Analysis of the galactose signal transduction pathway in Saccharomyces cerevisiae: Interaction between Gal3p and Gal80p

Molecular and Cellular Biology

Volumn 16, Issue 5, 1996, Pages 2504-2508

  Suzuki Fujimoto, Tomoko ^a   Fukuma, Mariko ^a   Yano, Ken Ichi ^b   Sakurai, Hiroshi ^a   Vonika, Alin ^c   Johnston, Stephen Albert ^c   Fukasawa, Toshio ^b  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KAZUSA DNA RESEARCH INSTITUTE   (Japan)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GALACTOSE;

ARTICLE; CARBOHYDRATE METABOLISM; COMPLEX FORMATION; DNA SEQUENCE; ENZYME METABOLISM; GENE EXPRESSION; GENE INDUCTION; GENETIC ANALYSIS; GENETIC DISORDER; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; YEAST CELL;

SACCHAROMYCES CEREVISIAE;

EID: 0029963566     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.5.2504     Document Type: Article

References (34)

1. Gal elements in common with GAL1, GAL2, GAL7, GAL10, GAL80, and MEL1; encoded protein strikingly similar to yeast and Escherichia coli galactokinases Mol. Cell. Biol. 8:3439-3447.
2. Bhat, P. J., and J. E. Hopper. 1991 The mechanism of inducer formation in gal3 mutants of the yeast galactose system is independent of normal galac; tose metabolism and mitochondrial respiratory function. Genetics 128:233-239.
3. Bhat, P. J., and J. E. Hopper. 1992 Overproduction of the GAL1 or GAL3 protein causes galactose-independent activation of the GAL4 protein: evidence for a new model of induction for the yeast GAL/MEL regulon Mol. Cell. Biol. 12:2701-2707.
4. Bhat, P. J., D. Oh, and J. E. Hopper. 1990. Analysis of the GAL3 signal transduction pathway activating GAL4 protein-dependent transcription in Saccharomyces cerevisiae. Genetics 125:281-291.
5. Broach, J. R. 1979. Galactose regulation in Saccharomyces cerevisiae The enzymes encoded by the GAL7, 10, 1 cluster are co-ordinately transcribed and separately translated. J. Mol. Biol. 131:41-53
6. Carlson, M., and D. Botstein. 1982. Two differentially regulated mRNAs with different 5′ ends encode secreted and intracellular forms of yeast invertase Cell 28:145-154.
7. Chasman, D. I., and R. D. Kornberg. 1990. GAL4 protein purification, association with GAL80 protein, and conserved domain structure. Mol. Cell. Biol. 10:2916-2923
8. Dohmen, R. J., A. W. M. Strasser, C. B. Hoener, and C. P. Hollenberg. 1991 An efficient transformation procedure enabling long-term storage of competent cells of various yeast genera Yeast 7:691-692.
9. Douglas, H. C., and D. C. Hawthorne. 1966 Regulation of genes controlling inducibility of the galactose pathway enzymes in yeast. Genetics 54:911-916
10. Douglas, H. C., and G. Pelroy. 1963. A gene controlling inducibility of the galactose pathway enzymes in Saccharomyces cerevisiae Biochim Biophys Acta 68:155-156.
11. Fukasawa, T., T. Segawa, and Y. Nogi. 1982. Uridine diphosphoglucose-4-epimerase and galactose-1-phosphate uridylyl transferase from Saccharomyces cerevisiae. Methods Enzymol. 89:584-589.
12. Hashimoto, H., Y. Kikuchi, Y. Nogi, and T. Fukasawa. 1983. Regulation of expression of the galactose gene cluster in Saccharomyces cerevisiae Mol Gen. Genet. 191:31-38.
13. Johnston, M., and M. Carlson. 1992. Regulation of carbon and phosphate utilizatiun, p 193-281. In E. W. Jones, J. R. Pringel, and J. R. Broach (ed), The molecular and cellular biology of the yeast Saccharomyces. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
14. Johnston, S. A., and J. E. Hopper. 1982. Isolation of the yeast regulatory gene GAL4 and analysis of its dosage effects on the galactose/melibiose regulon. Proc Natl Acad. Sci. USA 79:6971-6975.
