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Volumn 4 NOV, Issue , 2013, Pages

Novel therapeutic strategies targeting tumor-stromal interactions in pancreatic cancer

Author keywords

Angiotensin receptor blocker; Cell survival; Chemoresistance; Desmoplasia; Pancreatic stellate cells; Sonic hedgehog inhibitor

Indexed keywords

1 (2 BROMOPHENYL) 3 (2 HYDROXY 4 NITROPHENYL)UREA; ANGIOTENSIN RECEPTOR ANTAGONIST; APOCYNIN; CANDESARTAN; CONNECTIVE TISSUE GROWTH FACTOR; CURCUMIN; CYCLOPAMINE; DENDRITIC CELL VACCINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIPHENYLIODONIUM SALT; DNA VACCINE; ELLAGIC ACID; FG 3019; GEMCITABINE; LOSARTAN; OLMESARTAN; PACLITAXEL; POLYPHENOL; SARIDEGIB; SONIC HEDGEHOG PROTEIN;

EID: 84889651721     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2013.00331     Document Type: Review
Times cited : (37)

References (67)
  • 1
    • 0036051343 scopus 로고    scopus 로고
    • Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta
    • doi: 10.1038/ncb826
    • Abreu, J. G., Ketpura, N. I., Reversade, B., and De Robertis, E. M. (2002). Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta. Nat. Cell Biol. 4, 599-604. doi: 10.1038/ncb826
    • (2002) Nat. Cell Biol. , vol.4 , pp. 599-604
    • Abreu, J.G.1    Ketpura, N.I.2    Reversade, B.3    De Robertis, E.M.4
  • 2
    • 84883143193 scopus 로고    scopus 로고
    • Stromal disrupting effects of nab-paclitaxel in pancreatic cancer
    • doi: 10.1038/bjc.2013.415
    • Alvarez, R., Musteanu, M., Garcia-Garcia, E., Lopez-Casas, P. P., Megias, D., Guerra, C., et al. (2013). Stromal disrupting effects of nab-paclitaxel in pancreatic cancer. Br. J. Cancer 109, 926-933. doi: 10.1038/bjc.2013.415
    • (2013) Br. J. Cancer , vol.109 , pp. 926-933
    • Alvarez, R.1    Musteanu, M.2    Garcia-Garcia, E.3    Lopez-Casas, P.P.4    Megias, D.5    Guerra, C.6
  • 3
    • 4644317795 scopus 로고    scopus 로고
    • Desmoplastic reaction in pancreatic cancer: role of pancreatic stellate cells
    • doi: 10.1097/00006676-200410000-00002
    • Apte, M. V., Park, S., Phillips, P. A., Santucci, N., Goldstein, D., Kumar, R. K., et al. (2004). Desmoplastic reaction in pancreatic cancer: role of pancreatic stellate cells. Pancreas 29, 179-187. doi: 10.1097/00006676-200410000-00002
    • (2004) Pancreas , vol.29 , pp. 179-187
    • Apte, M.V.1    Park, S.2    Phillips, P.A.3    Santucci, N.4    Goldstein, D.5    Kumar, R.K.6
  • 4
    • 17144404527 scopus 로고    scopus 로고
    • Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells
    • doi: 10.1053/j.gastro.2004.12.036
    • Bachem, M. G., Schunemann, M., Ramadani, M., Siech, M., Beger, H., Buck, A., et al. (2005). Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells. Gastroenterology 128, 907-921. doi: 10.1053/j.gastro.2004.12.036
    • (2005) Gastroenterology , vol.128 , pp. 907-921
    • Bachem, M.G.1    Schunemann, M.2    Ramadani, M.3    Siech, M.4    Beger, H.5    Buck, A.6
  • 5
    • 58149143021 scopus 로고    scopus 로고
    • Sonic hedgehog promotes desmoplasia in pancreatic cancer
    • doi: 10.1158/1078-0432.CCR-08-0291
    • Bailey, J. M., Swanson, B. J., Hamada, T., Eggers, J. P., Singh, P. K., Caffery, T., et al. (2008). Sonic hedgehog promotes desmoplasia in pancreatic cancer. Clin. Cancer Res. 14, 5995-6004. doi: 10.1158/1078-0432.CCR-08-0291
    • (2008) Clin. Cancer Res. , vol.14 , pp. 5995-6004
    • Bailey, J.M.1    Swanson, B.J.2    Hamada, T.3    Eggers, J.P.4    Singh, P.K.5    Caffery, T.6
  • 6
    • 59149092493 scopus 로고    scopus 로고
    • The role of tumor cell-derived connective tissue growth factor (CTGF/CCN2) in pancreatic tumor growth
    • doi: 10.1158/0008-5472.CAN-08-0987
    • Bennewith, K. L., Huang, X., Ham, C. M., Graves, E. E., Erler, J. T., Kambham, N., et al. (2009). The role of tumor cell-derived connective tissue growth factor (CTGF/CCN2) in pancreatic tumor growth. Cancer Res. 69, 775-784. doi: 10.1158/0008-5472.CAN-08-0987
    • (2009) Cancer Res. , vol.69 , pp. 775-784
    • Bennewith, K.L.1    Huang, X.2    Ham, C.M.3    Graves, E.E.4    Erler, J.T.5    Kambham, N.6
  • 7
    • 0036682041 scopus 로고    scopus 로고
    • Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297
    • doi: 10.1200/JCO.2002.11.149
    • Berlin, J. D., Catalano, P., Thomas, J. P., Kugler, J. W., Haller, D. G., and Benson, A. B. 3rd. (2002). Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297. J. Clin. Oncol. 20, 3270-3275. doi: 10.1200/JCO.2002.11.149
    • (2002) J. Clin. Oncol. , vol.20 , pp. 3270-3275
    • Berlin, J.D.1    Catalano, P.2    Thomas, J.P.3    Kugler, J.W.4    Haller, D.G.5    Benson III, A.B.6
  • 8
    • 8244254377 scopus 로고    scopus 로고
    • Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial
    • Burris, H. A. 3rd. Moore, M. J., Andersen, J., Green, M. R., Rothenberg, M. L., Modiano, M. R., et al. (1997). Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J. Clin. Oncol. 15, 2403-2413.
