P53 mutation is a rare event in Merkel cell carcinoma of the head and neck

European Archives of Oto-Rhino-Laryngology

Volumn 268, Issue 11, 2011, Pages 1639-1646

  Lill, Claudia ^a   Schneider, Sven ^a   Item, Chike B ^a   Loewe, Robert ^b   Houben, Roland ^c   Halbauer, Daniel ^a   Heiduschka, Gregor ^a   Brunner, Markus ^a   Thurnher, Dietmar ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b Universitatsklinik fur Dermatologie   (Austria)

^c UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

High resolution melt analysis; Merkel cell carcinoma; p53 mutation

Indexed keywords

CISPLATIN; CYCLOPHOSPHAMIDE; DACARBAZINE; DOXORUBICIN; ETOPOSIDE; IFOSFAMIDE; PROTEIN P53; VINCRISTINE;

ADULT; AGED; ARTICLE; CANCER LOCALIZATION; CANCER RADIOTHERAPY; CANCER SURGERY; CLINICAL ARTICLE; CODON; CONTROLLED STUDY; DNA EXTRACTION; FEMALE; HEAD AND NECK TUMOR; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MERKEL CELL TUMOR; METASTASIS; MISSENSE MUTATION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RNA EXTRACTION;

AGED; AGED, 80 AND OVER; BLOTTING, WESTERN; CARCINOMA, MERKEL CELL; CELL LINE, TUMOR; DNA, NEOPLASM; FEMALE; FOLLOW-UP STUDIES; GENES, P53; HEAD AND NECK NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MUTATION; PROGNOSIS; REAL-TIME POLYMERASE CHAIN REACTION; RETROSPECTIVE STUDIES; SKIN NEOPLASMS;

EID: 80755135561     PISSN: 09374477     EISSN: 14344726     Source Type: Journal    
DOI: 10.1007/s00405-011-1529-7     Document Type: Article

References (32)

