Dopaminergic Modulation of Cognition in Human Aging

Imaging the Aging Brain

Volumn , Issue , 2010, Pages

  Li, Shu Chen ^a   Lindenberger, Ulman ^a   Nyberg, Lars ^b   Heekeren, Hauke R ^c   Bäckman, Lars ^d  

^a MAX PLANCK INSTITUTE FOR HUMAN DEVELOPMENT   (Germany)

^b UMEÅ UNIVERSITY   (Sweden)

^c FREIE UNIVERSITÄT BERLIN   (Germany)

^d AGING RESEARCH CENTER   (Sweden)

Author keywords

Aging; Cognition; Dopamine; Genes; Genomic imaging; Multimodal imaging; Norepinephrine; Receptor imaging; Serotonin

Indexed keywords

EID: 84920075695     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1093/acprof:oso/9780195328875.003.0005     Document Type: Chapter

References (179)

1. Aalto, S., Brück, A., Laine, M., Någren, K., and Rinne, J. O. (2005). Frontal and temporal dopamine release during working memory and attention tasks in healthy humans: A PET study using the high-affinity dopamine D2 receptor ligand [11C] FLB 457. Journal of Neuroscience, 25: 2471-2477.
2. Adcock, R. A., Thangavel, A., Whitfield-Gabrieli, S., Knutson, B., and Gabrieli, J. D. E. (2006). Reward-motivated learning: Mesolimbic activation precedes memory formation. Neuron, 50: 507-517.
3. Alexander, G. E., DeLong, M. R., and Strick, P. L. (1986). Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annual Review of Neuroscience, 9: 357-381.
4. Antonini, A., Leenders, K. L., Reist, H., Thomann, R., Beer, H.-F., and Locher, J. (1993). Effect of age on D2 dopamine receptors in normal human brain measured by positron emission tomography and [11C] raclopride. Archives of Neurology, 50: 474-480.
5. Bäckman, L. and Farde, L. (2005). The role of dopamine functions in cognitive aging. In R. Cabeza, L. Nyberg, and D. C. Park (eds), Cognitive Neuroscience of Aging: Linking Cognitive and Cerebral Aging (pp. 58-84). New York: Oxford University Press.
6. Bäckman, L., Ginovart, N., Dixon, R. A., Robins Wahlin, T. B., Wahlin, Å., Halldin, C., and Farde, L. (2000). Age-related cognitive deficits mediated by changes in the striatal dopamine system. American Journal of Psychiatry, 157: 635-637.
7. Bäckman, L., Nyberg, L., Lindenberger, U., Li, S.-C., and Farde, L. (2006). The correlative triad among aging, dopamine, and cognition: Current status and future prospects. Neuroscience and Biobehavioral Reviews, 30: 791-807.
8. Bäckman, L., Robins-Wahlin, T.-B., Lundin, A., Ginovart, N., and Farde, L. (1997). Cognitive deficits in Huntingtonś disease are predicted by dopaminergic PET markers and brain volumes. Brain, 120: 2207-2217.
9. Badgaiyan, R. D., Fischman, A. J., and Alpert, N. M. (2007). Striatal dopamine release in sequential learning. NeuroImage, 38: 549-556.
10. Barnett, J. H., Jones, P. B., Robbins, T. W., and Müller, U. (2007). Effects of the catechol-O-methyltransferase Val/158Met polymorphism on executive function: A meta-analysis of the Wisconsin Card Sorting in schizophrenia and healthy controls. Molecular Psychiatry, 12: 502-509.
11. Bertolino, A., Giorgio, D. A., Blasi, G., Sambataro, F., Caforio, G., Sinibaldi, L. et al. (2008). Epistasis between dopamine regulating genes identifies a nonlinear response of the human hippocampus during memory tasks. Biological Psychiatry, 64: 226-234.
12. Bilder, R. M., Volavka, J., Lachman, H. M., and Grace, A. A. (2004). The catechol-O-methyltransferase polymorphism: Relations to the tonic-phasic dopamine hypothesis and neuropsychiatric disorders. Neuropsychopharmacology, 29: 1943-1961.
13. Björklund, A. and Dunnett, S. B. (2007). Dopamine neuron systems in the brain: An update. Trends in Neuroscience, 30: 194-202.
14. Bogacz, R. (2007) Optimal decision-making theories: Linking neurobiology with behaviour. Trends Cognitive Science, 11: 118-125.
15. Brandt, J. and Butters, N. (1986). The neuropsychology of Huntingtonś disease. Trends in Neuroscience, 9: 118-120.
16. Brown, R. G. and Marsden, C. D. (1990). Cognitive function in Parkinsonś disease: From description to theory. Trends in Neuroscience, 13: 21-29.
17. Brown, R. M. and Goldman, P. S. (1977). Catecholamines in neocortex of Rhesus monkey: Regional distribution and ontogenetic development. Brain Research, 124, 576-580.
18. Bruck, A., Aalto, S., Nurmi, E., Bergman, H. Rinne, J. O. (2005). Cortical 6-%F18&fluoro-L-dopa uptake and frontal cognitive functions in early Parkinson's disease. Neurobiology of Aging, 26: 891-898.
19. Bush, G., Shin, L. M., Holmes, J., Rosen, B. R., and Vogt, B. A. (2003). The Multi-Source Interference Task: Validation study with fMRI in individual subjects. Molecular Psychiatry, 8: 60-70.