    • (1997) J. Clin. Oncol. , vol.15 , pp. 2403-2413
    • Burris III, H.A.1    Moore, M.J.2    Andersen, J.3    Green, M.R.4    Rothenberg, M.L.5    Modiano, M.R.6
  • 9
    • 84885129359 scopus 로고    scopus 로고
    • Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels
    • doi: 10.1038/ncomms3516
    • Chauhan, V. P., Martin, J. D., Liu, H., Lacorre, D. A., Jain, S. R., Kozin, S. V., et al. (2013). Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels. Nat. Commun. 4, 2516. doi: 10.1038/ncomms3516
    • (2013) Nat. Commun. , vol.4 , pp. 2516
    • Chauhan, V.P.1    Martin, J.D.2    Liu, H.3    Lacorre, D.A.4    Jain, S.R.5    Kozin, S.V.6
  • 10
    • 35148814410 scopus 로고    scopus 로고
    • Dynamics of the immune reaction to pancreatic cancer from inception to invasion
    • doi: 10.1158/0008-5472.CAN-07-0175
    • Clark, C. E., Hingorani, S. R., Mick, R., Combs, C., Tuveson, D. A., and Vonderheide, R. H. (2007). Dynamics of the immune reaction to pancreatic cancer from inception to invasion. Cancer Res. 67, 9518-9527. doi: 10.1158/0008-5472.CAN-07-0175
    • (2007) Cancer Res. , vol.67 , pp. 9518-9527
    • Clark, C.E.1    Hingorani, S.R.2    Mick, R.3    Combs, C.4    Tuveson, D.A.5    Vonderheide, R.H.6
  • 11
    • 84865863438 scopus 로고    scopus 로고
    • Japan pancreatic cancer registry; 30th year anniversary: Japan pancreas society
    • doi: 10.1097/MPA.0b013e318258055c
    • Egawa, S., Toma, H., Ohigashi, H., Okusaka, T., Nakao, A., Hatori, T., et al. (2012). Japan pancreatic cancer registry; 30th year anniversary: Japan pancreas society. Pancreas 41, 985-992. doi: 10.1097/MPA.0b013e318258055c
    • (2012) Pancreas , vol.41 , pp. 985-992
    • Egawa, S.1    Toma, H.2    Ohigashi, H.3    Okusaka, T.4    Nakao, A.5    Hatori, T.6
  • 12
    • 84855201311 scopus 로고    scopus 로고
    • StellaTUM: current consensus and discussion on pancreatic stellate cell research
    • doi: 10.1136/gutjnl-2011-301220
    • Erkan, M., Adler, G., Apte, M. V., Bachem, M. G., Buchholz, M., Detlefsen, S., et al. (2012). StellaTUM: current consensus and discussion on pancreatic stellate cell research. Gut 61, 172-178. doi: 10.1136/gutjnl-2011-301220
    • (2012) Gut , vol.61 , pp. 172-178
    • Erkan, M.1    Adler, G.2    Apte, M.V.3    Bachem, M.G.4    Buchholz, M.5    Detlefsen, S.6
  • 13
    • 34247236139 scopus 로고    scopus 로고
    • Periostin creates a tumor-supportive microenvironment in the pancreas by sustaining fibrogenic stellate cell activity
    • doi: 10.1053/j.gastro.2007.01.031
    • Erkan, M., Kleeff, J., Gorbachevski, A., Reiser, C., Mitkus, T., Esposito, I., et al. (2007). Periostin creates a tumor-supportive microenvironment in the pancreas by sustaining fibrogenic stellate cell activity. Gastroenterology 132, 1447-1464. doi: 10.1053/j.gastro.2007.01.031
    • (2007) Gastroenterology , vol.132 , pp. 1447-1464
    • Erkan, M.1    Kleeff, J.2    Gorbachevski, A.3    Reiser, C.4    Mitkus, T.5    Esposito, I.6
  • 14
    • 84866450512 scopus 로고    scopus 로고
    • The role of inflammatory cells in fostering pancreatic cancer cell growth and invasion
    • doi: 10.3389/fphys.2012.00270
    • Evans, A., and Costello, E. (2012). The role of inflammatory cells in fostering pancreatic cancer cell growth and invasion. Front. Physiol. 3:270. doi: 10.3389/fphys.2012.00270
    • (2012) Front. Physiol. , vol.3 , pp. 270
    • Evans, A.1    Costello, E.2
  • 15
    • 33646821004 scopus 로고    scopus 로고
    • A novel integrin alpha5beta1 binding domain in module 4 of connective tissue growth factor (CCN2/CTGF) promotes adhesion and migration of activated pancreatic stellate cells
    • doi: 10.1136/gut.2005.079178
    • Gao, R., and Brigstock, D. R. (2006). A novel integrin alpha5beta1 binding domain in module 4 of connective tissue growth factor (CCN2/CTGF) promotes adhesion and migration of activated pancreatic stellate cells. Gut 55, 856-862. doi: 10.1136/gut.2005.079178
    • (2006) Gut , vol.55 , pp. 856-862
    • Gao, R.1    Brigstock, D.R.2
  • 16
    • 84878849679 scopus 로고    scopus 로고
    • Dendritic cell immunotherapy combined with gemcitabine chemotherapy enhances survival in a murine model of pancreatic carcinoma
    • doi: 10.1007/s00262-013-1407-9
