Galactose regulon of yeast: From genetics to systems biology

Galactose Regulon of Yeast: From Genetics to Systems Biology

Volumn , Issue , 2008, Pages 1-219

  Bhat, Paike Jayadeva ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY BOMBAY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84920096322     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-540-74015-5     Document Type: Book

References (326)

1. Bowler PJ (1990) Charles Darwin: The man and his influence. Blackwell Publishers, Oxford
2. Delbruck M (1966) A physicist looks at biology. In: Cairns J, Stent GS, Watson JD (eds) Phage and the origins of molecular biology. Cold Spring Harbor Laboratory of Quantitative Biology, Cold Spring Harbor, New York
3. Fisher RA (1918) The correlation between relatives on the supposition of Mendelian inheritance. Trans R Soc 52:393-433
4. Forest DW (1974) Francis Galton: The life and work of a Victorian genius. Elek, London
5. Grene M, Dephew D (2004) The philosophy of biology. Cambridge University Press, Cambridge
6. Harold FM (2001) The way of the cell. Oxford University Press, Oxford
7. Horecker BL (1978) Yeast enzymology: retrospectives and perspectives. In: Metry B, Horekar BL, Stoppani AOM (eds) Biochemestry and genetics of yeast. Academic Press, New York, pp 1-15
8. Lahav N (1999) Biogenesis: theories of life's origin. Oxford University Press, Oxford
9. Mayr E (2004) What makes biology unique? Cambridge University Press, New York
10. Tudge T (2000) In Mendel's footnotes. Jonathan Cape, London
11. Adams A, Gottschling DE, Kaiser C, Stearns T (1997) Methods in yeast genetics. CSHL Press, Long Island
12. Bates AD, Maxwell A (2005) DNA topology. Oxford University Press, New York
13. Breitenbach M, Laun P, Heeren G, Jarolim A, Pichova A (2004) Mother cell-specific aging. In: Dickinso JR, Schweizer M (eds) The metabolism and molecular physiology of Saccharomyces cerevisiae. CRC Press, Boca Raton, FL, pp 20-41
14. Burnett J (2003) Fungal populations and species. Oxford University Press, Oxford
15. Calladine CR, Drew HR, Luise BF, Travers AA (2004) Understanding DNA. Academic Press
16. Carlile MJ, Watkinson SC (1994) The fungi. Academic Press, London
17. Davis RH (2003) The microbial models of molecular biology. Oxford University Press, Oxford
18. David M, Frazer LN (2002) Essential fungal genetics. Springer, Berlin Heidelberg New York
19. Dickinson JR (2004) Life cycle and morphogenesis. In: Dickinson JR, Schweizer M (eds) The metabolism and molecular physiology of Saccharomyces cerevisiae. CRC Press, Boca Raton, FL, pp 1-19
20. Fincham J R S (1994) Genetic analysis. Blackwell Science, London
21. Gow N A R, Gadd GM (1995) The growing fungus. Chapman Hall, London
22. Hans SD, Bostein KA (1986) Control of cell growth and division in Saccharomyces cerevisiae. CRC Crit Rev Biochem 21:153-220
23. Herskowitz I (1988) Life cycle of the budding yeasts Saccharomyces cerevisiae. Microbiol Rev 52:536-553
24. Kurtzman CP, Fell JW (2000) The yeasts: a taxonomic study. Elsevier, Amsterdam
25. Lord M, Chen T, Fujita A, Chant J (2002) Analysis of budding pattern. In: Guthrie C, Fink GR (eds) Methods in enzymology: guide to yeast genetics and molecular biology, vol. 350, Part B. Academic Press, New York, pp 131-141
26. Maheshwari R (2005) Fungi: experimental methods in biology. Taylor and Francis Group, LLC
27. Sherman F (2002) Getting started with yeast. In: Guthrie C, Fink GR (eds) Methods in enzymology: guide to yeast genetics and molecular biology, vol. 350, Part B. Academic Press, New York, pp 131-141
28. Strachan T, Read AP (1999) Human molecular genetics. Wiley, New York
29. Winderickx J, Holsbecks I, Lagatie O, Giots F, Thevelein J, Winde H (2003) From feast to famine: adaptation to nutrient availability in yeast. In: Hohmann S, Mager PWH (eds) Yeasts stress responses. Springer, Berlin Heidelberg New York, pp 305-389
30. Battley EH (1987) Energetics of microbial growth. Wiley, New York
31. Bullock C (2000) The archaea: a biochemical perspective. Biochem Mol Biol Educ 28:186-191
32. Cartledge TG, Drijver-de Haas JS, Jenkins RO, Middelbeek EJ (1992) In: Cartledge TG (ed) In vitro cultivation of microorganisms. Butterworth-Heinemann Ltd., Oxford, pp 80-106
33. Gilbert HF (2000) Basic concepts in biochemistry. McGraw-Hill, New York
34. Harold FM (2001) The way of the cell. Oxford University Press, New York
35. Haynie DT (2001) Biological thermodynamics. Cambridge University Press, Cambridge
36. Khron SJ (2002) Digital time-lapse microscopy of yeast cell growth. In: Guthrie C, Fink GR (eds) Methods in enzymology. Guide to yeast genetics and molecular and cell biology, vol. 350, Part C. Academic Press, New York, pp 3-41
37. Segel IH (1976) Biochemical calculations. Wiley, New York
38. Simpkins I (1993) General principles of biochemical investigations in practical biochemistry. In: Wilson K, Walker J (eds) Practical biochemistry. Cambridge University Press, New York, pp 1-79
39. Vol'kenshtein MV (1970) Molecules and life: an introduction to molecular biology. Plenum Press, New York
40. Wood WB, Wilson JH, Benbow RM, Hood LE (1981) Biochemistry: A problems approach. Benjamin/Cummings Publishing Company, Inc., Menlo Park
41. Wilkinson JF (1986) Introduction to microbiology. In: Both IR, Gooday GW, Gow NAR, Hamilton WA, Prosser JI (Eds) Basic microbiology series, vol. 1. Blackwell Science Publications, Oxford
42. Moller K, Olsson L, Piskur J (2001) Ability for anerobic growth is not sufficient for development of the petite phenotype in Saccharomyces kluyveri. J Bacteriol 183:2484-2489
43. Deken RH (1966) The Crabtree effect: a regulatory system in yeast. J Gen Microbiol 44:149-156
44. Prosser JI (1995) Kinetics of filamentous growth and branching. In: Gow AR, Gadd GM (eds) The growing fungus. Chapman and Hall, London, pp 301-335