20. Cabeza, R., Nyberg, L., and Park, D. (2005). Cognitive Neuroscience of Aging. New York: Oxford University Press.
21. Cai, J. X. and Arnsten, A. F. (1997). Dose-dependent effects of the dopamine receptor agonists A77636 and SKF81297 on spatial working memory in aged monkeys. Journal of Pharmacology and Experimental Therapeutics, 283: 183-189.
22. Carlsson, A. (1975). Drugs acting through dopamine release. Pharmacological Therapy, 1; 401-405.
23. Castner, S. A. and Williams, G. (2007). Tuning the engine of cognition: A focus on NMDA/D1 receptor interactions in prefrontal cortex. Brain and Cognition, 63: 94-122.
24. Cervenka, S., Bäckman, L., Cselényi, Z., Halldin, C., and Farde, L. (2008). Associations between dopamine D2-recptor binding and cognitive performance indicate functional compartmentalization of the human striatum. NeuroImage, 40: 1287-1295.
25. Chen, J., Myerson, J., and Hale, S. (2002). Age-related dedifferentiation of visuospatial abilities. Neuropsychologia, 40: 2050-2056.
26. Chen, M. K., Kuwabara, H., Zhou, Y., Adams, R. J., Brasic, J. R., McGlothan, J. L. et al. (2008). VMAT2 and dopamine neuron loss in a primate model of Parkinson's disease. Journal of Neurochemistry, 105: 78-90.
27. Cohen, J. D. and Servan-Schreiber, D. (1992). Context, cortex, and dopamine: A connectionist approach to behavior and biology in schizophrenia. Psychological Review, 99: 45-77.
28. Cools, R., Braker, R. A., Sahakian, B. J., and Robbins, T. W. (2001). Enhanced or impaired cognitive function in Parkinson's disease as a function of dopaminergic medication and task demands. , 11: 1136-1143.
29. Cools, R., Gibbs, S. E., Miyakawa, A., Jagust, W., and D'Esposito, M. (2008). Working memory capacity predicts dopamine synthesis capacity in the human striatum. Journal of Neuroscience, 28: 1208-1212.
30. Cornish, K. M., Manly, T., Savage, R., Swanson, J., Morisano, D., Butler, N., Grant, C., Cross, G., Bentley, L., and Hollis, C. P. (2005). Association of the dopamine transporter (DAT1) 10/10-repeat genotype with ADHD symptoms and response inhibition in a general population sample. Molecular Psychiatry, 10: 686-698.
31. Craik, F. I. M. and Salthouse, T. (2007). The Handbook of Aging and Cognition. New York: Psychological Press.
32. Cropley, V. L., Fujita, M., Innis, R. B., and Nathan, P. J. (2006). Molecular imaging of the dopaminergic system and its association with human cognitive function. Biological Psychiatry 59: 898-907.
33. Dahlin, E., Neely Stigsdotter, A., Larsson, A., Bäckman, L., and Nyberg, L. (2008). Transfer of learning after updating training mediated by the striatum. Science, 320: 1510-1512.
34. D'Ardenne, K., McClure, S. M., Nystrom, L. E., and Cohen, J. D. (2008). Bold responses reflecting dopaminergic signals in the human ventral tegmental area. Science, 318: 1264-1267.
35. Deary, I. J., Wright, A. F., Harris, S. E. Whalley, L. J., and Starr, J. M. (2004). Searching for genetic influences on normal cognitive aging. Trends in Cognitive Sciences, 8: 178-184.
36. de Frias, C. M., Annerbrink, K., Westberg, L., Eriksson, E., Adolfsson, R., and Nilsson L.-G. (2004). COMT gene polymorphism is associated with declarative memory in adulthood and old age. Behavior Genetics, 34: 533-539.
37. de Frias, C. M., Annerbrink, K., Westberg, L., Eriksson, E., Adolfsson, R., Nilsson, L.-G. (2005). Catechol O-methyltransferase Val158Met polymorphism is associated with cognitive performance in nondemented adults. Journal of Cognitive Neuroscience, 17: 1018-1025.
38. de Frias, C. M., Lövdén, M., Lindenberger, U., and Nilsson, L.-G. (2007). Revisiting the dedifefrentiation hypothesis with longitudinal multi-cohort data. Intelligence, 35: 381-392.
39. de Frias, C. M., Marklund, P., Eriksson, E., Larsson, A., Öman, L., Annerbrink, L. et al. (2008). Influence of COMT Gene Polymorphism on fMRI-Assessed Sustained and Transient Activity during a Working Memory Task. Manuscript submitted for publication.
40. De Keyser, J., De Backer, J. P., Vauquelin, G., and Ebinger, G. (1990). The effect of aging on the D1 dopamine receptors in human frontal cortex. Brain Research, 528, 308-310.
41. Durstewitz, D., Seamans, J. K., and Sejnowksi, T. J. (2000). Dopaminemediated stablization of delay-period activity in network model of prefrontal cortex. Journal of Neurophysiology, 93: 1733-1750.
42. Eberling, J. L., Pivirotto, P., Bringas, J., and Bankiewicz, K. S. (2004). Comparison of two methods for the analysis of [18F]-6-fluoro-L-m-tyrosine PET dopamineta. NeuroImage, 23: 358-363.
