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Volumn 88, Issue 10, 2014, Pages 1881-1906

Effects of SiO2, ZrO2, and BaSO4 nanomaterials with or without surface functionalization upon 28-day oral exposure to rats

Author keywords

Metabolomics; Nanomaterial (NM); OECD test guideline 407; Oral route of exposure; Subacute toxicity; Surface functionalization

Indexed keywords

ALPHA 2 MACROGLOBULIN; BARIUM SULFATE NANOPARTICLE; HAPTOGLOBIN; NANOPARTICLE; SILICA NANOPARTICLE; TROPONIN I; UNCLASSIFIED DRUG; ZIRCONIUM DIOXIDE NANOPARTICLE; BARIUM SULFATE; NANOMATERIAL; SILICON DIOXIDE; ZIRCONIUM; ZIRCONIUM OXIDE;

EID: 84919905019     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1337-0     Document Type: Article
Times cited : (42)

References (75)
  • 2
    • 84919907475 scopus 로고    scopus 로고
    • Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC
    • Anon (2006) Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC. OJ L 396:1, 30 December 2006
    • OJ L , vol.396 , Issue.1 , pp. 30
  • 3
    • 85028156394 scopus 로고    scopus 로고
    • Types and uses of nanomaterials, including safety aspects (COM(2012) 572 final. SWD(2012) 288 final
    • Anon (2012) Commission staff working paper accompanying the Communication from the Commission to the European Parliament, the Council and the European Economic and Social Committee on the second regulatory review on nanomaterials: Types and uses of nanomaterials, including safety aspects (COM(2012) 572 final. SWD(2012) 288 final. Brussels, 3 October 2012
    • Brussels , pp. 3
  • 5
    • 77949399860 scopus 로고    scopus 로고
    • NMR-based metabonomic study of the sub-acute toxicity of titanium dioxide nanoparticles in rats after oral administration
    • Bu Q, Yan G, Deng P, Peng F, Lin H, Xu Y, Cao Z, Zhou T, Xue A, Wang Y, Cen X, Zhao YL (2010) NMR-based metabonomic study of the sub-acute toxicity of titanium dioxide nanoparticles in rats after oral administration. Nanotechnol 21:125105
    • (2010) Nanotechnol , vol.21 , pp. 125105
    • Bu, Q.1    Yan, G.2    Deng, P.3    Peng, F.4    Lin, H.5    Xu, Y.6    Cao, Z.7    Zhou, T.8    Xue, A.9    Wang, Y.10    Cen, X.11    Zhao, Y.L.12
  • 6
    • 84875296181 scopus 로고    scopus 로고
    • Comparative absorption, distribution, and excretion of titanium dioxide and zinc oxide nanoparticles after repeated oral administration
    • PID: 23531334, COI: 1:CAS:528:DC%2BC3sXns1Ors7s%3D
    • Cho WS, Kang BC, Lee JK, Jeong J, Che JH, Seok SH (2013) Comparative absorption, distribution, and excretion of titanium dioxide and zinc oxide nanoparticles after repeated oral administration. Part Fibre Toxicol 10:9
    • (2013) Part Fibre Toxicol , vol.10 , pp. 9
    • Cho, W.S.1    Kang, B.C.2    Lee, J.K.3    Jeong, J.4    Che, J.H.5    Seok, S.H.6
  • 7
    • 84871622942 scopus 로고    scopus 로고
    • Drug delivery to inflamed colon by nanoparticles: comparison of different strategies
    • PID: 22820482, COI: 1:CAS:528:DC%2BC38XhtF2hsLvI
    • Coco R, Plapied L, Pourcelle V, Jérôme C, Brayden DJ, Schneider YJ, Préat V (2013) Drug delivery to inflamed colon by nanoparticles: comparison of different strategies. Int J Pharm 440:3–12
    • (2013) Int J Pharm , vol.440 , pp. 3-12
    • Coco, R.1    Plapied, L.2    Pourcelle, V.3    Jérôme, C.4    Brayden, D.J.5    Schneider, Y.J.6    Préat, V.7
