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Volumn 43, Issue 4, 2014, Pages 1199-1213

A global immune deficit in alzheimer's disease and mild cognitive impairment disclosed by a novel data mining process

Author keywords

Artificial neural network; machine learning; neurodegeneration; oxidative stress; pattern recognition; relationships

Indexed keywords

ANTIOXIDANT; GLUTATHIONE; MALONALDEHYDE; OXIDIZED LOW DENSITY LIPOPROTEIN; REACTIVE OXYGEN METABOLITE; UBIDECARENONE;

EID: 84919929885     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-141116     Document Type: Article
Times cited : (23)

References (82)
  • 1
    • 47749126515 scopus 로고    scopus 로고
    • Why neurodegenerative diseases are progressive: Uncontrolled inflammation drives disease progression
    • Gao H, Hong J (2008) Why neurodegenerative diseases are progressive: Uncontrolled inflammation drives disease progression. Trends Immunol 29, 357-365.
    • (2008) Trends Immunol , vol.29 , pp. 357-365
    • Gao, H.1    Hong, J.2
  • 3
    • 24144453087 scopus 로고    scopus 로고
    • Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism
    • Block MLHJ (2005) Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism. Prog Neurobiol 76, 77-98.
    • (2005) Prog Neurobiol , vol.76 , pp. 77-98
    • Block, M.L.H.J.1
  • 4
    • 0035170589 scopus 로고    scopus 로고
    • T-cell-and macrophage-mediated axon damage in the absence of a CNS-specific immune response: Involvement of metalloproteinases
    • Newman T,Woolley S, Hughes P, Sibson N, AnthonyD, Perry V (2001) T-cell-and macrophage-mediated axon damage in the absence of a CNS-specific immune response: Involvement of metalloproteinases. Brain 124, 2203-2214.
    • (2001) Brain , vol.124 , pp. 2203-2214
    • Newman, T.1    Woolley, S.2    Hughes, P.3    Sibson, N.4    Anthony, D.5    Perry, V.6
  • 6
    • 33750442559 scopus 로고    scopus 로고
    • Protective effects of an anti-inflammatory cytokine, interleukin-4, on motoneuron toxicity induced by activated microglia
    • Zhao W, Xie W, Xiao Q, Beers D, Appel S (2006) Protective effects of an anti-inflammatory cytokine, interleukin-4, on motoneuron toxicity induced by activated microglia. J Neurochem 99, 1176-1187.
    • (2006) J Neurochem , vol.99 , pp. 1176-1187
    • Zhao, W.1    Xie, W.2    Xiao, Q.3    Beers, D.4    Appel, S.5
  • 7
    • 0035400122 scopus 로고    scopus 로고
    • Neuronal survival after CNS insult is determined by a genetically encoded autoimmune response
    • Kipnis J, Yoles E, Schori H, Hauben E, Shaked I, SchwartzM (2001) Neuronal survival after CNS insult is determined by a genetically encoded autoimmune response. J Neurosci 21, 4564-4571.
    • (2001) J Neurosci , vol.21 , pp. 4564-4571
    • Kipnis, J.1    Yoles, E.2    Schori, H.3    Hauben, E.4    Shaked, I.5    Schwartz, M.6
  • 9
    • 10944246635 scopus 로고    scopus 로고
    • Vaccination with autoantigen protects against aggregated beta-amyloid and glutamate toxicity by controlling microglia: Effect of CD4+CD25+ T cells
    • Avidan H, Kipnis J, Butovsky O, Caspi R, Schwartz M (2004) Vaccination with autoantigen protects against aggregated beta-amyloid and glutamate toxicity by controlling microglia: Effect of CD4+CD25+ T cells. Eur J Immunol 34, 3434-3445.
    • (2004) Eur J Immunol , vol.34 , pp. 3434-3445
    • Avidan, H.1    Kipnis, J.2    Butovsky, O.3    Caspi, R.4    Schwartz, M.5
  • 10
    • 54449086944 scopus 로고    scopus 로고
    • Anti-inflammatory drugs fall short in Alzheimer's disease
    • (2008) Anti-inflammatory drugs fall short in Alzheimer's disease. Nat Med 14, 916.