43. Egan, M. F., Goldberg, T. E., Kolachana, B. S., Callicott, J. H., Mazzanti, C. M., Straub, R. E. et al. (2001). Effect of COMT Val108/158Met genotype on frontal lobe function and risk for schizophrenia. Proceedings of the National Academy of Sciences of the USA, 98: 6917-6922.
44. Erixon-Lindroth, N., Farde, L., Robins Wahlin, T. B., Sovago, J., Halldin, C., and Bäckman, L. (2005). The role of the striatal dopamine transporter in cognitive aging. Psychiatry Research: Neuroimaging, 138: 1-12.
45. Farde, L., Ginovart, N., Halldin, C., Chou, Y., Olsson, H., and Swahn, C. (2000). A PET-study of [11C]b-CIT-FE binding to the dopamine transporter in the moneky and human brain. International Journal of Clinical Neuropsychopharmacology, 3: 203-214.
46. Farde, L., Hall, H., Ehrin, E., and Sedvall, G. (1986). Quantitative analysis of D2 dopamine receptor binding in the living human brain by PET. Science, 231: 258-261.
47. Farde, L., Halldin, C., Stone-Elander, S., and Sedvall, G. (1987). PET analysis of human dopamine receptor subtypes using 11C-SCH 23390 and 11Craclopride. Psychopharmacology, 92: 278-284.
48. Farde, L., Suhara, T., Nyberg, S., Karlsson, P., Nakashima, Y., Hietala, J. et al. (1997). A PET-study of [11C]FLB 457 binding to extrastriatal D2-dopamine receptors in healthy subjects and antipsychotic drug treated patients. Psychopharmacology, 133: 396-404.
49. Fearnley, J. M. and Lees, A. J. (1991). Aging and Parkinsonś disease: Substantia nigra regional selectivity. Brain, 114: 2283-2301.
50. Fischer, H., Nyberg, L., Karlsson, P., Farde, L., Karlsson, S., MacDonald, S. W. S. et al. (2008). Simulating Cognitive Aging: Effects of a Dopaminergic Antagonist on Brain Activation Patterns in Young Adults. Manuscript submitted.
51. Foley, T. E. and Fleshner, M. (2008). Neuroplasticity of dopamine circuits after exercise: Implications for central fatigue. Neuromolecular Medicine, 10: 67-80.
52. Frankle, W. G. (2007). Neuroreceptor imaging studies in schizophrenia. Harvard Review of Psychiatry, 15: 213-232.
53. Frey, K. A., Vander Borght, T. M., Killbourn, J. N., DaSilva, J. E., Carey, J. E., and Kuhl, D. E. (1995). In vivo imaging of the brain vesicular monoamine transporter. Journal Nuclear Medicine, 36: 2252-2260.
54. Garnett, E. S., Firnau, G., and Nahmias, C. (1983). Dopamine visualized in the basal ganglia of living man. Nature, 305: 137-138.
55. Gaspar, P., Berger, B., Febvret, A., Vigny, A., and Henry, J. P. (1989). Catecholamine innervation of the human cerebral cortex as revealed by comparative immunohistochemistry of tyroxine-hydroxylase and dopaminebeta-hydroxylase. Journal of Comparative Neurology, 279: 249-271.
56. Girault. J. A. and Greengard, P. (2004). The neurobiology of dopamine signaling. Archives of Neurology, 61: 641-644.
57. Giros, B., El Mestikawy, S., Godinot, N., Zheng, K. Q., Han, H., Yangfeng, T. et al. (1992). Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter. Molecular Pharmacology, 3: 383-390.
58. Giros, B., Jaber, M., Jones, S. R., Wightman, R. M., and Caron, M. G. (1996). Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature, 379: 606-612.
59. Goldberg, T. E. and Weinberger, D. R. (2004). Genes and the parsing of cognitive processes. Trends in Cognitive Sciences, 8: 325-335.
60. Goldman-Rakic, P. S., Muly, E. C., and Williams, G. V. (2000). D1 receptors in prefrontal cells and circuits. Brain Research Review, 31: 295-301.
61. Gopnic, A., Meltzoff, A., and Kuhl, P. (1999). The Scientist in the Crib: What Early Learning Tells Us About the Mind. New York: HarperCollins.
62. Grace, A. A., Floresco, S. B., Goto, Y., and Lodge, D. J. (2007). Regulation of firing of dopaminergic neurons and control of gioal-directed behaviors. Trends in Neurosciences, 30: 220-227.
63. Grady, C. L. (2002). Age-related differences in face processing: A metaanalysis of three functional neuroimaging experiments. Canadian Journal of Experimental Psychology, 56: 208-220.
64. Green, A. E., Munafo, M. R., DeYoung, C. G. (2008). Using genetic data in cognitive neuroscience: from growing pains to genuine insights. Nature Reviews Neuroscience, 9: 710-720.
65. Hall, H., Sedvall, G., Magnusson, O., Kopp, J., Halldin, C., and Farde, L. (1994). Distribution of D1-and D2-dopamine receptors and dopamine and its metabolites in the human brain. Neuropsychopharmacology, 11: 245-256.
66. Halldin, C., Erixon-Lindroth, N., Pauli, S., Chou, Y. H., Okubo, Y. Karlsson, P. et al. (2003). [11C]PE2I: A highly selective radioligand for PET examination of the dopamine transporter in monkey and human brain. European Journal of Nuclear Medicine, 30: 1220-1230.
