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Volumn 6, Issue 4, 2014, Pages 2116-2136

Mutational analysis of merkel cell carcinoma

Author keywords

Merkel cell carcinoma; Merkel cell polyomavirus; Mutational analysis; Oncogene; Prognostic algorithm; Tumor suppressor

Indexed keywords

CABOZANTINIB; CIXUTUMUMAB; EVEROLIMUS; IMATINIB; KIT PROTEIN; MICRORNA; NELFINAVIR; PAZOPANIB; PDGFRA PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PIK3CA PROTEIN; PROTEIN KINASE B; PROTEIN P53; PROTEIN TYROSINE KINASE; RB1 PROTEIN; TEMSIROLIMUS; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; VATALANIB;

EID: 84919762473     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers6042116     Document Type: Review
Times cited : (39)

References (107)
  • 2
    • 0032558684 scopus 로고    scopus 로고
    • Merkel-cell carcinomas in patients treated with methoxsalen and ultraviolet a radiation
    • Lunder, E.J.; Stern, R.S. Merkel-cell carcinomas in patients treated with methoxsalen and ultraviolet a radiation. N. Engl. J. Med. 1998, 339, 1247-1248.
    • (1998) N. Engl. J. Med. , vol.339 , pp. 1247-1248
    • Lunder, E.J.1    Stern, R.S.2
  • 5
    • 84922479831 scopus 로고    scopus 로고
    • Rb1 gene in merkel cell carcinoma: Hypermethylation in all tumors and concurrent heterozygous deletions in the polyomavirus-negative subgroup
    • Sahi, H.; Savola, S.; Sihto, H.; Koljonen, V.; Bohling, T.; Knuutila, S. Rb1 gene in merkel cell carcinoma: Hypermethylation in all tumors and concurrent heterozygous deletions in the polyomavirus-negative subgroup. APMIS 2014, doi:10.1111/apm.12274.
    • (2014) APMIS
    • Sahi, H.1    Savola, S.2    Sihto, H.3    Koljonen, V.4    Bohling, T.5    Knuutila, S.6
  • 6
    • 0037140912 scopus 로고    scopus 로고
    • Uv-b-type mutations and chromosomal imbalances indicate common pathways for the development of merkel and skin squamous cell carcinomas
    • Popp, S.; Waltering, S.; Herbst, C.; Moll, I.; Boukamp, P. Uv-b-type mutations and chromosomal imbalances indicate common pathways for the development of merkel and skin squamous cell carcinomas. Int. J. Cancer 2002, 99, 352-360.
    • (2002) Int. J. Cancer , vol.99 , pp. 352-360
    • Popp, S.1    Waltering, S.2    Herbst, C.3    Moll, I.4    Boukamp, P.5
  • 8
    • 55549121216 scopus 로고    scopus 로고
    • Merkel cell carcinoma: Histologic features and prognosis
    • Andea, A.A.; Coit, D.G.; Amin, B.; Busam, K.J. Merkel cell carcinoma: Histologic features and prognosis. Cancer 2008, 113, 2549-2558.
    • (2008) Cancer , vol.113 , pp. 2549-2558
    • Andea, A.A.1    Coit, D.G.2    Amin, B.3    Busam, K.J.4
  • 9
    • 0030685775 scopus 로고    scopus 로고
    • Merkel cell carcinoma: Analysis of clinical, histologic, and immunohistologic features of 132 cases with relation to survival
    • Skelton, H.G.; Smith, K.J.; Hitchcock, C.L.; McCarthy, W.F.; Lupton, G.P.; Graham, J.H. Merkel cell carcinoma: Analysis of clinical, histologic, and immunohistologic features of 132 cases with relation to survival. J. Am. Acad. Dermatol. 1997, 37, 734-739.
    • (1997) J. Am. Acad. Dermatol , vol.37 , pp. 734-739
    • Skelton, H.G.1    Smith, K.J.2    Hitchcock, C.L.3    McCarthy, W.F.4    Lupton, G.P.5    Graham, J.H.6
  • 10
    • 78349270929 scopus 로고    scopus 로고
    • Merkel cell carcinoma. Arch. Pathol. Lab
    • Wong, H.H.; Wang, J. Merkel cell carcinoma. Arch. Pathol. Lab. Med. 2010, 134, 1711-1716.
    • (2010) Med , vol.134 , pp. 1711-1716
    • Wong, H.H.1    Wang, J.2
  • 11
    • 0033999509 scopus 로고    scopus 로고
    • Analysis of thyroid transcription factor-1 and cytokeratin 20 separates merkel cell carcinoma from small cell carcinoma of lung
    • Hanly, A.J.; Elgart, G.W.; Jorda, M.; Smith, J.; Nadji, M. Analysis of thyroid transcription factor-1 and cytokeratin 20 separates merkel cell carcinoma from small cell carcinoma of lung. J. Cutan. Pathol. 2000, 27, 118-120.
    • (2000) J. Cutan. Pathol. , vol.27 , pp. 118-120
    • Hanly, A.J.1    Elgart, G.W.2    Jorda, M.3    Smith, J.4    Nadji, M.5
  • 12
    • 84882631501 scopus 로고    scopus 로고
    • Which are the cells of origin in merkel cell carcinoma?
