Transcriptional control of the GAL/MEL regulon of yeast Saccharomyces cerevisiae: Mechanism of galactose-mediated signal transduction

Molecular Microbiology

Volumn 40, Issue 5, 2001, Pages 1059-1066

  Jayadeva Bhat, P ^a   Murthy, T V S ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY BOMBAY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

GALACTOSE;

ENERGY METABOLISM; GENE INDUCTION; NONHUMAN; PRIORITY JOURNAL; REGULON; SACCHAROMYCES CEREVISIAE; SHORT SURVEY; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; KLUYVEROMYCES; MUTATION; REGULON; REPRESSOR PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

SACCHAROMYCES CEREVISIAE;

EID: 0034967623     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2001.02421.x     Document Type: Article

References (44)

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4. Analysis of the GAL3 signal transduction pathway activating GAL4 protein-dependent transcription in Saccharomyces cerevisiae
5. Novel Gal3 proteins showing altered Gal80p binding cause constitutive transcription of Gal4p-activated genes in Saccharomyces cerevisiae
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7. Constitutive expression in gal7 mutants of Kluyveromyces lactis is due to internal production of galactose as an inducer of the GAL/LAC regulon
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11. Autogenous regulation of gene expression
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13. Feasting, fasting and fermenting. Glucose sensing in yeast and other cells
14. Regulation of carbon and phosphate utilisation
15. Nondissociation of GAL4 and GAL80 in vivo after galactose induction
16. Transcriptional regulation in the yeast GAL gene family: A complex genetic network
17. Interaction of GAL4 and GAL80 gene regulatory proteins in vitro
18. GAL1 of Kluyveromyces lactis is required for the induction of the Lelior enzymes and can complement the gal3 long term adaptation phenotype in Saccharomyces cerevisiae
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21. Disruption of galactokinase signature sequence in GAL3 of Saccharomyces cerevisiae does not lead to loss of signal transduction function
22. GAL3 gene product is required for maintenance of the induced state of the GAL cluster genes in Saccharomyces cerevisiae
23. Functional domains of a negative regulatory protein, GAL80, of Saccharomyces cerevisiae
24. The transcription factor LAC9 from Kluyveromyces lactis-like GAL4 from Saccharomyces cerevisiae forms a Zn(II)2Cys6 binuclear cluster
25. Evidence for Gal3p's cytoplasmic location and Gal80p's dual cytoplasmic-nuclear location implicates new mechanisms for controlling Gal4p activity in Saccharomyces cerevisiae
26. The yeast galactose genetic switch is mediated by the formation of a Gal4p-Gal80p-Gal3p complex
27. Insertion of two amino acids into a transcriptional inducer converts it into a galactokinase
28. GAL4 of Saccharomyces cerevisiae activates the lactose-galactose regulon of Kluyveromyces lactis and creates a new phenotype: Glucose repression of the regulon
29. Multiple signals regulate GAL transcription in yeast
30. Phosphorylation of Gal4p at a single C-terminal residue is necessary for galactose inducible transcription
31. Analysis of the Kluyveromyces lactis positive regulatory gene LAC9 reveals functional homology to, but sequence divergence from the Saccharomyces cerevisiae GAL4 gene
32. Controlled transcription of the yeast regulatory gene GAL80
33. The Gal3p-Gal80p-Gal4p transcription switch of yeast: Gal3p destabilizes the Gal80p-Gal4p complex in response to galactose and ATP
34. Analysis of the galactose signal transduction pathway in Saccharomyces cerevisiae interaction between Gal3p and Gal80p
35. Genetic and molecular analysis of the GAL3 gene in the expression of the galactose/melibiose regulon of Saccharomyces cerevisiae
36. Population analysis of the deinduction kinetics of galactose long term adaptation mutants of yeast
37. Dilution kinetic studies of yeast populations: In vivo aggregation of galactose utilizing enzymes and positive regulator molecules
38. Quantitative model for Gal4p-mediated expression of the galactose/melibiose regulon in Saccharomyces cerevisiae
39. Galactose induction in yeast involves association of Gal80p with Gallp or Gal3p
40. Inheritance of enzymatic characters in yeast and the phenomenon of long term adaptation
41. Galactose-dependent reversible interaction of Gal3p with Gal80p in the induction pathway of Gal4p-activated genes of Saccharomyces cerevisiae
42. Purification and characterization of the yeast negative regulatory protein GAL80
43. Gal80 proteins of Kluyveromyces lactis and Saccharomyces cerevisiae are highly conserved but contribute differently to glucose repression of the galactose regulon
44. Activation of Gal4p by galactose-dependent interaction of galactokinase and Gal80p