    • (2008) Nat Med , vol.14 , pp. 916
  • 11
    • 84871060866 scopus 로고    scopus 로고
    • Harnessing monocytederived macrophages to control central nervous system pathologies: No longer "if" but "how"
    • Shechter R, Schwartz M (2013) Harnessing monocytederived macrophages to control central nervous system pathologies: No longer "if" but "how". J Pathol 229, 332-346.
    • (2013) J Pathol , vol.229 , pp. 332-346
    • Shechter, R.1    Schwartz, M.2
  • 16
    • 77952317299 scopus 로고    scopus 로고
    • Implementing BreimanTM s Random Forest Algorithm intoWeka-ECE591Q
    • Livingston F (2005) Implementing BreimanTM s Random Forest Algorithm intoWeka-ECE591Q. In Machine Learning Conference Papers.
    • (2005) Machine Learning Conference Papers
    • Livingston, F.1
  • 17
    • 0025725905 scopus 로고
    • Instance-based learning algorithms
    • Aha D, Kibler D (1991) Instance-based learning algorithms. In Machine Learning, pp. 37-66.
    • (1991) Machine Learning , pp. 37-66
    • Aha, D.1    Kibler, D.2
  • 21
    • 84881507884 scopus 로고    scopus 로고
    • Training with Input Selection and Testing (TWIST) algorithm: A significant advance in pattern recognition performance of machine learning
    • Buscema M, Breda M, Lodwick W (2013) Training With Input Selection and Testing (TWIST) algorithm: A significant advance in pattern recognition performance of machine learning. J Intell Learn Syst Appl 5, 29-38.
    • (2013) J Intell Learn Syst Appl , vol.5 , pp. 29-38
    • Buscema, M.1    Breda, M.2    Lodwick, W.3
  • 22
    • 2942607503 scopus 로고    scopus 로고
    • Genetic doping algorithm (GenD): Theory and application
    • BuscemaM(2004) Genetic doping algorithm (GenD): Theory and application. Expert Syst 21, 63-79.
    • (2004) Expert Syst , vol.21 , pp. 63-79
    • Buscema, M.1
  • 23
    • 77956908693 scopus 로고    scopus 로고
    • Polymorphisms in folate-metabolizing genes, chromosome damage, and risk of Down syndrome in Italian women: Identification of key factors using artificial neural networks
    • Coppedè F, Grossi E, Migheli FML (2010) Polymorphisms in folate-metabolizing genes, chromosome damage, and risk of Down syndrome in Italian women: Identification of key factors using artificial neural networks. BMC Med Genomics 3, 42.
    • (2010) BMC Med Genomics , vol.3 , pp. 42
    • Coppedè, F.1    Grossi, E.2    Migheli, F.M.L.3
  • 24
    • 27644455880 scopus 로고    scopus 로고
    • Assessment of the role of genetic polymorphism in venous thrombosis through artificial neural networks
    • Penco S, Grossi E, Cheng S, Intraligi M, Maurelli G (2005) Assessment of the role of genetic polymorphism in venous thrombosis through artificial neural networks. AnnHumGenet 69 (Pt 6), 693-706.
    • (2005) AnnHumGenet , vol.69 , pp. 693-706
    • Penco, S.1    Grossi, E.2    Cheng, S.3    Intraligi, M.4    Maurelli, G.5
  • 25
    • 33846683604 scopus 로고    scopus 로고
    • International experience on the use of artificial neural networks in gastroenterology
    • Grossi E, Mancini A, Buscema M (2007) International experience on the use of artificial neural networks in gastroenterology. Dig Liver Dis 39, 278-285.
    • (2007) Dig Liver Dis , vol.39 , pp. 278-285
    • Grossi, E.1    Mancini, A.2    Buscema, M.3
  • 26
    • 22044454320 scopus 로고    scopus 로고
    • An optimized experimental protocol based on neuroevolutionary algorithms. Application to the classification of dyspeptic patients and to the prediction of the effectiveness of their treatment
    • Buscema M, Grossi E, Intraligi M, Garbagna N, Andriulli A (2005) An optimized experimental protocol based on neuroevolutionary algorithms. Application to the classification of dyspeptic patients and to the prediction of the effectiveness of their treatment. Artif Intell Med 34, 279-305.