45. Scheeler P, Bianchi DE (1987) Cell and molecular biology. Third edition. John Wiley and Sons (Asia) Pte. Ltd.
46. Van Uden N (1971) Kinetics and energetics of yeast growth. In: Rose AH, Harrison JS (eds) The yeasts, vol. 2. Academic Press, New York, pp 75-118
47. De Robichion-Szulmajster H (1958) Induction of enzymes of galactose pathway in mutants of Saccharomyces cerevisiae. Science 127:28-29
48. Frey PA (1996) The Leloir pathway: a mechanistic imperative for three enzymes to change the stereochemical configuration of a single carbon in galactose. FASEB J 462:461-470
49. Holden HM, Ratment I, Thoden JB (2003) Structure and function of enzymes of the Leloir pathway of galactose metabolism J Biol Chem 278:43885-43888
50. Holton JB, Walter JH, Tyfield LA (2000) In: Scriver CR, Beaudet Al, Sly SW, Valle D (eds) Metabolic and molecular basis of inherited diseases, 8th edn. McGraw Hill, New York, pp 1553-1587
51. Johnston M (1987) A model fungal gene regulatory mechanism: The GAL genes of Saccharomyces cerevisiae. Microbiol Reviews pp 458-476
52. Lindegren CC, Lindegren G (1947) Mendelian inheritance of genes affecting vitamin synthesizing ability in Saccharomyces. Ann Missouri, Botan Garden 34:95-99
53. Monod J (2003) From enzymatic adaptation to allosteric transitions. In: Ullmann U (ed) Origins of molecular biology. ASM Press, Am Soc Microbiol, Washington, DC, pp 295-317
54. Mortimer RK (1993) Ojvind Winge: founder of yeast genetics. In: Hall MN, Linder P (eds) The early days of yeast genetics. Cold Spring Laboratory Press, pp 3-16
55. Mujumdar S, Ghatak J, Mukherji S, Bhattacharji H, Bhaduri A (2004) UDP galactose 4 - Epimerase from Saccharomyces cerevisiae. A bifunctional enzyme with aldose 1-epimerase activity. Eur J Biochem 271:753-759
56. Muller-Hill B (1996) The lac operon: a short history of genetic paradigm. Walter de Gruyter, Berlin
57. Segal S (1998) Galactosemia today: the enigma and the challenge. J Inher Metab Dis 21:455-471
58. Sherman JR and Adler J (1963) Galactokinase from E. coli. J. Biol. Chem. 238:873-878
59. Spiegelman S, DeLorenzo WF, Campbell AM (1950) A single-cell analysis of the transmission of enzyme-forming capacity in yeast. J Bacteriol 37:513-523
60. Speigelman S, Sussman RR, Pinska E (1950) On the cytoplasmic nature of "long-term adaptation in yeast". Proc Natl Acad Sci USA 36:591-605
61. Timson DJ, Reece RJ (2003) Sugar recognition by human galactokinase. BMC Biochem 4:1-8
62. Winge O, Roberts C (1948) Inheritance of enzymatic characters in yeasts and the phenomenon of long-term adaptation. C. R. Trav. Lab. Carlberg. Ser Physiol 24:264-315
63. Yang J (2003) Studies in the substrate specificity of Escherichia coli galactokinase. Organ Lett 5:2223-2226
64. Hopper JE, Rowe LB (1978) Molecular expression and regulation of the galactose pathway genes in Saccharomyces cerevisiae. J Biol Chem 253:7566-7569
65. Hopper JE, Broach JR, Rowe LB (1978) Regulation of the galactose pathway in Saccharomyces cerevisiae: induction of uridyl transferase mRNA and dependency on GAL4 gene function. Proc Natl Acad Sci USA 75:2878-2882
66. Voet D, Voet JG (1990) Biochemistry. John Wiley and Sons Inc.
67. Wilson K, Walker J (2000) Practical Biochemistry Cambridge University press
68. Bassel J, Mortimer R (1971) Genetic order of the galactose structural genes in Saccharomyces cerevisiae. J Bacteriol 108:179-183
69. Douglas HC, Hawthorne DC (1964) Enzymatic expression and genetic linkage of genes controlling galactose utilization in Saccharomyces. Genetics 19:837-844
70. Fincham J R S (1994) Genetic analysis. Blackwell Scientific Publications, Oxford
71. Griffiths AF, Miller JH, Suzuki DT, Lewontin RC, Gelbert WM (1996) An introduction to genetic analysis. W. H. Freeman and Company, New York
72. Griffiths JD, Harris LD (1988) DNA strand exchanges. CRC Crit Rev Biochem Suppl 23:43-86
73. Hawthorne DC (1993) Saccharomyces studies 1950-1960. In: Hall MN, Linder P (eds) The early days of yeast genetics. Cold Spring Laboratory Press, Woodbury, NY
74. Hawthorne D, Condie F (1954) The genetic control of galactose utilization in Saccharomyces cerevisiae. J Bacteriol 68:662-670
75. Matsumuto K, Adachi Y, Toh EA, Oshima Y (1980) Function of positive regulatory gene gal4 in the synthesis of galactose pathway enzymes in Saccharomyces cerevisiae: evidence that the GAL81 region codes for the part of the gal4 protein. J Bacteriol 141:508-527
76. Mortimer RK, Hawthorne DC (1964) Genetic mapping in yeast, Chap. 12, Meth Cell Biol 11:221-233
77. Holliday R (1964) A mechanism for gene conversion in fungi. Genet Res Camb 5:282-304
78. Holiday R (1974) Molecular aspects of genetic exchange and gene conversion. Genetics 78:273-287
79. Ott J (1991) Analysis of human genetic linkage. The Johns Hopkins University Press
80. Stahl FW (1989) Genetic recombination. Sci Am 256:91-101
81. Szostak J, Orr-Weaver TL, Rothstein RJ, Stahl FW (1983) The double-strand-break-repair model for recombination. Cell 33:25-35
82. Bassel J, Mortimer RK (1971) Genetic order of the galactose structural genes in Saccharomyces cerevisiae. J Bacteriol 108:179-181
83. Chandra HS, Nanjundiah V (1990) The evolution of genomic imprinting. Dev Suppl, pp 47-53
84. Douglas HC, Hawthorne DC (1964) Enzymatic expression and genetic linkage of genes controlling galactose utilization in Saccharomyces. Genetics 49:837-844
85. Fincham J R S, Day PR (1971) Fungal genetics, vol. 4. In: Burnett JH (ed) Botanical monographs, vol. 4. Blackwell Science Publications, Oxford
86. Fincham J R S (1994) Genetic analysis. Blackwell Science Publications, Oxford
87. Hawthorne DC, Mortimer RK (1960) Chromosome mapping in Saccharomyces. Centromerelinked genes. Genetics 45:1085-1110
88. Holliday R (1989) A different kind of inheritance. Scientific American, pp 40-48
89. McKusick VA, Ruddle F (1977) The status of the gene map of the human chromosome. Science 196:390-405
90. Mortimer RK, Hawthorne DC (1966) Genetic mapping in Saccharomyces. Genetics 53:165-173
91. Mortimer RK, Hawthorne DC (1975) Genetic mapping in yeast. Meth Cell Biol 11:221-232
92. Mortimer RK, Schild D (1982) Genetic mapping in Saccharomyces cerevisiae. Molecular biology of Saccharomyces, Cold Spring Harbor Monogram, vol. 1, 11-26
93. Risch N (1992) Interpreting Lod scores. Science 255:803-804
94. Risch N (2000) Searching for genetic determinants in the new millennium. Nature 405:847-855
