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Volumn 11, Issue 1, 2014, Pages

Application of short-term inhalation studies to assess the inhalation toxicity of nanomaterials

Author keywords

BaSO4; Bronchoalveolar lavage; CeO2; Cytokine chemokine; Inhalation; Nanomaterial; Rat; Respiratory tract histopathology; SiO2; TiO2; ZnO; ZrO2

Indexed keywords

ADMINISTRATION, INHALATION; AEROSOLS; ANIMALS; APOPTOSIS; BARIUM SULFATE; BODY BURDEN; BRONCHOALVEOLAR LAVAGE FLUID; CELL PROLIFERATION; CERIUM; COATED MATERIALS, BIOCOMPATIBLE; LUNG; MALE; MICROSCOPY, ELECTRON, SCANNING; NANOSTRUCTURES; OXIDES; RATS; RATS, WISTAR; SILICON DIOXIDE; TITANIUM; WEIGHT GAIN; ZINC OXIDE; ZIRCONIUM;

EID: 84899482733     PISSN: None     EISSN: 17438977     Source Type: Journal    
DOI: 10.1186/1743-8977-11-16     Document Type: Article
Times cited : (133)

References (73)
  • 1
    • 60749113148 scopus 로고    scopus 로고
    • Development of a short-term inhalation test in the rat using nano-titanium dioxide as a model substance
    • 10.1080/08958370802361057, 18800274
    • Ma-Hock L, Burkhardt S, Strauss V, Gamer AO, Wiench K, van Ravenzwaay B, Landsiedel R. Development of a short-term inhalation test in the rat using nano-titanium dioxide as a model substance. Inhal Toxicol 2009, 21:102-118. 10.1080/08958370802361057, 18800274.
    • (2009) Inhal Toxicol , vol.21 , pp. 102-118
    • Ma-Hock, L.1    Burkhardt, S.2    Strauss, V.3    Gamer, A.O.4    Wiench, K.5    van Ravenzwaay, B.6    Landsiedel, R.7
  • 2
    • 1342267646 scopus 로고    scopus 로고
    • Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles
    • 10.1093/toxsci/kfh019, 14600271
    • Bermudez E, Mangum JB, Wong BA, Asgharian B, Hext PM, Warheit DB, Everitt JI. Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles. Toxicol Sci 2004, 77:347-357. 10.1093/toxsci/kfh019, 14600271.
    • (2004) Toxicol Sci , vol.77 , pp. 347-357
    • Bermudez, E.1    Mangum, J.B.2    Wong, B.A.3    Asgharian, B.4    Hext, P.M.5    Warheit, D.B.6    Everitt, J.I.7
  • 3
    • 84866052772 scopus 로고    scopus 로고
    • Hazard identification of inhaled nanomaterials: making use of short-term inhalation studies
    • 10.1007/s00204-012-0834-2, 22532024
    • Klein CL, Wiench K, Wiemann M, Ma-Hock L, van Ravenzwaay B, Landsiedel R. Hazard identification of inhaled nanomaterials: making use of short-term inhalation studies. Arch Toxicol 2012, 86:1137-1151. 10.1007/s00204-012-0834-2, 22532024.
    • (2012) Arch Toxicol , vol.86 , pp. 1137-1151
    • Klein, C.L.1    Wiench, K.2    Wiemann, M.3    Ma-Hock, L.4    van Ravenzwaay, B.5    Landsiedel, R.6
  • 5
    • 34548366466 scopus 로고    scopus 로고
    • The pro-inflammatory effects of low-toxicity low-solubility particles, nanoparticles and fine particles, on epithelial cells in vitro: the role of surface area
    • 10.1136/oem.2005.024802, 2092561, 17409182
    • Monteiller C, Tran L, Macnee W, Faux S, Jones A, Miller B, Donaldson K. The pro-inflammatory effects of low-toxicity low-solubility particles, nanoparticles and fine particles, on epithelial cells in vitro: the role of surface area. Occup Environ Med 2007, 64:609-615. 10.1136/oem.2005.024802, 2092561, 17409182.