    • Ghansah, T., Vohra, N., Kinney, K., Weber, A., Kodumudi, K., Springett, G., et al. (2013). Dendritic cell immunotherapy combined with gemcitabine chemotherapy enhances survival in a murine model of pancreatic carcinoma. Cancer Immunol. Immunother. 62, 1083-1091. doi: 10.1007/s00262-013-1407-9
    • (2013) Cancer Immunol. Immunother. , vol.62 , pp. 1083-1091
    • Ghansah, T.1    Vohra, N.2    Kinney, K.3    Weber, A.4    Kodumudi, K.5    Springett, G.6
  • 17
    • 84871335067 scopus 로고    scopus 로고
    • Role of radiation therapy in the management of pancreatic cancer
    • doi: 10.1002/jso.23137
    • Goodman, K. A., and Hajj, C. (2013). Role of radiation therapy in the management of pancreatic cancer. J. Surg. Oncol. 107, 86-96. doi: 10.1002/jso.23137
    • (2013) J. Surg. Oncol. , vol.107 , pp. 86-96
    • Goodman, K.A.1    Hajj, C.2
  • 18
    • 84860431671 scopus 로고    scopus 로고
    • Pancreatic stellate cells enhance stem cell-like phenotypes in pancreatic cancer cells
    • doi: 10.1016/j.bbrc.2012.04.014
    • Hamada, S., Masamune, A., Takikawa, T., Suzuki, N., Kikuta, K., Hirota, M., et al. (2012). Pancreatic stellate cells enhance stem cell-like phenotypes in pancreatic cancer cells. Biochem. Biophys. Res. Commun. 421, 349-354. doi: 10.1016/j.bbrc.2012.04.014
    • (2012) Biochem. Biophys. Res. Commun. , vol.421 , pp. 349-354
    • Hamada, S.1    Masamune, A.2    Takikawa, T.3    Suzuki, N.4    Kikuta, K.5    Hirota, M.6
  • 19
    • 33748445708 scopus 로고    scopus 로고
    • Randomized phase III trial of gemcitabine plus cisplatin compared with gemcitabine alone in advanced pancreatic cancer
    • doi: 10.1200/JCO.2005.05.1490
    • Heinemann, V., Quietzsch, D., Gieseler, F., Gonnermann, M., Schonekas, H., Rost, A., et al. (2006). Randomized phase III trial of gemcitabine plus cisplatin compared with gemcitabine alone in advanced pancreatic cancer. J. Clin. Oncol. 24, 3946-3952. doi: 10.1200/JCO.2005.05.1490
    • (2006) J. Clin. Oncol. , vol.24 , pp. 3946-3952
    • Heinemann, V.1    Quietzsch, D.2    Gieseler, F.3    Gonnermann, M.4    Schonekas, H.5    Rost, A.6
  • 20
    • 84887076296 scopus 로고    scopus 로고
    • Tumour-stroma interactions in pancreatic ductal adenocarcinoma: rationale and current evidence for new therapeutic strategies
    • doi: 10.1016/j.ctrv.2013.04.004. [Epub ahead of print].
    • Heinemann, V., Reni, M., Ychou, M., Richel, D. J., Macarulla, T., and Ducreux, M. (2013). Tumour-stroma interactions in pancreatic ductal adenocarcinoma: rationale and current evidence for new therapeutic strategies. Cancer Treat. Rev. doi: 10.1016/j.ctrv.2013.04.004. [Epub ahead of print].
    • (2013) Cancer Treat. Rev.
    • Heinemann, V.1    Reni, M.2    Ychou, M.3    Richel, D.J.4    Macarulla, T.5    Ducreux, M.6
  • 21
    • 33646155953 scopus 로고    scopus 로고
    • CCN2, connective tissue growth factor, stimulates collagen deposition by gingival fibroblasts via module 3 and alpha6- and beta1 integrins
    • doi: 10.1002/jcb.20810
    • Heng, E. C., Huang, Y., Black, S. A. Jr., and Trackman, P. C. (2006). CCN2, connective tissue growth factor, stimulates collagen deposition by gingival fibroblasts via module 3 and alpha6- and beta1 integrins. J. Cell. Biochem. 98, 409-420. doi: 10.1002/jcb.20810
    • (2006) J. Cell. Biochem. , vol.98 , pp. 409-420
    • Heng, E.C.1    Huang, Y.2    Black Jr., S.A.3    Trackman, P.C.4
  • 22
    • 34250180939 scopus 로고    scopus 로고
    • Gemcitabine plus capecitabine compared with gemcitabine alone in advanced pancreatic cancer: a randomized, multicenter, phase III trial of the Swiss group for clinical cancer research and the Central European cooperative oncology group
    • doi: 10.1200/JCO.2006.09.0886
    • Herrmann, R., Bodoky, G., Ruhstaller, T., Glimelius, B., Bajetta, E., Schuller, J., et al. (2007). Gemcitabine plus capecitabine compared with gemcitabine alone in advanced pancreatic cancer: a randomized, multicenter, phase III trial of the Swiss group for clinical cancer research and the Central European cooperative oncology group. J. Clin. Oncol. 25, 2212-2217. doi: 10.1200/JCO.2006.09.0886
    • (2007) J. Clin. Oncol. , vol.25 , pp. 2212-2217
    • Herrmann, R.1    Bodoky, G.2    Ruhstaller, T.3    Glimelius, B.4    Bajetta, E.5    Schuller, J.6
  • 23
    • 77951755278 scopus 로고    scopus 로고
    • Pancreatic cancer
    • doi: 10.1056/NEJMra0901557
    • Hidalgo, M. (2010). Pancreatic cancer. N. Engl. J. Med. 362, 1605-1617. doi: 10.1056/NEJMra0901557