95. Sapienza C (1990) Parental imprinting of genes. Scientific American, October, pp 26-33
96. Schmiegelow K et al (1986) Linkage between the loci for cystic fibrosis and paraoxonase. Clin Genet 29:374-377
97. Sherman F (2002) Getting started with yeast. In: Guthrie C, Fink GR (eds) Methods in enzymology, vol. 350. Guide to yeast genetics and molecular and cell biology. Academic Press, New York, pp 3-41
98. Strachan T, Read AP (1999) Human molecular genetics. Bios Scientific Publ Ltd
99. White R, Laiouei J (1988) Chromosome mapping with DNA markers. Scientific American 258(2):20-28
100. Douglas HC, Pelroy G (1963) A gene controlling inducibility of the galactose pathway enzymes in Saccharomyces. Biochim Biophys Acta 68:155-156
101. Douglas HC, Hawthorne DC (1966) Regulation of genes controlling synthesis of the galactose pathway enzymes in yeast. Genetics 54:911-916
102. Douglas HC, Hawthorne DC (1972) Uninducible mutants in the GAL i locus of Saccharomyces cerevisiae. J Bacteriol 109:1139-1143
103. Agius L, Aiston S, Newgard CB (2000) The control strength of glucokinase in hepatocytes: a predictor of metabolic defects in maturity onset diabetes of the young, Type 2. In: Cornish-Bowden AJ, Cardenas ML (eds) Technological and medical implications of metabolic control analysis. Kluwer Academic Publishers, Dordrecht, pp 109-115
104. Herskowitz I (1987) Functional inactivation of genes by dominant negative mutations. Nature 329:219-222
105. Kacser H, Burns JA (1981) The molecular basis of dominance. Genetics 97:639-666
106. Keightley PD (1996) A metabolic basis for dominance and recessivity. Genetics 143:621-625
107. Leslie ND, Lager KI, McNamara PD, Segal S (1996) A mouse model of galactose-1-phosphate uridyl transferase. Biochem Mol Med 59:7-12
108. Manson MD (2000) Allele-specific suppression as a tool to study protein-protein interaction in bacteria. Methods 20:18-34
109. Matsumoto K, Adachi Y, Toh-e A, Oshima Y (1980) Function of positive regulatory gene gal4 in the synthesis of galactose pathway enzymes in Saccharomyces cerevisiae. Evidence that the GAL81 region codes for a part of the GAL4 protein. J Bacteriol 141:508-527
110. Nogi Y, Matsumoto K, Toh-e A, Oshima Y (1977) Interaction of superepresible and dominant constitutive mutations for the synthesis of galactose pathway enzymes in S. cerevisiae. Mol Genet 152:137
111. Stearns T, Botstein D (1988) Unlinked non-complementation: isolation of new conditional lethal mutations in each of the tubulin genes of Saccharomyces cerevisiae. Genetics 119:249-260
112. Wilkie A O M (1994) The molecular basis of genetic dominance. J Med Gen 31:89-98
113. Edgar RS (1966) Conditional lethals. In: Cairns J, Stent GS, Watson JD (eds) The phage and the origins of molecular biology. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, pp 166-170
114. Nogi Y (1986) Gal3 gene product is required for maintenance of the induced state of the GAL cluster genes in Saccharomyces cerevisiae. J Bacteriol 165:101-106
115. Klar A J S, Halvorson HO (1974) Studies on the positive regulatory gene GAL4 in regulation of galactose catabolic enzymes in Saccharomyces cerevisiae. Mol Genet 125:203-212
116. Matsumoto K, Toh-e A, Oshima Y (1978) Genetic control of galactokinase synthesis in Saccharomyces cerevisiae: evidence for constitutive expression of the positive regulatory gene Gal4. J Bacteriol 134:446-457
117. Nogi Y, Matsumoto K, Toh-e A, Oshima Y (1977) Interaction of super-repressible and dominant constitutive mutations for the synthesis of galactose pathway enzymes in Saccharomyces cerevisiae Mol Genet 152:137-144
118. Perlman D, Hopper JE (1979) Constitutive synthesis of GAL4 protein, a galactose pathway regulator in Saccharomyces cerevisiae. Cell 16:89-95
119. Matsumoto K, Adachi Y, Toh-e A, Oshima Y (1980) Function of positive regulatory gene of Gal4 in the synthesis of galactose pathway enzymes in Saccharomyces cerevisiae: evidence that the GAL81 region codes for part of the gal4 protein. J Bacteriol 141:508-527
120. Hopper JE (1981) Regulation of gene expression in the galactose mebiose regulation. In: von Wettstein D, Friis J, Kielland-Brandt M, Stenderup A (eds) Molecular genetics in yeast. Munksgaard, Copenhagen
121. Manson MD (2000) Allele-specific suppression as a tool to study protein-protein interaction in bacteria. Methods 20:18-34
122. Bhat PJ, Oh D, Hopper JE (1990) Analysis of the GAL3 signal-transduction pathway activating GAL4 protein-dependent transcription in Saccharomyces cerevisiae. Genetics 125:281-291
123. Bhat PJ, Murthy T V S (2001) Transcriptional control of the GAL/MEL regulon of yeast Saccharomyces cerevisiae: mechanism of galactose mediated signal transduction. Mol Microbiol 40:1059-1066
124. Broach JR (1979) Galactose regulation in Saccharomyces cerevisiae. The enzymes encoded by the GAL1, 7, 10 are coordinately controlled and separately translated. J Mol Biol 131:41-53
125. Tsuyumu S, Adams BG (1973) Population analysis of the deinduction kinetics of galactose longterm adaptation mutants of yeast. Proc Nat Acad Sci USA 70:919-923
126. Tsuyumu S, Adams BG (1974) Dilution kinetic studies of yeast populations: in vivo aggregation of galactose-utilizing enzymes and positive regulator molecules. Genetics 77:491-505
127. Adams A, Gattschling DE, Kaiser, CA, Stearns T (1998) Methods in yeast genetics. Cold Spring Harbor Laboratory Press, New York
128. Beggs JD (1978) Transformation of yeast by a replicating hybrid plasmid. Nature 275:104-109
129. Botstein D, Davis RW (1982) Principles and practice of recombinant DNA research with yeast. In: Strathern JN, Hicks JB (eds) The molecular biology of the yeast Saccharomyces: metabolism and gene expression. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, pp 607-636
130. Citron BA, Feiss M, Donelson JE (1979) expression of the yeast galactokinase gene in E. coli. Gene 6:251-264
131. Cohen SN, Chang A C Y, Hsu L (1972) Nonchromosomal antibiotic resistance in Bacteria: genetic transformation of E. coli by R-factor DNA. Proc Nat Acad Sci USA 69:2110-2114
132. Carbon J (1993) Genes, replicators, and centromeres: the first artificial chromosomes. In: Hall MN, Linders P (eds) The early days of yeast genetics. Cold Spring Harbor Laboratory Press, New York, pp 375-390
133. Davis RH (2003) The microbial models of molecular biology. From genes to genomes. Oxford University Press