    • (2007) Occup Environ Med , vol.64 , pp. 609-615
    • Monteiller, C.1    Tran, L.2    Macnee, W.3    Faux, S.4    Jones, A.5    Miller, B.6    Donaldson, K.7
  • 7
    • 0036850471 scopus 로고    scopus 로고
    • Long-term pulmonary responses of three laboratory rodent species to subchronic inhalation of micron-scale titanium dioxide particles
    • 10.1093/toxsci/70.1.86, 12388838
    • Bermudez E, Mangum JB, Asgharian B, Wong BA, Reverdy EE, Janszen DB, Hext PM, Warheit DB, Everitt JI. Long-term pulmonary responses of three laboratory rodent species to subchronic inhalation of micron-scale titanium dioxide particles. Toxicol Sci 2002, 70:86-97. 10.1093/toxsci/70.1.86, 12388838.
    • (2002) Toxicol Sci , vol.70 , pp. 86-97
    • Bermudez, E.1    Mangum, J.B.2    Asgharian, B.3    Wong, B.A.4    Reverdy, E.E.5    Janszen, D.B.6    Hext, P.M.7    Warheit, D.B.8    Everitt, J.I.9
  • 8
    • 34347234840 scopus 로고    scopus 로고
    • Assessing toxicity of fine and nanoparticles: comparing in vitro measurements to in vivo pulmonary toxicity profiles
    • 10.1093/toxsci/kfm018, 17301066
    • Sayes CM, Reed KL, Warheit DB. Assessing toxicity of fine and nanoparticles: comparing in vitro measurements to in vivo pulmonary toxicity profiles. Toxicol Sci 2007, 97:163-180. 10.1093/toxsci/kfm018, 17301066.
    • (2007) Toxicol Sci , vol.97 , pp. 163-180
    • Sayes, C.M.1    Reed, K.L.2    Warheit, D.B.3
  • 9
    • 78650269106 scopus 로고    scopus 로고
    • Metal oxide nanoparticles induce unique inflammatory footprints in the lung: important implications for nanoparticle testing
    • 10.1289/ehp.1002201, 3002189, 20729176
    • Cho WS, Duffin R, Poland CA, Howie SE, Macnee W, Bradley M, Megson IL, Donaldson K. Metal oxide nanoparticles induce unique inflammatory footprints in the lung: important implications for nanoparticle testing. Environ Health Perspect 2010, 118:1699-1706. 10.1289/ehp.1002201, 3002189, 20729176.
    • (2010) Environ Health Perspect , vol.118 , pp. 1699-1706
    • Cho, W.S.1    Duffin, R.2    Poland, C.A.3    Howie, S.E.4    Macnee, W.5    Bradley, M.6    Megson, I.L.7    Donaldson, K.8
  • 11
    • 0033931563 scopus 로고    scopus 로고
    • Pulmonary chemokine and mutagenic responses in rats after subchronic inhalation of amorphous and crystalline silica
    • 10.1093/toxsci/56.2.405, 10911000
    • Johnston CJ, Driscoll KE, Finkelstein JN, Baggs R, O'Reilly MA, Carter J, Gelein R, Oberdörster G. Pulmonary chemokine and mutagenic responses in rats after subchronic inhalation of amorphous and crystalline silica. Toxicol Sci 2000, 56:405-413. 10.1093/toxsci/56.2.405, 10911000.
    • (2000) Toxicol Sci , vol.56 , pp. 405-413
    • Johnston, C.J.1    Driscoll, K.E.2    Finkelstein, J.N.3    Baggs, R.4    O'Reilly, M.A.5    Carter, J.6    Gelein, R.7    Oberdörster, G.8
  • 12
    • 34547728156 scopus 로고    scopus 로고
    • Five-day inhalation toxicity study of three types of synthetic amorphous silicas in Wistar rats and post-exposure evaluations for up to 3 months
    • 10.1016/j.fct.2007.04.001, 17524541
    • Arts JH, Muijser H, Duistermaat E, Junker K, Kuper CF. Five-day inhalation toxicity study of three types of synthetic amorphous silicas in Wistar rats and post-exposure evaluations for up to 3 months. Food Chem Toxicol 2007, 45:1856-1867. 10.1016/j.fct.2007.04.001, 17524541.