    • Tilling, T.; Moll, I. Which are the cells of origin in merkel cell carcinoma? J. Skin Cancer 2012, doi:10.1155/2012/680410.
    • (2012) J. Skin Cancer
    • Tilling, T.1    Moll, I.2
  • 13
    • 39749113080 scopus 로고    scopus 로고
    • Clonal integration of a polyomavirus in human merkel cell carcinoma
    • Feng, H.; Shuda, M.; Chang, Y.; Moore, P.S. Clonal integration of a polyomavirus in human merkel cell carcinoma. Science 2008, 319, 1096-1100.
    • (2008) Science , vol.319 , pp. 1096-1100
    • Feng, H.1    Shuda, M.2    Chang, Y.3    Moore, P.S.4
  • 14
    • 84880159392 scopus 로고    scopus 로고
    • Human merkel cell polyomavirus: Virological background and clinical implications
    • Coursaget, P.; Samimi, M.; Nicol, J.T.; Gardair, C.; Touze, A. Human merkel cell polyomavirus: Virological background and clinical implications. APMIS 2013, 121, 755-769.
    • (2013) APMIS , vol.121 , pp. 755-769
    • Coursaget, P.1    Samimi, M.2    Nicol, J.T.3    Gardair, C.4    Touze, A.5
  • 16
    • 38949125129 scopus 로고    scopus 로고
    • Clinical characteristics of merkel cell carcinoma at diagnosis in 195 patients: The aeiou features
    • Heath, M.; Jaimes, N.; Lemos, B.; Mostaghimi, A.; Wang, L.C.; Penas, P.F.; Nghiem, P. Clinical characteristics of merkel cell carcinoma at diagnosis in 195 patients: The aeiou features. J. Am. Acad. Dermatol. 2008, 58, 375-381.
    • (2008) J. Am. Acad. Dermatol , vol.58 , pp. 375-381
    • Heath, M.1    Jaimes, N.2    Lemos, B.3    Mostaghimi, A.4    Wang, L.C.5    Penas, P.F.6    Nghiem, P.7
  • 17
    • 77958518731 scopus 로고    scopus 로고
    • Merkel cell carcinoma, chronic lymphocytic leukemia and other lymphoproliferative disorders: An old bond with possible new viral ties
    • Tadmor, T.; Aviv, A.; Polliack, A. Merkel cell carcinoma, chronic lymphocytic leukemia and other lymphoproliferative disorders: An old bond with possible new viral ties. Ann. Oncol. 2011, 22, 250-256.
    • (2011) Ann. Oncol , vol.22 , pp. 250-256
    • Tadmor, T.1    Aviv, A.2    Polliack, A.3
  • 19
    • 84882318903 scopus 로고    scopus 로고
    • Merkel cell polyomavirus small T antigen controls viral replication and oncoprotein expression by targeting the cellular ubiquitin ligase SCFFbw7
    • Kwun, H.J.; Shuda, M.; Feng, H.; Camacho, C.J.; Moore, P.S.; Chang, Y. Merkel cell polyomavirus small T antigen controls viral replication and oncoprotein expression by targeting the cellular ubiquitin ligase SCFFbw7. Cell Host Microbe 2013, 14, 125-135.
    • (2013) Cell Host Microbe , vol.14 , pp. 125-135
    • Kwun, H.J.1    Shuda, M.2    Feng, H.3    Camacho, C.J.4    Moore, P.S.5    Chang, Y.6
  • 20
    • 80052371597 scopus 로고    scopus 로고
    • Human merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4e-bp1 translation regulator
    • Shuda, M.; Kwun, H.J.; Feng, H.; Chang, Y.; Moore, P.S. Human merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4e-bp1 translation regulator. J. Clin. Investig. 2011, 121, 3623-3634.
    • (2011) J. Clin. Investig , vol.121 , pp. 3623-3634
    • Shuda, M.1    Kwun, H.J.2    Feng, H.3    Chang, Y.4    Moore, P.S.5
  • 21
    • 84900861444 scopus 로고    scopus 로고
    • Merkel cell polyomavirus-positive merkel cell carcinoma requires viral small T-antigen for cell proliferation
    • Shuda, M.; Chang, Y.; Moore, P.S. Merkel cell polyomavirus-positive merkel cell carcinoma requires viral small T-antigen for cell proliferation. J. Investig. Dermatol. 2014, 134, 1479-1481.
    • (2014) J. Investig. Dermatol , vol.134 , pp. 1479-1481
    • Shuda, M.1    Chang, Y.2    Moore, P.S.3
  • 22
    • 84881238348 scopus 로고    scopus 로고
    • Merkel cell polyomavirus large T antigen disrupts host genomic integrity and inhibits cellular proliferation
    • Li, J.; Wang, X.; Diaz, J.; Tsang, S.H.; Buck, C.B.; You, J. Merkel cell polyomavirus large T antigen disrupts host genomic integrity and inhibits cellular proliferation. J. Virol. 2013, 87, 9173-9188.