    • (2005) Artif Intell Med , vol.34 , pp. 279-305
    • Buscema, M.1    Grossi, E.2    Intraligi, M.3    Garbagna, N.4    Andriulli, A.5
  • 27
    • 40049096029 scopus 로고    scopus 로고
    • Artificial neural networks in the recognition of the presence of thyroid disease in patients with atrophic body gastritis
    • Lahner E, Intraligi M, Buscema M, Centanni M, Vannella L (2008) Artificial neural networks in the recognition of the presence of thyroid disease in patients with atrophic body gastritis. World J Gastroenterol 14, 563-568.
    • (2008) World J Gastroenterol , vol.14 , pp. 563-568
    • Lahner, E.1    Intraligi, M.2    Buscema, M.3    Centanni, M.4    Vannella, L.5
  • 28
    • 77953233327 scopus 로고    scopus 로고
    • Appropriateness guidelines and predictive rules to select patients for upper endoscopy: A nationwide multicenter study
    • Buri L, Hassan C, Bersani G, AntiM,BiancoM(2010) Appropriateness guidelines and predictive rules to select patients for upper endoscopy: A nationwide multicenter study. Am J Gastroenterol 105, 1327-1337.
    • (2010) Am J Gastroenterol , vol.105 , pp. 1327-1337
    • Buri, L.1    Hassan, C.2    Bersani, G.3    Anti, M.4    Bianco, M.5
  • 29
    • 46349084176 scopus 로고    scopus 로고
    • Placental determinants of fetal growth: Identification of key factors in the insulin-like growth factor and cytokine systems using artificial neural networks
    • Street M, Grossi E,Volta C, Faleschini E, Bernasconi S (2008) Placental determinants of fetal growth: Identification of key factors in the insulin-like growth factor and cytokine systems using artificial neural networks. BMC Pediatr 8, 24.
    • (2008) BMC Pediatr , vol.8 , pp. 24
    • Street, M.1    Grossi, E.2    Volta, C.3    Faleschini, E.4    Bernasconi, S.5
  • 30
    • 77949727193 scopus 로고    scopus 로고
    • The IFAST model allows the prediction of conversion to Alzheimer disease in patients with mild cognitive impairment with high degree of accuracy
    • Buscema M, Grossi E, Capriotti M, Babiloni C, Rossini P (2010) The IFAST model allows the prediction of conversion to Alzheimer disease in patients with mild cognitive impairment with high degree of accuracy. Curr Alzheimer Res 7, 173-187.
    • (2010) Curr Alzheimer Res , vol.7 , pp. 173-187
    • Buscema, M.1    Grossi, E.2    Capriotti, M.3    Babiloni, C.4    Rossini, P.5
  • 31
    • 79551655286 scopus 로고    scopus 로고
    • Artificial neural networks accurately predict mortality in patients with non variceal upper GI bleeding
    • Rotondano G, Cipolletta L, Grossi E, Koch M, Intraligi M (2011) Artificial neural networks accurately predict mortality in patients with non variceal upper GI bleeding. Gastrointest Endosc 73, 218-226.
    • (2011) Gastrointest Endosc , vol.73 , pp. 218-226
    • Rotondano, G.1    Cipolletta, L.2    Grossi, E.3    Koch, M.4    Intraligi, M.5
  • 32
    • 77957581691 scopus 로고    scopus 로고
    • Is it possible to clinically differentiate erosive from non erosive reflux disease patients? A study using an artificial neural networks-assisted algorithm
    • Pace F, Riegler G, de Leone A, Pace M, Cestari R (2010) Is it possible to clinically differentiate erosive from non erosive reflux disease patients? A study using an artificial neural networks-assisted algorithm. Eur J Gastroenterol Hepatol 22, 1163-1168.
    • (2010) Eur J Gastroenterol Hepatol , vol.22 , pp. 1163-1168
    • Pace, F.1    Riegler, G.2    De Leone, A.3    Pace, M.4    Cestari, R.5
  • 33
    • 58149346011 scopus 로고    scopus 로고
    • The semantic connectivity map: An adapting self organising knowledge discovery method in data bases. Experience in gastro-oesophageal reflux disease
    • Buscema M, Grossi E (2008) The semantic connectivity map: An adapting self organising knowledge discovery method in data bases. Experience in gastro-oesophageal reflux disease. Int J Data Min Bioinform 2, 362-404.