67. Halldin, C., Foged, C., Karlsson, P., Swahn, C.-G., Sedvall, G., and Farde, L. (1998). [11C]NNC 112: A radioligand for PET examination of striatal and extrastriatal D1-dopamine receptors. Journal of Nuclear Medicine, 39: 2061-2068.
68. Halldin, C., Gulyas, B., Langer, O., and Farde, L. (2001). Brain radioligands -State of the art and new trends. Quarterly Journal of Nuclear Medicine, 45: 139-152.
69. Halliday, R., Naylor, H., Brandeis, D., Callaway, E., Yano, L., and Herzig, K. (1994). The effect of d-amphetamine, clonidine, and yohimbine on human information processing. Psychophysiology, 31: 331-337.
70. Hariri, A. R. and Weinberger, D. R. (2003). Imaging genomics. British Medical Bulletin, 65: 259-270.
71. Harris, S. E., Wright, A. F., Hayward, C., Starr, J. M., Whalley, L. J., and Deary, I. J. (2005). The functional COMT polymorphism, Val158Met, is associated with logical memory and the personality trait intellect/imagination in a cohort of healthy 79 year olds. Neuroscience Letters, 385: 1-6.
72. Heekeren, H. R., Marrett, S., and Ungerleider, L. G. (2008) The neural systems that mediate human perceptual decision making. Nature Reviews Neuroscience, 9: 467-479.
73. Heinz, A., Siessmeier, T., Wrase, J., Hermann, D., Grusser, S. M. Flor, H. et al. (2004). Correlation between dopamine D-2 receptors in the ventral striatum and central processing of alcohol cues and craving. American Journal of Psychiatry, 161: 1783-1789.
74. Hill, R. D., Bäckman, L., and Stigsdotter-Neely, A. (eds). (2000). Cognitive Rehabilitation in Old Age. New York: Oxford University Press.
75. Inoue, M., Suhara, T., Sudo, Y., Okubo, Y., Yasuno, F., Kishimoto, T. et al. (2001). Age-related reduction of extrastriatal dopamine D2 receptor measured by PET. Life Sciences, 69: 1079-1084.
76. Ito, H., Takahashi, H., Arakawa, R., Takano, H., and Suhara, T. (2008). Normal database of dopaminergic neurotransmission system in human brain measured by positron emission tomography. NeuroImage, 39: 555-565.
77. Jaber, M., Jones, S., Giros, B., and Caron, M. G. (1997). The dopamine transporter: A crucial component regulating dopamine transmission. Movement Disorders, 12, 629-633.
78. Jones, S. R., Gainetdinov, R. R., Jaber, M., Giros, B., Wightman, R. M., and Caron, M. G. (1998). Profound neural plasticity in response to inactivation of the dopamine transporter. Proceedings of the National Academy of Sciences of the USA, 95: 4029-4034.
79. Kaasinen, V. and Rinne, J. O. (2002). Functional imaging studies of dopamine system and cognition in normal aging and Parkinson's disease. Neuroscience and Biobehavioral Reviews, 26: 785-793.
80. Kaasinen, V., Vilkman, H., Hietala, J., Nagren, K., Helenius, H. Olsson, H. et al. (2000). Age-related D2/D3 receptor loss in extrastriatal regions of the human brain. Neurobiology of Aging, 21: 683-688.
81. Karlsson, S., Nyberg, L., Karlsson, P., Farde, L., Fischer, H., MacDonald, S. W. S. et al. (2008). Age-related differences in reduction of dopamine D1 receptor binding measured with [11 C] SCH 23390 during cognitive activity compared to resting state. Manuscript submitted.
82. Kessler, R. M., Whetsell, W. O., Ansari, M. S. et al. (1993). Identification of extrastriatal dopamine D2 receptors in post mortem human brain with [125I]epidepride. Brain Research, 609: 237-243.
83. Kimberg, D. Y. and D'Esposito, M. (2003). Cognitive effects of the dopamine receptor agonist pergolide. Neuropsychologia, 41: 1020-1027.
84. Kimberg, D. Y., D'Esposito, M., and Farah, M. J. (1997). Effects of bromocriptine on human subjects depend on working memory capacity. NeuroReport, 8: 3581-3585.
85. Koepp, M. J., Gunn, R. N., Lawrence, A. D., Cunningham, V. J., Dagher, A., Jones, T. et al. (1998). Evidence for striatal dopamine release during a video game. Nature, 393: 266-268.
86. Kohler, C., Ericson, H. and Radesater, A. C. (1991). Different laminar distributions of dopamine D1 and D2 receptors in the rat hippocampal region. Neuroscience Letters, 126: 107-109.
87. Knutson, B. and Gibbs, S. E. B. (2007). Linking nucleus accumbens dopamine and blood oxygenation. Psychopharmacology, 191: 813-822.
88. Lacor, P. N. (2007). Advances on the understanding of synaptic pathology in AD. Current Genomics, 8: 486-508.
89. Larkin, G. R. S., Gibs, S. E. B., Khanna, K., Nielsen, L., Castensen, L., and Knuston, B. (2007). Anticipation of mentary gain but not loss in healthy older adults. Nature Neuroscience, 10: 787-791.
90. Laruelle, M. (2000). Imaging synaptic neurotransmission with in vivo binding competition techniques: A critical review. Journal of Cerebral Blood Flow and Metabolism, 20: 423-451.