1. A Lassacher E Heitzer H Kerl P Wolf 2008 P14ARF hypermethylation is common but INK4a-ARF locus or p53 mutations are rare in merkel cell carcinoma J Invest Dermatol 128 1788 1796 18219279 10.1038/sj.jid.5701256 1:CAS:528:DC%2BD1cXntVertL0%3D (Pubitemid 351847382)
2. JC Becker D Schrama R Houben 2008 Merkel cell carcinoma Cell Mol Life Sci 66 1 8 10.1007/s00018-008-8483-6
3. J Girschik L Fritschi T Threlfall T Slevin 2008 Deaths from non-melanoma skin cancer in Western Australia Cancer Causes Control 19 8 879 885 18386140 10.1007/s10552-008-9150-9 1:STN:280:DC%2BD1cnhtlyqsw%3D%3D
4. K Weller C Vetter-Kauzcok K Kähler, et al. 2008 Guideline implementation in merkel cell carcinoma: an example of a rare disease Dtsch Aerztebl 103 2791 2796
5. Woo K, Choi Y, Jung HS et al (2010) Merkel cell carcinoma: our experience with seven patients in Korea and a literature review. J Plast Reconstr Aesthet Surg (ahead of print)
6. A Zampetti C Feliciani G Massi A Tulli 2010 Updated review of the pathogenesis and management of merkel cell carcinoma J Cutan Med Surg 14 2 51 61 20338120
7. J Declercq F Van Dyck B Van Damme WJ Van de Ven 2008 Upregulation of Igf and Wnt signalling associated genes in pleomorphic adenomas of the salivary glands in PLAG1 transgenic mice Int J Oncol 32 5 1041 1047 18425330 1:CAS:528:DC%2BD1cXmtlSnt7g%3D
8. A Nordkvist E Roijer G Bang, et al. 2000 Expression and mutation patterns of p53 in benign and malignant salivary gland tumors Int J Oncol 16 3 477 483 10675478 1:CAS:528:DC%2BD3cXhsF2mtbs%3D
9. L Freitas V Araujo M Martins C Chone A Crespo A Altemani 2005 Biomarker analysis in carcinoma wx pleomorphic adenoma at an early phase of carcinomatous transformation Int J Surg Path 13 4 337 342 10.1177/106689690501300405 1:CAS:528:DC%2BD2MXht1GhtL7P (Pubitemid 41688595)
10. Lamb P, Crawford L (1986) Characterization of the human p53 gene. Molecul Cell Biol 6(5):1379-1385 (Pubitemid 16089471)
11. Y Goan H Chang H Hsu YO Chou JT Cheng 2005 Risk of p53 gene mutation in esophageal squamous cell carcinoma and habit of betel quid chewing in Taiwanese Cancer Sci 96 11 758 765 16271069 10.1111/j.1349-7006.2005.00115.x 1:CAS:528:DC%2BD2MXhtlers7jL (Pubitemid 43019826)
12. S Popp S Waltering Ch Herbst I Moll P Boukamp 2002 UV-B type mutations and chromosomal imbalances indicate common pathways for the development of merkel and skin squamous cell carcinomas Int J Cancer 99 352 360 11992403 10.1002/ijc.10321 1:CAS:528:DC%2BD38XjsFagtLk%3D (Pubitemid 34495849)
13. M Van Gele M Kaghad JH Leonard, et al. 2000 Mutation analysis of p73 and TP53 in merkel cell carcinoma Br J Cancer 82 4 823 826 10732753 10.1054/bjoc.1999.1006 (Pubitemid 30085233)
14. R Houben D Schrama J Becker 2009 Molecular pathogenesis of merkel cell carcinoma Exp Dermatol 18 193 198 19400830 10.1111/j.1600-0625.2009.00853.x 1:CAS:528:DC%2BD1MXjvFOiurc%3D
15. L Matizonkas-Antonio R de Mesquita S de Souza F Nunes 2005 TP53 mutations in salivary gland neoplasms Barz Dent J 16 2 162 166 10.1590/S0103- 64402005000200014 (Pubitemid 41718218)
16. Bosch FX, Homann N, Conradt C, Dietz A, Erber R (1999) P53 Mutationen/p53-Proteinüberexpression. HNO, pp 833-843
17. X Li T Tsuji S Wen Y Mimura K Sasaki F Shinozaki 1997 Detection of numeric abnormalities of chromosome 17 and p53 deletions by fluorescence in situ hybridization in pleomorphic adenomas and carcinomas in pleomorphic adenoma. Correlation with p53 expression Cancer 79 12 2314 2319 9191518 10.1002/(SICI)1097-0142(19970615)79:12<2314::AID-CNCR4>3.0.CO;2-L 1:STN:280:DyaK2szjsVymsA%3D%3D (Pubitemid 27251013)