134. Hall BD (1993) Starting to probe for yeast genes. In: Hall MN, Linders P (eds) The early days of yeast genetics. Cold Spring Harbor Laboratory Press, New York, pp 391-404
135. Hicks JB, Hinnen A, Fink GR (1980) Properties of yeast transformation. Cold Spring Harbor Symp Quant Biol 43:1305-1313
136. Struhl K (1983) The new yeast genetics. Nature 304:391-397
137. Struhl K, Stinchcomb DT, Scherer S, Davis RW (1979) High-frequency transformation of yeast: autonomous replication of hybrid DNA molecules. Proc Nat Acad Sci USA 76:1035-1039
138. Guarente L, Yocum RR, Clifford P (1982) A GAL10-CYC1 yeast hybrid promoter identifies the GAL4 regulatory region as an upstream site. Proc Nat Acad Sci USA 79:7410-7414
139. St. John TP, Davis RW (1979) Isolation of galactose-inducible DNA sequences from Saccharomyces cerevisiae by differential plaque filter hybridization. Cell 16:443-452
140. St. John TP, Davis RW (1981) The organization and transcription of the galactose gene cluster of Saccharomyces. J Mol Biol 152:285-315
141. Johnston M, Davis RW (1984) Sequences that regulate the divergent GAL1-10 promoter in Saccharomyces cerevisiae. Mol Cell Biol 4:1440-1448
142. Oh D, Hopper JE (1990) Transcription of a yeast phosphoglucomutase isozyme gene is galactose inducible and glucose repressible. Mol Cell Biol 10:1415-1422
143. Post-Beittenmiller MA, Hamilton RW, Hopper JE (1984) Regulation of basal and induced levels of the MEL1 transcript in Saccharomyces cerevisiae. Mol Cell Biol 4:1238-1245
144. Segal S (1998) Galactosemia today: The enigma and the challenge J Inner Metab Dis 21:455-471
145. Stambolian D et al (1995) Cloning of the galactokinase cDNA and identification of mutations in two families with cataracts. Nature Genetics 10:307-312
146. Szkutnicka K, Tschoop JF, Andrews L, Cirillo VP (1989) Sequence and structure of the yeast galactose transporter. J Bacteriol 171:4486-4493
147. West Jr RW, Yocum RR, Ptashne M (1984) Saccharomyces cerevisiae GAL1-GAL10 divergent promoter region: location and function of the upstream activating sequence UASg. Mol Cell Biol 4:2467-2478
148. Yocum RR, Hanley S, West Jr R, Ptashne M (1984) Use of lac Z fusions to delimit regulatory elements of the inducible divergent GAL1-10 promoter in Saccharomyces cerevisiae. Mol Cell Biol 4:1985-1988
149. Ansari AZ, Reece RJ, Ptashne M (1998) A transcriptional activating region with two contrasting modes of protein interaction. Proc Nat Acad Sci USA 95:13543-13548
150. Berg P (1991) Reverse genetics: Its origin and prospects. Biotechnology 9:342-344
151. Bram RJ, Kornberg RD (1985) Specific protein binding to far upstream activating sequences in polymerase II promoters. Proc Nat Acad Sci USA 82:43-47
152. Brent R, Ptashne M (1985) A eukaryotic transcriptional activator bearing the DNA specificity of a prokaryotic repressor. Cell 43:729-735
153. Chasman D, Kornberg, RD (1990) GAL4 protein: purification and association with GAL80 protein and conserved domain structure. Mol Cell Biol 10:2916-2923
154. Giniger E, Varnum SM, Ptashne M (1985) Specific DNA binding of the GAL4: a positive regulatory protein of yeast. Cell 40:764-774
155. Han Ying, Kodadek T (2000) Peptides selected to bind the GAL80 repressor are potent transcriptional activation domains in yeast. J Biol Chem 275:14979-14984
156. Hishimoto H, Kikuchi Y, Nogi Y, Fukasawa T (1983) Regulation of expression of the galactose gene cluster in Saccharomyces cerevisiae. Mol Gen 191:31-38
157. Johnston M (1987) A model fungal gene regulatory mechanism: the GAL genes of Saccharomyces cerevisiae. Microbiol Rev 51:458-476
158. Johnston M (1987) Genetic evidence that zinc is an essential co-factor in the DNA-binding domain of Gal4p. Nature 328:353-355
159. Johnston SA, Hopper JE (1982) Isolation of the yeast regulatory gene GAL4 and analysis of its dosage effects on the galactose/melibiose regulon. Proc Nat Acad Sci USA 79:6971-6975
160. Johnston M, Dover J (1987) Mutations that inactivate a yeast transcriptional regulatory protein cluster in an evolutionary conserved domain. Proc Nat Acad Sci USA 84:2401-2405
161. Johnston M, Dover J (1988) Mutational analysis of the GAL4 encoded transcriptional activator protein of Saccharomyces cerevisiae. Genetics 120:63-74
162. Johnston SA, Salmeron JM, Dincher Jr SS (1987) Interaction of positive and negative regulatory proteins in the galactose regulon of yeast. Cell 50:143-146
163. Johnston SA, Zavortink MJ, Hopper JE, Debouck C, Hopper JE (1986) Functional domains of the yeast regulatory protein GAL4. Proc Nat Acad Sci USA 83:6553-6557
164. Keegan L, Gill G, Ptashne M (1986) Separation of DNA binding from the transcription activating function of a eukaryotic regulatory protein. Science 231:699-703
165. Laughon A, Gesteland RF (1982) Isolation and preliminary characterization of the GAL4 gene, a positive regulator of transcription in yeast. Proc Nat Acad Sci USA 79:6827-6831
166. Laughon A, Gesteland RF (1984) Primary structure of the Saccharomyces cerevisiae GAL4 gene. Mol Cell Biol 4:260-267
167. Lohr D, Hopper JE (1985) The relationship of regulatory proteins and DNAse I hypersensitive sites in yeast GAL1-10 genes. Nucleic Acids Res 13(23):8409-8423
168. Lohr D, Venkov P, Zlatanova J (1995) Transcriptional regulation in the yeast GAL gene family: a complex genetic network. FASEB J 9:777-786
169. Ma J, Ptashne M (1987) The carboxy terminal 30 amino acids of GAL4 are recognized by GAL80. Cell 50:137-142
170. Ma J, Ptashne M (1988) Converting a eukaryotic transcriptional inhibitor into an activator. Cell 55:443-446
171. Marmorstein R, Carey M, Ptashne M, Harrison C (1992) DNA recognition by GAL4: structure of a protein-DNA complex. Nature 356:408-414
172. Melcher K (1996) Galactose metabolism in Saccharomyces cerevisiae: a paradigm for eukaryotic gene regulation. In: Zimmermann K, Entian KD (eds) Yeast sugar metabolism. Technomic Publishing Co., Lancaster, PA
173. Parthun M, Jaehning JA (1992) A transcriptionally active form of GAL4 is phosphorylated and associated with GAL80. J Biol Chem 12:4981-4987
174. Ptashne M (1992) A genetic switch: phage lambda and higher organisms, 2nd edn. Cell Press & Blackwell Scientific Publications, Cambridge
175. Vashee S, Xu H, Johnston SA, Kodadek T (1993) How do "Zn2 Cys" proteins distinguish between similar upstream activation sites. J Biol Chem 268:24699-24706.
