Application of in vivo metabolomics to preclinical/toxicological studies: Case study on phenytoin-induced systemic toxicity

Bioanalysis

Volumn 4, Issue 18, 2012, Pages 2291-2301

  Kamp, H ^a   Fabian, E ^a   Groeters, S ^a   Herold, M ^b   Krennrich, G ^a   Looser, R ^b   Mattes, W ^c   Mellert, W ^a   Prokoudine, A ^b   Ruiz Noppinger, P ^b   Strauss, V ^a   Walk, T ^b   Wiemer, J ^b   Van Ravenzwaay, B ^a  

^a BASF SE   (Germany)

^b Metanomics Health GmbH   (Germany)

^c PharmPoint Consulting   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL COMPOUND; LIVER ENZYME; PHENYTOIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONTROLLED STUDY; DATA BASE; DIET; DRUG INTOXICATION; ENZYME INDUCTION; FEMALE; IN VIVO STUDY; KIDNEY; LIVER HISTOLOGY; LIVER HYPERTROPHY; LIVER TOXICITY; MALE; METABOLOME; METABOLOMICS; METAMAP TOX; NONHUMAN; RAT; REVIEW; THYROID GLAND; TOXICITY TESTING; WISTAR RAT;

ANIMALS; BIOMARKERS, PHARMACOLOGICAL; DRUG EVALUATION, PRECLINICAL; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; LIVER; MALE; METABOLOME; METABOLOMICS; PHENYTOIN; RATS; RATS, WISTAR; TANDEM MASS SPECTROMETRY;

EID: 84867344552     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.12.214     Document Type: Review

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