S., and Samali, A. (2009) TRAIL receptor signalling and modulation: Are we on the right TRAIL? Cancer Treat. Rev. 35, 280-288
-
(2009)
Cancer Treat. Rev.
, vol.35
, pp. 280-288
-
-
Mahalingam, D.1
Szegezdi, E.2
Keane, M.3
De Jong, S.4
Samali, A.5
-
52
-
-
0033566163
-
The antiapoptotic decoy receptor TRID/TRAIL-R3 is a p53-regulated DNA damage-inducible gene that is overexpressed in primary tumors of the gastrointestinal tract
-
DOI 10.1038/sj.onc.1202763
-
Sheikh, M. S., Huang, Y., Fernandez-Salas, E. A., El-Deiry, W. S., Friess, H., Amundson, S., Yin, J., Meltzer, S. J., Holbrook, N. J., and Fornace, A. J., Jr. (1999) The antiapoptotic decoy receptor TRID/TRAIL-R3 is a p53-regulated DNA damage-inducible gene that is overexpressed in primary tumors of the gastrointestinal tract. Oncogene 18, 4153-4159 (Pubitemid 29363923)
-
(1999)
Oncogene
, vol.18
, Issue.28
, pp. 4153-4159
-
-
Sheikh, M.S.1
Huang, Y.2
Fernandez-Salas, E.A.3
El-Deiry, W.S.4
Friess, H.5
Amundson, S.6
Yin, J.7
Meltzer, S.J.8
Holbrook, N.J.9
Fornace Jr., A.J.10
-
53
-
-
0021118703
-
Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors
-
Chou, T. C., and Talalay, P. (1984) Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors. Adv. Enzyme Regul. 22, 27-55
-
(1984)
Adv. Enzyme Regul.
, vol.22
, pp. 27-55
-
-
Chou, T.C.1
Talalay, P.2
-
54
-
-
0028943734
-
Apoptosis in the pathogenesis and treatment of disease
-
Thompson, C. B. (1995) Apoptosis in the pathogenesis and treatment of disease. Science 267, 1456-1462
-
(1995)
Science
, vol.267
, pp. 1456-1462
-
-
Thompson, C.B.1
-
55
-
-
0000005230
-
Differential localization and regulation of death and decoy receptors for TNF-related apoptosis-inducing ligand (TRAIL) in human melanoma cells
-
Zhang, X. D., Franco, A. V., Nguyen, T., Gray, C. P., and Hersey, P. (2000) Differential localization and regulation of death and decoy receptors for TNF-related apoptosis-inducing ligand (TRAIL) in human melanoma cells. J. Immunol. 164, 3961-3970 (Pubitemid 30215048)
-
(2000)
Journal of Immunology
, vol.164
, Issue.8
, pp. 3961-3970
-
-
Zhang, X.D.1
Franco, A.V.2
Nguyen, T.3
Gray, C.P.4
Hersey, P.5
-
56
-
-
0034812659
-
Preclinical studies to predict the disposition of Apo2L/tumor necrosis factor-related apoptosis-inducing ligand in humans: Characterization of in vivo efficacy, pharmacokinetics, and safety
-
Kelley, S. K., Harris, L. A., Xie, D., Deforge, L., Totpal, K., Bussiere, J., and Fox, J. A. (2001) Preclinical studies to predict the disposition of Apo2L/tumor necrosis factor-related apoptosis-inducing ligand in humans: Characterization of in vivo efficacy, pharmacokinetics, and safety. J. Pharmacol. Exp. Ther. 299, 31-38 (Pubitemid 32905115)
-
(2001)
Journal of Pharmacology and Experimental Therapeutics
, vol.299
, Issue.1
, pp. 31-38
-
-
Kelley, S.K.1
Harris, L.A.2
Xie, D.3
Deforge, L.4
Totpal, K.5
Bussiere, J.6
Fox, J.A.7
-
57
-
-
2442528511
-
Ubiquitin-proteasome pathway as a primary defender against TRAIL-mediated cell death
-
DOI 10.1007/s00018-004-3477-5
-
Kim, S., Choi, K., Kwon, D., Benveniste, E. N., and Choi, C. (2004) Ubiquitin-proteasome pathway as a primary defender against TRAIL-mediated cell death. Cell. Mol. Life Sci. 61, 1075-1081 (Pubitemid 38626510)
-
(2004)
Cellular and Molecular Life Sciences
, vol.61
, Issue.9
, pp. 1075-1081
-
-
Kim, S.1
Choi, K.2
Kwon, D.3
Benveniste, E.N.4
Choi, C.5
-
58
-
-
79953714000
-
The proteasome inhibitor bortezomib sensitizes AML with myelomonocytic differentiation to TRAIL mediated apoptosis