    • (2008) Int J Data Min Bioinform , vol.2 , pp. 362-404
    • Buscema, M.1    Grossi, E.2
  • 34
    • 53549114784 scopus 로고    scopus 로고
    • Autocontractive maps: An artificial adaptive system for data mining. An application to Alzheimer disease
    • Buscema M, Grossi E, Snowdon D, Antuono P (2008) Autocontractive maps: An artificial adaptive system for data mining. An application to Alzheimer disease. Curr Alzheimer Res 5, 481-498.
    • (2008) Curr Alzheimer Res , vol.5 , pp. 481-498
    • Buscema, M.1    Grossi, E.2    Snowdon, D.3    Antuono, P.4
  • 35
    • 84872106441 scopus 로고    scopus 로고
    • A novel data mining system points out hidden relationships between immunological markers in multiple sclerosis
    • Gironi M, Saresella M, Rovaris M, Vaghi M, Nemni R (2013) A novel data mining system points out hidden relationships between immunological markers in multiple sclerosis. Immun Ageing 10, 1.
    • (2013) Immun Ageing , vol.10 , pp. 1
    • Gironi, M.1    Saresella, M.2    Rovaris, M.3    Vaghi, M.4    Nemni, R.5
  • 37
    • 80053130719 scopus 로고    scopus 로고
    • An essential role of the transcription factor GATA-3 for the function of regulatory T cells yunqi
    • Wang I, Su M, Wan I (2011) An essential role of the transcription factor GATA-3 for the function of regulatory T cells yunqi. Immunity 35, 337-348.
    • (2011) Immunity , vol.35 , pp. 337-348
    • Wang, I.1    Su, M.2    Wan, I.3
  • 38
    • 0025753852 scopus 로고
    • The molecular pathology of Alzheimer's disease
    • Selkoe D (1991) The molecular pathology of Alzheimer's disease. Neuron 6, 487-498.
    • (1991) Neuron , vol.6 , pp. 487-498
    • Selkoe, D.1
  • 40
    • 84871658247 scopus 로고    scopus 로고
    • Understanding risk factors for Alzheimer's disease: Interplay of neuroinflammation, connexin-based communication and oxidative stress
    • Quintanilla R, Orellana J, von Bernhardi R (2012) Understanding risk factors for Alzheimer's disease: Interplay of neuroinflammation, connexin-based communication and oxidative stress. Arch Med Res 43, 632-644.
    • (2012) Arch Med Res , vol.43 , pp. 632-644
    • Quintanilla, R.1    Orellana, J.2    Von Bernhardi, R.3
  • 41
    • 84880117155 scopus 로고    scopus 로고
    • Down's syndrome, neuroinflammation, and Alzheimer neuropathogenesis
    • Wilcock DM, Griffin WS (2013) Down's syndrome, neuroinflammation, and Alzheimer neuropathogenesis. J Neuroinflammation 10, 84.
    • (2013) J Neuroinflammation , vol.10 , pp. 84
    • Wilcock, D.M.1    Griffin, W.S.2
  • 42
    • 33646841989 scopus 로고    scopus 로고
    • Beta-amyloid stimulates murine postnatal and adult microglia cultures in a unique manner
    • Floden AM, Combs CK (2006) Beta-amyloid stimulates murine postnatal and adult microglia cultures in a unique manner. J Neurosci 26, 4644-4648.
    • (2006) J Neurosci , vol.26 , pp. 4644-4648
    • Floden, A.M.1    Combs, C.K.2
  • 43
    • 7244242262 scopus 로고    scopus 로고
    • Induction of inflammatory mediators and microglial activation in mice transgenic for mutant human P301S tau protein
    • Bellucci A,Westwood AJ, Ingram E, Casamenti F, Goedert M, Spillantini MG (2004) Induction of inflammatory mediators and microglial activation in mice transgenic for mutant human P301S tau protein. Am J Pathol 165, 1643-1652.