    • (2007) Food Chem Toxicol , vol.45 , pp. 1856-1867
    • Arts, J.H.1    Muijser, H.2    Duistermaat, E.3    Junker, K.4    Kuper, C.F.5
  • 13
    • 0033646585 scopus 로고    scopus 로고
    • Inhalation of poorly soluble particles. II. Influence of particle surface area on inflammation and clearance
    • 10.1080/08958370050166796, 11114784
    • Tran CL, Buchanan D, Cullen RT, Searl A, Jones AD, Donaldson K. Inhalation of poorly soluble particles. II. Influence of particle surface area on inflammation and clearance. Inhal Toxicol 2000, 12:1113-1126. 10.1080/08958370050166796, 11114784.
    • (2000) Inhal Toxicol , vol.12 , pp. 1113-1126
    • Tran, C.L.1    Buchanan, D.2    Cullen, R.T.3    Searl, A.4    Jones, A.D.5    Donaldson, K.6
  • 14
    • 33645793105 scopus 로고    scopus 로고
    • Carcinogenicity study with nineteen granular dusts in rats
    • Pott F, Roller M. Carcinogenicity study with nineteen granular dusts in rats. Eur J Oncol 2005, 10:249-281.
    • (2005) Eur J Oncol , vol.10 , pp. 249-281
    • Pott, F.1    Roller, M.2
  • 15
    • 79960698500 scopus 로고    scopus 로고
    • Acute inhalation toxicity of cerium oxide nanoparticles in rats
    • 10.1016/j.toxlet.2011.05.1027, 21624445
    • Srinivas A, Rao PJ, Selvam G, Murthy PB, Reddy PN. Acute inhalation toxicity of cerium oxide nanoparticles in rats. Toxicol Lett 2011, 205:105-115. 10.1016/j.toxlet.2011.05.1027, 21624445.
    • (2011) Toxicol Lett , vol.205 , pp. 105-115
    • Srinivas, A.1    Rao, P.J.2    Selvam, G.3    Murthy, P.B.4    Reddy, P.N.5
  • 17
    • 77249100279 scopus 로고    scopus 로고
    • Pulmonary toxicity induced by intratracheal instillation of coarse and fine particles of cerium dioxide in male rats
    • 10.2486/indhealth.48.3, 20160402
    • Toya T, Takata A, Otaki N, Takaya M, Serita F, Yoshida K, Kohyama N. Pulmonary toxicity induced by intratracheal instillation of coarse and fine particles of cerium dioxide in male rats. Ind Health 2010, 48:3-11. 10.2486/indhealth.48.3, 20160402.
    • (2010) Ind Health , vol.48 , pp. 3-11
    • Toya, T.1    Takata, A.2    Otaki, N.3    Takaya, M.4    Serita, F.5    Yoshida, K.6    Kohyama, N.7
  • 18
    • 0028807445 scopus 로고
    • Rare earth (cerium oxide) pneumoconiosis: analytical scanning electron microscopy and literature review
    • McDonald JW, Ghio AJ, Sheehan CE, Bernhardt PF, Roggli VL. Rare earth (cerium oxide) pneumoconiosis: analytical scanning electron microscopy and literature review. Mod Pathol 1995, 8:859-865.
    • (1995) Mod Pathol , vol.8 , pp. 859-865
    • McDonald, J.W.1    Ghio, A.J.2    Sheehan, C.E.3    Bernhardt, P.F.4    Roggli, V.L.5
  • 19
    • 67349116785 scopus 로고    scopus 로고
    • Are rat results from intratracheal instillation of 19 granular dusts a reliable basis for predicting cancer risk?
