Array-CGH reveals recurrent genomic changes in merkel cell carcinoma including amplification of L-Myc

Journal of Investigative Dermatology

Volumn 129, Issue 6, 2009, Pages 1547-1555

  Paulson, Kelly G ^a,b   Lemos, Bianca D ^a,b   Feng, Bin ^c   Jaimes, Natalia ^d   Pẽas, Pablo F ^e   Bi, Xiaohui ^f   Maher, Elizabeth ^g   Cohen, Lisa ^h,i   Leonard, J Helen ^j   Granter, Scott R ^k,l   Chin, Lynda ^c,l   Nghiem, Paul ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d UNIVERSIDAD PONTIFICIA BOLIVARIANA   (Colombia)

^e UNIVERSITY OF SYDNEY   (Australia)

^f University of Medicine and Dentistry of New Jersey   (United States)

^g UNIVERSITY OF TEXAS AT DALLAS   (United States)

^h Caris Cohen Dx   (United States)

ⁱ TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^j QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^k BRIGHAM AND WOMEN S HOSPITAL   (United States)

^l HARVARD MEDICAL SCHOOL   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BETA ACTIN; PROTEIN RB1; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; VIRUS DNA;

ADULT; AGED; ARTICLE; CANCER PATIENT; CANCER SURVIVAL; CHROMOSOME 1; CHROMOSOME 10; CHROMOSOME 13; CHROMOSOME 1P; CHROMOSOME 3P; CHROMOSOME 3Q; CHROMOSOME 4; CHROMOSOME 5P; CHROMOSOME 5Q; CHROMOSOME 6; CHROMOSOME 7; CLINICAL ARTICLE; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; DNA MICROARRAY; FEMALE; GENE AMPLIFICATION; GENE DELETION; HUMAN; HUMAN TISSUE; L MYC GENE; LUNG SMALL CELL CANCER; MALE; MERKEL CELL TUMOR; ONCOGENE; ONCOGENE C MYC; PATHOGENESIS; POLYOMA VIRUS; PRIORITY JOURNAL;

AGED; AGED, 80 AND OVER; CARCINOMA, MERKEL CELL; CELL LINE, TUMOR; CHROMOSOME MAPPING; COMPARATIVE GENOMIC HYBRIDIZATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, MYC; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTO-ONCOGENE PROTEINS C-MYC; RECURRENCE; SKIN NEOPLASMS; SMALL CELL LUNG CARCINOMA;

EID: 67349267297     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2008.365     Document Type: Article

References (38)

