Comparison of antiproliferative effects of 1-histamine-2 receptor antagonists, cimetidine, ranitidine, and famotidine, in gastric cancer cells

International Journal of Immunopharmacology

Volumn 18, Issue 6-7, 1996, Pages 393-399

  Hahm, Ki Baik ^a   Park, In Suh ^b   Kim, Hyo Churl ^a   Lee, Kwang Jae ^a   Kim, Jin Hong ^a   Cho, Sung Won ^a   Lee, Sang In ^a  

^a Ajou University School of Medicine   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

Author keywords

Antiproliferation; Gastric cancer; Histamine 2 receptor antagonist

Indexed keywords

CIMETIDINE; FAMOTIDINE; HISTAMINE; HISTAMINE H2 RECEPTOR ANTAGONIST; RANITIDINE;

ADENOCARCINOMA; ARTICLE; CANCER CELL; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; STOMACH CANCER;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS; CELL COUNT; CELL DIVISION; CIMETIDINE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; FAMOTIDINE; HISTAMINE; HISTAMINE H2 ANTAGONISTS; HUMANS; ORNITHINE DECARBOXYLASE; RANITIDINE; STOMACH NEOPLASMS; THYMIDINE; TUMOR CELLS, CULTURED;

EID: 18744428631     PISSN: 01920561     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0192-0561(96)00044-6     Document Type: Article

References (28)

