FGFR3 mutations in epidermal nevi and seborrheic keratoses: Lessons from urothelium and skin

Journal of Investigative Dermatology

Volumn 127, Issue 7, 2007, Pages 1572-1573

  Hafner, Christian ^a   Hartmann, Arndt ^a   Vogt, Thomas ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR RECEPTOR 3;

ACANTHOSIS NIGRICANS; BLADDER CANCER; CROUZON SYNDROME; GENE MUTATION; GENE OVEREXPRESSION; GENE SEQUENCE; HISTOPATHOLOGY; HUMAN; MULTIPLE MYELOMA; NEVUS; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; SEBORRHEIC KERATOSIS; SEQUENCE ANALYSIS; SEVERE ACHONDROPLASIA WTIH DEVELOPMENTAL DELAY AND ACANTHOSIS NIGRICANS; SKIN; SKIN TUMOR; UROTHELIAL CARCINOMA; UROTHELIUM;

EID: 34250637875     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/sj.jid.5700772     Document Type: Note

References (11)

1. Dunois-Larde C, Levrel O, Brams A, Thiery JP, Radvanyi F (2005) Absence of FGFR3 mutations in urinary bladder tumours of rats and mice treated with N-butyl-N-(4-hydroxyb utyl)nitrosamine. Mol Carcinog 42:142-9
2. Hafner C, van Oers JM, Hartmann A, Landthaler M, Stoehr R, Blaszyk H et al. (2006a) High frequency of FGFR3 mutations in adenoid seborrheic keratoses. J Invest Dermatol 126:2404-7
3. Hafner C, van Oers JM, Vogt T, Landthaler M, Stoehr R, Blaszyk H et al. (2006b) Mosaicism of activating FGFR3 mutations in human skin causes epidermal nevi. J Clin Invest 116:2201-7
4. Hafner C, Vogt T, Hartmann A (2006c) FGFR3 Mutations in benign skin tumors. Cell Cycle 5:2723-8
5. Hernandez S, Lopez-Knowles E, Lloreta J, Kogevinas M, Amoros A, Tardon A et al. (2006) Prospective study of FGFR3 mutations as a prognostic factor in nonmuscle invasive urothelial bladder carcinomas. J Clin Oncol 24:3664-71
6. Hernández S, Toll A, Baselga E, Ribé A, Azua-Romeo J, Pujol RM et al. (2007) Fibroblast growth factor receptor 3 mutations in epidermal nevi and associated low grade bladder tumors. J Invest Dermatol 127:1664-66.
7. Kwon OS, Hwang EJ, Bae JH, Park HE, Lee JC, Youn JI et al. (2003) Seborrheic keratosis in the Korean males: causative role of sunlight. Photodermatol Photoimmunol Photomed 19:73-80
8. L'Hote CG, Knowles MA (2005) Cell responses to FGFR3 signalling: growth, differentiation and apoptosis. Exp Cell Res 304:417-31
9. Logie A, Dunois-Larde C, Rosty C, Levrel O, Blanche M, Ribeiro A et al. (2005) Activating mutations of the tyrosine kinase receptor FGFR3 are associated with benign skin tumors in mice and humans. Hum Mol Genet 14:1153-60
10. Naski MC, Wang Q, Xu J, Ornitz DM (1996) Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia. Nat Genet 13:233-7
11. van Oers JM, Adam C, Denzinger S, Stoehr R, Bertz S, Zaak D et al. (2006) Chromosome 9 deletions are more frequent than FGFR3 mutations in flat urothelial hyperplasias of the bladder. Int J Cancer 119:1212-5