    • (2013) J. Virol , vol.87 , pp. 9173-9188
    • Li, J.1    Wang, X.2    Diaz, J.3    Tsang, S.H.4    Buck, C.B.5    You, J.6
  • 23
    • 84894543613 scopus 로고    scopus 로고
    • High-affinity Rb binding, p53 inhibition, subcellular localization, and transformation by wild-type or tumor-derived shortened merkel cell polyomavirus large T antigens
    • Borchert, S.; Czech-Sioli, M.; Neumann, F.; Schmidt, C.; Wimmer, P.; Dobner, T.; Grundhoff, A.; Fischer, N. High-affinity Rb binding, p53 inhibition, subcellular localization, and transformation by wild-type or tumor-derived shortened merkel cell polyomavirus large T antigens. J. Virol. 2014, 88, 3144-3160.
    • (2014) J. Virol , vol.88 , pp. 3144-3160
    • Borchert, S.1    Czech-Sioli, M.2    Neumann, F.3    Schmidt, C.4    Wimmer, P.5    Dobner, T.6    Grundhoff, A.7    Fischer, N.8
  • 24
    • 83955161771 scopus 로고    scopus 로고
    • An intact retinoblastoma protein-binding site in merkel cell polyomavirus large T antigen is required for promoting growth of merkel cell carcinoma cells
    • Houben, R.; Adam, C.; Baeurle, A.; Hesbacher, S.; Grimm, J.; Angermeyer, S.; Henzel, K.; Hauser, S.; Elling, R.; Brocker, E.B., et al. An intact retinoblastoma protein-binding site in merkel cell polyomavirus large T antigen is required for promoting growth of merkel cell carcinoma cells. Int. J. Cancer 2012, 130, 847-856.
    • (2012) Int. J. Cancer , vol.130 , pp. 847-856
    • Houben, R.1    Adam, C.2    Baeurle, A.3    Hesbacher, S.4    Grimm, J.5    Angermeyer, S.6    Henzel, K.7    Hauser, S.8    Elling, R.9    Brocker, E.B.10
  • 26
    • 84878175474 scopus 로고    scopus 로고
    • Merkel cell polyomavirus large T antigen has growth-promoting and inhibitory activities
    • Cheng, J.; Rozenblatt-Rosen, O.; Paulson, K.G.; Nghiem, P.; DeCaprio, J.A. Merkel cell polyomavirus large T antigen has growth-promoting and inhibitory activities. J. Virol. 2013, 87, 6118-6126.
    • (2013) J. Virol , vol.87 , pp. 6118-6126
    • Cheng, J.1    Rozenblatt-Rosen, O.2    Paulson, K.G.3    Nghiem, P.4    Decaprio, J.A.5
  • 28
    • 67649639499 scopus 로고    scopus 로고
    • Clinical factors associated with merkel cell polyomavirus infection in merkel cell carcinoma
    • Sihto, H.; Kukko, H.; Koljonen, V.; Sankila, R.; Bohling, T.; Joensuu, H. Clinical factors associated with merkel cell polyomavirus infection in merkel cell carcinoma. J. Natl. Cancer Inst. 2009, 101, 938-945.
    • (2009) J. Natl. Cancer Inst , vol.101 , pp. 938-945
    • Sihto, H.1    Kukko, H.2    Koljonen, V.3    Sankila, R.4    Bohling, T.5    Joensuu, H.6
  • 29
    • 77955671981 scopus 로고    scopus 로고
    • Immunological detection of viral large T antigen identifies a subset of merkel cell carcinoma tumors with higher viral abundance and better clinical outcome
    • Bhatia, K.; Goedert, J.J.; Modali, R.; Preiss, L.; Ayers, L.W. Immunological detection of viral large T antigen identifies a subset of merkel cell carcinoma tumors with higher viral abundance and better clinical outcome. Int. J. Cancer 2010, 127, 1493-1496.
    • (2010) Int. J. Cancer , vol.127 , pp. 1493-1496
    • Bhatia, K.1    Goedert, J.J.2    Modali, R.3    Preiss, L.4    Ayers, L.W.5
  • 31
    • 79955002016 scopus 로고    scopus 로고
    • Transcriptome-wide studies of merkel cell carcinoma and validation of intratumoral cd8+ lymphocyte invasion as an independent predictor of survival
    • Paulson, K.G.; Iyer, J.G.; Tegeder, A.R.; Thibodeau, R.; Schelter, J.; Koba, S.; Schrama, D.; Simonson, W.T.; Lemos, B.D.; Byrd, D.R., et al. Transcriptome-wide studies of merkel cell carcinoma and validation of intratumoral cd8+ lymphocyte invasion as an independent predictor of survival. J. Clin. Oncol. 2011, 29, 1539-1546.
    • (2011) J. Clin. Oncol , vol.29 , pp. 1539-1546
    • Paulson, K.G.1    Iyer, J.G.2    Tegeder, A.R.3    Thibodeau, R.4    Schelter, J.5    Koba, S.6    Schrama, D.7    Simonson, W.T.8    Lemos, B.D.9    Byrd, D.R.10
  • 33
    • 84875254157 scopus 로고    scopus 로고
    • The role of the immune response in merkel cell carcinoma
    • Triozzi, P.L.; Fernandez, A.P. The role of the immune response in merkel cell carcinoma. Cancers 2013, 5, 234-254.