-
Dijk, M. v., Murphy, E., Morrell, R., Knapper, S., O'Dwyer, M., Samali, A., and Szegezdi, E. (2011) The proteasome inhibitor bortezomib sensitizes AML with myelomonocytic differentiation to TRAIL mediated apoptosis. Cancers 3, 1329-1350
-
(2011)
Cancers
, vol.3
, pp. 1329-1350
-
-
Dijk, M.V.1
Murphy, E.2
Morrell, R.3
Knapper, S.4
O'Dwyer, M.5
Samali, A.6
Szegezdi, E.7
-
59
-
-
0037025346
-
Single-cell fluorescence resonance energy transfer analysis demonstrates that caspase activation during apoptosis is a rapid process: Role of caspase-3
-
DOI 10.1074/jbc.M110789200
-
Rehm, M., Dussmann, H., Janicke, R. U., Tavare, J. M., Kogel, D., and Prehn, J. H. (2002) Single-cell fluorescence resonance energy transfer analysis demonstrates that caspase activation during apoptosis is a rapid process: Role of caspase-3. J. Biol. Chem. 277, 24506-24514 (Pubitemid 34951976)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.27
, pp. 24506-24514
-
-
Rehm, M.1
Dussmann, H.2
Janicke, R.U.3
Tavare, J.M.4
Kogel, D.5
Prehn, J.H.M.6
-
60
-
-
52049091499
-
Real time analysis of tumor necrosis factor-related apoptosis-inducing ligand/cycloheximide-induced caspase activities during apoptosis initiation
-
Hellwig, C. T., Kohler, B. F., Lehtivarjo, A. K., Dussmann, H., Courtney, M. J., Prehn, J. H., and Rehm, M. (2008) Real time analysis of tumor necrosis factor-related apoptosis-inducing ligand/cycloheximide-induced caspase activities during apoptosis initiation. J. Biol. Chem. 283, 21676-21685
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 21676-21685
-
-
Hellwig, C.T.1
Kohler, B.F.2
Lehtivarjo, A.K.3
Dussmann, H.4
Courtney, M.J.5
Prehn, J.H.6
Rehm, M.7
-
61
-
-
66249136447
-
Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis
-
Spencer, S. L., Gaudet, S., Albeck, J. G., Burke, J. M., and Sorger, P. K. (2009) Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature 459, 428-432
-
(2009)
Nature
, vol.459
, pp. 428-432
-
-
Spencer, S.L.1
Gaudet, S.2
Albeck, J.G.3
Burke, J.M.4
Sorger, P.K.5
-
62
-
-
51449118394
-
Targeting TRAIL death receptors
-
Oldenhuis, C. N., Stegehuis, J. H., Walenkamp, A. M., de Jong, S., and de Vries, E. G. (2008) Targeting TRAIL death receptors. Curr. Opin. Pharmacol. 8, 433-439
-
(2008)
Curr. Opin. Pharmacol.
, vol.8
, pp. 433-439
-
-
Oldenhuis, C.N.1
Stegehuis, J.H.2
Walenkamp, A.M.3
De Jong, S.4
De Vries, E.G.5
-
63
-
-
34547451794
-
Repression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) but not its receptors during oral cancer progression
-
Vigneswaran, N., Baucum, D. C., Wu, J., Lou, Y., Bouquot, J., Muller, S., and Zacharias, W. (2007) Repression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) but not its receptors during oral cancer progression. BMC Cancer 7, 108
-
(2007)
BMC Cancer
, vol.7
, pp. 108
-
-
Vigneswaran, N.1
Baucum, D.C.2
Wu, J.3
Lou, Y.4
Bouquot, J.5
Muller, S.6
Zacharias, W.7
-
64
-
-
0013583837
-
Relation of TNF-related apoptosis-inducing ligand (TRAIL) receptor and FLICE-inhibitory protein expression to TRAIL-induced apoptosis of melanoma
-
Zhang, X. D., Franco, A., Myers, K., Gray, C., Nguyen, T., and Hersey, P. (1999) Relation of TNF-related apoptosis-inducing ligand (TRAIL) receptor and FLICE-inhibitory protein expression to TRAIL-induced apoptosis of melanoma. Cancer Res. 59, 2747-2753 (Pubitemid 29269125)
-
(1999)
Cancer Research
, vol.59
, Issue.11
, pp. 2747-2753
-
-
Zhang, X.D.1
Franco, A.2
Myers, K.3
Gray, C.4
Nguyen, T.5
Hersey, P.6
|