176. Riggs AD, Suzuki H, Bourgeosis S (1970) Lac repressor operator interactions I. Equilibrium studies. J Mol Biol 48:67-83
177. Selleck SB, Majors JE (1987) In vivo DNA-binding properties of a yeast transcription activator. Mol Cell Biol 7:3260-3267
178. Salmeron JM Jr, Leuther KK, Johnston SA (1990) GAL4 mutations that separate the transcriptional activation and GAL80 interactive functions of the yeast GAL4 protein. Genetics 125(1):21-27
179. Fried M, Crothers DM (1981) Equilibra and kinetics of lac repressor operator interactions by polyacrylamide gel electrophoresis of protein DNA complexes. Nucl Acids Res 9:6506-6525
180. Garner M, Revzin A (1981) A gel electrophoresis method for quantifying the binding of proteintospecific DNA regions. Application to the components of the E. coli lactose operon system. Nucl Acids Res 9:3047-3060
181. Goldberg RF (1974) Autogenous expression of gene expression. Science 183:810-816
182. Igarashi M, Segawa T, Nogi Y, Suzuki Y, Fukasawa T (1987) Autogenous regulation of the Saccharomyces cerevisiae regulatory gene GAL80. Mol Genet 207:273-279
183. Nogi Y, Fukasawa T (1984) Nucleotide sequence of the yeast regulatory gene GAL80. Nucl Acid Res 12:9287-9298
184. Nogi Y, Shimada H, Matsuzuki Y, Hashimoto H, Fukasawa T (1984) Regulation of expression of the galactose gene cluster in Saccharomyces cerevisiae. Mol Genet 195:29-34
185. Shimada H, Fukasawa T (1985) Controlled transcription of the yeast regulatory gene GAL80. Gene 39:1-9
186. Torchia TE, Hamilton RW, Cano CL, Hopper JE (1984) Disruption of regulatory gene GAL80 in Saccharomyces cerevisiae: effects on carbon-controlled regulation of the galactose/melibiose pathway genes. Mol Cell Biol 4:1521-1527
187. Yun S, Hiraoka Y, Nishizava M, Takio K, Titani K, Nogi Y, Fukasawa T (1991) Purification and characterization of the yeast-negative regulatory protein Gal80. J Biol Chem 266:693-697
188. Zheng W, Eric Xu H, Johnston S (1997) The cystine-peptidase bleomycin hydrolase is a member of the galactose regulon in yeast. J Biol Chem 272:30350-30355
189. Bajwa W, Torchia TE, Hopper JE (1988) Yeast regulatory gene GAL3: carbon regulation, UASg elements common with GAL1, 2, 7, 10, 80 and MEL1; encoded protein is strikingly similar to yeast and E. coli galactokinases. Mol Cell Biol 8:3439-3447
190. Bhat PJ, Oh D, Hopper JE (1990) Analysis of the Gal3 signal-transduction pathway activating Gal4 protein-dependent transcription in Saccharomyces cerevisiae. Genetics 125:281-291
191. Bhat PJ, Hopper JE (1991) The mechanism of inducer formation in Gal3 mutants of the yeast galactose system is independent of normal galactose metabolism and mitochondrial respiratory function. Genetics 128:133-139
192. Botstein D, White RL, Skolnick M, Davis RW (1980) Construction of a genetic linkage map in man using restriction fragment length polymorphism. Am J Hum Genet 32:314-331
193. Collins FS (1992) Cystic fibrosis: molecular biology and therapeutic implications. Science 256:774-779
194. Knowlton et al (1985) A polymorphic DNA marker linked to cystic fibrosis is located on chromosome 7. Nature 318:380-382
195. Leppert MF (1990) Gene mapping and other tools for discovery. Epilepsia 31(Suppl 3):S11-S18
196. Mayers J, Walker-Jonah A, Hollenberg CP (1991) Galactokinase encoded by GAL1 is a bifunctional protein required for induction of the GAL genes in Kluyveromyces lactis and is able to suppress the gal3 phenotype in Saccharomyces cerevisiae. Mol Cell Biol 11:5454-5461
197. Mount DW (2001) Bioinformatics: Sequence and genome analysis. Cold Spring Harbor Laboratory Press. New York
198. Ott J (1991) Analysis of human genetic linkage. The John Hopkins University Press, Baltimore
199. Schmiegelow et al (1986) Linkage between the loci for cystic fibrosis and paraoxonase. Clin Genet 29:374-377
200. Torchia TE, Hopper JE (1986) Genetic and molecular analysis of the GAL3 gene in the expression of the galactose/melibiose regulon of Saccharomyces cerevisiae. Genetics 113:229-246
201. Tsui Lap-Chee et al (1985) Cystic fibrosis locus defined by a genetically linked polymorphic DNA marker. Science 230:1054-1057
202. White R, Laiouei J (1988) Chromosomal mapping with DNA markers. Scientific American 258:20-28
203. Wilmut I et al. (1997) Viable offspring derived from fetal and adult mammalian cells. Nature 385:810-813
204. Bhaumik SR, Raha T, Aiello DP, Green MR (2004) In vivo target of a transcriptional activator revealed by fluorescence resonance energy transfer. Genes Dev 18:333-343
205. Bhat PJ, Hopper JE (1992) Overproduction of the GAL1 or GAL3 protein causes galactoseindependent activation of the GAL4 protein. Evidence for a novel model of induction for the yeast GAL/MEL regulon. Mol Cell Biol 12:2701-2707
206. Kuo M, Allis CD (1999) In vivo cross linking and immunoprecipitation for studying dynamic protein: DNA associations in a chromatin environment. Methods 19:425-433
207. Peng G, Hopper JE (2000) Evidence for Gal3p's cytoplasmic location and Gal80p's dual cytoplasmic nuclear location implicates new mechanisms for controlling Gal4p activity in Saccharomyces cerevisiae. Mol Cell Biol 20:5140-5148
208. Peng G, Hopper JE (2002) Gene activation by interaction of an inhibitor with a cytoplasmic signaling protein. Proc Nat Acad Sci USA 99:8548-8553
209. Platt A, Reece RJ (1998) The yeast galactose genetic switch is mediated by the formation of a Gal4p-Gal80p-Gal3p complex. EMBO J 17:4086-4091
210. Sil AK, Alam S, Xin P, Ma L, Morgan M, Lebo CM, Woods MP, Hopper JE (1999) The Gal3p-Gal80p-Gal4p transcription switch of yeast: Gal3p destabilizes the Gal80p-Gal4p complex in response to galactose and ATP. Mol Cell Biol 19:7828-7840
