The secretable form of trimeric TRAIL, a potent inducer of apoptosis

Biochemical and Biophysical Research Communications

Volumn 321, Issue 4, 2004, Pages 930-935

  Kim, Mi Hyang ^a   Billiar, Timothy R ^a   Seol, Dai Wu ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Gene therapy; Secretion; TRAIL; Trimer

Indexed keywords

PROTEIN DERIVATIVE; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

APOPTOSIS; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DIMERIZATION; EXPRESSION VECTOR; GENE; GENE CONTROL; GENE EXPRESSION; GENE SEQUENCE; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN SECRETION; SUPERNATANT; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND GENE;

AMINO ACID SEQUENCE; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL LINE; GENE THERAPY; HELA CELLS; HUMANS; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; NEOPLASMS; PROTEIN SORTING SIGNALS; PROTEIN STRUCTURE, QUATERNARY; RECOMBINANT PROTEINS; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR NECROSIS FACTOR-ALPHA;

VECTORS;

EID: 3843107921     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.07.046     Document Type: Article

References (32)

1. H. Hsu, J. Xiong, and D.V. Goeddel The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation Cell 81 1995 495 504
2. H. Hsu, H.B. Shu, M.G. Pan, and D.V. Goeddel TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways Cell 84 1996 299 308
3. M.P. Boldin, E.E. Varfolomeev, Z. Pancer, I.L. Mett, J.H. Camonis, and D. Wallach A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain J. Biol. Chem. 270 1995 7795 7798
4. A.M. Chinnaiyan, K. O'Rourke, M. Tewari, and V.M. Dixit FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis Cell 81 1995 505 512
5. A.M. Chinnaiyan, C.G. Tepper, M.F. Seldin, K. O'Rourke, F.C. Kischkel, S. Hellbardt, P.H. Krammer, M.E. Peter, and V.M. Dixit FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis J. Biol. Chem. 271 1996 4961 4965
6. P. Juo, C.J. Kuo, J. Yuan, and J. Blenis Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade Curr. Biol. 8 1998 1001 1008
7. X. Liu, P. Li, P. Widlak, H. Zou, X. Luo, W.T. Garrard, and X. Wang The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis Proc. Natl. Acad. Sci. USA 95 1998 8461 8466
8. H. Li, H. Zhu, C.J. Xu, and J. Yuan Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis Cell 94 1998 491 501
9. Q.L. Deveraux, R. Takahashi, G.S. Salvesen, and J.C. Reed X-linked IAP is a direct inhibitor of cell-death proteases Nature 388 1997 300 304
10. G. Pan, K. O'Rourke, and V.M. Dixit Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex J. Biol. Chem. 273 1998 5841 5845
11. M. Enari, H. Sakahira, H. Yokoyama, K. Okawa, A. Iwamatsu, and S. Nagata A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD Nature 391 1998 43 50
12. S.S. Cha, M.S. Kim, Y.H. Choi, B.J. Sung, N.K. Shin, H.C. Shin, Y.C. Sung, and B.H. Oh 2.8Å resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity Immunity 11 1999 253 261
13. S.G. Hymowitz, H.W. Christinger, G. Fuh, M. Ultsch, M. O'Connell, R.F. Kelley, A. Ashkenazi, and A.M. de Vos Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5 Mol. Cell 4 1999 563 571
14. S.R. Wiley, K. Schooley, P.J. Smolak, W.S. Din, C.P. Huang, J.K. Nicholl, G.R. Sutherland, T.D. Smith, C. Rauch, and C.A. Smith Identification and characterization of a new member of the TNF family that induces apoptosis Immunity 3 1995 673 682
