Multi factorial interactions in the pathogenesis pathway of Alzheimer's disease: A new risk charts for prevention of dementia

Immunity and Ageing

Volumn 7, Issue SUPPL. 1, 2010, Pages

  Licastro, Federico ^a   Porcellini, Elisa ^a   Forti, Paola ^b   Buscema, Massimo ^c   Carbone, Ilaria ^a   Ravaglia, Giovanni ^b   Grossi, Enzo ^d  

^a Department of Experimental Pathology ^*  (Italy)

^b University School of Medicine   (Italy)

^c Semeion centro ricerche di scienze della communicazione   (Italy)

^d Centro Diagnostico Italiano   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; AGING; ALZHEIMER DISEASE; ARTICLE; COGNITIVE DEFECT; DEMENTIA; GENETIC VARIABILITY; HUMAN; INCIDENCE; NUTRITION; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; RISK ASSESSMENT; STATISTICAL ANALYSIS;

EID: 78650836932     PISSN: None     EISSN: 17424933     Source Type: Journal    
DOI: 10.1186/1742-4933-7-S1-S4     Document Type: Article

References (29)

1. Bruunsgaard H, Pedersen M, Pedersen BK. Aging and proinflammatory cytokines. Curr Opin Hematol 2001, 131:131-136.
2. Baggio G, Donazzan S, Monti D, Mari D, Martini S, Gabelli C, Dalla M, Previato L, Guido M, Pigozzo S, Cortella I, Crepaldi G, Franceschi C. Lipoprotein(a) and lipoprotein profile in healthy centenarians: a reappraisal of vascular risk factors. FASEB J 1998, 12:433-437.
3. Dumont P, Balbeur L, Remacle J, Toussaint O. Appearance of biomarkers of in vitro ageing after successive stimulation of WI-38 fibroblasts with IL-1alpha and TNF-alpha: senescence associated beta-galactosidase activity and morphotype transition. J Anat 2000, 197:529-537. 1468167, 11197525.
4. Pawelec G, Barnett Y, Forsey R, Frasca D, Globerson A, McLeod J, Caruso C, Franceschi C, Fulop T, Gupta S, Mariani E, Mocchegiani E, Solana R. T cells and aging. Front Biosci 2002, 7:d1056-1183.
5. Candore G, Colonna-Romano G, Lio D, Caruso C. Immunological and Immunogenetic markers of successful and unsuccessful ageing. Advances in Cell Aging and Gerontology 2003, 13:29-45.
6. Franceschi C, Bonafe M, Valensin S, Olivieri F, De Luca M, Ottaviani E, De Benedictis G. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci 2000, 908:208-218.
7. Franceschi C, Bonafe M. Centenarians as a model for healthy aging. Biochem Soc Trans 2003, 31:457-461.
8. Krabbe KS, Pedersen M, Bruunsgaard H. Inflammatory mediators in the elderly. Exp Gerontol 2004, 39:687-699.
9. Brookmeyer R, Gray S, Kawas C. Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset. Am J Public Health 1998, 88:1337-1342. 1509089, 9736873.
10. Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 2001, 81:741-766.
11. Ritchie K, Lovestone S. The dementias. Lancet 2002, 360:1759-1766.
12. McGeer EG, McGeer PL. The importance of inflammatory mechanisms in Alzheimer disease. Exp Geront 1998, 33:371-378.
13. Licastro F. Genomics of immune molecules: early detection of cognitive decline and new therapeutic interventions. Expert Rev Neurotherapeutics 2002, 2:639-645. 19810979 .
14. Lee YB, Nagai A, Kim SU. Cytokines, chemokines, and cytokine receptors in human microglia. J Neurosci Res 2002, 69:94-103.
15. int' Veld BA, Ruitenberg A, Hofman A. Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease. N Engl J Med 2001, 345:1515-1521.
16. Vagnucci AH, Li WW. Alzheimer's disease and angiogenesis. Lancet 2003, 361:605-608.
17. Schmidt R, Schmidt H, Curb JD, Masaki K, White LR, Launer LJ. Early inflammation and dementia: a 25-year follow-up of the Honolulu-Asia Aging Study. Ann Neurol 2002, 52:168-174.
18. Licastro F, Pedrini S, Caputo L, Annoni G, Davis LJ, Ferri C, Casadei V, Grimaldi LM. Increased plasma levels of interleukin-1, interleukin-6 and alpha-1-antichymotrypsin in patients with Alzheimer's disease: peripheral inflammation or signals from the brain?. J Neuroimmunol 2000, 103:97-102.
19. Licastro F, Pedrini S, Ferri C, et al. Gene polymorphism affecting alpha1-antichymotrypsin and interleukin-1 plasma levels increases Alzheimer's disease risk. Ann Neurol 2000, 48:388-391.
20. De Luigi A, Fragiacomo C, Lucca U, Quadri P, Tettamanti M, Grazia M. Inflammatory markers in Alzheimer's disease and multi-infarct dementia. Mech Ageing Dev 2001, 122:1985-1995.
21. Licastro F, Chiappelli M. Brain immune responses cognitive decline and dementia: relationship with phenotype expression and genetic background. Mech Ageing Dev 2003, 124:525-528.
22. Licastro F, Grimaldi LM, Bonafe M, Martina C, Olivieri F, Cavallone L, Giovanietti S, Masliah E, Franceschi C. Interleukin-6 gene alleles affect the risk of Alzheimer's disease and levels of the cytokine in blood and brain. Neurobiol Aging 2003, 24:921-926.
23. Massimo B, Enzo G. The Semantic Connectivity Map: an adapting self-organizing knowledge discovery method in data bases. Experience in Gastro-oesophageal reflux disease. International Journal & data Mining Bioinformatics, .
24. Grossi E, Buscema MP, Snowdon D, Antuono P. Neuropathological findings processed by artificial neural networks (ANNs) can perfectly distinguish Alzheimer's patients from controls in the Nun Study. BMC Neurol 2007, 21:7-15. 17584929.
25. Ravaglia G, Forti P, Maioli F, Orlanducci P, Sacchetti L, Flisi E, Dalmonte E, Martignani A, Cucinotta D, Cavalli G. Conselice study: a population based survey of brain aging in a muncipality of the Emilia Romagna region: (A.U.S.L. Ravenna). Design and methods. Arch. Gerontol., Geriatr 2001, 7:313-324. 11431080.
26. Ravaglia G, Forti P, Maioli F, Montesi F, Rietti E, Pisacane N, Rolfo E, Scali CR, Dalmonte E. Risk factors for dementi: data from the Conselice study of brain aging. Arch. Gerontol., Geriatr. 2007, (Suppl 1):311-320. 17317467.
27. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984, 34(7):939-44.
28. Roman GC, Tatemichi TK, Erkinjuntti T, Cummings JL, Masdeu JC, Garcia JH, Amaducci L, Orgogozo JM, Brun A, Hofman A, et al. Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology 1993, 43(2):250-60.
29. Ravaglia G, Forti P, Maioli F, Scali RC, Arnone G, Talerico T, Pantieri T, Nativio V, Mantovani V, Bianchin M. Common polymorphisms in methylentetrahydropholate reductase (MTHFR): relationship with plasma homocyteine concentrations and cognitive status in elderly northern Italian subjects. Arch Gerontol Geriat Suppl 2004, 9:339-348.