  • 8
    • 84877288651 scopus 로고    scopus 로고
    • Knowledge gaps in risk assessment of nanosilica in food: evaluation of the dissolution and toxicity of different forms of silica
    • COI: 1:CAS:528:DC%2BC3sXnt12qt7k%3D
    • Dekkers S, Bouwmeester H, Bos PMJ, Peters RJB, Rietveld AG, Oomen AG (2013) Knowledge gaps in risk assessment of nanosilica in food: evaluation of the dissolution and toxicity of different forms of silica. Nanotoxicol 7(4):367–377
    • (2013) Nanotoxicol , vol.7 , Issue.4 , pp. 367-377
    • Dekkers, S.1    Bouwmeester, H.2    Bos, P.M.J.3    Peters, R.J.B.4    Rietveld, A.G.5    Oomen, A.G.6
  • 9
    • 0032402219 scopus 로고    scopus 로고
    • Evaluation of nano- and microparticle uptake by the gastrointestinal tract
    • PID: 10837679, COI: 1:CAS:528:DyaK1cXnsFWlt7w%3D
    • Delie F (1998) Evaluation of nano- and microparticle uptake by the gastrointestinal tract. Adv Drug Deliv Rev 34:221–233
    • (1998) Adv Drug Deliv Rev , vol.34 , pp. 221-233
    • Delie, F.1
  • 10
    • 4243730494 scopus 로고    scopus 로고
    • Recognition of, and differentiation between, adverse and non-adverse effects in toxicology studies. Technical Report No. 85. ISSN-0773-6347-85, Brussels
    • ECETOC (2002) Recognition of, and differentiation between, adverse and non-adverse effects in toxicology studies. Technical Report No. 85. ISSN-0773-6347-85, Brussels, December 2002
    • (2002) December , pp. 2002
  • 11
    • 85028167871 scopus 로고    scopus 로고
    • WR 11. Workshop on the application of ‘omics’ in toxicology and ecotoxicology: case studies and risk assessment
    • ECETOC (2008) WR 11. Workshop on the application of ‘omics’ in toxicology and ecotoxicology: case studies and risk assessment. Brussels, July 2008. http://www.ecetoc.org/workshop-reports
    • (2008) Brussels, July , pp. 2008
  • 12
    • 85028141329 scopus 로고    scopus 로고
    • WR 19. Omics in (eco)toxicology: case studies and risk assessment
    • ECETOC (2010) WR 19. Omics in (eco)toxicology: case studies and risk assessment. June 2010. http://www.ecetoc.org/workshop-reports
    • (2010) June , pp. 2010
  • 13
    • 85028160268 scopus 로고    scopus 로고
    • WR 25. ‘Omics and risk assessment science
    • ECETOC (2013) WR 25. ‘Omics and risk assessment science. October 2013. http://www.ecetoc.org/workshop-reports
    • (2013) October , pp. 2013
  • 14
    • 85028143100 scopus 로고    scopus 로고
    • Appendix R7-1 Recommendations for nanomaterials applicable to Chapter R7a Endpoint specific guidance
    • ECHA (2012) Guidance on information requirements and chemical safety assessment. Appendix R7-1 Recommendations for nanomaterials applicable to Chapter R7a Endpoint specific guidance. European Chemicals Agency ECHA-12-G-03-EN, April 2012. 60 pp. http://echa.europa.eu/documents/10162/13632/appendix_r7a_nanomaterials_en.pdf
    • European Chemicals Agency ECHA-12-G-03-EN , pp. 60
  • 15
    • 85028166918 scopus 로고    scopus 로고
    • EFSA (2009) Scientific opinion on the potential risks arising from nanoscience and nanotechnologies on food and feed safety. Response to question EFSA-Q-2007-124a. 10 February 2009. EFSA J 958:1–39. http://www.efsa.europa.eu/en/efsajournal/doc/1052.pdf
    • EFSA J , vol.958 , pp. 1-39
  • 16
    • 85068523285 scopus 로고    scopus 로고