    • (2010) N. Engl. J. Med. , vol.362 , pp. 1605-1617
    • Hidalgo, M.1
  • 24
    • 19344362405 scopus 로고    scopus 로고
    • Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
    • doi: 10.1016/j.ccr.2005.04.023
    • Hingorani, S. R., Wang, L., Multani, A. S., Combs, C., Deramaudt, T. B., Hruban, R. H., et al. (2005). Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 7, 469-483. doi: 10.1016/j.ccr.2005.04.023
    • (2005) Cancer Cell , vol.7 , pp. 469-483
    • Hingorani, S.R.1    Wang, L.2    Multani, A.S.3    Combs, C.4    Deramaudt, T.B.5    Hruban, R.H.6
  • 25
    • 0036096946 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of ABI-007, a Cremophor-free, protein-stabilized, nanoparticle formulation of paclitaxel
    • Ibrahim, N. K., Desai, N., Legha, S., Soon-Shiong, P., Theriault, R. L., Rivera, E., et al. (2002). Phase I and pharmacokinetic study of ABI-007, a Cremophor-free, protein-stabilized, nanoparticle formulation of paclitaxel. Clin. Cancer Res. 8, 1038-1044.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 1038-1044
    • Ibrahim, N.K.1    Desai, N.2    Legha, S.3    Soon-Shiong, P.4    Theriault, R.L.5    Rivera, E.6
  • 26
    • 80053405625 scopus 로고    scopus 로고
    • Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma
    • doi: 10.1172/JCI42754
    • Ijichi, H., Chytil, A., Gorska, A. E., Aakre, M. E., Bierie, B., Tada, M., et al. (2011). Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma. J. Clin. Invest. 121, 4106-4117. doi: 10.1172/JCI42754
    • (2011) J. Clin. Invest. , vol.121 , pp. 4106-4117
    • Ijichi, H.1    Chytil, A.2    Gorska, A.E.3    Aakre, M.E.4    Bierie, B.5    Tada, M.6
  • 27
    • 84871157346 scopus 로고    scopus 로고
    • Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer
    • doi: 10.1136/gutjnl-2012-302529
    • Jacobetz, M. A., Chan, D. S., Neesse, A., Bapiro, T. E., Cook, N., Frese, K. K., et al. (2013). Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer. Gut 62, 112-120. doi: 10.1136/gutjnl-2012-302529
    • (2013) Gut , vol.62 , pp. 112-120
    • Jacobetz, M.A.1    Chan, D.S.2    Neesse, A.3    Bapiro, T.E.4    Cook, N.5    Frese, K.K.6
  • 28
    • 60849118097 scopus 로고    scopus 로고
    • A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development
    • doi: 10.1158/1535-7163.MCT-08-0924
    • Jimeno, A., Feldmann, G., Suarez-Gauthier, A., Rasheed, Z., Solomon, A., Zou, G. M., et al. (2009). A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development. Mol. Cancer Ther. 8, 310-314. doi: 10.1158/1535-7163.MCT-08-0924
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 310-314
    • Jimeno, A.1    Feldmann, G.2    Suarez-Gauthier, A.3    Rasheed, Z.4    Solomon, A.5    Zou, G.M.6
  • 29
    • 84872277773 scopus 로고    scopus 로고
    • Immunotherapeutic benefit of alpha-interferon (IFNalpha) in survivin2B-derived peptide vaccination for advanced pancreatic cancer patients
    • doi: 10.1111/cas.12046
    • Kameshima, H., Tsuruma, T., Kutomi, G., Shima, H., Iwayama, Y., Kimura, Y., et al. (2013). Immunotherapeutic benefit of alpha-interferon (IFNalpha) in survivin2B-derived peptide vaccination for advanced pancreatic cancer patients. Cancer Sci. 104, 124-129. doi: 10.1111/cas.12046
    • (2013) Cancer Sci. , vol.104 , pp. 124-129
    • Kameshima, H.1    Tsuruma, T.2    Kutomi, G.3    Shima, H.4    Iwayama, Y.5    Kimura, Y.6
  • 30
    • 33646058889 scopus 로고    scopus 로고
    • Hedgehog signaling in the normal and diseased pancreas
    • doi: 10.1097/01.mpa.0000202937.55460.0c
    • Kayed, H., Kleeff, J., Osman, T., Keleg, S., Buchler, M. W., and Friess, H. (2006). Hedgehog signaling in the normal and diseased pancreas. Pancreas 32, 119-129. doi: 10.1097/01.mpa.0000202937.55460.0c
    • (2006) Pancreas , vol.32 , pp. 119-129
    • Kayed, H.1    Kleeff, J.2    Osman, T.3    Keleg, S.4    Buchler, M.W.5    Friess, H.6
  • 31
    • 84055217292 scopus 로고    scopus 로고
    • IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors
    • doi: 10.1172/JCI58814
    • Kerkar, S. P., Goldszmid, R. S., Muranski, P., Chinnasamy, D., Yu, Z., Reger, R. N., et al. (2011). IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors. J. Clin. Invest. 121, 4746-4757. doi: 10.1172/JCI58814
    • (2011) J. Clin. Invest. , vol.121 , pp. 4746-4757
    • Kerkar, S.P.1    Goldszmid, R.S.2    Muranski, P.3    Chinnasamy, D.4    Yu, Z.5    Reger, R.N.6