15. Leuther, K. K., and S. A. Johnston. 1992. Nondissociation of GAL4 and GAL80 in vivo after galactose induction Science 256:1333-1335.
16. Meyer, J., A. Walker-Jonah, and C. P. Hollenberg. 1991. Galactokinase encoded by GAL1 is a bifunctional protein required for induction of the GAL genes in Kluyveromyces lactis and is able to suppress the gal3 phenotype in Saccharomyces cerevisiae. Mol. Cell. Biol. 11:5454-5461.
17. Nogi, Y. 1986. GAL3 gene product is required for maintenance of the induced state of the GAL cluster genes in Saccharomyces cerevisiae. J. Bacteriol. 165:101-106
18. Nogi, Y., and T. Fukasawa. 1984. Nucleotide sequence of the yeast regulatory gene GAL80. Nucleic Acids Res. 12:9287-9298.
19. Nogi, Y., and T. Fukasawa. 1989. Functional domains of a negative regulatory protein, GAL80, of Saccharomyces cerevisiae. Mol. Cell. Biol. 9:3009-3017.
20. Oshima, Y. 1982. Regulatory circuits for gene expression: the metabolism of galactose and phosphate, p. 159-180. In J. R. Broach, E. W. Jones, and J N. Strathern (ed.), The molecular biology of the yeast Saccharomyces. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
21. Parthun, M. R., and J. A. Jaehning. 1990. Purification and characterization of the yeast transcriptional activator GAL4. J. Biol. Chem. 265:209-213
22. Rose, M. D., and J. R. Broach. 1991. Cloning genes by complementation in yeast. Methods Enzymol. 194:195-238.
23. Shimada, H., and T. Fukasawa. 1985 Controlled transcription of the yeast regulatory gene GAL80 Gene 39:1-9
24. Silhavy, T. J., M. J. Herman, and L. W. Enquist. 1984. Experiments with gene fusions, p. 133-134. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
25. Smits, P. H. M., M. De Hann, C. Maat, and L. A. Grivell. 1994. The complete sequence of a 33 kb fragment on the right arm of chromosome II from Saccharomyces cerevisiae reveals 16 open reading frames, including ten new open reading frames, five previously identified genes and a homologue of the SCO1 gene. Yeast 10:75-80.
26. Stinchcomb, D. T., C. Mann, and R. W. Davis. 1982. Centromeric DNA from Saccharomyces cerevisiae. J. Mol. Biol. 158:157-179.
27. St. John, T. P., and R. W. Davis. 1979. Isolation of galactose-inducible DNA sequences from Saccharomyces cerevisiae by differential plaque hybridization. Cell 16:443-452.
28. St. John, T. P., and R. W. Davis. 1981. The organization and transcription of the galactose gene cluster of Saccharomyces. J. Mol Biol. 152:285-315
29. Tajima, M., Y. Nogi, and T. Fukasawa. 1985. Primary structure of the yeast GAL7 gene. Yeast 1:67-77.
30. Torchia, T. E., and J. E. Hopper. 1986. Genetic and molecular analysis of the GAL3 gene in the expression of the galactose/melibiose regulon of Saccharomyces cerevisiae. Genetics 113:229-246.
31. Tsuyumu, S., and B. G. Adams. 1974. Dilution kinetic studies of yeast population, in vivo aggregation of galactose utilizing enzymes and positive regulator molecules. Genetics 77:491-505.
32. Vernet, T., D. Dignard, and D. Y. Thomas. 1987. A family of yeast expression vectors containing the phage f1 intergenic region. Gene 52:225-233
33. Winge, O., and C. Roberts. 1948. Inheritance of enzymatic characters in yeast and the phenomenon of long-term adaptation. C. R Trav. Lab. Carlsberg Ser. Physiol. 24:214-315.
34. Yun, S.-J., Y. Hiraoka, M. Nishizawa, K. Takio, K. Titani, Y. Nogi, and T. Fukasawa. 1991. Purification and characterization of the yeast negative regulatory protein GAL80. J. Biol Chem. 266:693-697.