    • (2004) Am J Pathol , vol.165 , pp. 1643-1652
    • Bellucci, A.1    Westwood, A.J.2    Ingram, E.3    Casamenti, F.4    Goedert, M.5    Spillantini, M.G.6
  • 44
    • 0026730350 scopus 로고
    • Amyloidogenicity of beta A4 and beta A4-bearing amyloid protein precursor fragments by metal-catalyzed oxidation
    • Dyrks T, Dyrks E, Hartmann T, Masters C, Beyreuther K (1992) Amyloidogenicity of beta A4 and beta A4-bearing amyloid protein precursor fragments by metal-catalyzed oxidation. J Biol Chem 267, 1821-1827.
    • (1992) J Biol Chem , vol.267 , pp. 1821-1827
    • Dyrks, T.1    Dyrks, E.2    Hartmann, T.3    Masters, C.4    Beyreuther, K.5
  • 45
    • 84863672009 scopus 로고    scopus 로고
    • Microglia in Alzheimer's disease: It's all about context
    • Weitz TM, Town T (2012) Microglia in Alzheimer's disease: It's all about context. Int J Alzheimers Dis 2012, 314185.
    • (2012) Int J Alzheimers Dis , vol.2012 , pp. 314185
    • Weitz, T.M.1    Town, T.2
  • 46
    • 78650836932 scopus 로고    scopus 로고
    • Multi factorial interactions in the pathogenesis pathway of Alzheimer's disease: A new risk charts for prevention of dementia
    • Licastro F, Porcellini E, Forti P, Buscema M, Carbone I, Ravaglia G, Grossi E (2010) Multi factorial interactions in the pathogenesis pathway of Alzheimer's disease: A new risk charts for prevention of dementia. Immun Ageing 7 (Suppl 1), S4.
    • (2010) Immun Ageing , vol.7 , pp. S4
    • Licastro, F.1    Porcellini, E.2    Forti, P.3    Buscema, M.4    Carbone, I.5    Ravaglia, G.6    Grossi, E.7
  • 47
    • 34447304358 scopus 로고    scopus 로고
    • Neuropathological findings processed by artificial neural networks (ANNs) can perfectly distinguish Alzheimer's patients from controls in the Nun Study
    • Grossi E, Buscema MP, Snowdon D, Antuono P (2007) Neuropathological findings processed by artificial neural networks (ANNs) can perfectly distinguish Alzheimer's patients from controls in the Nun Study. BMC Neurol 7, 15.
    • (2007) BMC Neurol , vol.7 , pp. 15
    • Grossi, E.1    Buscema, M.P.2    Snowdon, D.3    Antuono, P.4
  • 48
    • 79551687962 scopus 로고    scopus 로고
    • Increased activity of Th-17 and Th-9 lymphocytes and a skewing of the post-thymic differentiation pathway are seen in Alzheimer's disease
    • Saresella M, Calabrese E, Marventano I, Piancone F, Gatti A, Alberoni M, Nemni R, ClericiM(2011) Increased activity of Th-17 and Th-9 lymphocytes and a skewing of the post-thymic differentiation pathway are seen in Alzheimer's disease. Brain Behav Immun 25, 539-547.
    • (2011) Brain Behav Immun , vol.25 , pp. 539-547
    • Saresella, M.1    Calabrese, E.2    Marventano, I.3    Piancone, F.4    Gatti, A.5    Alberoni, M.6    Nemni, R.7    Clerici, M.8
  • 50
    • 27744464859 scopus 로고    scopus 로고
    • The microglial "activation" continuum: From innate to adaptive responses
    • Town T, Nikolic V, Tan J (2005) The microglial "activation" continuum: From innate to adaptive responses. J Neuroinflammation 2, 24.
    • (2005) J Neuroinflammation , vol.2 , pp. 24
    • Town, T.1    Nikolic, V.2    Tan, J.3
  • 51
    • 70449534695 scopus 로고    scopus 로고
    • CNS infiltration of peripheral immune cells: D-Day for neurodegenerative disease?
    • Rezai-Zadeh K, Gate D, Town T (2009) CNS infiltration of peripheral immune cells: D-Day for neurodegenerative disease? J Neuroimmune Pharmacol 4, 462-475.