1. Aguirre AJ, Brennan C, Bailey G, Sinha R, Feng B, Leo C et al. (2004) High-resolution characterization of the pancreatic adenocarcinoma genome. Proc Natl Acad Sci USA 101:9067-72
2. Allen PJ, Bowne WB, Jaques DP, Brennan MF, Busam K, Coit DG (2005) Merkel cell carcinoma: prognosis and treatment of patients from a single institution. J Clin Oncol 23:2300-9
3. American Cancer Society (2006) Cancer Facts and Figures 2006. Atlanta: American Cancer Society: 2006.
4. Birrer MJ, Segal S, DeGreve JS, Kaye F, Sausville EA, Minna JD (1988) L-myc cooperates with ras to transform primary rat embryo fibroblasts. Mol Cell Biol 8:2668-73
5. Boulais N, Misery L (2007) Merkel cells. J Am Acad Dermatol 57: 147-165
6. Brennan C, Zhang Y, Leo C, Feng B, Cauwels C, Aguirre AJ et al. (2004) High-resolution global profiling of genomic alterations with long oligonucleo-tide microarray. Cancer Res 64:4744-8
7. Cimmino A, Calin GA, Fabbri M, Iorio MV, Ferracin M, Shimizu M et al. (2005) Mir-15 and mir-16 induce apoptosis by targeting bcl2. Proc Natl Acad Sci USA 102:13944-9
8. Dosaka-Akita H, Akie K, Hiroumi H, Kinoshita I, Kawakami Y, Murakami A (1995) Inhibition of proliferation by L-Myc antisense DNA for the translational initiation site in human small cell lung cancer. Cancer Res 55:1559-64
9. Feng H, Shuda M, Chang Y, Moore PS (2008) Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science 319:1096-100
10. Garneski KM, Decaprio JA, Nghiem P (2008a) Does a new polyomavirus contribute to Merkel cell carcinoma? Genome Biol 9:228
11. Garneski KM, Warcola AH, Feng Q, Kiviat NB, Leonard JH, Nghiem P (2008b) Merkel cell polyomavirus is more frequently present in North American than Australian Merkel cell carcinoma tumors. J Invest Dermatol, E-pub ahead of print July 24, 2008.
12. Gotte M, Yip GW (2006) Heparanase, hyaluronan, and cd44 in cancers: a breast carcinoma perspective. Cancer Res 66:10233-7
13. Haeberle H, Fujiwara M, Chuang J, Medina MM, Panditrao MV, Bechstedt S et al. (2004) Molecular profiling reveals synaptic release machinery in Merkel cells. Proc Natl Acad Sci USA 101:14503-8
14. Harle M, Arens N, Moll I, Back W, Schulz T, Scherthan H (1996) Comparative genomic hybridization (CGH) discloses chromosomal and subchromo-somal copy number changes in Merkel cell carcinomas. J Cutan Pathol 23:391-7
15. Heath M, Jaimes N, Lemos B, Mostaghimi A, Wang LC, Penas PF et al. (2008) Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features. J Am Acad Dermatol 58:375-81
16. Hodgson NC (2005) Merkel cell carcinoma: changing incidence trends. J Surg Oncol 89:1-4
17. Houben R, Michel B, Vetter-Kauczok CS, Pfohler C, Laetsch B, Wolter MD et al. (2006) Absence of classical map kinase pathway signalling in Merkel cell carcinoma. J Invest Dermatol 126:1135-42
18. Johannsdottir HK, Jonsson G, Johannesdottir G, Agnarsson BA, Eerola H, Arason A et al. (2006) Chromosome 5 imbalance mapping in breast tumors from brca1 and brca2 mutation carriers and sporadic breast tumors. Int J Cancer 119:1052-60
19. Kennedy MM, Blessing K, King G, Kerr KM (1996) Expression of bcl-2 and p53 in Merkel cell carcinoma. An immunohistochemical study. Am J Dermatopathol 18:273-7
20. Kim YH, Girard L, Giacomini CP, Wang P, Hernandez-Boussard T, Tibshirani R et al. (2006) Combined microarray analysis of small cell lung cancer reveals altered apoptotic balance and distinct expression signatures of myc family gene amplification. Oncogene 25:130-8
21. Larramendy ML, Koljonen V, Bohling T, Tukiainen E, Knuutila S (2004) Recurrent DNA copy number changes revealed by comparative genomic hybridization in primary Merkel cell carcinomas. Mod Pathol 17:561-7
22. Lemos B, Nghiem P (2007) Merkel cell carcinoma: more deaths but still no pathway to blame. J Invest Dermatol 127:2100-3
23. Leonard JH, Williams G, Walters MK, Nancarrow DJ, Rabbitts PH (1996) Deletion mapping of the short arm of chromosome 3 in Merkel cell carcinoma. Genes Chromosomes Cancer 15:102-7
24. Lingjaerde OC, Baumbusch LO, Liestol K, Glad IK, Borresen-Dale AL (2005) CGH-Explorer: a program for analysis of array-CGH data. Bioinformatics 21:821-2
25. Liu S, Daa T, Kashima K, Kondoh Y, Yokoyama S (2007) The wnt-signaling pathway is not implicated in tumorigenesis of Merkel cell carcinoma. J Cutan Pathol 34:22-6
26. Meza-Zepeda LA, Kresse SH, Barragan-Polania AH, Bjerkehagen B, Ohnstad HO, Namlos HM et al. (2006) Array comparative genomic hybridization reveals distinct DNA copy number differences between gastrointestinal stromal tumors and leiomyosarcomas. Cancer Res 66:8984-93
27. Nau MM, Brooks BJ, Battey J, Sausville E, Gazdar AF, Kirsch IR et al. (1985) L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer. Nature 318:69-73
28. Plettenberg A, Pammer J, Tschachler E (1996) Merkel cells and Merkel cell carcinoma express the bcl-2 proto-oncogene. Exp Dermatol 5: 183-188
29. Popp S, Waltering S, Herbst C, Moll I, Boukamp P (2002) Uv-b-type mutations and chromosomal imbalances indicate common pathways for the development of Merkel and skin squamous cell carcinomas. Int J Cancer 99:352-60
30. Protopopov A, Feng B, Chin L (2008) Full complexity genomic hybridization on 60-mer oligonucleotide microarrays for array comparative genomic hybridization (ACGH). In: Genomics Protocols: Second edition, Methods in Molecular Biology. (Starkey M, Elaswarapu R, eds) Humana Press Inc.: Totowa, NJ, 87-100
31. Sackstein R, Merzaban JS, Cain DW, Dagia NM, Spencer JA, Lin CP et al. (2008) Ex vivo glycan engineering of cd44 programs human multipotent mesenchymal stromal cell trafficking to bone. Nat Med 14:181-7
32. Schlagbauer-Wadl H, Klosner G, Heere-Ress E, Waltering S, Moll I, Wolff K et al. (2000) Bcl-2 antisense oligonucleotides (g3139) inhibit Merkel cell carcinoma growth in scid mice. J Invest Dermatol 114:725-30
33. Spanos WC, Hoover A, Harris GF, Wu S, Strand GL, Anderson ME et al. (2008) The pdz binding motif of human papillomavirus type 16 e6 induces ptpn13 loss, which allows anchorage-independent growth and synergizes with ras for invasive growth. J Virol 82: 2493-2500
34. Swick BL, Ravdel L, Fitzpatrick JE, Robinson WA (2007) Merkel cell carcinoma: evaluation of kit (cd117) expression and failure to demonstrate activating mutations in the c-kit proto-oncogene- implications for treatment with imatinib mesylate. J Cutan Pathol 34:324-9
35. Tonon G, Wong KK, Maulik G, Brennan C, Feng B, Zhang Y et al. (2005) High-resolution genomic profiles of human lung cancer. Proc Natl Acad Sci USA 102:9625-30
36. Van Gele M, Kaghad M, Leonard JH, Van Roy N, Naeyaert JM, Geerts ML et al. (2000) Mutation analysis of p73 and tp53 in Merkel cell carcinoma. Br J Cancer 82:823-6
37. Van Gele M, Leonard JH, Van Roy N, Van Limbergen H, Van Belle S, Cocquyt V et al. (2002) Combined karyotyping, CGH and m-fish analysis allows detailed characterization of unidentified chromosomal rearrangements in Merkel cell carcinoma. Int J Cancer 101:137-45
38. Van Gele M, Speleman F, Vandesompele J, Van Roy N, Leonard JH (1998) Characteristic pattern of chromosomal gains and losses in Merkel cell carcinoma detected by comparative genomic hybridization. Cancer Res 58:1503-8