    • (2013) Cancers , vol.5 , pp. 234-254
    • Triozzi, P.L.1    Fernandez, A.P.2
  • 35
    • 37848999306 scopus 로고    scopus 로고
    • Platelet-derived growth factor receptor alpha mutational status and immunohistochemical expression in merkel cell carcinoma: Implications for treatment with imatinib mesylate
    • Swick, B.L.; Ravdel, L.; Fitzpatrick, J.E.; Robinson, W.A. Platelet-derived growth factor receptor alpha mutational status and immunohistochemical expression in merkel cell carcinoma: Implications for treatment with imatinib mesylate. J. Cutan. Pathol. 2008, 35, 197-202.
    • (2008) J. Cutan. Pathol , vol.35 , pp. 197-202
    • Swick, B.L.1    Ravdel, L.2    Fitzpatrick, J.E.3    Robinson, W.A.4
  • 36
    • 77957164870 scopus 로고    scopus 로고
    • Merkel cell carcinoma: Correlation of kit expression with survival and evaluation of kit gene mutational status
    • Andea, A.A.; Patel, R.; Ponnazhagan, S.; Kumar, S.; DeVilliers, P.; Jhala, D.; Eltoum, I.E.; Siegal, G.P. Merkel cell carcinoma: Correlation of kit expression with survival and evaluation of kit gene mutational status. Hum. Pathol. 2010, 41, 1405-1412.
    • (2010) Hum. Pathol , vol.41 , pp. 1405-1412
    • Andea, A.A.1    Patel, R.2    Ponnazhagan, S.3    Kumar, S.4    Devilliers, P.5    Jhala, D.6    Eltoum, I.E.7    Siegal, G.P.8
  • 37
    • 84879142758 scopus 로고    scopus 로고
    • Specific analysis of KIT and PDGFR-alpha expression and mutational status in merkel cell carcinoma
    • Swick, B.L.; Srikantha, R.; Messingham, K.N. Specific analysis of KIT and PDGFR-alpha expression and mutational status in merkel cell carcinoma. J. Cutan. Pathol. 2013, 40, 623-630.
    • (2013) J. Cutan. Pathol , vol.40 , pp. 623-630
    • Swick, B.L.1    Srikantha, R.2    Messingham, K.N.3
  • 38
    • 38649101275 scopus 로고    scopus 로고
    • Silent mutations in kit and pdgfra and coexpression of receptors with SCF and PDGFA in merkel cell carcinoma
    • Kartha, R.V.; Sundram, U.N. Silent mutations in kit and pdgfra and coexpression of receptors with SCF and PDGFA in merkel cell carcinoma: Implications for tyrosine kinase-based tumorigenesis. Mod. Pathol. 2008, 21, 96-104.
    • (2008) Implications for Tyrosine Kinase-Based Tumorigenesismod. Pathol , vol.21 , pp. 96-104
    • Kartha, R.V.1    Sundram, U.N.2
  • 40
    • 33344462540 scopus 로고    scopus 로고
    • Mutation of the PIK3CA oncogene in human cancers
    • Karakas, B.; Bachman, K.E.; Park, B.H. Mutation of the PIK3CA oncogene in human cancers. Br. J. Cancer 2006, 94, 455-459.
    • (2006) Br. J. Cancer , vol.94 , pp. 455-459
    • Karakas, B.1    Bachman, K.E.2    Park, B.H.3
  • 42
    • 34250637875 scopus 로고    scopus 로고
    • FGFR3 mutations in epidermal nevi and seborrheic keratoses: Lessons from urothelium and skin
    • Hafner, C.; Hartmann, A.; Vogt, T. FGFR3 mutations in epidermal nevi and seborrheic keratoses: Lessons from urothelium and skin. J. Investig. Dermatol. 2007, 127, 1572-1573.
    • (2007) J. Investig. Dermatol , vol.127 , pp. 1572-1573
    • Hafner, C.1    Hartmann, A.2    Vogt, T.3
  • 44
    • 0035342578 scopus 로고    scopus 로고
    • Frequent allelic loss at 10q23 but low incidence of pten mutations in merkel cell carcinoma
    • Van Gele, M.; Leonard, J.H.; van Roy, N.; Cook, A.L.; de Paepe, A.; Speleman, F. Frequent allelic loss at 10q23 but low incidence of pten mutations in merkel cell carcinoma. Int. J. Cancer 2001, 92, 409-413.
    • (2001) Int. J. Cancer , vol.92 , pp. 409-413
    • Van Gele, M.1    Leonard, J.H.2    van Roy, N.3    Cook, A.L.4    De Paepe, A.5    Speleman, F.6
  • 55
    • 79958072212 scopus 로고    scopus 로고
    • Association of merkel cell polyomavirus infection with tumor p53, KIT, stem cell factor, PDGFR-alpha and survival in merkel cell carcinoma
    • Waltari, M.; Sihto, H.; Kukko, H.; Koljonen, V.; Sankila, R.; Bohling, T.; Joensuu, H. Association of merkel cell polyomavirus infection with tumor p53, KIT, stem cell factor, PDGFR-alpha and survival in merkel cell carcinoma. Int. J. Cancer 2011, 129, 619-628.
