The antifungal drug itraconazole inhibits Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) glycosylation, trafficking, and signaling in endothelial cells

Journal of Biological Chemistry

Volumn 286, Issue 51, 2011, Pages 44045-44056

  Nacev, Benjamin A ^a   Grassi, Paola ^b   Dell, Anne ^b   Haslam, Stuart M ^b   Liu, Jun O ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS; ANTI-ANGIOGENIC ACTIVITY; ANTIFUNGAL DRUGS; CELL SURFACE EXPRESSION; CELLULAR CHOLESTEROL; CHOLESTEROL ACCUMULATION; CLINICAL TRIAL; EPIDERMAL GROWTH FACTOR RECEPTORS; GROWTH FACTOR; ITRACONAZOLE; MAMMALIAN TARGET OF RAPAMYCIN (MTOR); N-GLYCANS; PHOSPHOLIPASE C; RENAL CELL CARCINOMA; SMALL MOLECULES; TUMOR GROWTH; VASCULAR ENDOTHELIAL GROWTH FACTOR; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR; VEGFR-2;

ANTIBIOTICS; CELL MEMBRANES; CHOLESTEROL; ESTERIFICATION; GLYCOSYLATION; MAMMALS; PEPTIDES; SURFACE DEFECTS; TUMORS;

ENDOTHELIAL CELLS;

CHOLESTEROL; EPIDERMAL GROWTH FACTOR RECEPTOR; GLYCAN DERIVATIVE; ITRACONAZOLE; MAMMALIAN TARGET OF RAPAMYCIN; N GLYCAN; PHOSPHOLIPASE C GAMMA1; POLY N ACETYLLACTOSAMINE; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

ARTICLE; CELL LEVEL; CELL SURFACE; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DRUG EFFECT; DRUG TARGETING; ENDOTHELIUM CELL; ENZYME INHIBITION; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; PROTEIN TRANSPORT; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

ANTIFUNGAL AGENTS; BIOTINYLATION; CELL LINE; CELL PROLIFERATION; ENDOTHELIAL CELLS; GLYCOSYLATION; HUMANS; ITRACONAZOLE; MODELS, BIOLOGICAL; NEOVASCULARIZATION, PATHOLOGIC; POLYSACCHARIDES; SIGNAL TRANSDUCTION; STEROLS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 83755162608     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.278754     Document Type: Article

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