    • Scientific opinion: guidance on the risk assessment of the application of nanoscience and nanotechnologies in the food and feed chain. 10 May 2011
    • EFSA (2011) Scientific opinion: guidance on the risk assessment of the application of nanoscience and nanotechnologies in the food and feed chain. 10 May 2011. EFSA J 9:2140. http://www.efsa.europa.eu/de/efsajournal/pub/2140.htm
    • (2011) EFSA J , vol.9 , pp. 2140
  • 17
    • 0032999413 scopus 로고    scopus 로고
    • Intraluminal pH of the human gastrointestinal tract
    • PID: 10421978, COI: 1:STN:280:DyaK1MzltVykug%3D%3D
    • Fallingborg J (1999) Intraluminal pH of the human gastrointestinal tract. Dan Med Bull 46:183–196
    • (1999) Dan Med Bull , vol.46 , pp. 183-196
    • Fallingborg, J.1
  • 18
    • 77958576318 scopus 로고    scopus 로고
    • An insight into the metabolic responses of ultra-small superparamagnetic particles of iron oxide using metabonomic analysis of biofluids
    • Feng J, Liu H, Zhang L, Bhakoo K, Lu L (2010) An insight into the metabolic responses of ultra-small superparamagnetic particles of iron oxide using metabonomic analysis of biofluids. Nanotechnol 21:395101
    • (2010) Nanotechnol , vol.21 , pp. 395101
    • Feng, J.1    Liu, H.2    Zhang, L.3    Bhakoo, K.4    Lu, L.5
  • 19
    • 0030993565 scopus 로고    scopus 로고
    • The oral absorption of micro- and nanoparticulates: neither exceptional nor unusual
    • COI: 1:CAS:528:DyaK2sXisVGlsro%3D
    • Florence AT (1997) The oral absorption of micro- and nanoparticulates: neither exceptional nor unusual. Pharmaceut Res 14:259–266
    • (1997) Pharmaceut Res , vol.14 , pp. 259-266
    • Florence, A.T.1
  • 20
    • 21744458087 scopus 로고    scopus 로고
    • Nanoparticle uptake by the oral route: fulfilling its potential?
    • COI: 1:CAS:528:DC%2BD2MXpvFOmt7c%3D
    • Florence AT (2005) Nanoparticle uptake by the oral route: fulfilling its potential? Drug Discovery Today: Technol 2:75–81
    • (2005) Drug Discovery Today: Technol , vol.2 , pp. 75-81
    • Florence, A.T.1
  • 21
    • 84155162845 scopus 로고    scopus 로고
    • Models for oral uptake of nanoparticles in consumer products
    • Fröhlich E, Roblegg E (2012) Models for oral uptake of nanoparticles in consumer products. Toxicol 291:10–17
    • (2012) Toxicol , vol.291 , pp. 10-17
    • Fröhlich, E.1    Roblegg, E.2
  • 22
    • 33845457251 scopus 로고    scopus 로고
    • Nonclinical vehicle use in studies by multiple routes in multiple species
    • PID: 17132609, COI: 1:CAS:528:DC%2BD2sXntF2qsg%3D%3D
    • Gad SC, Cassidy CD, Aubert N, Spainhour B, Robbe H (2006) Nonclinical vehicle use in studies by multiple routes in multiple species. Int J Toxicol 25:499–521
    • (2006) Int J Toxicol , vol.25 , pp. 499-521
    • Gad, S.C.1    Cassidy, C.D.2    Aubert, N.3    Spainhour, B.4    Robbe, H.5
  • 23
    • 84888802356 scopus 로고    scopus 로고
    • Oral toxicity of silver ions, silver nanoparticles and colloidal silver—a review
    • PID: 24231525, COI: 1:CAS:528:DC%2BC2cXlt1Wktg%3D%3D
    • Hadrup N, Lam HR (2014) Oral toxicity of silver ions, silver nanoparticles and colloidal silver—a review. Regul Toxicol Pharmacol 68:1–7
    • (2014) Regul Toxicol Pharmacol , vol.68 , pp. 1-7
    • Hadrup, N.1    Lam, H.R.2
  • 25
    • 84866877678 scopus 로고    scopus 로고
    • Nanoparticulate silver increases uric acid and allantoin excretion in rats, as identified by metabolomics