    • (2011) Int. J. Cancer , vol.129 , pp. 619-628
    • Waltari, M.1    Sihto, H.2    Kukko, H.3    Koljonen, V.4    Sankila, R.5    Bohling, T.6    Joensuu, H.7
  • 56
    • 45349106896 scopus 로고    scopus 로고
    • P14ARF hypermethylation is common but INK4a-ARF locus or p53 mutations are rare in merkel cell carcinoma
    • Lassacher, A.; Heitzer, E.; Kerl, H.; Wolf, P. p14ARF hypermethylation is common but INK4a-ARF locus or p53 mutations are rare in merkel cell carcinoma. J. Investig. Dermatol. 2008, 128, 1788-1796.
    • (2008) J. Investig. Dermatol , vol.128 , pp. 1788-1796
    • Lassacher, A.1    Heitzer, E.2    Kerl, H.3    Wolf, P.4
  • 58
    • 0027489384 scopus 로고
    • Clinical implications of the p53 tumor-suppressor gene
    • Harris, C.C.; Hollstein, M. Clinical implications of the p53 tumor-suppressor gene. N. Engl. J. Med. 1993, 329, 1318-1327.
    • (1993) N. Engl. J. Med , vol.329 , pp. 1318-1327
    • Harris, C.C.1    Hollstein, M.2
  • 59
    • 0026649648 scopus 로고
    • The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
    • Momand, J.; Zambetti, G.P.; Olson, D.C.; George, D.; Levine, A.J. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 1992, 69, 1237-1245.
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3    George, D.4    Levine, A.J.5
  • 60
    • 0026740449 scopus 로고
    • Amplification of a gene encoding a p53-associated protein in human sarcomas
    • Oliner, J.D.; Kinzler, K.W.; Meltzer, P.S.; George, D.L.; Vogelstein, B. Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature 1992, 358, 80-83.
    • (1992) Nature , vol.358 , pp. 80-83
    • Oliner, J.D.1    Kinzler, K.W.2    Meltzer, P.S.3    George, D.L.4    Vogelstein, B.5
  • 62
    • 0030953421 scopus 로고    scopus 로고
    • Loss of heterozygosity of chromosome 13 in merkel cell carcinoma
    • Leonard, J.H.; Hayard, N. Loss of heterozygosity of chromosome 13 in merkel cell carcinoma. Genes Chromosomes Cancer 1997, 20, 93-97.
    • (1997) Genes Chromosomes Cancer , vol.20 , pp. 93-97
    • Leonard, J.H.1    Hayard, N.2
  • 63
    • 84905463439 scopus 로고    scopus 로고
    • Retinoblastoma gene mutations detected by whole exome sequencing of merkel cell carcinoma
    • Cimino, P.J.; Robirds, D.H.; Tripp, S.R.; Pfeifer, J.D.; Abel, H.J.; Duncavage, E.J. Retinoblastoma gene mutations detected by whole exome sequencing of merkel cell carcinoma. Mod. Pathol. 2014, 27, 1073-1087.
    • (2014) Mod. Pathol , vol.27 , pp. 1073-1087
    • Cimino, P.J.1    Robirds, D.H.2    Tripp, S.R.3    Pfeifer, J.D.4    Abel, H.J.5    Duncavage, E.J.6
  • 64
    • 3042803287 scopus 로고    scopus 로고
    • Copy number changes revealed by comparative genomic hybridization in primary merkel cell carcinomas. Mod
    • Larramendy, M.L.; Koljonen, V.; Bohling, T.; Tukiainen, E.; Knuutila, S. Recurrent DNA copy number changes revealed by comparative genomic hybridization in primary merkel cell carcinomas. Mod. Pathol. 2004, 17, 561-567.
    • (2004) Pathol , vol.17 , pp. 561-567
    • Larramendy, M.L.1    Koljonen, V.2    Bohling, T.3    Tukiainen, E.4    Knuutila, S.5    Recurrent, D.6
  • 65
    • 0029955911 scopus 로고    scopus 로고
    • Comparative genomic hybridization (cgh) discloses chromosomal and subchromosomal copy number changes in merkel cell carcinomas
    • Harle, M.; Arens, N.; Moll, I.; Back, W.; Schulz, T.; Scherthan, H. Comparative genomic hybridization (cgh) discloses chromosomal and subchromosomal copy number changes in merkel cell carcinomas. J. Cutan. Pathol. 1996, 23, 391-397.
    • (1996) J. Cutan. Pathol , vol.23 , pp. 391-397
    • Harle, M.1    Arens, N.2    Moll, I.3    Back, W.4    Schulz, T.5    Scherthan, H.6
  • 66
    • 0037056227 scopus 로고    scopus 로고
    • Combined karyotyping, CGH and M-FISH analysis allows detailed characterization of unidentified chromosomal rearrangements in merkel cell carcinoma
    • Van Gele, M.; Leonard, J.H.; van Roy, N.; van Limbergen, H.; van Belle, S.; Cocquyt, V.; Salwen, H.; de Paepe, A.; Speleman, F. Combined karyotyping, CGH and M-FISH analysis allows detailed characterization of unidentified chromosomal rearrangements in merkel cell carcinoma. Int. J. Cancer 2002, 101, 137-145.
