Association between decline in brain dopamine activity with age and cognitive and motor impairment in healthy individuals

American Journal of Psychiatry

Volumn 155, Issue 3, 1998, Pages 344-349

  Volkow, Nora D ^a   Gur, Ruben C ^b   Wang, Gene Jack ^b   Fowler, Joanna S ^b   Moberg, Paul J ^b   Ding, Yu Shin ^b   Hitzemann, Robert ^b   Smith, Gwenn ^b   Logan, Jean ^b  

^a BROOKHAVEN NATIONAL LABORATORY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE 2 RECEPTOR; RACLOPRIDE;

ADULT; AGED; AGING; ARTICLE; CLINICAL ARTICLE; COGNITIVE DEFECT; DEGENERATIVE DISEASE; DISEASE ASSOCIATION; DOPAMINERGIC SYSTEM; FRONTAL CORTEX; HUMAN; MOTOR DYSFUNCTION; NEUROPSYCHOLOGICAL TEST; NORMAL HUMAN; PATHOGENESIS; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; QUALITY OF LIFE;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; BRAIN; BRAIN CHEMISTRY; CEREBELLUM; COGNITION DISORDERS; CORPUS STRIATUM; DOPAMINE; GERIATRIC ASSESSMENT; HUMANS; MIDDLE AGED; MOTOR SKILLS; MOTOR SKILLS DISORDERS; NEUROPSYCHOLOGICAL TESTS; QUALITY OF LIFE; RACLOPRIDE; RECEPTORS, DOPAMINE D2; SALICYLAMIDES; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0031894838     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Joseph JA, Roth GS, Strong R:The striatum, a microcosm for the examination of age-related alterations in the CNS: a selected review. Rev Biol Res Aging 1990; 4:181-199
2. Pradhan SN:Central neurotransmittcrs and aging. Life Sci 1980; 26:1643-1656
3. Morris JC, Storandt M, McKeel DW Jr, Ruhin EH, Price JL, Berg L:Cerebral amyloid deposition and diffuse plaques in "normal" aging: evidence of presymptomaric and very mild Alzheimer's disease. Neurology 1996; 46:707-719
4. Volkow ND, Fowler JS, Gatley JS, Logan J, Wang G-J, Ding Y-S, Dewey SL:Evaluation of the human brain dopamine system with PET: review and update of tracers. J Nucl Med 1996; 37:1242- 1256
5. 18F]N-methylspiroperidol. Psychiatry Res 1996; 67:11-16
6. Suhara T, Fukuda H, Inoue O, Itoh T, Suzuki K, Yamasaki T, Tateno Y:Age-related changes in human D1 dopamine receptors measured by positron emission tomography. Psychopharmacology (Berl) 1991; 103:41-45
7. Volkow ND, Ding Y-S, Fowler JS, Wang G-J, Logan J, Gatley SJ, Hitzemann R, Smith G, Fields F, Gur R, Wolf AP:Dopamine transporters decrease with age in healthy subjects. J Nucl Med 1996; 37:554-558
8. Eidelberg D, Takikawa S, Dhawan V, Chaly T, Robeson W, Dahl R, Margouleff D, Moeller JR, Patlak CS, Fahn S:Striatal 18F- DOPA uptake: absence of an aging effect. J Cereb Blood Flow Metab 1993; 13:881-888
9. Hamilton M:A rating scale for depression. J Neurol Neurosurg Psychiatry 1960; 23:56-62
10. Berg EA:A simple objective test for measuring flexibility in thinking. J Geriatric Psychol 1948; 39:15-22
11. Stroop JR:Studies of interference in serial verbal reactions. J Exp Psychol 1935; 18:643-662
12. Reitan R:Validity of the Trail Making Test as an indication of organic brain damage. Percept Mot Skills 1958; 8:271-276
13. Spreen O, Strauss E:A Compendium of Neuropsychological Tests. New York, Oxford University Press, 1991
14. Talland GA, Schwab RS:Performance with multiple sets in Parkinson's disease. Neuropsychologia 1964; 2:45-53
15. Smith A:The Symbol Digit Modalities Test: a neuropsychologic test for economic screening of learning and other cerebral disorders. Learning Disorders 1968; 3:83-91
16. Raven JC:Guide to the Standard Progressive Matrices. London, HK Lewis, 1960
17. DeFillipis NA, McCampbell E, Rogers P:Development of a booklet form of the Category Test: normative and validity data. J Clin Neuropsychol 1979; 1:339-342
18. Wechsler D:Wechsler Adult Intelligence Scale - Revised: Manual. New York, Psychological Corp, 1981
19. Jastak JF, Jastak SR:The Wide Range Achievement Test - Revised: Manual. Wilmington, Del, Guidance Associates, 1978
20. Wechsler D:Wechsler Memory Scale - Revised: Manual. New York, Psychological Corp, 1987
21. Benton AL:The Revised Visual Retention Test, 4th ed. New York, Psychological Corp, 1974
22. Stern Y, Langston J:Intellectual changes in patients with MPTP- induced parkinsonism. Neurology 1985; 35:1506-1509
23. Stern Y, Tetraud J, Martin W, Kutner S, Langston J:Cognitive change following MPTP exposure. Neurology 1990; 40:261-264
24. Blonder LX, Gur RE, Gur RC, Saykin AJ, Hurtig HI:Neuropsychological functioning in hemiparkinsonism. Brain Cogn 1989; 9:177-190