1. Adams, W. J., Lawson, J. A. & Morris, D. L. (1994) Cimetidine inhibits in vivo growth of human colon cancer and reverses histamine stimulated in vitro and in vivo growth. Gut, 35, 1632-1636.
2. Adams, W. J., Lawson, J. A., Nicholson, S. E., Cook, T. E. & Morris, D. L. (1993) The growth of carcinogen induced colon cancer in rats is inhibited by cimetidine. Eur. J. Surg. Oncol., 19, 332-335.
3. Armitage, J. Q. & Sidner, R. D. (1979) Antitumor effect of cimetidine?. Lancet, i, 882-883.
4. Bartholyns, J. & Bouclier, M. (1984) Involvement of histamine in growth of mouse and rat tumors: antitumoral properties of monofluoromethylhistidine, an enzyme activated irreversible inhibitor of histidine decarboxylase. Cancer Res., 44, 639-645.
5. Bartholyns, J. & Fozard, J. R. (1985) Role of histamine in tumor development. Trends Pharmacol. Sci., 6, 123-125.
6. Beer, D. J. & Rocklin, R. E. (1984) Histamine-induced suppressor cell activity. J. Allergy clin. Immun., 73, 439-452.
7. Feldman, M. & Cunningham, D. (1990) Histamine 2-receptor antagonists-standard therapy for aid-peptic diseases. New Eng. J. Med., 323, 1672-1680.
8. Findlay, M. & Cunningham, D. (1993) Chemotherapy of carcinoma of the stomach. Cancer Treatment Rev., 19, 29-44.
9. Gifford, M., Ferguson, R. & Voss, B. (1981) Cimetidine reduction of tumor formation in mice. Lancet, i, 638-639.
10. Gifford, R. R. M., Hatfield, S. M. & Schmidtke, J. R. (1980) Cimetidine-induced, augmentation of human lymphocyte blastogenesis by mitogen, bacterial antigen, and alloantigen. Transplantation, 29, 143-148.
11. Gifford, R. R. M., Voss, B. V., Schmidtke, J. R. & Ferguson, R. M. (1988) Histamine type-2 receptor antagonist immune modulation I. Increased cell-mediated cytotoxicity in normal and down-regulated system. Surgery, 103, 184-192.
12. Hahm, K. B., Lee, S. I., Chung, J. P., Kim, W. H., Kim, J. H., Park, I. S. (1994) Comparison of immunomodulative effects of histamine-2 receptor antagonists in gastric cancer patients: focus on the lymphoblastogenesis and cytotoxicity of peripheral blood mononuclear cells. Int. J. Immunopharmac., 16, 985-993.
13. Hahm, K. B., Park, I. S., Kim, W. H., Han, K. H., Moon, Y. M. & Kang, J. K. (1993) Identification of the presence of histamine-2 receptor in peripheral blood mononuclear cells and cultured gastric cancer cells, KATO-III and AGS (Abstract). Kor. J. Gastroenterol., 25, 24.
14. Kikuchi, Y., Oomori, K. & Kato, K. (1985) Effects of cimetidine on growth and immune function in nude mice bearing human ovarian carcinoma. J. natn. Cancer Inst., 74, 495-498.
15. Laboisse, C. L., Augeron, C., Couturier-Turpin, M., Gespach, C., Cheret, A. & Potet, F. (1982) Characterization of a newly established human gastric cancer cell line HGT-1 bearing histamine H2-receptors. Cancer Res., 42, 1541-1548.
16. McKenna, P., Williams, J. M., Gespach, C. P. & Hanson, P. J. (1993) Protein kinase C inhibits cyclic adenosine monophosphate generation by histamine and truncated glucagon like peptide 1 in the human gastric cancer cell line HGT-1. Gut, 34, 953-957.
17. Mosmann, T. (1983) Rapid calorimetric assay for cellular growth and survival; application to proliferation and cytotoxicity assay. J. Immun. Meth., 65, 55-63.
18. Obsand, M., Shen, Y. J., Shlesinger, M., Brown, A., Hamilton, D. & Cohen, E. (1981) Successful immunotherapy with cimetidine in mice. Lancet, i, 636-638.
19. Roskoski, R. (1983) Assays of protein kinase. Meth. Enzymol., 99, 3-6.
20. Rocklin, R. E. (1976) Modulation of cellular-immune response in vivo and in vitro by histamine receptor-bearing lymphocytes. J. clin. Invest., 57, 1051-1058.
21. Rocklin, R. E., Breard, J., Gupta, S., Good, R. A. & Melmon, K. L. (1980) Characterization of the human blood lymphocytes that produce a histamine-induced suppressor factor (HSF). Cell. Immun., 51, 226-237.
22. Thornes, R. D., Lynch. E. & Sheehan, M. V. (1982) Cimetidine and coumarin therapy of melanoma. Lancet, ii, 328.
23. Tonnesen, H., Knigges, U., Bulow, S., Damm, P., Fischerman, K., Hesselfeld, P., Hjortrup, A., Pedersen, I. K., Pedersen, V. M., Siemssen, O. J., Svendsen, L. B. & Christiansen, P. M. (1988) Effect of cimetidine on survival after gastric cancer. Lancet, ii, 990-991.
24. Tsunoda, T., Tanimura, H., Yamaue, H., Iwahashi, M., Tani, M., Tamai, M., Arii, K. & Noguchi, K. (1992) In vitro augmentation of the cytotoxic activity of peripheral blood mononuclear cells and tumor-infiltrating lymphocytes by famotidine in cancer patients. Int. J. Immunopharmac., 14, 75-81.
25. Wang, S. R. & Zweiman, B. (1978) Histamine suppression of human lymphocyte response to mitogens. Cell. Immun., 36, 28-36.
26. Watson, S. A., Wilkinson, L. J., Robertson, J. F. R. & Hardcastle, J. D. (1993) Effect of histamine on the growth of human gastrointestinal tumors: reversal by cimetidine. Gut, 34, 1091-1096.
27. Whitehead, R. L, Talor, D., Evanson, J., Hart, I. & Woolley, D. (1988) Demonstration of histamine H2 receptors on human melanoma cells. Biochem. biophys. Res. Commun., 151, 518-523.
28. Wolfe, M. M. (1991) At long last - the histamine H2-receptor gene is cloned. Gastroenterology, 101, 554-555.