    • 10.1016/j.yrtph.2009.02.008, 19275925
    • Valberg PA, Bruch J, McCunney RJ. Are rat results from intratracheal instillation of 19 granular dusts a reliable basis for predicting cancer risk?. Regul Toxicol Pharmacol 2009, 54:72-83. 10.1016/j.yrtph.2009.02.008, 19275925.
    • (2009) Regul Toxicol Pharmacol , vol.54 , pp. 72-83
    • Valberg, P.A.1    Bruch, J.2    McCunney, R.J.3
  • 21
    • 84899492591 scopus 로고    scopus 로고
    • Notice IIIb 3 - 35125 - 5 of the BMAS, German Federal Ministry of Labour and Social Affairs (BMAS; Bundesministerium für Arbeit und Soziales)
    • German Federal Ministry of Labour and Social Affairs (BMAS; Bundesministerium für Arbeit und Soziales) Bekanntmachung von technischen Regeln. (Notice of technical provisions). TRGS 900 Arbeitsplatzgrenzwerte (Workplace limits) 2014, Notice IIIb 3 - 35125 - 5 of the BMAS, German Federal Ministry of Labour and Social Affairs (BMAS; Bundesministerium für Arbeit und Soziales).
    • (2014) Bekanntmachung von technischen Regeln. (Notice of technical provisions). TRGS 900 Arbeitsplatzgrenzwerte (Workplace limits)
  • 26
    • 0033659166 scopus 로고    scopus 로고
    • Inhalation of poorly soluble particles. I. Differences in inflammatory response and clearance during exposure
    • 10.1080/08958370050166787, 11114783
    • Cullen RT, Tran CL, Buchanan D, Davis JM, Searl A, Jones AD, Donaldson K. Inhalation of poorly soluble particles. I. Differences in inflammatory response and clearance during exposure. Inhal Toxicol 2000, 12:1089-1111. 10.1080/08958370050166787, 11114783.
    • (2000) Inhal Toxicol , vol.12 , pp. 1089-1111
    • Cullen, R.T.1    Tran, C.L.2    Buchanan, D.3    Davis, J.M.4    Searl, A.5    Jones, A.D.6    Donaldson, K.7
  • 27
    • 61849123712 scopus 로고    scopus 로고
    • Comparing fate and effects of three particles of different surface properties: nano-TiO2, micron-scale TiO2 and quartz
    • 10.1016/j.toxlet.2008.11.020, 19114093
    • van Ravenzwaay B, Landsiedel R, Fabian E, Burkhardt S, Strauss V, Ma-Hock L. Comparing fate and effects of three particles of different surface properties: nano-TiO2, micron-scale TiO2 and quartz. Toxicol Lett 2009, 186:152-159. 10.1016/j.toxlet.2008.11.020, 19114093.
    • (2009) Toxicol Lett , vol.186 , pp. 152-159
    • Van Ravenzwaay, B.1    Landsiedel, R.2    Fabian, E.3    Burkhardt, S.4    Strauss, V.5    Ma-Hock, L.6
  • 28
    • 0019440764 scopus 로고
    • Evaluation of an occupational respiratory exposure to a zirconium-containing dust
    • Hadjimichael OC, Brubaker RE. Evaluation of an occupational respiratory exposure to a zirconium-containing dust. J Occup Med 1981, 23:543-547.
    • (1981) J Occup Med , vol.23 , pp. 543-547
    • Hadjimichael, O.C.1    Brubaker, R.E.2
  • 29
    • 0029883435 scopus 로고    scopus 로고
    • A study of lung function and chest radiographs in men exposed to zirconium compounds
    • 10.1093/occmed/46.2.109, 8776246
    • Marcus RL, Turner S, Cherry NM. A study of lung function and chest radiographs in men exposed to zirconium compounds. Occup Med (Lond) 1996, 46:109-113. 10.1093/occmed/46.2.109, 8776246.