  • 32
    • 78650175637 scopus 로고    scopus 로고
    • Pancreatic stellate cells promote epithelial-mesenchymal transition in pancreatic cancer cells
    • doi: 10.1016/j.bbrc.2010.11.040
    • Kikuta, K., Masamune, A., Watanabe, T., Ariga, H., Itoh, H., Hamada, S., et al. (2010). Pancreatic stellate cells promote epithelial-mesenchymal transition in pancreatic cancer cells. Biochem. Biophys. Res. Commun. 403, 380-384. doi: 10.1016/j.bbrc.2010.11.040
    • (2010) Biochem. Biophys. Res. Commun. , vol.403 , pp. 380-384
    • Kikuta, K.1    Masamune, A.2    Watanabe, T.3    Ariga, H.4    Itoh, H.5    Hamada, S.6
  • 33
    • 77955887676 scopus 로고    scopus 로고
    • Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: phase III trial of the Cancer and Leukemia Group B (CALGB 80303)
    • doi: 10.1200/JCO.2010.28.1386
    • Kindler, H. L., Niedzwiecki, D., Hollis, D., Sutherland, S., Schrag, D., Hurwitz, H., et al. (2010). Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: phase III trial of the Cancer and Leukemia Group B (CALGB 80303). J. Clin. Oncol. 28, 3617-3622. doi: 10.1200/JCO.2010.28.1386
    • (2010) J. Clin. Oncol. , vol.28 , pp. 3617-3622
    • Kindler, H.L.1    Niedzwiecki, D.2    Hollis, D.3    Sutherland, S.4    Schrag, D.5    Hurwitz, H.6
  • 34
    • 84856547073 scopus 로고    scopus 로고
    • Gemcitabine plus sorafenib in patients with advanced pancreatic cancer: a phase II trial of the University of Chicago Phase II Consortium
    • doi: 10.1007/s10637-010-9526-z
    • Kindler, H. L., Wroblewski, K., Wallace, J. A., Hall, M. J., Locker, G., Nattam, S., et al. (2012). Gemcitabine plus sorafenib in patients with advanced pancreatic cancer: a phase II trial of the University of Chicago Phase II Consortium. Invest. New Drugs 30, 382-386. doi: 10.1007/s10637-010-9526-z
    • (2012) Invest. New Drugs , vol.30 , pp. 382-386
    • Kindler, H.L.1    Wroblewski, K.2    Wallace, J.A.3    Hall, M.J.4    Locker, G.5    Nattam, S.6
  • 35
    • 2342634392 scopus 로고    scopus 로고
    • Phase 1B study to improve immune responses in head and neck cancer patients using escalating doses of 25-hydroxyvitamin D3
    • doi: 10.1007/s00262-003-0459-7
    • Lathers, D. M., Clark, J. I., Achille, N. J., and Young, M. R. (2004). Phase 1B study to improve immune responses in head and neck cancer patients using escalating doses of 25-hydroxyvitamin D3. Cancer Immunol. Immunother. 53, 422-430. doi: 10.1007/s00262-003-0459-7
    • (2004) Cancer Immunol. Immunother. , vol.53 , pp. 422-430
    • Lathers, D.M.1    Clark, J.I.2    Achille, N.J.3    Young, M.R.4
  • 36
    • 77958171910 scopus 로고    scopus 로고
    • Stromal SPARC expression and patient survival after chemoradiation for non-resectable pancreatic adenocarcinoma
    • doi: 10.4161/cbt.7.11.6846
    • Mantoni, T. S., Schendel, R. R., Rodel, F., Niedobitek, G., Al-Assar, O., Masamune, A., et al. (2008). Stromal SPARC expression and patient survival after chemoradiation for non-resectable pancreatic adenocarcinoma. Cancer Biol. Ther. 7, 1806-1815. doi: 10.4161/cbt.7.11.6846
    • (2008) Cancer Biol. Ther. , vol.7 , pp. 1806-1815
    • Mantoni, T.S.1    Schendel, R.R.2    Rodel, F.3    Niedobitek, G.4    Al-Assar, O.5    Masamune, A.6
  • 37
    • 84876501232 scopus 로고    scopus 로고
    • The angiotensin II type I receptor blocker olmesartan inhibits the growth of pancreatic cancer by targeting stellate cell activities in mice
    • doi: 10.3109/00365521.2013.777776
    • Masamune, A., Hamada, S., Kikuta, K., Takikawa, T., Miura, S., Nakano, E., et al. (2013). The angiotensin II type I receptor blocker olmesartan inhibits the growth of pancreatic cancer by targeting stellate cell activities in mice. Scand. J. Gastroenterol. 48, 602-609. doi: 10.3109/00365521.2013.777776
    • (2013) Scand. J. Gastroenterol. , vol.48 , pp. 602-609
    • Masamune, A.1    Hamada, S.2    Kikuta, K.3    Takikawa, T.4    Miura, S.5    Nakano, E.6
  • 38
    • 21044443467 scopus 로고    scopus 로고
    • Green tea polyphenol epigallocatechin-3-gallate blocks PDGF-induced proliferation and migration of rat pancreatic stellate cells
    • Masamune, A., Kikuta, K., Satoh, M., Suzuki, N., and Shimosegawa, T. (2005a). Green tea polyphenol epigallocatechin-3-gallate blocks PDGF-induced proliferation and migration of rat pancreatic stellate cells. World J. Gastroenterol. 11, 3368-3374.