15. R.M. Pitti, S.A. Marsters, S. Ruppert, C.J. Donahue, A. Moore, and A. Ashkenazi Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family J. Biol. Chem. 271 1996 12687 12690
16. J. Ogasawara, R. Watanabe-Fukunaga, M. Adachi, A. Matsuzawa, T. Kasugai, Y. Kitamura, N. Itoh, T. Suda, and S. Nagata Lethal effect of the anti-Fas antibody in mice Nature 364 1993 806 809
17. P.R. Galle, W.J. Hofmann, H. Walczak, H. Schaller, G. Otto, W. Stremmel, P.H. Krammer, and L. Runkel Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage J. Exp. Med. 182 1995 1223 1230
18. H. Walczak, R.E. Miller, K. Ariail, B. Gliniak, T.S. Griffith, M. Kubin, W. Chin, J. Jones, A. Woodward, T. Le, C. Smith, P. Smolak, R.G. Goodwin, C.T. Rauch, J.C. Schuh, and D.H. Lynch Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo Nat. Med. 5 1999 157 163
19. A. Ashkenazi, R.C. Pai, S. Fong, S. Leung, D.A. Lawrence, S.A. Marsters, C. Blackie, L. Chang, A.E. McMurtrey, A. Hebert, L. DeForge, I.L. Koumenis, D. Lewis, L. Harris, J. Bussiere, H. Koeppen, Z. Shahrokh, and R.H. Schwall Safety and antitumor activity of recombinant soluble Apo2 ligand J. Clin. Invest 104 1999 155 162
20. D.W. Seol, and T.R. Billiar A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosis J. Biol. Chem. 274 1999 2072 2076
21. T.M. Ritty, T. Broekelmann, C. Tisdale, D.M. Milewicz, and R.P. Mecham Processing of the fibrillin-1 carboxyl-terminal domain J. Biol. Chem. 274 1999 8933 8940
22. P.B. Harbury, P.S. Kim, and T. Alber Crystal structure of an isoleucine-zipper trimer Nature 371 1994 80 83
23. D.W. Seol, and T.R. Billiar Cysteine 230 modulates tumor necrosis factor-related apoptosis-inducing ligand activity Cancer Res. 60 2000 3152 3154
24. D.W. Seol, J. Li, M.H. Seol, S.Y. Park, R.V. Talanian, and T.R. Billiar Signaling events triggered by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL): caspase-8 is required for TRAIL-induced apoptosis Cancer Res. 61 2001 1138 1143
25. J.A. Martial, R.A. Hallewell, J.D. Baxter, and H.M. Goodman Human growth hormone: complementary DNA cloning and expression in bacteria Science 205 1979 602 607
26. J.B. Denault, and R. Leduc Furin/PACE/SPC1: a convertase involved in exocytic and endocytic processing of precursor proteins FEBS Lett. 379 1996 113 116
27. Y.M. Kim, T.H. Kim, D.W. Seol, R.V. Talanian, and T.R. Billiar Nitric oxide suppression of apoptosis occurs in association with an inhibition of Bcl-2 cleavage and cytochrome c release J. Biol. Chem. 273 1998 31437 31441
28. S.G. Hymowitz, M.P. O'Connell, M.H. Ultsch, A. Hurst, K. Totpal, A. Ashkenazi, A.M. de Vos, and R.F. Kelley A unique zinc-binding site revealed by a high-resolution X-ray structure of homotrimeric Apo2L/TRAIL Biochemistry 39 2000 633 640
29. D. Trabzuni, K.S. Famulski, and M. Ahmad Functional analysis of tumour necrosis factor-alpha-related apoptosis-inducing ligand (TRAIL): cysteine-230 plays a critical role in the homotrimerization and biological activity of this novel tumoricidal cytokine Biochem. J. 350 Pt. 2 2000 505 510
30. Y. Kim, and D.W. Seol TRAIL, a mighty apoptosis inducer Mol. Cells 15 2003 283 293
31. M. Jo, T.H. Kim, D.W. Seol, J.E. Esplen, K. Dorko, T.R. Billiar, and S.C. Strom Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand Nat. Med. 6 2000 564 567
32. Y.J. Lee, K.H. Lee, H.R. Kim, J.M. Jessup, D.W. Seol, T.H. Kim, T.R. Billiar, and Y.K. Song Sodium nitroprusside enhances TRAIL-induced apoptosis via a mitochondria-dependent pathway in human colorectal carcinoma CX-1 cells Oncogene 20 2001 1476 1485