    • (2009) J Neuroimmune Pharmacol , vol.4 , pp. 462-475
    • Rezai-Zadeh, K.1    Gate, D.2    Town, T.3
  • 56
    • 0342939538 scopus 로고    scopus 로고
    • Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity
    • Shaw PX, Hörkkö S, Chang M, Curtiss LK, Palinski W, Silverman GJ, Witztum JL (2000) Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity. J Clin Invest 105, 1731-1740.
    • (2000) J Clin Invest , vol.105 , pp. 1731-1740
    • Shaw, P.X.1    Hörkkö, S.2    Chang, M.3    Curtiss, L.K.4    Palinski, W.5    Silverman, G.J.6    Witztum, J.L.7
  • 57
    • 0033990553 scopus 로고    scopus 로고
    • Inverse relationship between circulating oxidized low density lipoprotein (oxLDL) and anti-oxLDL antibody levels in healthy subjects
    • Shoji T, Nishizawa Y, Fukumoto M, Shimamura K, Kimura J, Kanda H, EmotoM,KawagishiT, MoriiH(2000) Inverse relationship between circulating oxidized low density lipoprotein (oxLDL) and anti-oxLDL antibody levels in healthy subjects. Atherosclerosis 148, 171-177.
    • (2000) Atherosclerosis , vol.148 , pp. 171-177
    • Shoji, T.1    Nishizawa, Y.2    Fukumoto, M.3    Shimamura, K.4    Kimura, J.5    Kanda, H.6    Emoto, M.7    Kawagishi, T.8    Morii, H.9
  • 59
    • 0035936802 scopus 로고    scopus 로고
    • Atherosclerosis. The road ahead
    • Glass C, Witztum J (2001) Atherosclerosis. The road ahead. Cell 104, 503-516.
    • (2001) Cell , vol.104 , pp. 503-516
    • Glass, C.1    Witztum, J.2
  • 62
    • 84862705994 scopus 로고    scopus 로고
    • The prognostic value of amyloid imaging
    • Gelosa G, Brooks D (2012) The prognostic value of amyloid imaging. Eur J Nucl Med Mol Imaging 39, 1207-1219.
    • (2012) Eur J Nucl Med Mol Imaging , vol.39 , pp. 1207-1219
    • Gelosa, G.1    Brooks, D.2
  • 63
    • 84890423856 scopus 로고    scopus 로고
    • Associations between Alzheimer disease biomarkers, neurodegeneration, and cognition in cognitively normal older people
    • Wirth M, Villeneuve S, Haase C, Madison C, Oh H, Landau S, Rabinovici G, Jagust W (2013) Associations between Alzheimer disease biomarkers, neurodegeneration, and cognition in cognitively normal older people. JAMA Neurol 70, 1512-1519.
    • (2013) JAMA Neurol , vol.70 , pp. 1512-1519
    • Wirth, M.1    Villeneuve, S.2    Haase, C.3    Madison, C.4    Oh, H.5    Landau, S.6    Rabinovici, G.7    Jagust, W.8
  • 65
    • 84857883847 scopus 로고    scopus 로고
    • Macrophage plasticity and polarization: In vivo veritas
    • Sica A, MantovaniA(2012) Macrophage plasticity and polarization: In vivo veritas. J Clin Invest 122, 787-795.
    • (2012) J Clin Invest , vol.122 , pp. 787-795
    • Sica, A.1    Mantovani, A.2
  • 67
    • 67650485985 scopus 로고    scopus 로고
    • Alternative activation of macrophages:Animmunologic functional perspective
    • Martinez F, Helming L, Gordon S (2009) Alternative activation of macrophages:Animmunologic functional perspective. Annu Rev Immunol 27, 451-483.
    • (2009) Annu Rev Immunol , vol.27 , pp. 451-483
    • Martinez, F.1    Helming, L.2    Gordon, S.3
  • 68
    • 77956976681 scopus 로고    scopus 로고
    • Macrophage plasticity and interaction with lymphocyte subsets: Cancer as a paradigm
    • Biswas S, Mantovani A (2010) Macrophage plasticity and interaction with lymphocyte subsets: Cancer as a paradigm. Nat Immunol 11, 889-896.