    • (2005) World J. Gastroenterol. , vol.11 , pp. 3368-3374
    • Masamune, A.1    Kikuta, K.2    Satoh, M.3    Suzuki, N.4    Shimosegawa, T.5
  • 39
    • 23744492100 scopus 로고    scopus 로고
    • Ellagic acid blocks activation of pancreatic stellate cells
    • doi: 10.1016/j.bcp.2005.06.008
    • Masamune, A., Satoh, M., Kikuta, K., Suzuki, N., Satoh, K., and Shimosegawa, T. (2005b). Ellagic acid blocks activation of pancreatic stellate cells. Biochem. Pharmacol. 70, 869-878. doi: 10.1016/j.bcp.2005.06.008
    • (2005) Biochem. Pharmacol. , vol.70 , pp. 869-878
    • Masamune, A.1    Satoh, M.2    Kikuta, K.3    Suzuki, N.4    Satoh, K.5    Shimosegawa, T.6
  • 40
    • 65049091645 scopus 로고    scopus 로고
    • Signal transduction in pancreatic stellate cells
    • doi: 10.1007/s00535-009-0013-2
    • Masamune, A., and Shimosegawa, T. (2009). Signal transduction in pancreatic stellate cells. J. Gastroenterol. 44, 249-260. doi: 10.1007/s00535-009-0013-2
    • (2009) J. Gastroenterol. , vol.44 , pp. 249-260
    • Masamune, A.1    Shimosegawa, T.2
  • 41
    • 84877984622 scopus 로고    scopus 로고
    • Pancreatic stellate cells-multi-functional cells in the pancreas
    • doi: 10.1016/j.pan.2012.12.058
    • Masamune, A., and Shimosegawa, T. (2013). Pancreatic stellate cells-multi-functional cells in the pancreas. Pancreatology 13, 102-105. doi: 10.1016/j.pan.2012.12.058
    • (2013) Pancreatology , vol.13 , pp. 102-105
    • Masamune, A.1    Shimosegawa, T.2
  • 42
    • 33645212674 scopus 로고    scopus 로고
    • Curcumin blocks activation of pancreatic stellate cells
    • doi: 10.1002/jcb.20698
    • Masamune, A., Suzuki, N., Kikuta, K., Satoh, M., Satoh, K., and Shimosegawa, T. (2006). Curcumin blocks activation of pancreatic stellate cells. J. Cell. Biochem. 97, 1080-1093. doi: 10.1002/jcb.20698
    • (2006) J. Cell. Biochem. , vol.97 , pp. 1080-1093
    • Masamune, A.1    Suzuki, N.2    Kikuta, K.3    Satoh, M.4    Satoh, K.5    Shimosegawa, T.6
  • 44
    • 84872066969 scopus 로고    scopus 로고
    • Current concepts and novel targets in advanced pancreatic cancer
    • doi: 10.1136/gutjnl-2012-303588
    • Michl, P., and Gress, T. M. (2013). Current concepts and novel targets in advanced pancreatic cancer. Gut 62, 317-326. doi: 10.1136/gutjnl-2012-303588
    • (2013) Gut , vol.62 , pp. 317-326
    • Michl, P.1    Gress, T.M.2
  • 45
    • 33749461167 scopus 로고    scopus 로고
    • All-trans-retinoic acid improves differentiation of myeloid cells and immune response in cancer patients
    • doi: 10.1158/0008-5472.CAN-06-1690
    • Mirza, N., Fishman, M., Fricke, I., Dunn, M., Neuger, A. M., Frost, T. J., et al. (2006). All-trans-retinoic acid improves differentiation of myeloid cells and immune response in cancer patients. Cancer Res. 66, 9299-9307. doi: 10.1158/0008-5472.CAN-06-1690
    • (2006) Cancer Res. , vol.66 , pp. 9299-9307
    • Mirza, N.1    Fishman, M.2    Fricke, I.3    Dunn, M.4    Neuger, A.M.5    Frost, T.J.6
  • 46
    • 78650224339 scopus 로고    scopus 로고
    • Inhibition of renin-angiotensin system affects prognosis of advanced pancreatic cancer receiving gemcitabine
    • doi: 10.1038/sj.bjc.6605955
    • Nakai, Y., Isayama, H., Ijichi, H., Sasaki, T., Sasahira, N., Hirano, K., et al. (2010). Inhibition of renin-angiotensin system affects prognosis of advanced pancreatic cancer receiving gemcitabine. Br. J. Cancer 103, 1644-1648. doi: 10.1038/sj.bjc.6605955
    • (2010) Br. J. Cancer , vol.103 , pp. 1644-1648
    • Nakai, Y.1    Isayama, H.2    Ijichi, H.3    Sasaki, T.4    Sasahira, N.5    Hirano, K.6
  • 47
    • 84880658054 scopus 로고    scopus 로고
    • CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer
    • doi: 10.1073/pnas.1300415110
    • Neesse, A., Frese, K. K., Bapiro, T. E., Nakagawa, T., Sternlicht, M. D., Seeley, T. W., et al. (2013a). CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer. Proc. Natl. Acad. Sci. U.S.A. 110, 12325-12330. doi: 10.1073/pnas.1300415110
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 12325-12330
    • Neesse, A.1    Frese, K.K.2    Bapiro, T.E.3    Nakagawa, T.4    Sternlicht, M.D.5    Seeley, T.W.6
  • 48
    • 84899954489 scopus 로고    scopus 로고
    • SPARC independent drug delivery and antitumour effects of nab-paclitaxel in genetically engineered mice
    • doi: 10.1136/gutjnl-2013-305559. [Epub ahead of print].
    • Neesse, A., Frese, K. K., Chan, D. S., Bapiro, T. E., Howat, W. J., Richards, F. M., et al. (2013b). SPARC independent drug delivery and antitumour effects of nab-paclitaxel in genetically engineered mice. Gut doi: 10.1136/gutjnl-2013-305559. [Epub ahead of print].
