Expression of β-catenin and cyclin D1 in Merkel cell carcinomas of the head and neck

Wiener Klinische Wochenschrift

Volumn 125, Issue 17-18, 2013, Pages 501-507

  Lill, Claudia ^a   Schneider, Sven ^a   Ghanim, Bahil ^a   Brunner, Markus ^a   Heiduschka, Gregor ^a   Loewe, Robert ^b   Thurnher, Dietmar ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b Universitatsklinik fur Dermatologie   (Austria)

Author keywords

Cyclin D1; Merkel cell carcinoma; Prognostic factor; catenin

Indexed keywords

BETA CATENIN; CYCLIN D1;

ADULT; AGED; ARTICLE; CANCER CELL CULTURE; CANCER SURVIVAL; CONTROLLED STUDY; CYTOPLASM; FEMALE; HEAD AND NECK CARCINOMA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MERKEL CELL TUMOR; OVERALL SURVIVAL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN EXPRESSION; WESTERN BLOTTING;

AGED; AGED, 80 AND OVER; BETA CATENIN; CARCINOMA, MERKEL CELL; CYCLIN D1; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEAD AND NECK NEOPLASMS; HUMANS; MALE; MIDDLE AGED; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TUMOR MARKERS, BIOLOGICAL;

EID: 84885673451     PISSN: 00435325     EISSN: 16137671     Source Type: Journal    
DOI: 10.1007/s00508-013-0406-3     Document Type: Article

References (37)