    • (1996) Occup Med (Lond) , vol.46 , pp. 109-113
    • Marcus, R.L.1    Turner, S.2    Cherry, N.M.3
  • 30
    • 77957178470 scopus 로고
    • A multiple-path model of particle deposition in the rat lung
    • 10.1006/faat.1995.1144, 8566482
    • Anjilvel S, Asgharian B. A multiple-path model of particle deposition in the rat lung. Fundam Appl Toxicol 1995, 28:41-50. 10.1006/faat.1995.1144, 8566482.
    • (1995) Fundam Appl Toxicol , vol.28 , pp. 41-50
    • Anjilvel, S.1    Asgharian, B.2
  • 31
    • 33744804668 scopus 로고    scopus 로고
    • Bilthoven, The Netherlands: RIVA Report 650010030, RIVM (Netherlands National Institute for Public Health and the Environment)
    • RIVM (Netherlands National Institute for Public Health and the Environment) Multiple Path Particle Dosimetry Model (MPPD v 1.0): A Model for Human and Rat Airway Particle Dosimetry 2002, Bilthoven, The Netherlands: RIVA Report 650010030, RIVM (Netherlands National Institute for Public Health and the Environment).
    • (2002) Multiple Path Particle Dosimetry Model (MPPD v 1.0): A Model for Human and Rat Airway Particle Dosimetry
  • 32
    • 0027520021 scopus 로고
    • Role of alveolar macrophage chemotaxis and phagocytosis in pulmonary clearance responses to inhaled particles: comparisons among rodent species
    • 10.1002/jemt.1070260509, 8286787
    • Warheit DB, Hartsky MA. Role of alveolar macrophage chemotaxis and phagocytosis in pulmonary clearance responses to inhaled particles: comparisons among rodent species. Microsc Res Tech 1993, 26:412-422. 10.1002/jemt.1070260509, 8286787.
    • (1993) Microsc Res Tech , vol.26 , pp. 412-422
    • Warheit, D.B.1    Hartsky, M.A.2
  • 33
    • 33749371029 scopus 로고    scopus 로고
    • Dissolving behavior and stability of ZnO wires in biofluids: a study on biodegradability and biocompatibility of ZnO nanostructures
    • Zhou J, Xu N, Wang ZL. Dissolving behavior and stability of ZnO wires in biofluids: a study on biodegradability and biocompatibility of ZnO nanostructures. Adv Mater 2006, 18:2432-2435.
    • (2006) Adv Mater , vol.18 , pp. 2432-2435
    • Zhou, J.1    Xu, N.2    Wang, Z.L.3
  • 38
  • 40
    • 38849165400 scopus 로고    scopus 로고
    • Concordance between in vitro and in vivo dosimetry in the proinflammatory effects of low-toxicity, low-solubility particles: the key role of the proximal alveolar region
    • 10.1080/08958370701758742, 18236223
    • Donaldson K, Borm PJ, Oberdörster G, Pinkerton KE, Stone V, Tran CL. Concordance between in vitro and in vivo dosimetry in the proinflammatory effects of low-toxicity, low-solubility particles: the key role of the proximal alveolar region. Inhal Toxicol 2008, 20:53-62. 10.1080/08958370701758742, 18236223.
    • (2008) Inhal Toxicol , vol.20 , pp. 53-62
    • Donaldson, K.1    Borm, P.J.2    Oberdörster, G.3    Pinkerton, K.E.4    Stone, V.5    Tran, C.L.6
  • 42
    • 0029784622 scopus 로고    scopus 로고
    • Relationship between induction of macrophage chemotactic factors and formation of granulomas caused by mycoloyl glycolipids from Rhodococcus ruber (Nocardia rubra)
    • 10.1093/oxfordjournals.jbchem.a021463, 8902634
    • Matsunaga I, Oka S, Fujiwara N, Yano I. Relationship between induction of macrophage chemotactic factors and formation of granulomas caused by mycoloyl glycolipids from Rhodococcus ruber (Nocardia rubra). J Biochem 1996, 120:663-670. 10.1093/oxfordjournals.jbchem.a021463, 8902634.