    • (2013) Gut
    • Neesse, A.1    Frese, K.K.2    Chan, D.S.3    Bapiro, T.E.4    Howat, W.J.5    Richards, F.M.6
  • 50
    • 84865204316 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled first in human study to investigate an oral vaccine aimed to elicit an immune reaction against the VEGF-Receptor 2 in patients with stage IV and locally advanced pancreatic cancer
    • doi: 10.1186/1471-2407-12-361
    • Niethammer, A. G., Lubenau, H., Mikus, G., Knebel, P., Hohmann, N., Leowardi, C., et al. (2012). Double-blind, placebo-controlled first in human study to investigate an oral vaccine aimed to elicit an immune reaction against the VEGF-Receptor 2 in patients with stage IV and locally advanced pancreatic cancer. BMC Cancer 12:361. doi: 10.1186/1471-2407-12-361
    • (2012) BMC Cancer , vol.12 , pp. 361
    • Niethammer, A.G.1    Lubenau, H.2    Mikus, G.3    Knebel, P.4    Hohmann, N.5    Leowardi, C.6
  • 51
    • 67149143399 scopus 로고    scopus 로고
    • Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
    • doi: 10.1126/science.1171362
    • Olive, K. P., Jacobetz, M. A., Davidson, C. J., Gopinathan, A., McIntyre, D., Honess, D., et al. (2009). Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 324, 1457-1461. doi: 10.1126/science.1171362
    • (2009) Science , vol.324 , pp. 1457-1461
    • Olive, K.P.1    Jacobetz, M.A.2    Davidson, C.J.3    Gopinathan, A.4    McIntyre, D.5    Honess, D.6
  • 53
    • 78650988960 scopus 로고    scopus 로고
    • A Cancer and Leukemia Group B phase II study of sunitinib malate in patients with previously treated metastatic pancreatic adenocarcinoma (CALGB 80603)
    • doi: 10.1634/theoncologist.2010-0152
    • O'Reilly, E. M., Niedzwiecki, D., Hall, M., Hollis, D., Bekaii-Saab, T., Pluard, T., et al. (2010). A Cancer and Leukemia Group B phase II study of sunitinib malate in patients with previously treated metastatic pancreatic adenocarcinoma (CALGB 80603). Oncologist 15, 1310-1319. doi: 10.1634/theoncologist.2010-0152
    • (2010) Oncologist , vol.15 , pp. 1310-1319
    • O'Reilly, E.M.1    Niedzwiecki, D.2    Hall, M.3    Hollis, D.4    Bekaii-Saab, T.5    Pluard, T.6
  • 54
    • 65249138393 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells: linking inflammation and cancer
    • doi: 10.4049/jimmunol.0802740
    • Ostrand-Rosenberg, S., and Sinha, P. (2009). Myeloid-derived suppressor cells: linking inflammation and cancer. J. Immunol. 182, 4499-4506. doi: 10.4049/jimmunol.0802740
    • (2009) J. Immunol. , vol.182 , pp. 4499-4506
    • Ostrand-Rosenberg, S.1    Sinha, P.2
  • 55
    • 79953826393 scopus 로고    scopus 로고
    • Involvement of angiotensin II and reactive oxygen species in pancreatic fibrosis
    • doi: 10.1159/000323478
    • Sakurai, T., Kudo, M., Fukuta, N., Nakatani, T., Kimura, M., Park, A. M., et al. (2011). Involvement of angiotensin II and reactive oxygen species in pancreatic fibrosis. Pancreatology 11(Suppl. 2), 7-13. doi: 10.1159/000323478
    • (2011) Pancreatology , vol.11 , Issue.SUPPL. 2 , pp. 7-13
    • Sakurai, T.1    Kudo, M.2    Fukuta, N.3    Nakatani, T.4    Kimura, M.5    Park, A.M.6
  • 56
    • 84879490648 scopus 로고    scopus 로고
    • Contribution of bone marrow derived cells to the pancreatic tumor microenvironment
    • doi: 10.3389/fphys.2013.00056
    • Scarlett, C. J. (2013). Contribution of bone marrow derived cells to the pancreatic tumor microenvironment. Front. Physiol. 4:56. doi: 10.3389/fphys.2013.00056
    • (2013) Front. Physiol. , vol.4 , pp. 56
    • Scarlett, C.J.1
  • 57
    • 84888610822 scopus 로고    scopus 로고
    • Dual inhibition of MEK1/2 and EGFR synergistically induces caspase-3-dependent apoptosis in EGFR inhibitor-resistant lung cancer cells via BIM upregulation
    • doi: 10.1007/s10637-013-0030-0. [Epub ahead of print].
    • Song, J. Y., Kim, C. S., Lee, J. H., Jang, S. J., Lee, S. W., Hwang, J. J., et al. (2013). Dual inhibition of MEK1/2 and EGFR synergistically induces caspase-3-dependent apoptosis in EGFR inhibitor-resistant lung cancer cells via BIM upregulation. Invest. New Drugs doi: 10.1007/s10637-013-0030-0. [Epub ahead of print].
    • (2013) Invest. New Drugs
    • Song, J.Y.1    Kim, C.S.2    Lee, J.H.3    Jang, S.J.4    Lee, S.W.5    Hwang, J.J.6
  • 58
    • 72949103044 scopus 로고    scopus 로고
    • Small-molecule modulators of the Sonic Hedgehog signaling pathway
    • doi: 10.1039/b910196a
    • Stanton, B. Z., and Peng, L. F. (2010). Small-molecule modulators of the Sonic Hedgehog signaling pathway. Mol. Biosyst. 6, 44-54. doi: 10.1039/b910196a
    • (2010) Mol. Biosyst. , vol.6 , pp. 44-54
    • Stanton, B.Z.1    Peng, L.F.2
  • 59
    • 79954987520 scopus 로고    scopus 로고
    • The role of interleukin-12 on modulating myeloid-derived suppressor cells, increasing overall survival and reducing metastasis
    • doi: 10.1111/j.1365-2567.2011.03429.x
    • Steding, C. E., Wu, S. T., Zhang, Y., Jeng, M. H., Elzey, B. D., and Kao, C. (2011). The role of interleukin-12 on modulating myeloid-derived suppressor cells, increasing overall survival and reducing metastasis. Immunology 133, 221-238. doi: 10.1111/j.1365-2567.2011.03429.x
    • (2011) Immunology , vol.133 , pp. 221-238
    • Steding, C.E.1    Wu, S.T.2    Zhang, Y.3    Jeng, M.H.4    Elzey, B.D.5    Kao, C.6
  • 60
    • 34247252488 scopus 로고    scopus 로고
    • Systematic review, including meta-analyses, on the management of locally advanced pancreatic cancer using radiation/combined modality therapy
    • doi: 10.1038/sj.bjc.6603719
    • Sultana, A., Tudur Smith, C., Cunningham, D., Starling, N., Tait, D., Neoptolemos, J. P., et al. (2007). Systematic review, including meta-analyses, on the management of locally advanced pancreatic cancer using radiation/combined modality therapy. Br. J. Cancer 96, 1183-1190. doi: 10.1038/sj.bjc.6603719
    • (2007) Br. J. Cancer , vol.96 , pp. 1183-1190
    • Sultana, A.1    Tudur Smith, C.2    Cunningham, D.3    Starling, N.4    Tait, D.5    Neoptolemos, J.P.6
  • 61
    • 84887016132 scopus 로고    scopus 로고
    • Clinical implications of T790M mutation in patients with acquired resistance to EGFR tyrosine kinase inhibitors
    • doi: 10.1016/j.lungcan.2013.08.023. [Epub ahead of print].