91. Laurier, L. G., O'Dowd, B. F., and George, S. R. (1994). Heterogeneous tissuespecific transcription of dopamine receptor subtype messenger RNA in rat brain. Brain Research and Molecular Brain Research, 25: 344-350.
92. Lawrence, A. D., Weeks, R. A., Brooks, D. J., Andrews, T. C., Watkins, L. H. A., Harding, A. E. et al. (1998). The relationship between dopamine receptor binding and cognitive performance in Huntington's disease. Brain, 121: 1343-1355.
93. Lewis, D. A. and Sesack, S. R. (1997). Dopamine systems in the primate brain. In E. F. Bloom, A. Björklund, and T. Hökfelt (eds), The Primate Nervous System Part 1 (pp. 263-375). Amsterdopaminem: Elsevier.
94. Li, S.-C., Biele, G., Mohr, P. N. C, and Heekeren, H. (2007). Aging and neuroeconomics: Insights from research on neuromodulation of rewardbased decision making. Analyse and Kritik, 29: 97-111.
95. Li, S.-C., Lindenberger, U., and Sikström, S. (2001). Aging cognition: From neuromodulation to representation to cognition. Trends in Cognitive Sciences, 5: 479-486.
96. Li, S.-C., Lindenberger, U., Hommel, B., Aschersleben, G., Prinz, W., and Baltes, P. B. (2004). Transformations in the couplings among intellectual abilities and constituent cognitive processes across the lifespan. Psychological Science, 15: 155-163.
97. Li, S.-C. and Sikström, S. (2002). Integrative neurocomputational perspectives on cognitive aging, neuromodulation, and representation. Neuroscience and Biobehavioral Reviews, 26: 795-808.
98. Li, S.-C., von Oertzen, T., and Lindenberger, U. (2006). A neurocomputational model of stochastic resonance and aging. Neurocomputing, 69: 1553-1560.
99. Lindenberger, U. and Baltes, P. B. (1994). Sensory functioning and intelligence in old age: A strong relation. Psychology and Aging, 9: 339-355.
100. Lindenberger, U., Li, S.-C., and Bäckman, L. (2006). (eds). Special issue: Brain-behavior dynamics across the lifespan. Neursocience and Biobehavioral Reviews, 30: 713-885.
101. Lindenberger, U., Nagel, I. E., Chicherio, C., Li, S.-C., Heekeren, H., and Bäckman, L. (2008). Age-related decline in brain resources modulates genetic effects on cognitive functioning. Frontier in Neuroscience, 2, 234-244.
102. Loo, S. K., Specter, E., Smolen, A., Hopper, C., Teale, P. D., and Reite, M. L. (2003). Functional effects of the DAT1 polymorphism on EEG measures in ADHD. Journal of the American Academy of Child and Adolescent Psychiatry, 42: 986-993.
103. Lotta, T., Vidgren, J., Tilgmann, C., Ulmanen, I., Julkunen, I., and Taskinen, J. (1995). Kinetics of human soluble and membrane-bound catechol-Omethyltransferase:A revised mechanism and description of the termolabile variant of the enzyme. Biochemistry, 34: 4202-4210.
104. Lövdèn, M., Li, S.-C., Shing, Y. L., and Lindenbeger, U. (2007). Within-person trial-to-trial variability precedes and predicts cognitive decline in old and very old age: Longitudinal data from the Berlin Aging Study. Neuropsychologia, 45: 2827-2838.
105. Luciana, M. and Collins, P. F. (1997). Dopamine modulates working memory for spatial but not object cues in normal humans. Journal of Cognitive Neuroscience, 9: 330-347.
106. MacDonald, S. W. S., Cervenka, S., Farde, L., Nyberg, L., and Bäckman, L. (in press). Extrastriatal Dopamine D2 receptor binding modulates intraindividual variability in episodic memory and executive functioning. Neuropsychologia.
107. MacDonald, S. W. S., Nyberg, L., and Bäckman, L. (2006). Intra-individual variability in behavior: Links to brain structure, neurotransmission, and neuronal activity. Trends in Neurosciences, 29: 474-480.
108. MacRae, P. G., Spirduso, W. W., and Wilcox, R. E. (1988). Reaction time and nigrostriatal dopamine function: The effects of age and practice. Brain Research, 451: 139-146.
109. Maher, B. S., Marazita, M. L., Ferrell, R. E., and Vanyukov, M. M. (2002). Dopamine system genes and attention deficit hyperactivity disorder: A metaanalysis. Psychiatric Genetics, 12: 207-215.
110. McGuire, P., Howes, O. D., Stone, J., and Fusar-Poli, P. (2008). Functional neuroimaging in schizophrenia: Diagnosis and drug discovery. Trends in Pharmacological Sciences, 29: 91-98.
111. Marschner, A., Mell, T., Wartenburger, I., Villringer, A., Reischies, F. M., and Heekeren, H. R. (2005). Reward-based decision making and aging. Brain Research Bulletin, 67: 382-390.
112. Mattay, V. S., Goldberg, T. E., Fera, F., Hariri, A. R., Tessitore, A., and Egan, M. F. (2003). Catechol-O-methyltransferase val(258)-met genotype and individual variation in he brain responses to amphetamine. Proceedings of the National Academy of Sciences of the USA, 100: 6186-6191.
113. Mattay, V. S., Goldberg, T. E., Sambataro, F., and Weinberger, D. R. (2008). Neurobiology of cognitive aging: Insights from imaging genetics. Biological Psychology, 79: 9-22.