    • (1996) J Biochem , vol.120 , pp. 663-670
    • Matsunaga, I.1    Oka, S.2    Fujiwara, N.3    Yano, I.4
  • 43
    • 0027131418 scopus 로고
    • Osteopontin: a protein with diverse functions
    • Denhardt DT, Guo X. Osteopontin: a protein with diverse functions. FASEB J 1993, 7:1475-1482.
    • (1993) FASEB J , vol.7 , pp. 1475-1482
    • Denhardt, D.T.1    Guo, X.2
  • 47
    • 4444288191 scopus 로고    scopus 로고
    • Osteopontin expression in particle-induced lung disease
    • 10.1080/01902140490476346, 15371094
    • Mangum J, Bermudez E, Sar M, Everitt J. Osteopontin expression in particle-induced lung disease. Exp Lung Res 2004, 30:585-598. 10.1080/01902140490476346, 15371094.
    • (2004) Exp Lung Res , vol.30 , pp. 585-598
    • Mangum, J.1    Bermudez, E.2    Sar, M.3    Everitt, J.4
  • 50
    • 2942724471 scopus 로고    scopus 로고
    • Contribution of IL-1 beta and TNF-alpha to the initiation of the peripheral lung response to atmospheric particulates (PM10)
    • 10.1152/ajplung.00290.2003, 15003925
    • Ishii H, Fujii T, Hogg JC, Hayashi S, Mukae H, Vincent R, van Eeden SF. Contribution of IL-1 beta and TNF-alpha to the initiation of the peripheral lung response to atmospheric particulates (PM10). Am J Physiol Lung Cell Mol Physiol 2004, 287:L176-L183. 10.1152/ajplung.00290.2003, 15003925.
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.287
    • Ishii, H.1    Fujii, T.2    Hogg, J.C.3    Hayashi, S.4    Mukae, H.5    Vincent, R.6    van Eeden, S.F.7
  • 51
    • 0032922359 scopus 로고    scopus 로고
    • The role of tumor necrosis factor in health and disease
    • Beutler BA. The role of tumor necrosis factor in health and disease. J Rheumatol Suppl 1999, 57:16-21.
    • (1999) J Rheumatol Suppl , vol.57 , pp. 16-21
    • Beutler, B.A.1
  • 52
    • 0028989599 scopus 로고
    • TNF-alpha mediates recruitment of polymorphonuclear neutrophils and eosinophils during airway inflammation
    • Lukacs NW, Strieter RM, Chensue SW, Widmer M, Kunkel SL. TNF-alpha mediates recruitment of polymorphonuclear neutrophils and eosinophils during airway inflammation. J Immunol 1995, 154:5411-5417.
    • (1995) J Immunol , vol.154 , pp. 5411-5417
    • Lukacs, N.W.1    Strieter, R.M.2    Chensue, S.W.3    Widmer, M.4    Kunkel, S.L.5
  • 53
    • 0026746568 scopus 로고
    • Recovery of rat alveolar macrophages by bronchoalveolar lavage under normal and activated conditions
    • 1519522, 1396444
    • Rehn B, Bruch J, Zou T, Hobusch G. Recovery of rat alveolar macrophages by bronchoalveolar lavage under normal and activated conditions. Environ Health Perspect 1992, 97:11-16. 1519522, 1396444.
    • (1992) Environ Health Perspect , vol.97 , pp. 11-16
    • Rehn, B.1    Bruch, J.2    Zou, T.3    Hobusch, G.4
  • 54
    • 0343446141 scopus 로고    scopus 로고
    • The relevance of the rat lung response to particle overload for human risk assessment: a workshop consensus report
    • ILSI Risk Science Institute Workshop Participants
    • ILSI Risk Science Institute Workshop Participants The relevance of the rat lung response to particle overload for human risk assessment: a workshop consensus report. Inhal Toxicol 2000, 12:1-17. ILSI Risk Science Institute Workshop Participants.
