Mutation analysis of P73 and TP53 in Merkel cell carcinoma

British Journal of Cancer

Volumn 82, Issue 4, 2000, Pages 823-826

  Van Gele, M ^a   Kaghad, M ^d   Leonard, J H ^c   Van Roy, N ^a   Naeyaert, J M ^a   Geerts, M L ^a   Van Belle, S ^a   Cocquyt, V ^a   Bridge, J ^e   Sciot, R ^b   De Wolf Peeters, C ^b   De Paepe, A ^a   Caput, D ^d   Speleman, F ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^c Queensland Radium Institute   (Australia)

^d SANOFI   (France)

^e UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

1p36; Merkel cell carcinoma; Mutation; p73; TP53

Indexed keywords

DNA; PROTEIN P53; PROTEIN P73;

ARTICLE; CANCER CELL CULTURE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; DNA SEQUENCE; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MERKEL CELL TUMOR; MISSENSE MUTATION; NONSENSE MUTATION; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

EID: 0033981734     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1054/bjoc.1999.1006     Document Type: Article

References (20)

1. Brash DE, Rudolph JA, Simon JA, Lin A, McKenna GJ, Baden HP, Halperin AJ and Ponten J (1991) A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proc Natl Acad Sci USA 88: 10124-10128
2. Cho Y, Gorina S, Jeffrey PD and Pavletich NP (1994) Crystal structure of a p53 tumour suppressor DNA complex: understanding tumorigenic mutations. Science 265: 346-355
3. Ichimiya S, Nimura Y, Kageyama H, Takeda N, Sunahara M, Shishikura T, Nakamura Y, Sakiyama S, Seki N, Ohira M, Kaneko Y, McKeon F, Caput D and Nakagawara A (1999) p73 at chromosome 1p36 is lost in advanced stage neuroblastoma but its mutation is infrequent. Oncogene 18: 1061-1066
4. Jost CA, Marin MC and Kaelin WG Jr (1997) p73 is a human p53-related protein that can induce apoptosis. Nature 389: 191-194
5. Kaghad M, Bonnet H, Yang A, Creancier L, Biscan JC, Valent A, Minty A, Chalon P, Lelias JM, Dumont X, Ferrara P, McKeon F and Caput D (1997) Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell 90: 809-819
6. Kovalev S, Marchenko N, Swendeman S, LaQuaglia M and Moll UM (1998) Expression level, allelic origin, and mutation analysis of the p73 gene in neuroblastoma tumours and cell lines. Cell Growth Diff 9: 897-903
7. Mai M, Huang H, Reed C, Qian C, Smith JS, Alderete B, Jenkins R, Smith DI and Liu W (1998a) Genomic organization and mutation analysis of p73 in oligodendrogliomas with chromosome 1 p-arm deletions. Genomics 51: 359-363
8. Mai M, Yokomizo A, Qian C, Yang P, Tindall DJ, Smith DI and Liu W (1998b) Activation of p73 silent allele in lung cancer. Cancer Res 58: 2347-2349
9. Mihara M, Nimura Y, Ichimiya S, Sakiyama S, Kajikawa S, Adachi W, Amano J and Nakagawara A (1999) Absence of mutation of the p73 gene localized at chromosome 1p36.3 in hepatocellular carcinoma. Br J Cancer 79: 164-167
10. Mitelman F, Johansson B and Mertens F (1998) Catalog of Chromosome Aberrations in Cancer '98. Version 1. Wiley-Liss: New York (CD-rom)
11. Nimura Y, Mihara M, Ichimiya S, Sakiyama S, Seki N, Ohira M, Nomura N, Fujimori M, Adachi W, Amano J, He M, Ping YM and Nakagawara A (1998) p73, a gene related to p53, is not mutated in esophageal carcinomas. Int J Cancer 78: 437-440
12. Nomoto S, Haruki N, Kondo M, Konishi H, Takahashi T, Takahashi T and Takahashi T (1998) Search for mutations and examination of allelic expression imbalance of the p73 gene at 1p36.33 in human lung cancers. Cancer Res 58: 1380-1383
13. Ratner D, Nelson BR, Brown MD and Johnson TM (1993) Merkel cell carcinoma. J Am Acad Dermatol 29: 143-156
14. Schmid M, Janßen K, Dockhorn-Dworniczak B, Metze D, Zelger BW, Luger TA and Schmid KW (1997) p53 abnormalities are rare events in neuroendocrine (Merkel cell) carcinoma of the skin. An immunohistochemical and SSCP analysis. Virchows Arch 430: 233-237
15. Schwab M, Praml C and Amler LC (1996) Genomic instability in 1p and human malignancies. Genes Chromosomes Cancer 16: 211-229
16. Sunahara M, Ichimiya S, Nimura Y, Takada N, Sakiyama S, Sato Y, Todo S, Adachi W, Amano J and Nakagawara A (1998) Mutational analysis of the p73 gene localized at chromosome 1p36.3 in colorectal carcinomas. Int J Oncol 13: 319-323
17. Takada N, Ozaki T, Ichimiya S, Todo S and Nakagawara A (1999) Identification of a transactivation activity in the COOH-terminal region of p73 which is impaired in the naturally occurring mutants found in human neuroblastomas. Cancer Res 59: 2810-2814
18. Takahashi H, Ichimiya S, Nimura Y, Watanabe M, Furusato M, Wakui S, Yatani R, Aizawa S and Nakagawara A (1998) Mutation, allelotyping, and transcription analyses of the p73 gene in prostatic carcinoma. Cancer Res 58: 2076-2077
19. Van Gele M, Van Roy N, Ronan SG, Messiaen L, Vandesompele J, Geerts ML, Naeyaert JM, Blennow E, Bar-Am I, Das Gupta TK, van der Drift P, Versteeg R, Leonard JH and Speleman F (1998) Molecular analysis of 1p36 breakpoints in two Merkel cell carcinomas. Genes Chromosomes Cancer 23: 67-71
20. Van Roy N, Laureys G, Cheng NC, Willem P, Opdenakker G, Versteeg R and Speleman F (1994) 1;17 translocations and other chromosome 17 rearrangements in human primary neuroblastoma tumours and cell lines. Genes Chromosomes Cancer 10: 103-114