114. Meador-Woodruff, J. H. (1994). Update on dopamine receptors. Annals of Clinical Psychiatry, 6: 79-90.
115. Mell, T., Heekeren, H. R., Marschner, A., Wartenburgerm, I., Villringer, A., and Reischies, F. M. (2005). Effect of aging on stimulus-related association learning. Neuropsychologia, 43: 554-563.
116. Mesco, E. R., Carlsson, S. G., Joseph, J. A., and Roth, G. S. (1993). Decreased striatal D2 dopamine receptor mRNA synthesis during aging. Molecular Brain Research, 17: 160-162.
117. Meyer-Lindenberg, A. and Weinberger, D. R. (2006). Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nature Reviews Neuroscience, 7: 818-827.
118. Meyer-Lindenberg, A., Straub, R. E., Lipska, B. K., Verchinski, B. A., Goldberg, T., and Callicott, J. H. et al. (2007). Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition. Journal of Clinical Investigations, 117: 672-682.
119. Martinez, D., Silfstein, M., Broft, A., Mawlawi, O., Hwang, D.-R., Huang, Y. et al. (2003). Imaging human mesolimbic dopamine transmission with positron emission tomography. Part II: Amphetamine-induced dopamine release in the functional subdivisions of the striatum. Journal of Cerebral Blood Flow and Metabolism, 23: 285-300.
120. Mitchell, R. J., Howlett, S., Earl, L., McComb, J., Schanfield, M. S., Briceno, I. et al. (2000). Distribution of the VNTR polymorphism in the human dopamine transporter gene in world populations. Human Biology, 72: 295-304.
121. Monchi, O., Ko, J. H., and Strafella, A. P. (2006). Striatal dopamine release during performance of executive functions: A [11C] raclopride PET study. Neuroimage, 33: 907-912.
122. Montague, P. R., Hyman, S. E., and Cohen, J. D. (2004). Computational roles for dopamine in behavioural control. Nature, 431: 760-767.
123. Morgan, D. G. and May, P. C. (1990). Age-related changes in synaptic neurochemistry. In Schneider and Row (eds), Handbook of the Biology of Aging (pp. 219-250). New York: Academic Press.
124. Mozley, L. H., Gur, R. C., Mozley, P. D., and Gur, R. E. (2001). Striatal dopamine transporters and cognitive functioning in healthy men and women. American Journal of Psychiatry, 158: 1492-1499.
125. Murtha, S., Cismaru, R., Waechter, R., and Chertkow, H. (2002). Increased variability accompanies frontal lobe damage in dementia. Journal of the International Neuropsychological Society, 8: 360-372.
126. Nagel, I. E., Chicherio, C., Li, S.-C., von Oertzen, T., Sander, T., Villringer, A. et al. (2008). Human aging magnifies genetic effects on executive functioning and working memory. Frontiers in Human Neuroscience, 2: 1-8.
127. Nahmias, C., Wahl, L. et al. (1995). A probe for intracerebral aromatic aminoacid decarboyxlase activity: distribution and kinetics of [18F]6-fluoro-L-mtyrosine in the human brain. Movement Disorder, 10: 298-304.
128. Neumeyer, J. L., Wang, S., Milius, R. A., Baldwin, R. M., Zeaponce, Y., Hoffer, P. B. et al. (1991). [123I]-2-b -carbomethoxy-3b-(4-iodophenyl)-tropane: Highaffinity SPECT radiotracer of monoamine reuptake sites in brain. Journal of Medicinal Chemistry, 34: 3144-3146.
129. Nordström, A. L., Farde, L., Pauli, S., Litton, J. E., and Halldin, C. (1992). PET analysis of [11C] raclopride binding in healthy young adults and schiziphrenic patients: Reliability and age effects. Human Psychopharmacology, 7: 157-165.
130. Nyberg, L., Sandblom, J., Jones, S., Stigsdotter-Neely, A., Petersson, K. M., Ingvar, M., and Bäckman, L. (2003). Neural correlates of training-related memory improvement in adulthood and aging. Proceedings of the National Academy of Sciences of the USA, 100: 13728-13733.
131. Nyberg, L., Andersson, M., Forsgren, L., Jakobsson-Mo, S., Larsson, A., Marklund, P. et al. (2008). Striatal dopamine D2 binding is related to frontal BOLD response during updating of long-term memory representations. Manuscript submitted.
132. O'Hara, R., Miller, E., Liao, C. P., Way, N., Lin, X. Y., and Hallmayer, J. (2006). COMT genotype, gender, and cognition in community dwelling, older adults. Neuroscience Letters, 409: 205-209.
133. O'Reilly, R. C. (2006). Biological based computational models of high-level cognition. Science, 314: 91-94.
134. O'Reilly, R. C. and Frank, M. J. (2006). Making working memory work: a computational model of learning in the frontal cortex and basal ganglia. Neural Computation, 18: 283-328.
135. Parent, A. and Hazrati, L. N. (1995). Functional anatomy of the basal ganglia. I. The cortico-basal ganglia-thalamo-cortical loop. Brain Research Review, 20: 91-127.