211. Suzuki-Fujimoto T, Fukuma M, Yano K, Sakurai H, Vonika A, Johnston SA, Fukasawa T (1996) Analysis of the galactose signal-transduction pathway in Saccharomyces cerevisiae: interaction between Gal3p and Gal80p. Mol Cell Biol 16:2504-2508
212. Yang T, Sinai P, Green G, Kitts PA, Chen Y, Lybarget L, Chevranak R, Patterson GH, Piston DW, Kain SR (1998) Improved fluorescence and dual color detection with enhanced blue and green variants of the green fluorescent protein. J Biol Chem 273:8212-8216
213. Yano Ken-Icji, Fukasawa T (1997) Galactose-dependent reversible interaction of Gal3p with Gal80p in the induction pathway of Gal4-activated genes of Saccharomyces cerevisiae Proc Nat Acad Sci USA 94:1721-1726
214. Zenke FT, Vollenbroich RE, Meyer VJ, Hollenberg CP, Breunig KD (1996) Activation of Gal4p by galactose-dependent interaction of galactokinase and Gal80p. Science 272:1662-1665
215. Bork P, Sander C, Valencia A (1993) Convergent evolution of similar enzymatic function on different protein folds: the hexokinase, ribokinase and galactokinase family of sugar kinases. Protein Sci 2:31-40
216. c interaction with Gal80 in the Saccharomyces cerevisiae GAL gene switch. Genetics 172:77-87
217. Lakshninarasimhan A, Bhat PJ (2005) Replacement of a conserved tyrosine by tryptophan in Gal3p of Saccharomyces cerevisiae reduces constitutive activity: implication for signal transduction in the GAL regulon. Mol Genet Genom 274:384-393
218. Melcher K (2005) Mutational hypersensitivity of a gene regulatory protein: Saccharomyces cerevisiae Gal80p. Genetics 171:469-476
219. Menezes RA, Amuel C, Engels R, Gengenbacher U, Labahan J, Hollenberg C (2003) Sites for interaction between Gal80p and Gal1p in Kluveromyces lactis: structural model of galactokinase based on homology to the GHMP protein family. J Mol Biol 333:479-492
220. Nogi Y, Fukasawa T (1989) Functional domains of a negative regulatory protein GAL80 of Saccharomyces cerevisiae. Mol Cell Biol 9:3009-3017
221. Pilauri V, Beweley M, Diep Q, Hopper JE (2005) Gal80 dimerisation and the yeast GAL gene switch. Genetics 169:1903-1914
222. Platt A, Ross HC, Hankin S, Reece R (2000) The insertion of two amino acids into a transcriptional inducer converts it into a galactokinase. Proc Nat Acad Sci USA 97:3154-3159
223. Thoden JB, Sellick CA, Timson DJ, Reece RJ, Holden H (2005) Molecular structure of Saccharomyces cerevisiae Gal1p, a functional galactokinase and transcriptional inducer. J Biol Chem 280:36905-36911
224. Timson DJ, Ross HC, Reece RJ (2002) Gal3p and Gal1p interact with the transcriptional repressor Gal80pto forma complex of 1:1 stoichiometry. Biochem J 363:515-520
225. Boeger H, Bushnell DA, Davis R, Griesenbeck J, Lorch Y, Strattan JS, Westover KD, Kornberg RD (2005) Structural basis of eukaryotic transcription. FEBS Lett 579:899-903
226. Bryant GO, Ptashne M (2003) Independent recruitment in vivo by Gal4 of two complexes required for transcription. Mol Cell 11:1301-1309
227. Frank CP, Holstege et al (1998) Dissecting the regulatory circuitry of a eukaryotic genome. Cell 95:717-728
228. Himmelfarb H, Pearlberg JJ, Last DH, Ptashne M (1990) GAL11P: a yeast mutation that potentiates the effect of the weak GAL4 derived activators. Cell 63:1299-1309
229. Kornberg RD (2005) Mediator and the mechanism of transcriptional activation. Trends Biochem Sci 30:235-239
230. Kornberg RD, Lorch Y (1999) Twenty-five years of the nucleosome: fundamental particle of the eukaryote chromosome. Cell 98:285-294
231. Nogi Y, Fukasawa T (1983) A novel mutation that affects utilization of galactose in Saccharomyces cerevisiae. Curr Genet 195:115-120
232. Ptashne M (2003) Regulated recruitment and co-operativity in the design of biological regulatory systems. Phil Trans R Soc Lond A 361:1223-1234
233. Reece RJ (2000) Molecular basis of nutrient-controlled gene expression in Saccharomyces cerevisiae. CMLS Cell Mol Life Sci 57:1161-1171
234. Reece RJ, Platt A (1997) Signalling activation and repression of RNA polymerase II transcription in yeast Bioassays 19:1001-1009
235. Sellick CA, Reece RJ (2005) Eucaryotic transcription factors as direct nutrient sensors. Trends Biochem Sci 30:405-412
236. Traven A, Jelicic B, Sopta M (2006) Yeast GAL4: a transcriptional paradigm revisited. EMBO Rep 7:496-499
237. Thomas MC, Miang CC (2006) The general transcription machinery and general co-factors. Crit Rev Biochem Mol Biol 41:105-178
238. Tsonis PA (2003) Anatomy of gene regulation. Three-dimensional structural analysis. Cambridge University Press, Cambridge
239. Adams BG (1972) Induction of galactokinase in Saccharomyces cerevisiae: kinetics of induction and glucose effects. J Bacteriol 111:308-315
240. Biggar SR, Crabtree GR (2001) Cell signaling can direct either binary or graded transcriptional responses. EMBO J 20:3167-3176
241. Carlson M (1999) Glucose repression in yeast. Curr Opin Microbiol 2:202-207
242. Ferrel Jr, JE (1996) Triping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs. Trends Biochem Sci 21:460-466
243. Gancedo JM (1992) Carbon catabolite repression in yeast. Eur J Biochem 206:297-313
244. Griggs DW, Johnston M (1991) Regulated expression of the GAL4 activator gene in yeast provides a sensitive switch for glucose repression. Proc Nat Acad Sci 88:8597-8601
245. Johnston M (1999) Feasting, fasting, and fermenting. Trends Genet 15:29-33
246. Klein CJ, Olsson L, Nielsen J (1998) Glucose control in Saccharomyces cerevisiae: the role of MIG1 in metabolic functions. Microbiology 144:13-24
247. Nehlin UO, Carlberg M, Ronne H (1991) Control of yeast GAL genes by MIG1 repressor: a transcriptional cascade in the glucose response. The EMBO J 10:3373-3377
