Regulated recruitment and cooperativity in the design of biological regulatory systems

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences

Volumn 361, Issue 1807, 2003, Pages 1223-1234

  Ptashne, Mark ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Cooperative binding; Enzyme specificity; Evolvability; Gene activation; Regulated recruitment; Synergy

Indexed keywords

ENZYME ACTIVATOR; PROTEIN;

ARTICLE; ENZYME STABILITY; FEEDBACK SYSTEM; GENE EXPRESSION REGULATION; GENETICS; MACROMOLECULE; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE; YEAST;

ENZYME ACTIVATORS; ENZYME STABILITY; FEEDBACK, BIOCHEMICAL; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MACROMOLECULAR SUBSTANCES; PROTEINS; SIGNAL TRANSDUCTION; SPECIES SPECIFICITY; YEASTS;

EID: 0042233986     PISSN: 1364503X     EISSN: None     Source Type: Journal    
DOI: 10.1098/rsta.2003.1195     Document Type: Conference Paper

References (5)

1. Graveley, B. R., Hertel, K. J. & Maniatis, T. 1998 SR proteins are 'locators' of the RNA splicing machinery. Curr. Biol. 9, R6-R7.
2. Pawson, T. 2003 Organization of cell-regulatory systems through modular-protein-interaction domains. Phil. Trans. R. Soc. Lond. A 361, 1251-1262.
3. Ptashne, M. 1992 A genetic switch: phage lambda and higher organisms, 2nd edn. Oxford: Blackwell Science.
4. Ptashne, M. & Gann, A. 1998 Imposing specificity by localization: mechanism and evolvability. Curr. Biol. 8, 812-822.
5. Ptashne, M. & Gann, A. 2002 Genes and signals. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.