136. Pasuit, J. B., Li, Z., and Kuzhikandathil, V. (2004). Journal of Neurochemistry, 89: 1508-1519.
137. Pizzagalli, D. A., Evins, A. E., Schetter, E. C., Frank, M. J., Pajtas, P. E., Santesso, D. L., and Culhane, M. (2008). Single dose of a dopamine agonist impairs reinforcement learning in humans: Behavioral evidence from a laboratory-based measure of reward responsiveness. Psychopharmacology, 196: 221-232.
138. Ramaekers, J. G., Louwerens, J. W., Muntjewerff, N. D., Milius, H., de Bie, A., Rosenzweig, P. et al. (1999). Psychomotor, cognitive, extrapyramidopaminel and affective functions of healthy volunteers during treatment with an atypical (amisulpiride) and a classic (haloperidol) antipsychotic. Journal of Clinical Psychopharmacology, 19: 209-221.
139. Raz, N., Williamson, A., Gunning-Dixon, F., Head, D., and Acker, J. D. (2000). Neuroanatomical and cognitive correlates of adult age differences in acquisition of a perceptual-motor skill. Microscopy Research and Technique, a Special Issue on Neuroimaging and Memory, 51: 85-93.
140. Rieck, R. W., Ansari, M. S., Whetsell, Jr., W. O., Deutch, A. Y., Kessler, R. M. (2004). Distribution of dopamine D2-like receptors in the human thalamus: autoradiographic and PET studies. Neuropsychopharmacology, 29: 362-372.
141. Rolls, E. T., Loh, M., Deco, G., and Winterer, G. (2008). Computational models of schizophrenia and dopamine modulation in the prefrontal cortex. Nature Reviews Neuroscience, 9: 696-709.
142. Roth, R. H. (1984). CNS dopamine autoreceptors: Distribution, pharmacology, and function. Annals of the New York Academy of Sciences, 430: 27-53.
143. Sánchez-González, M. A., García-Cabezas, M. A., Rico, B., and Cavada, C. (2005). The primate thalamus is a key target for brain dopamine. Journal of Neuroscience, 25: 6076-6083.
144. Sawaguchi, T. and Goldman-Rakic, P. S. (1991). D1 dopamine receptors in prefrontal cortex: Involvement in working memory. Science, 251: 947-950.
145. Sawamoto, N., Piccini, P., Hotton, G., Pavese, N., Thielemans, K., and Brooks, D. J. (2008). Cognitive deficits and striato-frontal dopamine release in Parkinson's disease. Brain, 131: 1294-1302.
146. Schambra, U. B., Duncan, G. E., Breese, G. R., Fornaretto, M. G., Caron, M. G., and Fremeau, J. R. (1994). Ontogeny of D1a and D2 dopamine receptor subtypes in rat brain using in situ hybridization and receptor binding. Neuroscience, 62: 65-85.
147. Schott, B. H., Minuzzi, L., Krebs, R. M., Elmenhorst, D., Lang, M., Winz, O. H. et al. (2008). Mesolimbic fMRI activations during reward anticipation correlate with reward-related ventral striatal dopamine release. Journal of Neuroscience, 28: 14311-14319.
148. Schultz, W., Studer, A., Romo, R., Sundstrom, E., Jonsson, G., and Scarnati, E. (1989). Deficits in reaction-times and movement times as correlates of hypokinesia in monkeys with MPTP-induced striatal dopamine depletion. Journal of Neurophysiology, 61, 651-668.
149. Schultz, W. (2006). Behavioral theories and the neurophysiology of reward. Annual Review of Psychology, 57: 87-115.
150. Seamans, J. K. and Yang, C. R. (2004). The principal features and mechanisms of dopamine modulation in the prefrontal cortex. Progress in Neurobiology, 74: 1-57.
151. Seeman, P., Bzowej, N. H., Guan, H. C., Bergeron, C., Becker, L. E., Reynolds, G. P. et al. (1987). Human brain dopamine receptors in children and aging adults. Synapse, 1: 399-404.
152. Segovia, G., Porras, A., Arco, A. D., and Mora, F. (2001). Glutamatergic neurotransmission in aging: A critical perspective. Mechanisms of Ageing and Development, 122: 1-29.
153. Servan-Schreiber, D., Printz, H., and Cohen, J. D. (1990). A network model of catecholamine effects: Gain, signal-to-noise ratio, and behavior. Science, 249: 892-895.
154. Servan-Schreiber, D., Carter, C. S., Bruno, R. M., and Cohen, J. D. (1998). Dopamine and the mechanisms of cognition: Part II. D-amphetamine effects in human subjects performing a selective attention task. Biological Psychiatry, 43: 723-729.
155. Severson, J. A., Marcusson, J., Winblad, B., and Finch, C. E. (1982). Agecorrelated loss of dopaminergic binding sites in human basal ganglia. Journal of Neurochemistry, 39: 1623-1631.
156. Shinkai, T., Zhang, L., Mathias, S. A., and Roth, G. S. (1997). Dopamine induces apoptosis in cultured rat striatal neurons: Possible mechanism of D2-dopamine receptor neuron loss during aging. Journal of Neuroscience Research, 47: 393-399.
157. Snow, B. J., Tooyama, I., McGeer, E. G., Yamada, T., Calne, D. B., Takahashi, H. et al. (1993). Human positron emission tomographic [18F]fluorodopa studies correlate with dopamine cell counts and levels. Annals of Neurology, 34: 324-330.
158. Starr, J. M., Fox, H., Harris, S. E., Deary, I. J., and Whalley, L. J. (2007). COMT genotype and cognitive ability: A longitudinal aging study. Neuroscience Letters, 421: 57-61.