    • (2000) Inhal Toxicol , vol.12 , pp. 1-17
  • 56
    • 75249100931 scopus 로고    scopus 로고
    • Subchronic 13-week inhalation exposure of rats to multiwalled carbon nanotubes: toxic effects are determined by density of agglomerate structures, not fibrillar structures
    • 10.1093/toxsci/kfp247, 19822600
    • Pauluhn J. Subchronic 13-week inhalation exposure of rats to multiwalled carbon nanotubes: toxic effects are determined by density of agglomerate structures, not fibrillar structures. Toxicol Sci 2010, 113:226-242. 10.1093/toxsci/kfp247, 19822600.
    • (2010) Toxicol Sci , vol.113 , pp. 226-242
    • Pauluhn, J.1
  • 57
    • 84866026788 scopus 로고    scopus 로고
    • Nanostructured calcium silicate hydrate seeds accelerate concrete hardening: a combined assessment of benefits and risks
    • 10.1007/s00204-012-0839-x, 22466068
    • Bräu M, Ma-Hock L, Hesse C, Nicoleau L, Strauss V, Treumann S, Wiench K, Landsiedel R, Wohlleben W. Nanostructured calcium silicate hydrate seeds accelerate concrete hardening: a combined assessment of benefits and risks. Arch Toxicol 2012, 86:1077-1087. 10.1007/s00204-012-0839-x, 22466068.
    • (2012) Arch Toxicol , vol.86 , pp. 1077-1087
    • Bräu, M.1    Ma-Hock, L.2    Hesse, C.3    Nicoleau, L.4    Strauss, V.5    Treumann, S.6    Wiench, K.7    Landsiedel, R.8    Wohlleben, W.9
  • 58
    • 0029620211 scopus 로고
    • Neoplastic lung lesions in rat after chronic exposure to crystalline silica
    • Muhle H, Kittel B, Ernst H, Mohr U, Mermelstein R. Neoplastic lung lesions in rat after chronic exposure to crystalline silica. Scand J Work Environ Health 1995, 21(Suppl 2):27-29.
    • (1995) Scand J Work Environ Health , vol.21 , Issue.SUPPL. 2 , pp. 27-29
    • Muhle, H.1    Kittel, B.2    Ernst, H.3    Mohr, U.4    Mermelstein, R.5
  • 59
    • 84864499129 scopus 로고    scopus 로고
    • Development of risk-based nanomaterial groups for occupational exposure control
    • Kuempel ED, Castranova V, Geraci CL, Schulte PA. Development of risk-based nanomaterial groups for occupational exposure control. J Nanopart Res 2012, 14:1029-1043.
    • (2012) J Nanopart Res , vol.14 , pp. 1029-1043
    • Kuempel, E.D.1    Castranova, V.2    Geraci, C.L.3    Schulte, P.A.4
  • 61
    • 79957595848 scopus 로고    scopus 로고
    • Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes
    • available at:
    • Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes. OJ 2010, L 276:33-79. available at: http://eur-lex.europa.eu/legalcontent/EN/TXT/?qid=1396877936469&uri=CELEX:32010L0063.
    • (2010) OJ , vol.L 276 , pp. 33-79
  • 63
    • 0020819944 scopus 로고
    • Urinary enzyme determination and its clinical significance C. Enzyme derived from the kidney tubular epithelium-N-acetyl-beta-D-glucosaminidase. 4. Preclinical evaluation of the urinary NAG activity and changes in renal diseases
    • Yakata M, Sugita O, Sakai T, Uchiyama K, Wada K. Urinary enzyme determination and its clinical significance C. Enzyme derived from the kidney tubular epithelium-N-acetyl-beta-D-glucosaminidase. 4. Preclinical evaluation of the urinary NAG activity and changes in renal diseases. Rinsho Byori 1983, 56:90-101.
