The functional differences between pro-survival and pro-apoptotic b cell lymphoma 2 (Bcl-2) proteins depend on structural differences in their Bcl-2 homology 3 (BH3) domains

Journal of Biological Chemistry

Volumn 289, Issue 52, 2014, Pages 36001-36017

  Lee, Erinna F ^a,b   Dewson, Grant ^a,b   Evangelista, Marco ^b   Pettikiriarachchi, Anne ^a   Gold, Grace J ^a,b   Zhu, Haoran ^a,b   Colman, Peter M ^a,b   Fairlie, W Douglas ^a,b  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CELL DEATH; ONCOLOGY; X RAY CRYSTALLOGRAPHY;

APOPTOTIC CELL DEATH; BINDING AFFINITIES; CRITICAL FEATURES; CRYSTALLOGRAPHIC STUDIES; PROTEASOMAL DEGRADATION; PROTEIN DESTABILIZATION; PROTEIN-PROTEIN INTERACTIONS; STRUCTURAL DIFFERENCES;

PROTEINS;

BCL2 RELATED PROTEIN A1; BH3 PROTEIN; CASPASE; CYTOCHROME C; PROTEIN BAK; PROTEIN BCL 2; PROTEIN BCL W; PROTEIN BCL XL; PROTEIN MCL 1; APOPTOSIS REGULATORY PROTEIN; BCL2L1 PROTEIN, HUMAN; BCL2L2 PROTEIN, HUMAN; PROTEIN BCL X; PROTEIN BINDING;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL DEATH; CELL KILLING; CONTROLLED STUDY; CRYSTAL STRUCTURE; EMBRYO; MOUSE; MUTANT; NONHUMAN; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION; WILD TYPE; X RAY CRYSTALLOGRAPHY; AMINO ACID SEQUENCE; ANIMAL; APOPTOSIS; CELL CULTURE; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; PROTEIN DOMAIN;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-X PROTEIN; CELL SURVIVAL; CELLS, CULTURED; CRYSTALLOGRAPHY, X-RAY; CYTOCHROMES C; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STABILITY;

EID: 84919797780     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.610758     Document Type: Article

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