25. 11C raclopride binding in the human brain. J Nucl Med 1993; 34:609-613
26. Wang G-J, Volkow ND, Levy AV, Fowler JS, Logan J, Alexoff D, Hitzemann RJ, Schlyer D:MR-PET image coregistration for quantitation of striatal dopamine D2 receptors. J Comput Assist Tomogr 1996; 20:423-428
27. Logan J, Fowler JS, Volkow ND, Wolf AP, Dewey SL, Schlyer D, MacGregor RR, Hitzemann R, Bendriem B, Gatley SJ, Christman DR:Graphical analysis of reversible binding from time-activity measurements. J Cereb Blood Flow Metab 1990; 10:740-747
28. 11C]raclopride binding in the brain: model simulations and kinetic analysis of PET data. J Cereb Blood Flow Metab 1994; 14:995-1010
29. Saykin AJ, Gur RC, Gur RE, Shtasel DL, Flanery KA, Mozley LH, Malamud BL, Watson B, Mozley PD:Normative neuropsychological test performance: effects of age, education, gender and ethnicity. Applied Neuropsychology 1995; 2:79-88
30. Brooks DJ, Salmon EP, Mathias CJ:The relationship between locomotor disability, autonomic dysfunction, and the integrity of the striatal dopaminergic system in patients with multiple system atrophy, pure autonomie failure, and Parkinson's disease: studies with positron emission tomography. Brain 1990; 113: 1539-1552
31. Holthoff VA, Kessler J, Pietrzyk U, Bonner J, Herholz K, Wienhard K, Wagner R, Vieregge P, Heiss W-D:Motor and cognitive deficits in Parkinson's disease are related to striatal dopamine uptake (abstract). J Cereb Blood Flow Metab 1993; 13:5253
32. Levin P, Janda JK, Joseph JA, Ingram DK, Roth GS:Peculiarities of the effect of hormones and transmitters during aging: modulation of changes in dopaminergic actions. Gerontology 1988; 34:22-28
33. Bernheimer H, Birkmayer W, Hornykiewicz O, Jellinger K, Seitelberger F:Brain dopamine and the syndromes of Parkinson and Huntington: clinical, morphological and neurochemical correlations. J Neurol Sci 1973; 20:415-455
34. Heaton RK, Grant I, Matthews CG:Comprehensive Norms for an Expanded Halstead-Reitan Battery: Demographic Corrections, Research Findings, and Clinical Applications. Odessa, Fla, Psychological Assessment Resources, 1991
35. Dolan RJ, Fletcher P, Frith CD, Friston KJ, Frackowiak RSJ, Grasby PM:Dopaminergic modulation of impaired cognitive activation in the anterior cingulate cortex in schizophrenia. Nature 1995; 378:180-182
36. Daniel DG, Weinberger DR, Jones DW, Zigun JR, Coppola R, Handel S, Bigelow LB, Goldberg TE, Berman KF, Kleinman JE:The effect of amphetamine on regional cerebral blood flow during cognitive activation in schizophrenia. J Neurosci 1991; 11: 1907-1917
37. Gur RC, Gur RE, Christ WD, Skolnick BE, Reivich M:Age and regional cerebral blood flow at rest and during cognitive activity. Arch Gen Psychiatry 1987; 44:617-621
38. Moeller JR, Ishikawa T, Dhawan V, Spetsieris P, Mande F, Alexander GE, Grady C, Pietrini P, Eidelberg D:The metabolic topography of normal aging. J Cereb Blood Flow Metab 1996; 16:385-398
39. Volkow ND, Fowler JS, Wang G-J, Hitzemann R, Logan J, Schlyer D, Dewey S, Wolf AP:Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers. Synapse 1993; 14:169-177
40. Ollat H:Dopaminergic insufficiency reflecting cerebral ageing: value of a dopaminergic agonist, piribedil. J Neurol 1992; 239 (supppl 1):S13-S16
41. DeCastro JM, Duncan G:Operamly conditioned running: effects on brain catecholamine concentrations and receptor densities in the rat. Biochem Behav 1985; 23:495-500
42. 3H-spiperone binding in rat striatum. Pharmacol Biochem Behav 1984; 20:863- 867
43. Dustman RE, Ruhling RO, Russell EM, Shearer DE, Bonekat HW, Shigeoka JW, Wood JS, Bradford DC:Aerobic exercise training and improved ncuropsychological function of older individuals. Neurobiol Aging 1984; 5:35-42
44. Cohen JD, Schreiber DS:Context, cortex and dopamine: a connectionist approach to behavior and biology in schizophrenia. Psychol Rev 1992; 99:45-77
45. Bowen HP, Kamienny RS, Burns MM, Yahr MD:Parkinsonism: effects of L-dopa treatment on concept formation. Neurology 1975; 25:701-704
46. Kasahara H, Yamada H, Tanno M, Kobayashi M, Karasawa A, Endo K, Ushijima S:Magnetic resonance imaging study of the brain in aged volunteers: T2 high intensity lesions and higher order cortical function. Psychiatry Clin Neurosci 1995; 49:273- 279