No toxicological effects on acute and repeated oral gavage doses of single-wall or multi-wall carbon nanotube in rats

Journal of Toxicological Sciences

Volumn 37, Issue 3, 2012, Pages 463-474

  Matsumoto, Mariko ^a   Serizawa, Hideki ^b   Sunaga, Masao ^c   Kato, Hina ^a   Takahashi, Mika ^a   Hirata Koizumi, Mutsuko ^a   Ono, Atsushi ^a   Kamata, Eiichi ^a   Hirose, Akihiko ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b BoZo Research Center Inc   (Japan)

^c Safety Research Institute for Chemical Compounds Co   (Japan)

Author keywords

Acute oral toxicity; Multi wall carbon nanotube; Rat; Repeated oral dose toxicity; Single wall carbon nanotube

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ALPHA GLOBIN; ASPARTATE AMINOTRANSFERASE; BETA GLOBIN; CHLORIDE; CHOLESTEROL; CREATININE; GAMMA GLOBIN; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; HEMOGLOBIN; MULTI WALLED NANOTUBE; NITROGEN; PHOSPHORUS; POTASSIUM; PROTEIN; SINGLE WALLED NANOTUBE; SODIUM; TRIACYLGLYCEROL; UREA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; AUTOPSY; CHLORIDE BLOOD LEVEL; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; ERYTHROCYTE COUNT; FECES ANALYSIS; FEEDING; FEMALE; FOAM CELL; FOOD INTAKE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HEMATOCRIT; HISTOPATHOLOGY; LD 50; LEUKOCYTE COUNT; LEUKOCYTE DIFFERENTIAL COUNT; LIVER CELL; MALE; MEAN CORPUSCULAR HEMOGLOBIN; MEAN CORPUSCULAR VOLUME; NONHUMAN; ORGAN WEIGHT; PHOSPHATE BLOOD LEVEL; POTASSIUM BLOOD LEVEL; PROTEIN BLOOD LEVEL; RAT; RETICULOCYTE; RISK ASSESSMENT; SODIUM BLOOD LEVEL; TOXICITY TESTING; TRIACYLGLYCEROL BLOOD LEVEL; UREA NITROGEN BLOOD LEVEL;

RATTUS;

EID: 84863113765     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.37.463     Document Type: Article

References (29)