    • (1983) Rinsho Byori , vol.56 , pp. 90-101
    • Yakata, M.1    Sugita, O.2    Sakai, T.3    Uchiyama, K.4    Wada, K.5
  • 64
    • 0032189266 scopus 로고    scopus 로고
    • Classification and properties of 64 multiplexed microsphere sets
    • 10.1002/(SICI)1097-0320(19981001)33:2<234::AID-CYTO19>3.0.CO;2-V, 9773885
    • Kettman JR, Davies T, Chandler D, Oliver KG, Fulton RJ. Classification and properties of 64 multiplexed microsphere sets. Cytometry 1998, 33:234-243. 10.1002/(SICI)1097-0320(19981001)33:2<234::AID-CYTO19>3.0.CO;2-V, 9773885.
    • (1998) Cytometry , vol.33 , pp. 234-243
    • Kettman, J.R.1    Davies, T.2    Chandler, D.3    Oliver, K.G.4    Fulton, R.J.5
  • 65
    • 33644963942 scopus 로고    scopus 로고
    • Multiplex bead array assays: performance evaluation and comparison of sensitivity to ELISA
    • 10.1016/j.ymeth.2005.11.010, 1534009, 16481199
    • Elshal MF, McCoy JP. Multiplex bead array assays: performance evaluation and comparison of sensitivity to ELISA. Methods 2006, 38:317-323. 10.1016/j.ymeth.2005.11.010, 1534009, 16481199.
    • (2006) Methods , vol.38 , pp. 317-323
    • Elshal, M.F.1    McCoy, J.P.2
  • 67
    • 25444482793 scopus 로고    scopus 로고
    • Simultaneous measurement of 25 inflammatory markers and neurotrophins in neonatal dried blood spots by immunoassay with xMAP technology
    • 10.1373/clinchem.2005.052241, 16081507
    • Skogstrand K, Thorsen P, Norgaard-Pedersen B, Schendel DE, Sorensen LC, Hougaard DM. Simultaneous measurement of 25 inflammatory markers and neurotrophins in neonatal dried blood spots by immunoassay with xMAP technology. Clin Chem 2005, 51:1854-1866. 10.1373/clinchem.2005.052241, 16081507.
    • (2005) Clin Chem , vol.51 , pp. 1854-1866
    • Skogstrand, K.1    Thorsen, P.2    Norgaard-Pedersen, B.3    Schendel, D.E.4    Sorensen, L.C.5    Hougaard, D.M.6
  • 70
    • 4143150883 scopus 로고    scopus 로고
    • Revised guides for organ sampling and trimming in rats and mice - part 3. A joint publication of the RITA and NACAD groups
    • 10.1078/0940-2993-00350, 15384249
    • Morawietz G, Ruehl-Fehlert C, Kittel B, Bube A, Keane K, Halm S, Heuser A, Hellmann J. Revised guides for organ sampling and trimming in rats and mice - part 3. A joint publication of the RITA and NACAD groups. Exp Toxicol Pathol 2004, 55:433-449. 10.1078/0940-2993-00350, 15384249.
    • (2004) Exp Toxicol Pathol , vol.55 , pp. 433-449
    • Morawietz, G.1    Ruehl-Fehlert, C.2    Kittel, B.3    Bube, A.4    Keane, K.5    Halm, S.6    Heuser, A.7    Hellmann, J.8
  • 71
    • 0009663357 scopus 로고
    • A multiple comparison procedure for comparing several treatments with a control
    • Dunnett CW. A multiple comparison procedure for comparing several treatments with a control. JASA 1955, 50:1096-1121.
    • (1955) JASA , vol.50 , pp. 1096-1121
    • Dunnett, C.W.1
  • 72
    • 0000080398 scopus 로고
    • New tables for multiple comparisons with a control
    • Dunnett CW. New tables for multiple comparisons with a control. Biometrics 1964, 20:482-491.
    • (1964) Biometrics , vol.20 , pp. 482-491
    • Dunnett, C.W.1


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