    • (2002) Int. J. Cancer , vol.101 , pp. 137-145
    • Van Gele, M.1    Leonard, J.H.2    van Roy, N.3    van Limbergen, H.4    van Belle, S.5    Cocquyt, V.6    Salwen, H.7    de Paepe, A.8    Speleman, F.9
  • 69
    • 0025870449 scopus 로고
    • Loss of allelic heterozygosity on distal chromosome 1p in merkel cell carcinoma. A marker of neural crest origins
    • Harnett, P.R.; Kearsley, J.H.; Hayward, N.K.; Dracopoli, N.C.; Kefford, R.F. Loss of allelic heterozygosity on distal chromosome 1p in merkel cell carcinoma. A marker of neural crest origins? Cancer Genet. Cytogenet. 1991, 54, 109-113.
    • (1991) Cancer Genet. Cytogenet. , vol.54 , pp. 109-113
    • Harnett, P.R.1    Kearsley, J.H.2    Hayward, N.K.3    Dracopoli, N.C.4    Kefford, R.F.5
  • 70
    • 0032054737 scopus 로고    scopus 로고
    • Characteristic pattern of chromosomal gains and losses in merkel cell carcinoma detected by comparative genomic hybridization
    • Van Gele, M.; Speleman, F.; Vandesompele, J.; van Roy, N.; Leonard, J.H. Characteristic pattern of chromosomal gains and losses in merkel cell carcinoma detected by comparative genomic hybridization. Cancer Res. 1998, 58, 1503-1508.
    • (1998) Cancer Res , vol.58 , pp. 1503-1508
    • Van Gele, M.1    Speleman, F.2    Vandesompele, J.3    van Roy, N.4    Leonard, J.H.5
  • 73
    • 42549143547 scopus 로고    scopus 로고
    • Trisomy of chromosome 6 in merkel cell carcinoma within lymph nodes
    • Vasuri, F.; Magrini, E.; Foschini, M.P.; Eusebi, V. Trisomy of chromosome 6 in merkel cell carcinoma within lymph nodes. Virchows Arch. 2008, 452, 559-563.
    • (2008) Virchows Arch , vol.452 , pp. 559-563
    • Vasuri, F.1    Magrini, E.2    Foschini, M.P.3    Eusebi, V.4
  • 74
    • 38149127172 scopus 로고    scopus 로고
    • The potential contribution of fluorescent in situ hybridization analysis to the cytopathological diagnosis of merkel cell carcinoma
    • Suciu, V.; Botan, E.; Valent, A.; Chami, L.; Spatz, A.; Vielh, P. The potential contribution of fluorescent in situ hybridization analysis to the cytopathological diagnosis of merkel cell carcinoma. Cytopathology 2008, 19, 48-51.
    • (2008) Cytopathology , vol.19 , pp. 48-51
    • Suciu, V.1    Botan, E.2    Valent, A.3    Chami, L.4    Spatz, A.5    Vielh, P.6
  • 75
    • 0023730731 scopus 로고
    • Short communication: Deletion 7q, trisomy 6 and 11 in a case of merkel-cell carcinoma. Cancer Genet
    • Sandbrink, F.; Muller, L.; Fiebig, H.H.; Kovacs, G. Short communication: Deletion 7q, trisomy 6 and 11 in a case of merkel-cell carcinoma. Cancer Genet. Cytogenet. 1988, 33, 305-309.
    • (1988) Cytogenet , vol.33 , pp. 305-309
    • Sandbrink, F.1    Muller, L.2    Fiebig, H.H.3    Kovacs, G.4
  • 76
    • 0024517677 scopus 로고
    • Involvement of chromosome 22 in a merkel cell carcinoma in a patient with a previous meningioma. Cancer Genet
    • Shabtai, F.; Sternberg, A.; Klar, D.; Reiss, R.; Halbrecht, I. Involvement of chromosome 22 in a merkel cell carcinoma in a patient with a previous meningioma. Cancer Genet. Cytogenet. 1989, 38, 43-48.
    • (1989) Cytogenet , vol.38 , pp. 43-48
    • Shabtai, F.1    Sternberg, A.2    Klar, D.3    Reiss, R.4    Halbrecht, I.5
  • 77
  • 79
    • 78751582416 scopus 로고    scopus 로고
    • Aberrant expression of mir-203 and its clinical significance in gastric and colorectal cancers
    • Chiang, Y.; Song, Y.; Wang, Z.; Chen, Y.; Yue, Z.; Xu, H.; Xing, C.; Liu, Z. Aberrant expression of mir-203 and its clinical significance in gastric and colorectal cancers. J. Gastrointest. Surg. 2011, 15, 63-70.