248. Novick A, Weiner M (1957) Enzyme induction as an all or none phenomenon. Proc Natl Acad Sci USA 43:553-566.
249. Ronne H (1995) Glucose repression in fungi. Trends Genet 11:12-17
250. Rossi FM, Kringstein AM, Spicher A, Guicherit OM, Blau HM (2000) Transcriptional control: rheostat converted to ON/OFF switch. Mol Cell 6:723-728
251. Ding WV, Johnston A (1997) The DNA-binding and activation domain of Gal4p are sufficient for conveying its regulatory signals. Mol Cell Biol 17:2538-2459
252. Lakshminarasimhan A, Bhat PJ (2005) Replacement of a conserved tyrosine by tryptophan in Gal3p of Saccharomyces cerevisiae reduces constitutive activity: implication for signal transduction in the GAL regulon. Mol Gen Genom 274:384-393
253. Novick A, Weiner M (1957) Enzyme induction as an all or none phenomenon Proc. Natl. Acad. Sci. USA 43:553-566
254. Melcher K, Xu HE (2001) Gal80-Gal80 interaction on adjacent Gal4p-binding sites is required for complete GAL gene repression. EMBO J 20:841-851
255. Muratani M, Kung C, Shokat KM, Tansey WP (2005) The F-box protein DSG1/MDM30 is a transcriptional co-activator that stimulates Gal4 turnover and co-transcriptional mRNA processing. Cell 120:887-899
256. Mylin LM, Bhat PJ, Hopper JE (1989) Regulated phosphorylation and dephosphorylation of GAL4, a transcriptional activator. Genes Dev 3:1157-1165
257. Gregar IH, Proudfoot NJ (1998) Poly (A) signals both transcriptional termination and initiation between the tandem GAL7 and GAL10 genes of Saccharomyces cerevisiae. EMBO J 17:4771-4779
258. Rohde JR, Trinh J, Sadowski I (2000) Multiple signals regulate transcription in yeast. Mol Cell Biol 20:3880-3886
259. Sadowski I, Costa C, Dhanawansa R (1996) Phosphorylation of Gal4p at a single C-terminal residue is necessary for galactose inducible transcription. Mol Cell Biol 16:4879-4887
260. Sadowski I, Niedbala D, Wood K, Ptashne M (1991) GAL4 is phosphorylated as a consequence of transcriptional activation. Proc Nat Acad Sci USA 88:10510-10514
261. St. John TP, Davis RW (1981) The organization and transcription of galactose gene cluster of Saccharomyces. J Mol Biol 152:285-315
262. Traven A, Jelicic B, Sopta M (2006) Yeast Gal4: a transcriptional paradigm revisited. EMBO Rep 7:496-499
263. Vashee S, Xu H, Johnston SA, Kodadek T (1993) How do Zn2 Cys6 proteins distinguish between similar upstream activation sites? J Biol Chem 268:24699-24706
264. Verma M, Bhat PJ, Venkatesh KV (2005) Steady state analysis of glucose repression reveals hirarchical expression of protein under Mig1p control in Saccharomyces cerevisiae. Biochem J 288:843-849
265. Xu HE, Kodadek T, Johnston, SA (1995) A single GAL4 dimer can maximally activate transcription under physiological conditions Proc Nat Acad Sci USA 92:7677-7680
266. Cornish-Bowden A, Cardenas M (2001) Complex network of interactions connect genes to phenotypes. Trends Biochem Sci 26:463-464
267. Fell D (2001) Beyond genomics. Trends Genet 17:680-682
268. Glaever et al (2002) Functional profiling of Saccharomyces cerevisiae genome. Nature 418:387-391
269. Hall BD, Spiegelman S (1961) Sequence complimentarity of T2 DNA and T2 specific RNA. Proc Nat Acad Sci USA 47:137-146
270. Hoheisel JD (2006) Microarray technology: beyond transcript profiling and genotype analysis. Nature Reviews 7:200-209
271. Idekar T et al (2001) Integrated genomic and proteomic analyses of a systematically perturbed metabolic network. Science 292:929-933
272. Ren B et al (2000) Genome-wide location and function of DNA-binding proteins. Science 290:2306-2309
273. Becskel MA, Oudenaarden A (2005) Enhancement of cellular memory by reducing stochastic transitions. Nature 435:228-232
274. Bhat PJ, Venkatesh KV (2005) Stochastic variation in the concentration of the repressor activates GAL genetic switch: implications in the evolution of regulatory network. FEBS Lett 579:597-603
275. Goldberger RF (1974) Autogenous regulation of gene expression. Science 183:810-816
276. Hawkins MK, Smolke CD (2006) The regulatory roles of the galactose permease and kinase in the induction response of the GAL network in Saccharomyces cerevisiae. J Biol Chem 281:13485-13492
277. Holde KE, Johnson van WC, Ho PS (1998) Principles of physical biochemistry. Prentice Hall, Upper Saddle
278. River, NJ Hwang D, Smith JJ, Leslie DM, Weston AD, Rust AG, Ramsey S, Atauri P, Siegel AF, Bolouri H, Aitchison JD, Hood L (2005) A data-integration methodology for systems biology: experimental verification. Proc Nat Acad Sci USA 102:17302-17307
279. Kew OM, Douglas HC (1976) Genetic co-regulation of galactose and melibiose utilization in Saccharomyces. J Bacteriol 125:33-41