18. A Yiengpruksawan DG Coit HT Thaler C Urmacher WK Knapper 1991 Merkel cell carcinoma. Prognosis and management Arch Surg 126 1514 1519 1842182 1:STN:280:DyaK3s%2FnsVeltw%3D%3D
19. P Guldberg T Nedergaard HJ Nielsen AC Olsen V Ahrenkiel J Zeuthen 1997 Single-step DGGE-based mutation scanning of the p53 gene: application to genetic diagnosis of colorectal cancer Hum Mutat 9 348 355 9101296 10.1002/(SICI)1098- 1004(1997)9:4<348::AID-HUMU8>3.0.CO;2-1 1:CAS:528:DyaK2sXis1Grur0%3D (Pubitemid 27157654)
20. M Sur H AlArdati C Ross S Alowami 2007 TdT expression in merkel cell carcinoma: potential diagnostic pitfall with blastic hematological malignancies and expanded immunohistochemical analysis Mod Pathol 20 1113 1120 17885674 10.1038/modpathol.3800936 1:CAS:528:DC%2BD2sXhtFOksb3J (Pubitemid 47609060)
21. M Brunner D Thurnher J Pammer, et al. 2009 Expression of Hedgehog signaling molecules in Merkel cell carcinoma Head Neck 32 3 3333 3340
22. HG Skelton KJ Smith CL Hitchcock WF McCarthy GP Lupton JH Graham 1997 Merkel cell carcinoma: analysis of clinical, histologic, and immunohistologic features of 132 cases with relation to survival J Am Acad Dermatol 37 734 739 9366819 10.1016/S0190-9622(97)70110-5 1:STN:280:DyaK1c%2FjtlKitg%3D%3D (Pubitemid 27500317)
23. NS Agar GM Halliday RS Barnetson HN Ananthaswamy M Wheeler AM Jones 2004 The basal layer in human squamous tumors harbors more UVA than UVB fingerprint mutations: a role for UVA in human skin carcinogenesis Proc Natl Acad Sci USA 101 4954 4959 15041750 10.1073/pnas.0401141101 1:CAS:528:DC%2BD2cXjsFCis78%3D (Pubitemid 38469184)
24. VO Melnikova A Pacifico S Chimenti K Peris HN Ananthaswamy 2005 Fate of UVB-induced p53 mutations in SKH-hr1 mouse skin after discontinuation of irradiation: relationship to skin cancer development Oncogene 24 7055 7063 16007135 10.1038/sj.onc.1208863 1:CAS:528:DC%2BD2MXhtFCru7%2FN (Pubitemid 41573634)
25. G Giglia-Mari A Sarasin 2003 TP53 mutations in human skin cancers Hum Mutat 21 3 217 228 12619107 10.1002/humu.10179 1:CAS:528:DC%2BD3sXis1yjtrk%3D (Pubitemid 36292964)
26. T Ramqvist T Dalianis 2010 Lessons from immune responses and vaccines against murine polyomavirus infection and polyomavirus-induced tumours potentially useful for studies on human polyomaviruses Anticancer Res 30 279 284 20332429 1:CAS:528:DC%2BC3cXksFCrtL8%3D
27. T Nakamura Y Sato D Watanabe, et al. 2010 Nuclear localization of Merkel Cell Polyomavirus large T antigen in Merkel Cell Carcinoma Virology 398 273 279 20074767 10.1016/j.virol.2009.12.024 1:CAS:528:DC%2BC3cXhs1yhur0%3D
28. EJ Duncavage BM Le D Wang JD Pfeifer 2009 Merkel Cell Polyomavirus: a specific marker for Merkel Cell Carcinoma in histologically similar tumors Am J Surg Pathol 33 12 1771 1777 19809278 10.1097/PAS.0b013e3181ba7b73
29. K Bhatia JJ Goedert R Modali L Preiss LW Ayers 2009 Merkel Cell Carcinoma subgroups by Merkel cell polyomavirus DNA relative abundance and oncogene expression Int J Cancer 126 2240 2246
30. M Feinmesser M Halpern E Fening, et al. 1999 Expression of the apoptosis-related oncogenes bcl-2, bax, and p53 in merkel cell carcinoma. Can they predict treatment response and clinical outcome? Hum Pathol 30 1367 1372 10571519 10.1016/S0046-8177(99)90070-9 1:CAS:528:DyaK1MXnvVGnuro%3D (Pubitemid 29534301)
31. M Kennedy K Blessing G King KM Kerr 1996 Expression of bcl-2 and p53 in merkel cell carcinoma. An immunohistochemical study Am J Dermatopathol 18 273 277 8806961 10.1097/00000372-199606000-00006 1:STN:280:DyaK28vgtVGrtw%3D%3D (Pubitemid 26230852)
32. Lill C et al (2010) Overexpression of Peptidyl-prolyl isomerase (PIN1) in Merkel Cell Carcinoma correlates significantly with overall survival of patients. Head Neck (manuscript ahead of print)