    • (2010) Nat Immunol , vol.11 , pp. 889-896
    • Biswas, S.1    Mantovani, A.2
  • 70
    • 70349807619 scopus 로고    scopus 로고
    • Immune activation in brain aging and neurodegeneration: Too much or too little?
    • Lucin K, Wyss-Coray T (2010) Immune activation in brain aging and neurodegeneration: Too much or too little? Neuron 64, 110-122.
    • (2010) Neuron , vol.64 , pp. 110-122
    • Lucin, K.1    Wyss-Coray, T.2
  • 72
    • 0025753852 scopus 로고
    • The molecular pathology of Alzheimer's disease
    • Selkoe D (1991) The molecular pathology of Alzheimer's disease. Neuron 6, 487-498.
    • (1991) Neuron , vol.6 , pp. 487-498
    • Selkoe, D.1
  • 74
    • 84875465982 scopus 로고    scopus 로고
    • Proton MRS in mild cognitive impairment
    • Kantarci K (2013) Proton MRS in mild cognitive impairment. J Magn Reson Imaging 37, 770-777.
    • (2013) J Magn Reson Imaging , vol.37 , pp. 770-777
    • Kantarci, K.1
  • 75
    • 84876936083 scopus 로고    scopus 로고
    • White matter abnormalities associated with Alzheimer's disease and mild cognitive impairment: A critical review of MRI studies
    • Radanovic M, Pereira F, Stella F, Aprahamian I, Ferreira L, Forlenza O, Busatto G (2013) White matter abnormalities associated with Alzheimer's disease and mild cognitive impairment: A critical review of MRI studies. Expert Rev Neurother 13, 483-493.
    • (2013) Expert Rev Neurother , vol.13 , pp. 483-493
    • Radanovic, M.1    Pereira, F.2    Stella, F.3    Aprahamian, I.4    Ferreira, L.5    Forlenza, O.6    Busatto, G.7
  • 76
    • 71849117051 scopus 로고    scopus 로고
    • Blood cell markers in Alzheimer Disease: Amyloid Precursor Protein form ratio in platelets
    • Borroni B, Agosti C, Marcello E, Di Luca M, Padovani A (2010) Blood cell markers in Alzheimer Disease: Amyloid Precursor Protein form ratio in platelets. Exp Gerontol 45, 53-56.
    • (2010) Exp Gerontol , vol.45 , pp. 53-56
    • Borroni, B.1    Agosti, C.2    Marcello, E.3    Di Luca, M.4    Padovani, A.5
  • 77
    • 84967318574 scopus 로고    scopus 로고
    • Platelets and Alzheimer's disease: Potential of APP as a biomarker
    • Evin G, Li Q-X (2012) Platelets and Alzheimer's disease: Potential of APP as a biomarker. World J Psychiatry 2, 102-113.
    • (2012) World J Psychiatry , vol.2 , pp. 102-113
    • Evin, G.1    Li, Q.-X.2
  • 80
    • 0037410074 scopus 로고    scopus 로고
    • Interleukin-1 and neuronal injury: Mechanisms, modification, and therapeutic potential
    • Rothwell N (2003) Interleukin-1 and neuronal injury: Mechanisms, modification, and therapeutic potential. Brain Behav Immun 17, 152-157.
    • (2003) Brain Behav Immun , vol.17 , pp. 152-157
    • Rothwell, N.1
  • 81
    • 13844281550 scopus 로고    scopus 로고
    • How chronic inflammation can affect the brain and support the development of Alzheimer's disease in old age: The role of microglia and astrocytes
    • Blasko I, Stampfer-Kountchev M, Robatscher P, Veerhuis R, Eikelenboom P, Grubeck-Loebenstein B (2004) How chronic inflammation can affect the brain and support the development of Alzheimer's disease in old age: The role of microglia and astrocytes. Aging Cell 3, 169-176.
    • (2004) Aging Cell , vol.3 , pp. 169-176
    • Blasko, I.1    Stampfer-Kountchev, M.2    Robatscher, P.3    Veerhuis, R.4    Eikelenboom, P.5    Grubeck-Loebenstein, B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.