    • (2011) J. Gastrointest. Surg , vol.15 , pp. 63-70
    • Chiang, Y.1    Song, Y.2    Wang, Z.3    Chen, Y.4    Yue, Z.5    Xu, H.6    Xing, C.7    Liu, Z.8
  • 81
    • 84891695147 scopus 로고    scopus 로고
    • Mir-203, a tumor suppressor frequently down-regulated by promoter hypermethylation in rhabdomyosarcoma
    • Diao, Y.; Guo, X.; Jiang, L.; Wang, G.; Zhang, C.; Wan, J.; Jin, Y.; Wu, Z. Mir-203, a tumor suppressor frequently down-regulated by promoter hypermethylation in rhabdomyosarcoma. J. Biol. Chem. 2014, 289, 529-539.
    • (2014) J. Biol. Chem , vol.289 , pp. 529-539
    • Diao, Y.1    Guo, X.2    Jiang, L.3    Wang, G.4    Zhang, C.5    Wan, J.6    Jin, Y.7    Wu, Z.8
  • 82
    • 84864368487 scopus 로고    scopus 로고
    • Expression of cxcr4, e-cadherin, bcl-2, and survivin in merkel cell carcinoma: An immunohistochemical study using a tissue microarray
    • Knapp, C.F.; Sayegh, Z.; Schell, M.J.; Rawal, B.; Ochoa, T.; Sondak, V.K.; Messina, J.L. Expression of cxcr4, e-cadherin, bcl-2, and survivin in merkel cell carcinoma: An immunohistochemical study using a tissue microarray. Am. J. Dermatopathol. 2012, 34, 592-596.
    • (2012) Am. J. Dermatopathol. , vol.34 , pp. 592-596
    • Knapp, C.F.1    Sayegh, Z.2    Schell, M.J.3    Rawal, B.4    Ochoa, T.5    Sondak, V.K.6    Messina, J.L.7
  • 83
    • 84894204533 scopus 로고    scopus 로고
    • Response of merkel cell polyomavirus-positive merkel cell carcinoma xenografts to a survivin inhibitor
    • Dresang, L.R.; Guastafierro, A.; Arora, R.; Normolle, D.; Chang, Y.; Moore, P.S. Response of merkel cell polyomavirus-positive merkel cell carcinoma xenografts to a survivin inhibitor. PLoS One 2013, 8, e80543.
    • (2013) Plos One , vol.8
    • Dresang, L.R.1    Guastafierro, A.2    Arora, R.3    Normolle, D.4    Chang, Y.5    Moore, P.S.6
  • 85
    • 84899902278 scopus 로고    scopus 로고
    • Good guy or bad guy: The opposing roles of microrna 125b in cancer
    • Banzhaf-Strathmann, J.; Edbauer, D. Good guy or bad guy: The opposing roles of microrna 125b in cancer. Cell Commun. Signal. 2014, doi:10.1186/1478-811X-12-30.
    • (2014) Cell Commun. Signal
    • Banzhaf-Strathmann, J.1    Edbauer, D.2
  • 87
    • 33947511415 scopus 로고    scopus 로고
    • Merkel cell carcinoma: Evaluation of kit (cd117) expression and failure to demonstrate activating mutations in the c-kit proto-oncogene—Implications for treatment with imatinib mesylate
    • Swick, B.L.; Ravdel, L.; Fitzpatrick, J.E.; Robinson, W.A. Merkel cell carcinoma: Evaluation of kit (cd117) expression and failure to demonstrate activating mutations in the c-kit proto-oncogene—Implications for treatment with imatinib mesylate. J. Cutan. Pathol. 2007, 34, 324-329.
    • (2007) J. Cutan. Pathol , vol.34 , pp. 324-329
    • Swick, B.L.1    Ravdel, L.2    Fitzpatrick, J.E.3    Robinson, W.A.4
  • 88
    • 33846080560 scopus 로고    scopus 로고
    • The wnt-signaling pathway is not implicated in tumorigenesis of merkel cell carcinoma
    • Liu, S.; Daa, T.; Kashima, K.; Kondoh, Y.; Yokoyama, S. The wnt-signaling pathway is not implicated in tumorigenesis of merkel cell carcinoma. J. Cutan. Pathol. 2007, 34, 22-26.
    • (2007) J. Cutan. Pathol , vol.34 , pp. 22-26
    • Liu, S.1    Daa, T.2    Kashima, K.3    Kondoh, Y.4    Yokoyama, S.5
  • 92
    • 84880329299 scopus 로고    scopus 로고
    • Expression of anaplastic lymphoma kinase in merkel cell carcinomas. Hum
    • Filtenborg-Barnkob, B.E.; Bzorek, M. Expression of anaplastic lymphoma kinase in merkel cell carcinomas. Hum. Pathol. 2013, 44, 1656-1664.
    • (2013) Pathol , vol.44 , pp. 1656-1664
    • Filtenborg-Barnkob, B.E.1    Bzorek, M.2
  • 94
    • 67650665722 scopus 로고    scopus 로고
    • Expression of notch-1 and alteration of the e-cadherin/beta-catenin cell adhesion complex are observed in primary cutaneous neuroendocrine carcinoma (merkel cell carcinoma)
    • Panelos, J.; Batistatou, A.; Paglierani, M.; Zioga, A.; Maio, V.; Santi, R.; Pimpinelli, N.; de Giorgi, V.; Santucci, M.; Massi, D., et al. Expression of notch-1 and alteration of the e-cadherin/beta-catenin cell adhesion complex are observed in primary cutaneous neuroendocrine carcinoma (merkel cell carcinoma). Mod. Pathol. 2009, 22, 959-968.