    • PID: 22610381, COI: 1:CAS:528:DC%2BC38XntFSrsrc%3D
    • Hadrup N, Lam HR, Loeschner K, Mortensen A, Larsen EH, Frandsen H (2012b) Nanoparticulate silver increases uric acid and allantoin excretion in rats, as identified by metabolomics. J Appl Toxicol 32:929–933
    • (2012) J Appl Toxicol , vol.32 , pp. 929-933
    • Hadrup, N.1    Lam, H.R.2    Loeschner, K.3    Mortensen, A.4    Larsen, E.H.5    Frandsen, H.6
  • 26
    • 84893368316 scopus 로고    scopus 로고
    • Specific advice on fulfilling information requirements for nanomaterials under REACH (RIP-oN 2)—final project peport. REACH-NANO consultation
    • Hankin SM, Peters SAK, Poland CA, Foss Hansen S, Holmqvist J, Ross BL, Varet J, Aitken RJ (2011) Specific advice on fulfilling information requirements for nanomaterials under REACH (RIP-oN 2)—final project peport. REACH-NANO consultation. RNC/RIP-oN2/FPR/1/FINAL. 356 pp. http://ec.europa.eu/environment/chemicals/nanotech/pdf/report_ripon2.pdf
    • (2011) RNC/RIP-oN2/FPR/1/FINAL , pp. 356
    • Hankin, S.M.1    Peters, S.A.K.2    Poland, C.A.3    Foss Hansen, S.4    Holmqvist, J.5    Ross, B.L.6    Varet, J.7    Aitken, R.J.8
  • 28
    • 0035206137 scopus 로고    scopus 로고
    • Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles
    • PID: 11745751, COI: 1:CAS:528:DC%2BD3MXpt1Cls7Y%3D
    • Hillyer JF, Albrecht RM (2001) Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles. J Pharm Sci 90:1927–1936
    • (2001) J Pharm Sci , vol.90 , pp. 1927-1936
    • Hillyer, J.F.1    Albrecht, R.M.2
  • 37
    • 84863002431 scopus 로고    scopus 로고
    • Repeated oral dose toxicity of iron oxide nanoparticles: biochemical and histopathological alterations in different tissues of rats
    • PID: 22755032, COI: 1:CAS:528:DC%2BC38XotFOnsbg%3D
    • Kumari M, Rajak S, Singh SP, Kumari SI, Kumar PU, Murty USN, Mahboob M, Grover P, Rahman MF (2012) Repeated oral dose toxicity of iron oxide nanoparticles: biochemical and histopathological alterations in different tissues of rats. J Nanosci Nanotechnol 12:2149–2159
    • (2012) J Nanosci Nanotechnol , vol.12 , pp. 2149-2159
    • Kumari, M.1    Rajak, S.2    Singh, S.P.3    Kumari, S.I.4    Kumar, P.U.5    Murty, U.S.N.6    Mahboob, M.7    Grover, P.8    Rahman, M.F.9
  • 38
    • 83655197690 scopus 로고    scopus 로고
    • Toward toxicity testing of nanomaterials in the 21st century: a paradigm for moving forward
    • PID: 21965171, COI: 1:CAS:528:DC%2BC38Xnslentg%3D%3D
    • Lai DY (2012) Toward toxicity testing of nanomaterials in the 21st century: a paradigm for moving forward. Wiley Interdiscip Rev Nanomed Nanobiotechnol 4:1–15
    • (2012) Wiley Interdiscip Rev Nanomed Nanobiotechnol , vol.4 , pp. 1-15
    • Lai, D.Y.1
  • 42
    • 84859097539 scopus 로고    scopus 로고
    • Gene expression profiling of nephrotoxicity from copper nanoparticles in rats after repeated oral administration
    • COI: 1:CAS:528:DC%2BC38Xls1entrw%3D
    • Liao MY, Liu HG (2012) Gene expression profiling of nephrotoxicity from copper nanoparticles in rats after repeated oral administration. Env Toxicol Pharmacol 34:67–80
    • (2012) Env Toxicol Pharmacol , vol.34 , pp. 67-80
    • Liao, M.Y.1    Liu, H.G.2
  • 43
    • 79957633238 scopus 로고    scopus 로고