159. Stefanis, N. C., van Os, J., Avramopoulos, D., Smyrnis, N., Evdokimidis, I., and Stefanis, C. N. (2005). Effect of COMT Val(158)Met polymorphism on the continuous performance test, identical pairs version: Tuning rather improving performance. American Journal of Psychiatry, 162: 1753-1754.
160. Stoessl, A. J. and de la Fuente-Fernandez, R. (2003). Dopamine receptors in Parkinson's disease: imaging studies. Advanced Neurology, 91: 65-71.
161. Stuss, D. T., Murphy, K. J., Binns, M. A., and Alexander, M. P. (2003), Staying on the job: The frontal lobes control individual performance variability. Brain, 126: 2363-2380.
162. Suhara, T., Fukudopamine, H., Inoue, O., Itoh, T., Suzuki, K., Yamasaki, T., Tateno, Y. (1991). Age-related changes in human D1 dopamine receptors measured by positron emission tomography. Psychopharmacology, 103: 41-45.
163. Takahashi, H., Kato, M., Hayashi, M., Okubo, Y., Takano, A., Ito, H. et al. (2006). Memory and frontal lobe functions: Possible relations with dopamine D2 receptors in the hippocampus. NeuroImage, 34: 1643-1649.
164. Tan, H. Y., Chen, Q, Sust, S., Buckholtz, W., Meyers, J. D., Egan, M. F. et al. (2007). Epistasis between catechol-O-Methyltransferase and type II metabotropic glutamate receptor 3 genes on working brain function. Proceedings of the National Academy of Sciences of the USA, 104: 12536-12541.
165. Taylor, S. F., Koeppe, R. A., Tandon, R., Zubieta, J. K., and Frey, K. A. (2000). In vivo measurement of the vesicular monoamine transporter in schizophrenia. Neuropsychopharmacology, 6: 667-675.
166. Ungerstedt, U. (1971). On the Anatomy, Pharmacology, and Function of the Nigrostriatal Dopamine System. Stockholm: Norstedts.
167. Volkow, N. D., Gur, R. C., Wang, G. J., Fowler, J. S., Moberg, P. J., Ding, Y. S. et al. (1998). Association between decline in brain dopamine activity with age and cognitive and motor impairment in healthy individuals. American Journal of Psychiatry, 157: 344-349.
168. Wang, M., Vijayraghavan, S., and Goldman-Rakic, P. S. (2004). Selective D2 receptor actions on the functional circuity of working memory. Science, 303: 853-856.
169. Wang, Y., Chan, G. L. Y., Holden, J. E., Dobko, T., Schulzer, M. E., Huser, J. M. et al. (1998). Age-dependent decline of dopamine D1 receptors in human brain: A PET study. Synapse, 30: 56-61.
170. Weinshilboum, R. M., Otterness, D. M., and Szumlanski, C. L. (1999). Methylation pharmacogenetics: Catechol-O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase. Annual Review of Pharmacology and Toxicology, 39: 19-52.
171. West, R., Murphy, K. J., Armilio, M. L., Craik, F. I. M., and Stuss, D. T. (2002). Lapses of intention and performance variability reveal age-related increases in fluctuations of executive control. Brain and Cognition, 49: 402-419.
172. Winterer, G., Coppola, R., Goldberg, T. E., Egan, M. F., Jones, D. W., Sanchez, C. E., and Weinberger, D. R. (2004). Prefrontal broadband noise, working memory, and genetic risk for schizophrenia. America Journal of Psychiatry, 161: 490-500.
173. Winterer, G. and Weinberger D. R. (2004) Genes, dopamine and cortical signal-to-noise ratio in schizophrenia. Trends in Neuroscience, 27: 683-690.
174. Winterer, G., Musso, F., Vucurevic, G., Stoeter, P., Konrad, A., Seker, B. et al. (2006). COMT genotype predicts BOLD signal and noise characteristics in prefrontal circuits. Neuroimage, 32: 1722-1732.
175. Williams, G. V. and Goldman-Rakic, P. S. (1995). Modulation of memory fields by dopamine D1 receptors in prefrontal cortex. Nature, 376: 572-575.
176. Wittmann, B. C., Schott, B. H., Guderian, S., Frey, J. U., Heinze, H. J., Duzel, E. (2005). Reward-related FMRI activation of dopaminergic midbrain is associated with enhanced hippocampus-dependent long-term memory formation. Neuron, 5: 459-467.
177. Yacubian, J., Sommer, T., Schroeder, K., Gläscher, J., Kalisch, R., Leuenberger, B. et al. (2007). Gene-gene interaction associated with neural reward sensitivity. Proceedings of the National Academy of Sciences of the USA, 104: 8125-8130.
178. Yang, Y. K., Chiu, N. T., Chen, C. C., Chen, M., Yeh, T. L., and Lee, I. H. (2003). Correlation between fine motor activity and striatal dopamine D2 receptor density in patients with schizophrenia and healthy controls. Psychiatry Research: Neuroimaging, 123: 191-197.
179. Zhang, L., Ravipati, A., Joseph, J., and Roth, G. S. (1995). Aging-related changes in rat striatal D2 dopamine receptor mRNA-containing neurons: A quantitative nonradioactive in situ hybridization study. Journal of Neuroscience, 15: 1735-1740.