High versus low blood-pressure target in patients with septic shock

New England Journal of Medicine

Volumn 370, Issue 17, 2014, Pages 1583-1593

  Asfar, Pierre ^a   Meziani, Ferhat ^b   Hamel, Jean François ^a   Grelon, Fabien ^c   Megarbane, Bruno ^d   Anguel, Nadia ^h   Mira, Jean Paul ^e   Dequin, Pierre François ⁱ   Gergaud, Soizic ^a   Weiss, Nicolas ^f   Legay, François ^j   Le Tulzo, Yves ^k   Conrad, Marie ^l   Robert, René ^m   Gonzalez, Frédéric ⁿ   Guitton, Christophe ^o   Tamion, Fabienne ^p   Tonnelier, Jean Marie ^q   Guezennec, Pierre ^r   Van Der Linden, Thierry ^s   Vieillard Baron, Antoine ^t   Mariotte, Eric ^g   Pradel, Gaël ^u   Lesieur, Olivier ^g   Ricard, Jean Damien ^v   Hervé, Fabien ^w   Du Cheyron, Damien ^x   Guerin, Claude ^y   Mercat, Alain ^a   Teboul, Jean Louis ^h   Radermacher, Peter ^z   more..

^a ANGERS UNIVERSITY HOSPITAL   (France)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c CENTRE HOSPITALIER DU MANS   (France)

^d HÔPITAL LARIBOISIÈRE   (France)

^e Institut Cochin   (France)

^f HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^g SAINT LOUIS HOSPITAL   (France)

^h BICÊTRE HOSPITAL   (France)

ⁱ UNIVERSITÉ DE TOURS   (France)

^j Saint Brieuc Hospital   (France)

^k RENNES UNIVERSITY HOSPITAL   (France)

^l UNIVERSITY HOSPITAL OF NANCY   (France)

^m POITIERS UNIVERSITY HOSPITAL   (France)

ⁿ AVICENNE HOSPITAL   (France)

^o NANTES UNIVERSITY HOSPITAL   (France)

^p ROUEN UNIVERSITY HOSPITAL   (France)

^q BREST UNIVERSITY HOSPITAL   (France)

^r CENTRE HOSPITALIER DE VERSAILLES   (France)

^s LILLE UNIVERSITY HOSPITAL   (France)

^t CIO de Boulogne Billancourt   (France)

^u Avignon Hospital   (France)

^v UNIVERSITÉ PARIS DESCARTES   (France)

^w Regional Hospital of Quimper   (France)

^x CAEN UNIVERSITY HOSPITAL   (France)

^y HOSPICES CIVILS DE LYON   (France)

^z UNIVERSITY HOSPITAL ULM   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; CREATININE; NORADRENALIN;

AGED; AKINESIA; ARTICLE; BLEEDING; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DEATH; DRUG USE; FEMALE; FLUID BALANCE; FLUID INTAKE; FLUID RESUSCITATION; HEART ATRIUM FIBRILLATION; HEART INFARCTION; HEART SUPRAVENTRICULAR ARRHYTHMIA; HEART VENTRICLE ARRHYTHMIA; HUMAN; HYPERTENSION; HYPOKINESIA; HYPOTENSION; INFUSION RATE; LIMB ISCHEMIA; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; MESENTERIC ISCHEMIA; MORTALITY; MULTICENTER STUDY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RENAL REPLACEMENT THERAPY; SEPTIC SHOCK; SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE; SIMPLIFIED ACUTE PHYSIOLOGY SCORE; TREATMENT DURATION; TREATMENT OUTCOME; URINE VOLUME;

AGED; ATRIAL FIBRILLATION; BLOOD PRESSURE; FEMALE; HUMANS; INCIDENCE; MALE; MIDDLE AGED; RENAL REPLACEMENT THERAPY; RESUSCITATION; SHOCK, SEPTIC; VASOCONSTRICTOR AGENTS;

EID: 84898820371     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1312173     Document Type: Article

References (19)

1. Dellinger RP, Levy MM, Rhodes A, et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 2013;41:580-637.
2. LeDoux D, Astiz ME, Carpati CM, Rackow EC. Effects of perfusion pressure on tissue perfusion in septic shock. Crit Care Med 2000;28:2729-32.
3. Bourgoin A, Leone M, Delmas A, Garnier F, Albanèse J, Martin C. Increasing mean arterial pressure in patients with septic shock: effects on oxygen variables and renal function. Crit Care Med 2005;33:780-6.
4. Rivers E, Nguyen B, Havstad S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001;345:1368-77.
5. Annane D, Vignon P, Renault A, et al. Norepinephrine plus dobutamine versus epinephrine alone for management of septic shock: a randomised trial. Lancet 2007;370:676-84. [Erratum, Lancet 2007;370:1034.] (Pubitemid 47299251)
6. López A, Lorente JA, Steingrub J, et al. Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock. Crit Care Med 2004;32:21-30. (Pubitemid 38125559)
7. De Backer D, Biston P, Devriendt J, et al. Comparison of dopamine and norepinephrine in the treatment of shock. N Engl J Med 2010;362:779-89.
8. Russell JA, Walley KR, Singer J, et al. Vasopressin versus norepinephrine infusion in patients with septic shock. N Engl J Med 2008;358:877-87. (Pubitemid 351397087)
9. Dünser MW, Takala J, Ulmer H, et al. Arterial blood pressure during early sepsis and outcome. Intensive Care Med 2009;35:1225-33.
10. Badin J, Boulain T, Ehrmann S, et al. Relation between mean arterial pressure and renal function in the early phase of shock: a prospective, explorative cohort study. Crit Care 2011;15:R135.
11. Strandgaard S, Olesen J, Skinhoj E, Lassen NA. Autoregulation of brain circulation in severe arterial hypertension. Br Med J 1973;1:507-10.
12. Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Chest 1992;101:1644-55.
13. Pottecher T, Calvat S, Dupont H, Durand-Gasselin J, Gerbeaux P. Haemodynamic management of severe sepsis: recommendations of the French Intensive Care Societies (SFAR/SRLF) Consensus Conference, 13 October 2005, Paris, France. Crit Care 2006;10:311.
14. Heyland DK, Muscedere J, Drover J, Jiang X, Day AG. Persistent organ dysfunction plus death: a novel, composite outcome measure for critical care trials. Crit Care 2011;15:R98.
15. Ranieri VM, Thompson BT, Barie PS, et al. Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med 2012;366:2055-64.
16. Perner A, Haase N, Guttormsen AB, et al. Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis. N Engl J Med 2012;367:124-34. [Erratum, N Engl J Med 2012;367:481.]
17. Walkey AJ, Wiener RS, Ghobrial JM, Curtis LH, Benjamin EJ. Incident stroke and mortality associated with new-onset atrial fibrillation in patients hospitalized with severe sepsis. JAMA 2011;306:2248-54.
18. Sprung CL, Annane D, Keh D, et al. Hydrocortisone therapy for patients with septic shock. N Engl J Med 2008;358:111-24.
19. Poukkanen M, Wilkman E, Vaara ST, et al. Hemodynamic variables and progression of acute kidney injury in critically ill patients with severe sepsis: data from the prospective observational FINNAKI study. Crit Care 2013;17:R295.