    • Distribution of silver in rats following 28 days of repeated oral exposure to silver nanoparticles or silver acetate
    • PID: 21631937, COI: 1:CAS:528:DC%2BC3MXpt1Grsbg%3D
    • Loeschner K, Hadrup N, Qvortrup K, Larsen A, Gao X, Vogel U, Mortensen A, Lam HR, Larsen EH (2011) Distribution of silver in rats following 28 days of repeated oral exposure to silver nanoparticles or silver acetate. Part Fibre Toxicol 8:18
    • (2011) Part Fibre Toxicol , vol.8 , pp. 18
    • Loeschner, K.1    Hadrup, N.2    Qvortrup, K.3    Larsen, A.4    Gao, X.5    Vogel, U.6    Mortensen, A.7    Lam, H.R.8    Larsen, E.H.9
  • 44
    • 79251568960 scopus 로고    scopus 로고
    • Integrated metabonomics analysis of the size-response relationship of silica nanoparticles-induced toxicity in mice
    • Lu X, Tian Y, Zhao Q, Jin T, Xiao S, Fan X (2011) Integrated metabonomics analysis of the size-response relationship of silica nanoparticles-induced toxicity in mice. Nanotechnol 22:055101
    • (2011) Nanotechnol , vol.22 , pp. 055101
    • Lu, X.1    Tian, Y.2    Zhao, Q.3    Jin, T.4    Xiao, S.5    Fan, X.6
  • 45
    • 84863113765 scopus 로고    scopus 로고
    • No toxicological effects on acute and repeated oral gavage doses of single-wall or multi-wall carbon nanotubes in rats
    • PID: 22687986, COI: 1:CAS:528:DC%2BC38XhtFajur%2FK
    • Matsumoto M, Serizawa H, Sunaga M, Kato H, Takahashi M, Hirata-Koizumi M, Ono A, Kamata E, Hirose A (2012) No toxicological effects on acute and repeated oral gavage doses of single-wall or multi-wall carbon nanotubes in rats. J Toxicol Sci 37:463–474
    • (2012) J Toxicol Sci , vol.37 , pp. 463-474
    • Matsumoto, M.1    Serizawa, H.2    Sunaga, M.3    Kato, H.4    Takahashi, M.5    Hirata-Koizumi, M.6    Ono, A.7    Kamata, E.8    Hirose, A.9
  • 47
    • 84875357552 scopus 로고    scopus 로고
    • st century: use of a predictive toxicological approach and high-throughput screening
    • PID: 22676423, COI: 1:CAS:528:DC%2BC38Xot1Olt78%3D
    • st century: use of a predictive toxicological approach and high-throughput screening. Acc Chem Res 46:607–621
    • (2013) Acc Chem Res , vol.46 , pp. 607-621
    • Nel, A.E.1    Xia, T.2    Meng, H.3    Wang, X.4    Lin, S.5    Ji, Z.6    Zhang, H.7
  • 48
    • 85028152249 scopus 로고    scopus 로고
    • List of manufactured nanomaterials and list of endpoints for phase one of the OECD testing programme. Series on the safety of manufactured nanomaterials, number 6. ENV/JM/MONO(2008)13/REV, OECD
    • OECD (2008a) List of manufactured nanomaterials and list of endpoints for phase one of the OECD testing programme. Series on the safety of manufactured nanomaterials, number 6. ENV/JM/MONO(2008)13/REV, OECD, Paris, 7 July 2008
    • (2008) Paris, 7 July , pp. 2008
  • 49
    • 85017728275 scopus 로고    scopus 로고
    • Repeated-dose 28-day oral toxicity study in rodents. OECD guidelines for the testing of chemicals No. 407. OECD
    • OECD (2008b) Repeated-dose 28-day oral toxicity study in rodents. OECD guidelines for the testing of chemicals No. 407. OECD, Paris, 3 October 2008
    • (2008) Paris, 3 October , pp. 2008
  • 50
    • 85028147587 scopus 로고    scopus 로고
    • OECD’s sponsorship programme; first revision. ENV-JM-MONO(2009)20-REV, OECD
    • OECD (2010) Guidance manual for the testing of manufactured nanomaterials: OECD’s sponsorship programme; first revision. ENV-JM-MONO(2009)20-REV, OECD, Paris, 2 June 2010