1. Deng, X., Jia, G., Wang, H., Sun, H., Wang, X., Yang, S., Wang, T. and Liu, Y. (2007): Translocation and fate of multi-walled carbon nanotubes in vivo. Carbon, 45, 1419-1424.
2. Elgrabli, D., Abella-Gallart, S., Robidel, F., Rogerieux, F., Boczkowski, J. and Lacroix, G. (2008): Induction of apoptosis and absence of inflammation in rat lung after intratracheal instillation of multiwalled carbon nanotubes. Toxicology, 253, 131-136.
3. Erdely, A., Hulderman, T., Salmen, R., Liston, A., Zeidler-Erdely, P.C., Schwegler-Berry, D., Castranova, V., Koyama, S., Kim, Y.A., Endo, M. and Simeonova, P.P. (2009): Cross-talk between lung and systemic circulation during carbon nanotube respiratory exposure. Potential biomarkers. Nano Lett., 9, 36-43.
4. Folkmann, J.K., Risom, L., Jacobsen, N.R., Wallin, H., Loft, S. and Moller, P. (2009): Oxidatively damaged DNA in rats exposed by oral gavage to C60 fullerenes and single-walled carbon nanotubes. Environ. Health. Perspect., 117, 703-708.
5. Han, S.G., Andrews, R., Gairola, C.G. and Bhalla, D.K. (2008): Acute pulmonary effects of combined exposure to carbon nanotubes and ozone in mice. Inhal. Toxicol., 20, 391-398.
6. Hussain, M.A., Kabir, M.A. and Soood, A.K. (2009): On the cytotoxicity of carbon nanotubes. Current Science, 96, 664-673.
7. Inoue, K., Koike, E., Yanagisawa, R., Hirano, S., Nishikawa, M. and Takano, H. (2009): Effects of multi-walled carbon nanotubes on a murine allergic airway inflammation model. Toxicol. Appl. Pharmacol., 237, 306-316.
8. Inoue, K., Takano, H., Koike, E., Yanagisawa, R., Sakurai, M., Tasaka, S., Ishizaka, A. and Shimada, A. (2008): Effects of pulmonary exposure to carbon nanotubes on lung and systemic inflammation with coagulatory disturbance induced by lipopolysaccharide in mice. Exp. Biol. Med. (Maywood), 233, 1583-1590.
9. Ji, Z., Zhang, D., Li, L., Shen, X., Deng, X., Dong, L., Wu, M. and Liu, Y. (2009): The hepatotoxicity of multi-walled carbon nanotubes in mice. Nanotechnology, 20, 445101.
10. Jia, G., Wang, H., Yan, L., Wang, X., Pei, R., Yan, T., Zhao, Y. and Guo, X. (2005): Cytotoxicity of carbon nanomaterials: singlewall nanotube, multi-wall nanotube, and fullerene. Environ. Sci. Technol., 39, 1378-1383.
11. Kobayashi, N., Ogura, I., Gamo, M., Kishimoto, A. and Nakanishi, J. (2009): Risk Assessment of Manufactured Nanomaterials-Carbon Nanotubes (CNTs)-Interim Report issued on October 16, 2009 Exective Summary. http://goodnanoguide.org/tiki-download_wiki_attachment.php?attId=31
12. Lam, C.W., James, J.T., McCluskey, R. and Hunter, R.L. (2004): Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation. Toxicol. Sci., 77, 126-134.
13. Lim, J.H., Kim, S.H., Shin, I.S., Park, N.H., Moon, C., Kang, S.S., Kim, S.H., Park, S.C. and Kim, J.C. (2011): Maternal exposure to multi-wall carbon nanotubes does not induce embryo-fetal developmental toxicity in rats. Birth. Defects. Res. B Dev. Reprod. Toxicol., 92, 69-76.
14. Magnuson, B.A., Jonaitis, T.S. and Card, J.W. (2011): A Brief Review of the occurrence, use, and safety of food-related nanomaterials. J. Food Sci., 76, R126-R133.
15. MHLW, J. (2010): The results of "An Investigative Research on Consumer's Safety in Utilizing Nanomaterials (2009)". www. nihs.go.jp/mhlw/chemical/nano/nanopdf/H21houkoku/honbun/all.pdf
16. Monteiro-Riviere, N.A., Nemanich, R.J., Inman, A.O., Wang, Y.Y. and Riviere, J.E. (2005): Multi-walled carbon nanotube interactions with human epidermal keratinocytes. Toxicol. Lett., 155, 377-384.
17. OECD (2010a): DRAFT DOSSIER DEVELOPMENT PLAN: Multi-walled Carbon Nanotubes (MWCNTs), April 28, 2010.
18. OECD (2010b): DRAFT DOSSIER DEVELOPMENT PLAN: Single-walled Carbon Nanotubes (SWCNTs), April 15, 2010.
19. OECD (2011): Sponsorship Programme for the Testing of Manufactured Nanomaterials. http://www.oecd.org/document/47/0,3746, en_2649_37015404_41197295_1_1_1_1,00.html
20. Pauluhn, J. (2010): Subchronic 13-week inhalation exposure of rats to multiwalled carbon nanotubes: toxic effects are determined by density of agglomerate structures, not fibrillar structures. Toxicol. Sci., 113, 226-242.
21. Philbrook, N.A., Walker, V.K., Afrooz, A.R., Saleh, N.B. and Winn, L.M. (2011): Investigating the effects of functionalized carbon nanotubes on reproduction and development in Drosophila melanogaster and CD-1 mice. Reprod. Toxicol., 32, 442-448
22. Pietroiusti, A., Massimiani, M., Fenoglio, I., Colonna, M., Valentini, F., Palleschi, G., Camaioni, A., Magrini, A., Siracusa, G., Bergamaschi, A., Sgambato, A. and Campagnolo, L. (2011): Low doses of pristine and oxidized single-wall carbon nanotubes affect mammalian embryonic development. ACS Nano, 5, 4624-4633.
23. Sakamoto, Y., Dai, N., Hagiwara, Y., Satoh, K., Ohashi, N., Fukamachi, K., Tsuda, H., Hirose, A., Nishimura, T., Hino, O. and Ogata, A. (2010): Serum level of expressed in renal carcinoma (ERC)/mesothelin in rats with mesothelial proliferative lesions induced by multi-wall carbon nanotube (MWCNT). J. Toxicol. Sci., 35, 265-270.
24. Sakamoto, Y., Nakae, D., Fukumori, N., Tayama, K., Maekawa, A., Imai, K., Hirose, A., Nishimura, T., Ohashi, N. and Ogata, A. (2009): Induction of mesothelioma by a single intrascrotal administration of multi-wall carbon nanotube in intact male Fischer 344 rats. J. Toxicol. Sci., 34, 65-76.
25. Shvedova, A.A., Kisin, E., Murray, A.R., Johnson, V.J., Gorelik, O., Arepalli, S., Hubbs, A.F., Mercer, R.R., Keohavong, P., Sussman, N., Jin, J., Yin, J., Stone, S., Chen, B.T., Deye, G., Maynard, A., Castranova, V., Baron, P.A. and Kagan, V.E. (2008): Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis. Am. J. Physiol. Lung Cell. Mol. Physiol., 295, L552-565.
26. Takagi, A., Hirose, A., Nishimura, T., Fukumori, N., Ogata, A., Ohashi, N., Kitajima, S. and Kanno, J. (2008): Induction of mesothelioma in p53+/-mouse by intraperitoneal application of multi-wall carbon nanotubes. J. Toxicol. Sci., 33, 105-116.
27. Takahashi, M., Kato, H., Doi, Y., Hagiwara, A., Hirata-Koizumi, M., Ono, A., Kubota, R., Nishimura, T. and Hirose, A. (2012) Sub-acute oral toxicity study with fullerene C60 in rats. J. Toxicol. Sci., 37, 353-61.
28. Warheit, D.B., Laurence, B.R., Reed, K.L., Roach, D.H., Reynolds, G.A. and Webb, T.R. (2004): Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats. Toxicol. Sci., 77, 117-125.
29. Yang, S.T., Wang, X., Jia, G., Gu, Y., Wang, T., Nie, H., Ge, C., Wang, H. and Liu, Y. (2008): Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice. Toxicol. Let., 181, 182-189.