280. McAdams HH, Adam A (1999) It is a noisy business. Trends Genet 15:65-69
281. Perutz MF (1998) I wish I had made you angry earlier. Oxford University Press.
282. Ptashne M (1992) A genetic switch: phage λ and higher organisms. Cell Press and Blackwell Scientific Publications, Cambridge
283. Ramsey SA, Smith JJ, Orrel D, Marelli M, Peterson TW, de Atauri, P Bolouri H, Aitchison JD (2006) Dual feedback loops in the GAL regulon suppress cellular heterogeneity in yeast (2006). Nature Genet 38:1082-1086
284. Verma M, Bhat PJ, Venkatesh KV (2003) Quantitative analysis of GAL genetic switch of Saccharomyces cerevisiae reveals that nucleocytoplasmic shuttling of Gal80p results in a highly sensitive response to galactose. J Biol Chem 278:48764-48769
285. Anders A, Liele H, Franke K, Kapp L, Stelling J, Giles ED, Breunig KD (2006) The galactose switch in K. lactis depends on nuclear competition between GAL1 and GAL4 for GAL80 binding. J Biol Chem 281:29337-29348
286. Bhat PJ, Murthy T V S (2001) Transcriptional control of GAL/MEL regulon of yeast Saccharomyces cerevisiae: mechanisms of galactose expression signal transduction. Microbiology 40:1059-1066
287. Bhat PJ (2003) Galactose-1-phosphate is a regulator of inositol monophosphatase: A fact or a fiction. Medical Hypothesis 60:123-128
288. Dietrich et al (2004) The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome. Science 304:5668-5674
289. Frey PA (1996) The Leloir pathway: a mechanistic imperative for three enzymes to change the stereochemical configuration of a single carbon in galactose. FASEB J 462:461-470
290. Hittinger CT, Rokas A, Carroll SB (2004) Parallel inactivation of multiple GAL pathway genes and ecological diversification in yeast. Proc Nat Acad Sci USA 101(9):14144-14149
291. Hittinger CT, Carrol SB (2007) Gene duplication and the adaptive evolution of a classic genetic switch. Nature 449:677-681
292. Janine R, Maria R, Guther LS, Miline KG, Ferguson M A J (2002) Galactose metabolism is essential for the African sleeping sickness parasite Trypanosoma Bruci. Proc Nat Acad Sci USA 99:5884-5889
293. Kalckar HM (1966) High-energy phosphate bonds: optional or obligatory? In: Cairns J, Stent G, Watson JD (eds) Phage and origins of molecular biology. Cold Spring Harbor Laboratory, Long Island, NY, pp 43-49
294. Kodama T, Hisatomi T, Kakiuchi M, Aya R, Yoshida K, Bando Y, Takami T, Tsuboi M (2003) Unique distribution of GAL genes on chromosome IX in the yeast Saccharomyces naganishi. Curr Microbiol 47:497-500
295. Kellis M, Birren W, Lander ES (2004) Proof and evolutionary analysis of ancient genome duplication in the yeast Saccharomyces cerevisiae. Nature 428:617-623
296. Lai K, Elsas LJ (2000) Over-expression of human UDPglucose pyrophosphorylase rescues galactose-1-phosphate uridyltransferase deficient. Biochem Biophys Res Commun 271:392-400
297. Mehta DV, Kabir A, Bhat PJ (1999) Expression of human inositol monophosphatase suppresses galactose toxicity in Saccharomyces cerevisiae: possible implications for galactosemia. Biochem Biophys Acta 1454:217-226
298. Moller K, Olsson L, Piskur J (2001) Ability for anaerobic growth is not sufficient for the development of the petite phenotype in Saccharomyces kluyveri. J Bacteriol 183:2485-2489
299. Rubio-Taxiera M (2005) A comparative analysis of the GAL genetic switch between not-so-distant cousins: Saccharomyces cerevisiae and Kluyveromyces lactis. FEMS Yeast Res 5:1115-1128
300. Semsey S, Vernik, K, Adya S (2006) Three-stage regulation of the amphibolic GAL regulon: from repressosome to GALR-free DNA. J Mol Biol 358:355-365
301. Teichmann SA, Veitia RA (2004) Genes encoding subunits of stable complexes are clustered on the yeast chromosomes: an interpretation from a dosage-balance perspective. Genetics 167:2121-2125
302. Fields S, Sternglanz R (1994) The two-hybrid system. Trends Genet 10(8):286-291
303. Field S, Song Ok-Kyu (1989) Novel genetic system to detect in vivo protein-protein interaction. Nature 340:245-246
304. Hwang D, Smith JJ, Leslie DM, Weston AD, Rust AG, Ramsey S, Atauri P, Siegel AF, Bolouri H, Aitchison JD, Hood L (2005) A data-integration methodology for systems biology: experimental verification. Proc Nat Acad Sci USA 102:17302-17307
305. Leuther KK, Johnston SA (1992) Non-dissociation of GAL4 and GAL80 in vivo after galactose induction. Science 256:1333-1335
306. Legrain P, Selig L (2000) Genome-wide protein interaction maps using two-hybrid system. FEBS Lett 480:32-36
307. Mylin LM, Hopper JE (1997) Inducible expression cassettes in yeast: GAL4. In: Taun R (ed) Recombinant gene expression protocols. Humana Press, Totowa, NJ, Meth Mol Biol Vol. 62
308. McGuire SE, Roman, Davis RL (2004) Gene expression systems in Drosophila: A synthesis of time and space. Trends Genet 20:384-391
309. Peccoud J, Veldern KV, Podlich D, Winkler C, Arthus L, Cooper M (2004) The selective values of alleles in a molecular network model are context-dependent. Genetics 166:1715-1725
310. Sweeney ST, Broadie K, Keane J, Niehemann H, O'Kane CJ (1995) Targeted expression of tetanus toxin light chain in Drosophila specifically eliminates and causes behavioral defects. Neuron 14:341-351
311. Yang XE, Hubbard JA, Carlson M (1992) A protein kinase substrate identified by two-hybrid system. Science 257:680-682
312. White MA (1996) The yeast two-hybrid system: forward and reverse. Proc Nat Acad Sci USA 93:10001-10003
313. Balaban NQ, Merrin J, Chait R, Kowalik L, Lebier S (2004) Bacterial persistence as a phenotypic switch. Science 305:1622-1625
314. Elowitz MB et al. (2002) Stochastic gene expression is a single cell. Science 297:1183-1186
315. Koern M, Elston TC, Blake WJ, Collins JJ (5005) Stochasticity in gene expression: from theories to phenotypes. Nature 6:451-464
316. Kemkemer R et al. (2002) Increased noise as an effect of haploinsufficiency of the tumor suppressor gene neurofibromatosis type1 in vitro. Proc Natl Acad Sci USA 99:13783-13788
317. Kupiec JJ (1997) Darwinian theory for the origin of cellular differentiation. Mol Gen 255:201-208
318. Hume DA (2000) Probability in transcriptional regulation and its implication for leukocyte differentiation and inducible gene expression Blood 96:2323-2328
319. McAdaams HH, Arkin A (1999) It is a noisy business. Trends Genet 15:65-69
320. Thattai M, van Oudenaaredn A (2004) Stochastic gene expression in fluctuating environment. Genetics 167:523-520
321. Gally AJ, Edelman GM (2001) Degeneracy and complexity in biological systems. Proc Nat Acad Sci USA 98:13763-13768
322. Raser MJ, O'Shea EK (2005) Noise in gene expression: Origins, consequence and control. Science 309:2010-2013
323. Swain PS, Elowitz MB, Siggia ED (2002) Intrinsic and extrinsic contributions to stochasticity in gene expression. Proc Nat Acad Sci USA 99:12795-12800
324. Stelling J, Sauer U, Szallasi Z, Doyle FJ, Doyle J (2004) Robustness of cellular functions. Cell 118:675-685
325. Wagner A (2005) Robustness and evolvability in living systems. Princeton University Press, Princeton
326. Alon U (2007) An introduction to systems biology. Chapman & Hall, New York