    • Sun, J. M., Ahn, M. J., Choi, Y. L., Ahn, J. S., and Park, K. (2013). Clinical implications of T790M mutation in patients with acquired resistance to EGFR tyrosine kinase inhibitors. Lung Cancer doi: 10.1016/j.lungcan.2013.08.023. [Epub ahead of print].
    • (2013) Lung Cancer
    • Sun, J.M.1    Ahn, M.J.2    Choi, Y.L.3    Ahn, J.S.4    Park, K.5
  • 62
    • 84880956327 scopus 로고    scopus 로고
    • miR-210 regulates the interaction between pancreatic cancer cells and stellate cells
    • doi: 10.1016/j.bbrc.2013.06.097
    • Takikawa, T., Masamune, A., Hamada, S., Nakano, E., Yoshida, N., and Shimosegawa, T. (2013). miR-210 regulates the interaction between pancreatic cancer cells and stellate cells. Biochem. Biophys. Res. Commun. 437, 433-439. doi: 10.1016/j.bbrc.2013.06.097
    • (2013) Biochem. Biophys. Res. Commun. , vol.437 , pp. 433-439
    • Takikawa, T.1    Masamune, A.2    Hamada, S.3    Nakano, E.4    Yoshida, N.5    Shimosegawa, T.6
  • 63
    • 83355169753 scopus 로고    scopus 로고
    • Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: a phase I/II trial
    • doi: 10.1200/JCO.2011.36.5742
    • Von Hoff, D. D., Ramanathan, R. K., Borad, M. J., Laheru, D. A., Smith, L. S., Wood, T. E., et al. (2011). Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: a phase I/II trial. J. Clin. Oncol. 29, 4548-4554. doi: 10.1200/JCO.2011.36.5742
    • (2011) J. Clin. Oncol. , vol.29 , pp. 4548-4554
    • Von Hoff, D.D.1    Ramanathan, R.K.2    Borad, M.J.3    Laheru, D.A.4    Smith, L.S.5    Wood, T.E.6
  • 64
    • 42049097658 scopus 로고    scopus 로고
    • Pancreatic stellate cells: partners in crime with pancreatic cancer cells
    • doi: 10.1158/0008-5472.CAN-07-2477
    • Vonlaufen, A., Joshi, S., Qu, C., Phillips, P. A., Xu, Z., Parker, N. R., et al. (2008). Pancreatic stellate cells: partners in crime with pancreatic cancer cells. Cancer Res. 68, 2085-2093. doi: 10.1158/0008-5472.CAN-07-2477
    • (2008) Cancer Res. , vol.68 , pp. 2085-2093
    • Vonlaufen, A.1    Joshi, S.2    Qu, C.3    Phillips, P.A.4    Xu, Z.5    Parker, N.R.6
  • 65
    • 78049398107 scopus 로고    scopus 로고
    • Distant metastasis occurs late during the genetic evolution of pancreatic cancer
    • doi: 10.1038/nature09515
    • Yachida, S., Jones, S., Bozic, I., Antal, T., Leary, R., Fu, B., et al. (2010). Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature 467, 1114-1117. doi: 10.1038/nature09515
    • (2010) Nature , vol.467 , pp. 1114-1117
    • Yachida, S.1    Jones, S.2    Bozic, I.3    Antal, T.4    Leary, R.5    Fu, B.6
  • 66
    • 0141630677 scopus 로고    scopus 로고
    • Candesartan, an angiotensin II receptor antagonist, suppresses pancreatic inflammation and fibrosis in rats
    • doi: 10.1124/jpet.103.053322
    • Yamada, T., Kuno, A., Masuda, K., Ogawa, K., Sogawa, M., Nakamura, S., et al. (2003). Candesartan, an angiotensin II receptor antagonist, suppresses pancreatic inflammation and fibrosis in rats. J. Pharmacol. Exp. Ther. 307, 17-23. doi: 10.1124/jpet.103.053322
    • (2003) J. Pharmacol. Exp. Ther. , vol.307 , pp. 17-23
    • Yamada, T.1    Kuno, A.2    Masuda, K.3    Ogawa, K.4    Sogawa, M.5    Nakamura, S.6
  • 67
    • 40449105940 scopus 로고    scopus 로고
    • Equilibrium between host and cancer caused by effector T cells killing tumor stroma
    • doi: 10.1158/0008-5472.CAN-07-5324
    • Zhang, B., Zhang, Y., Bowerman, N. A., Schietinger, A., Fu, Y. X., Kranz, D. M., et al. (2008). Equilibrium between host and cancer caused by effector T cells killing tumor stroma. Cancer Res. 68, 1563-1571. doi: 10.1158/0008-5472.CAN-07-5324
    • (2008) Cancer Res. , vol.68 , pp. 1563-1571
    • Zhang, B.1    Zhang, Y.2    Bowerman, N.A.3    Schietinger, A.4    Fu, Y.X.5    Kranz, D.M.6


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