Nitrated fatty acids reverse pulmonary fibrosis by dedifferentiating myofibroblasts and promoting collagen uptake by alveolar macrophages

FASEB Journal

Volumn 28, Issue 12, 2014, Pages 5299-5310

  Reddy, Aravind T ^a,b   Lakshmi, Sowmya P ^a,b   Zhang, Yingze ^a   Reddy, Raju C ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Collagen; MFG E8; TGF

Indexed keywords

10 NITROOLEIC ACID; 12 NITROLINOLEIC ACID; ALPHA SMOOTH MUSCLE ACTIN; ANTIFIBROTIC AGENT; COLLAGEN TYPE 1; FATTY ACID BINDING PROTEIN 4; FATTY ACID DERIVATIVE; GELATINASE A; LACTADHERIN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; BLEOMYCIN; COLLAGEN; FATTY ACID; NITRIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLEOMYCIN-INDUCED PULMONARY FIBROSIS; CELL DEDIFFERENTIATION; CELL TRANSDIFFERENTIATION; COLLAGEN DEGRADATION; CONTROLLED STUDY; DISEASE SEVERITY; DOWN REGULATION; FETUS; FIBROSING ALVEOLITIS; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LUNG ALVEOLUS MACROPHAGE; LUNG FIBROBLAST; MALE; MOLECULAR MODEL; MOUSE; MYOFIBROBLAST; NITRATION; NONHUMAN; PHENOTYPE; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CHEMICALLY INDUCED; DRUG EFFECTS; METABOLISM; PATHOLOGY; PULMONARY FIBROSIS; REAL TIME POLYMERASE CHAIN REACTION;

MUS;

ANIMALS; BLEOMYCIN; CELL DEDIFFERENTIATION; COLLAGEN; FATTY ACIDS; HUMANS; MACROPHAGES, ALVEOLAR; MALE; MICE; MICE, INBRED C57BL; NITRATES; PPAR GAMMA; PULMONARY FIBROSIS; REAL-TIME POLYMERASE CHAIN REACTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 84919798075     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.14-256263     Document Type: Article

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