    • Paris , pp. 2
  • 52
    • 77955419251 scopus 로고    scopus 로고
    • Repeated-dose toxicity and inflammatory responses in mice by oral administration of silver nanoparticles
    • COI: 1:CAS:528:DC%2BC3cXpvFSrtbY%3D
    • Park E-J, Bae E, Yi J, Kim Y, Choi K, Lee SH, Yoon J, Lee BC, Park K (2010) Repeated-dose toxicity and inflammatory responses in mice by oral administration of silver nanoparticles. Env Toxicol Pharmacol 30:162–168
    • (2010) Env Toxicol Pharmacol , vol.30 , pp. 162-168
    • Park, E.-J.1    Bae, E.2    Yi, J.3    Kim, Y.4    Choi, K.5    Lee, S.H.6    Yoon, J.7    Lee, B.C.8    Park, K.9
  • 53
    • 84872432794 scopus 로고    scopus 로고
    • NMR-based metabonomics study of sub-acute hepatotoxicity induced by silica nanoparticles in rats after intranasal exposure
    • PID: 23273212, COI: 1:CAS:528:DC%2BC3sXhtlSnt77M
    • Parveen A, Rizvi SH, Gupta A, Singh R, Ahmad I, Mahdi F, Mahdi AA (2012) NMR-based metabonomics study of sub-acute hepatotoxicity induced by silica nanoparticles in rats after intranasal exposure. Cell Mol Biol 58(1):196–203
    • (2012) Cell Mol Biol , vol.58 , Issue.1 , pp. 196-203
    • Parveen, A.1    Rizvi, S.H.2    Gupta, A.3    Singh, R.4    Ahmad, I.5    Mahdi, F.6    Mahdi, A.A.7
  • 54
    • 69749086208 scopus 로고    scopus 로고
    • 4 particle size additives on properties of PMMA bone cement
    • COI: 1:CAS:528:DC%2BD1cXlsV2qtbY%3D
    • 4 particle size additives on properties of PMMA bone cement. Int J Nanomed 3(1):125–132
    • (2008) Int J Nanomed , vol.3 , Issue.1 , pp. 125-132
    • Ricker, A.1    Liu-Snyder, P.2    Webster, T.J.3
  • 55
    • 85028160941 scopus 로고    scopus 로고
    • REACH implementation project. Substance identification of nanomaterials. Advisory Report. AA N° 070307/2009/DI/534733 between DG ENV and JRC. European Commission, Joint Research Centre
    • RIP-oN 1 (2011) REACH implementation project. Substance identification of nanomaterials. Advisory Report. AA N° 070307/2009/DI/534733 between DG ENV and JRC. European Commission, Joint Research Centre, Institute for Health and Consumer Protection. 76 pp. http://ec.europa.eu/environment/chemicals/nanotech/pdf/report_ripon1.pdf
    • (2011) Institute for Health and Consumer Protection , pp. 76
  • 56
    • 84885826839 scopus 로고    scopus 로고
    • Nanosafety in Europe 2015–20125: towards safe and sustainable nanomaterials and nanotechnology innovations. Finnish Institute of Occupational Health
    • Savolainen K, Backman U, Brouwer D, Fadeel B, Fernandes T, Kuhlbusch T, Landsiedel R, Lynch I, Pylkkänen L (2013) Nanosafety in Europe 2015–20125: towards safe and sustainable nanomaterials and nanotechnology innovations. Finnish Institute of Occupational Health, Finland. 218 pp. www.ttl.fi/en/publications/electronic_publications/pages/default.aspx
    • (2013) Finland , pp. 218
    • Savolainen, K.1    Backman, U.2    Brouwer, D.3    Fadeel, B.4    Fernandes, T.5    Kuhlbusch, T.6    Landsiedel, R.7    Lynch, I.8    Pylkkänen, L.9
  • 57
    • 84934437253 scopus 로고    scopus 로고
    • Metabolomics techniques in nanotoxicology studies
    • PID: 22975962, COI: 1:CAS:528:DC%2BC3sXit1aktr8%3D
    • Schnackenberg LK, Sun J, Beger RD (2012) Metabolomics techniques in nanotoxicology studies. Methods Mol Biol 926:141–156