    • (2009) Mod. Pathol , vol.22 , pp. 959-968
    • Panelos, J.1    Batistatou, A.2    Paglierani, M.3    Zioga, A.4    Maio, V.5    Santi, R.6    Pimpinelli, N.7    De Giorgi, V.8    Santucci, M.9    Massi, D.10
  • 95
    • 79960410503 scopus 로고    scopus 로고
    • Merkel cell polyomavirus infection, large T antigen, retinoblastoma protein and outcome in merkel cell carcinoma
    • Sihto, H.; Kukko, H.; Koljonen, V.; Sankila, R.; Bohling, T.; Joensuu, H. Merkel cell polyomavirus infection, large T antigen, retinoblastoma protein and outcome in merkel cell carcinoma. Clin. Cancer Res. 2011, 17, 4806-4813.
    • (2011) Clin. Cancer Res , vol.17 , pp. 4806-4813
    • Sihto, H.1    Kukko, H.2    Koljonen, V.3    Sankila, R.4    Bohling, T.5    Joensuu, H.6
  • 97
    • 79954994742 scopus 로고    scopus 로고
    • High levels of antibodies against merkel cell polyomavirus identify a subset of patients with merkel cell carcinoma with better clinical outcome
    • Touze, A.; le Bidre, E.; Laude, H.; Fleury, M.J.; Cazal, R.; Arnold, F.; Carlotti, A.; Maubec, E.; Aubin, F.; Avril, M.F., et al. High levels of antibodies against merkel cell polyomavirus identify a subset of patients with merkel cell carcinoma with better clinical outcome. J. Clin. Oncol. 2011, 29, 1612-1619.
    • (2011) J. Clin. Oncol , vol.29 , pp. 1612-1619
    • Touze, A.1    Le Bidre, E.2    Laude, H.3    Fleury, M.J.4    Cazal, R.5    Arnold, F.6    Carlotti, A.7    Maubec, E.8    Aubin, F.9    Avril, M.F.10
  • 100
    • 84868215418 scopus 로고    scopus 로고
    • Increasing tumor thickness is associated with recurrence and poorer survival in patients with merkel cell carcinoma
    • Lim, C.S.; Whalley, D.; Haydu, L.E.; Murali, R.; Tippett, J.; Thompson, J.F.; Hruby, G.; Scolyer, R.A. Increasing tumor thickness is associated with recurrence and poorer survival in patients with merkel cell carcinoma. Ann. Surg. Oncol. 2012, 19, 3325-3334.
    • (2012) Ann. Surg. Oncol. , vol.19 , pp. 3325-3334
    • Lim, C.S.1    Whalley, D.2    Haydu, L.E.3    Murali, R.4    Tippett, J.5    Thompson, J.F.6    Hruby, G.7    Scolyer, R.A.8
  • 102
    • 0042878669 scopus 로고    scopus 로고
    • Expression of muc 1 and ep-cam in merkel cell carcinomas: Implications for immunotherapy
    • Kurzen, H.; Kaul, S.; Egner, U.; Deichmann, M.; Hartschuh, W. Expression of muc 1 and ep-cam in merkel cell carcinomas: Implications for immunotherapy. Arch. Dermatol. Res. 2003, 295, 146-154.
    • (2003) Arch. Dermatol. Res. , vol.295 , pp. 146-154
    • Kurzen, H.1    Kaul, S.2    Egner, U.3    Deichmann, M.4    Hartschuh, W.5
  • 106
    • 80051721184 scopus 로고    scopus 로고
    • Significant correlation of peptidyl-prolyl isomerase overexpression in merkel cell carcinoma with overall survival of patients
    • Lill, C.; Schneider, S.; Pammer, J.; Loewe, R.; Gedlicka, W.; Houben, R.; Heiduschka, G.; Brunner, M.; Thurnher, D. Significant correlation of peptidyl-prolyl isomerase overexpression in merkel cell carcinoma with overall survival of patients. Head Neck 2011, 33, 1294-1300.
    • (2011) Head Neck , vol.33 , pp. 1294-1300
    • Lill, C.1    Schneider, S.2    Pammer, J.3    Loewe, R.4    Gedlicka, W.5    Houben, R.6    Heiduschka, G.7    Brunner, M.8    Thurnher, D.9
  • 107
    • 17444418678 scopus 로고    scopus 로고
    • Neuroendocrine differentiation in primary merkel cell carcinoma—Possible prognostic significance
    • Koljonen, V.; Haglund, C.; Tukiainen, E.; Bohling, T. Neuroendocrine differentiation in primary merkel cell carcinoma—Possible prognostic significance. Anticancer Res. 2005, 25, 853-858.
    • (2005) Anticancer Res , vol.25 , pp. 853-858
    • Koljonen, V.1    Haglund, C.2    Tukiainen, E.3    Bohling, T.4


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