1. Lassacher A, Heitzer E, Kerl H, et al. P15ARF hypermethylation is common but INK4a-ARF locus or p53 mutations are rare in Merkel cell carcinoma. J Invest Dermatol. 2008;128:1788-96.
2. Becker JC, Schrama D, Houben R. Merkel cell carcinoma. Cell Mol Life Sci. 2008;66:1-8.
3. 3 induces elevated expression of the cell cycle inhibitor p18 in a squamous cell carcinoma cell line of the head and neck. J Oral Pathol Med. 2006;35:472-8.
4. Weller K, Vetter-Kauzcok C, Kähler K, et al. Guideline implementation in Merkel cell carcinoma: an example of a rare disease. Dtsch Aerztebl. 2008;103:2791-6.
5. Lill C, Schneider S, Pammer J, et al. Significant correlation of peptidylprolyl isomerase overexpression in Merkel cell carcinoma with overall survival of patients. Head Neck. 2011 Sep;33(9):1294-300.
6. Woo K, Choi Y, Jung HS, et al. Merkel cell carcinoma: our experience with seven patients in Korea and a literature review. J Plast Reconstr Aesthet Surg. 2010 Dec;63(12):2064-70.
7. Zampetti A, Feliciani C, Massi G, Tulli A. Updated review of the pathogenesis and management of Merkel cell carcinoma. J Cutan Med Surg. 2010;14:51-61.
8. Zhou CX, Gao Y. Aberrant expression of beta-catenin, PIN1 and cyclin D1 in salivary adenoid cystic carcinoma: relation to tumor proliferation and metastasis. Oncol Rep. 2006;16(3):505-11.
9. Guo Q, Wu M, Lian P, et al. Synergistic effect of indomethacin and NGX6 on proliferation and invasion by human colorectal cancer cells through modulation of the Wnt/beta-catenin signaling pathway. Mol Cell Biochem. 2009;330(1-2):71-81.
10. Khramtsov AI, Khramtsova GF, Tretiakova M, et al. Wnt/β-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcome. Am J Pathol. 2010;176(6):2911-20.
11. 3 induces elevated expression of the cell cycle-regulating genes p21 and p27 in squamous carcinoma cell lines of the head and neck. Acta Otolarygol. 2001;121:103-9.
12. Bassiouny AE, Nosseir MM, Zoheiry MK, et al. Differential expression of cell cycle regulators in HCV-infection and related hepatocellular carcinoma. World J Hepatol. 2010;2(1):32-41.
13. Cao X, Fan L, Fang C, et al. The expression of SOX11, cyclin D1, cyclin D2, and cyclin D3 in B-cell lymphocytic proliferative diseases. Med Oncol. 2012;29(2):1190-6.
14. Nakashima M, Meirmanov S, Naruke Y, et al. Cyclin D1 overexpression in thyroid tumours from a radio-contaminated area and its correlation with Pin1 and aberrant β-catenin expression. J Pathol. 2004;202:446-55.
15. Peng H, Zhong XY, Liu KP, Li SM. Expression and significance of adenomatous polyposis coli, beta-catenin, E-cadherin and cyclin D1 in esophageal squamous cell carcinoma assessed by tissue microarray. Ai Zheng. 2009;28(1):38-41.
16. Yiengpruksawan A, Coit DG, Thaler HT, et al. Merkel cell carcinoma. Prognosis and management. Arch Surg. 1991;126:1514-9.
17. Beasley MB, Lantuejoul S, Abbondanzo S, et al. The p16/cyclin D1/Rb pathway in neuroendocrine tumors of the lung. Hum Pathol. 2003;34(2):136-42.
18. Sur M, Al Ardati H, Ross C, et al. TdT expression in Merkel cell carcinoma: potential diagnostic pitfall with blastic haematological malignancies and expanded immunohistochemical analysis. Mod Pathol. 2007;20:1113-20.
19. Brunner M, Thurnher D, Pammer J, et al. Expression of hedgehog signaling molecules in Merkel cell carcinoma. Head Neck. 2009;32:333-40.
20. Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature. 2002;417:949-54.
21. Brunner M, Thurnher D, Pammer J, et al. Expression of VEGF-A/C, VEGF-R2, PDGF-alpha/beta, c-kit, EGFR, Her-2/Neu, Mcl-1 and Bmi-1 in Merkel cell carcinoma. Mod Pathol. 2008;21:876-84.
22. Feinmesser M, Halpern M, Kaganovsky E, et al. C-kit expression in primary and metastatic Merkel cell carcinoma. Am J Dermatopathol. 2004;26:458-62.
23. Llombart B, Monteagudo C, Lopez-Guerrero JA, et al. Clinicopathological and immunohistochemical analysis of 20 cases of Merkel cell carcinoma in search of prognostic markers. Histopathology. 2005;46:622-34.
24. Strong S, Shalders K, Carr R, Snead DR. KIT receptor (CD 117) expression in Merkel cell carcinoma. Br J Dermatol. 2004;150:384-5.
25. Feinmesser M, Halpern M, Fenig E, et al. Expression of the apoptosis-related oncogenes bcl-2, bax, and p53 in Merkel cell carcinoma: can they predict treatment response and clinical outcome? Hum Pathol. 1999;30:1367-72.
26. Kennedy MM, Blessing K, King G, Kerr KM. Expression of bcl-2 and p53 in Merkel cell carcinoma. An immunohistochemical study. Am J Dermatopathol. 1996;18:273-7.
27. Houben R, Shuda M, Weinkam R, et al. Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens. J Virol. 2010;84(14):7064-72.
28. Declercq J, Van Dyck F, Van Damme B, Van de Ven WJ. Upregulation of Igf and Wnt signalling associated genes in pleomorphic adenomas of the salivary glands in PLAG1 transgenic mice. Int J Oncol. 2008;32(5):1041-7.
29. Lill C, Schneider S, Item CB, et al. P53 mutation is a rare event in Merkel cell carcinoma of the head and neck. Eur Arch Otorhinolaryngol. 2011;268(11):1639-46.
30. Nordkvist A, Roijer E, Bang G, et al. Expression and mutation patterns of p53 in benign and malignant salivary gland tumors. Int J Oncol. 2000;16(3):477-83.
31. Freitas L, Araujo V, Martins M, et al. Biomarker analysis in carcinoma ex pleomorphic adenoma at an early phase of carcinomatous transformation. Int J Surg Path. 2005;13(4):337-42.
32. Girschik J, Fritschi L, Threlfall T, et al. Deaths from non-melanoma skin cancer in western Australia. Cancer Causes Control. 2008;19:879-85.
33. Lamb P, Crawford L. Characterization of the human p53 gene. Mol Cell Biol. 1986;6(5):1379-85.
34. Wodarz A, Nusse R. Mechanisms of Wnt signalling in development. Annu Rev Cell Dev Biol. 1998;14:59-88.
35. Williams JM, SH Oh, Jorgensen M, et al. The role of the Wnt family of secreted proteins in rat oval "stem" cell-based liver regeneration. Am J Pathol. 2010;176(6):2732-42.
36. Goan Y, Chang H, Hsu H, et al. Risk of p53 gene mutation in esophageal squamous cell carinoma and habit of betel quid chewing in Taiwanese. Cancer Sci. 2005;96(11):758-65.
37. Liu S, Daa T, Kashima K, et al. The Wnt-signaling pathway is not implicated in tumorigenesis of Merkel cell carcinoma. J Cutan Pathol. 2007;34(2):22-6.