    • (2012) Methods Mol Biol , vol.926 , pp. 141-156
    • Schnackenberg, L.K.1    Sun, J.2    Beger, R.D.3
  • 60
    • 84860432043 scopus 로고    scopus 로고
    • Induction of oxidative stress, DNA damage and apoptosis in mouse liver after sub-acute oral exposure to zinc oxide nanoparticles
    • PID: 22198329, COI: 1:CAS:528:DC%2BC38XmsVeks74%3D
    • Sharma V, Singh P, Pandey AK, Dhawan A (2012) Induction of oxidative stress, DNA damage and apoptosis in mouse liver after sub-acute oral exposure to zinc oxide nanoparticles. Mutat Res 745:84–91
    • (2012) Mutat Res , vol.745 , pp. 84-91
    • Sharma, V.1    Singh, P.2    Pandey, A.K.3    Dhawan, A.4
  • 61
    • 84880963521 scopus 로고    scopus 로고
    • Toxicity assessment of manganese oxide micro and nanoparticles in Wistar rats after 28 days of repeated oral exposure
    • PID: 23702825, COI: 1:CAS:528:DC%2BC3sXotFSnsLY%3D
    • Singh SP, Kumari M, Kumari SI, Rahman MF, Mahboob M, Grover P (2013) Toxicity assessment of manganese oxide micro and nanoparticles in Wistar rats after 28 days of repeated oral exposure. J Appl Toxicol 33:1165–1179
    • (2013) J Appl Toxicol , vol.33 , pp. 1165-1179
    • Singh, S.P.1    Kumari, M.2    Kumari, S.I.3    Rahman, M.F.4    Mahboob, M.5    Grover, P.6
  • 62
    • 85028131713 scopus 로고    scopus 로고
    • NanoGEM deliverable 1.3.1: Characterization report for all nanoGEM materials
    • Hellak B, Hülser T, Izak E, Kuhlbusch T, Meyer F, Spree, M, Voetz M, Wiggers H, Wohlleben W (2012) NanoGEM deliverable 1.3.1: Characterization report for all nanoGEM materials. M24, 41 pp. http://www.nanogem.de/cms/nanogem/upload/Veroeffentlichungen/nanoGEM_Del1.3.1_Characterization_Materials_2013_04_24.pdf
    • (2012) M24 , pp. 41
    • Hellak, B.1    Hülser, T.2    Izak, E.3    Kuhlbusch, T.4    Meyer, F.5    Spree, M.6    Voetz, M.7    Wiggers, H.8    Wohlleben, W.9
  • 72
    • 84861575647 scopus 로고    scopus 로고
    • Use of ‘omics to elucidate mechanism of action and integration of ‘omics in a systems biology concept
    • PID: 22525362
    • van Ravenzwaay B, Brunborg G, Kleinjans J, Galay Burgos M, Vrijhof H (2012b) Use of ‘omics to elucidate mechanism of action and integration of ‘omics in a systems biology concept. Mutat Res 746:95–96
    • (2012) Mutat Res , vol.746 , pp. 95-96
    • van Ravenzwaay, B.1    Brunborg, G.2    Kleinjans, J.3    Galay Burgos, M.4    Vrijhof, H.5
  • 73
    • 84869444250 scopus 로고    scopus 로고
    • Validity range of centrifuges for the regulation of nanomaterials: from classification to as-tested coronas
    • PID: 23239934
    • Wohlleben W (2012) Validity range of centrifuges for the regulation of nanomaterials: from classification to as-tested coronas. J Nanopart Res 14:1300
    • (2012) J Nanopart Res , vol.14 , pp. 1300
    • Wohlleben, W.1
  • 75
    • 85060415646 scopus 로고    scopus 로고
    • Safety of nanomaterials along their lifecycle: release, exposure and human hazards. Taylor & Francis Oxford, New York
    • Wohlleben W, Kuhlbusch T, Lehr CM, Schnekenburger J (eds) (2014) Safety of nanomaterials along their lifecycle: release, exposure and human hazards. Taylor & Francis Oxford, New York, ISBN 978-1-46-656786-3, (in print)
    • (2014) ISBN 978-1-46-656786-3
    • Wohlleben, W.1    Kuhlbusch, T.2    Lehr, C.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.