Immunization with the glutamate receptor-derived peptide GluR3B induces neuronal death and reactive gliosis, but confers partial protection from pentylenetetrazole-induced seizures

Experimental Neurology

Volumn 195, Issue 1, 2005, Pages 92-102

  Ganor, Yonatan ^a   Gottlieb, Miroslav ^a   Eilam, Raya ^a   Otmy, Hanoch ^a   Teichberg, Vivian I ^a   Levite, Mia ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Autoantibodies; Epilepsy; GluR3; Pentylenetetrazole; Protection

Indexed keywords

ASPARAGINYLGLUTAMYLTYROSYLGLUTAMYLARGINYLPHENYLALANYLVALYLPROLYL PHENYLALANYLSERYLASPARTYLGLUTAMINYLGLUTAMINYLISOLEUCYLSERYLASPARAGINYLASPARTYL SERYLSERYLSERYLSERYLGLUTAMYLASPARAGINYLARGININE; AUTOANTIBODY; CONVULSANT AGENT; GLUTAMATE RECEPTOR 3B; PENTETRAZOLE; PEPTIDE DERIVATIVE; RECEPTOR ANTIBODY; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN BINDING; ARTICLE; CELL KILLING; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFECT; FEMALE; GLIA CELL; GLIOSIS; GRAND MAL SEIZURE; IMMUNIZATION; NERVE CELL EXCITABILITY; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SCORING SYSTEM; SEIZURE;

ANIMALS; AUTOANTIBODIES; BRAIN; CELL COUNT; CELL DEATH; FEMALE; GENE PRODUCTS, ENV; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIOSIS; IMMUNIZATION; IMMUNOHISTOCHEMISTRY; MICROTUBULE-ASSOCIATED PROTEINS; NEUROPEPTIDES; PENTYLENETETRAZOLE; PEPTIDE FRAGMENTS; PHOSPHOPYRUVATE HYDRATASE; RATS; RATS, INBRED LEW; RECEPTORS, AMPA; SEIZURES;

EID: 22844449251     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.expneurol.2005.04.002     Document Type: Article

References (27)

1. R. Ambalavanar, C.L. Ludlow, R.J. Wenthold, Y. Tanaka, M. Damirjian, and R.S. Petralia Glutamate receptor subunits in the nucleus of the tractus solitarius and other regions of the medulla oblongata in the cat J. Comp. Neurol. 402 1998 75 92
2. P.I. Andrews, M.A. Dichter, S.F. Berkovic, M.R. Newton, and J.O. McNamara Plasmapheresis in Rasmussen's encephalitis Neurology 46 1996 242 246
3. C. Antozzi, T. Granata, N. Aurisano, G. Zardini, P. Confalonieri, G. Airaghi, R. Mantegazza, and R. Spreafico Long-term selective IgG immuno-adsorption improves Rasmussen's encephalitis Neurology 51 1998 302 305
4. P. Bernasconi, B. Cipelletti, L. Passerini, T. Granata, C. Antozzi, R. Mantegazza, and R. Spreafico Similar binding to glutamate receptors by Rasmussen and partial epilepsy patients' sera Neurology 59 2002 1998 2001
5. C. Frassoni, R. Spreafico, S. Franceschetti, N. Aurisano, P. Bernasconi, R. Garbelli, C. Antozzi, S. Taverna, T. Granata, and R. Mantegazza Labeling of rat neurons by anti-GluR3 IgG from patients with Rasmussen encephalitis Neurology 57 2001 324 327
6. L. Gahring, N.G. Carlson, E.L. Meyer, and S.W. Rogers Granzyme B proteolysis of a neuronal glutamate receptor generates an autoantigen and is modulated by glycosylation J. Immunol. 166 2001 1433 1438
7. Y. Ganor, M. Besser, N. Ben-Zakay, T. Unger, and M. Levite Human T cells express a functional ionotropic glutamate receptor GluR3, and glutamate by itself triggers integrin-mediated adhesion to laminin and fibronectin and chemotactic migration J. Immunol. 170 2003 4362 4372
8. Y. Ganor, H. Goldberg-Stern, D. Amrom, T. Lerman-Sagie, V.I. Teichberg, D. Pelled, A.H. Futerman, B. Ben-Zeev, M. Freilinger, D. Verheulpen, P. Van Bogaert, and M. Levite Autoimmune epilepsy: some epilepsy patients harbor autoantibodies to glutamate receptors and dsDNA on both sides of the blood-brain barrier, which may kill neurons and decrease in brain fluids after hemispherotomy Clin. Dev. Immunol. 11 2004 241 252
9. Y. Ganor, H. Goldberg-Stern, T. Lerman-Sagie, V.I. Teichberg, and M. Levite Autoimmune epilepsy: distinct subpopulations of epilepsy patients harbor serum autoantibodies to either glutamate/AMPA receptor GluR3, glutamate/NMDA receptor subunit NR2A or double-stranded DNA Epilepsy Res. 2005 (in press)
10. Y. Ganor, M. Freilinger, O. Dulac, and M. Levite Monozygotic twins discordant for epilepsy differ in the levels of potentially pathogenic autoantibodies and cytokines Autoimmunity 2005 (in press)
11. X.P. He, M. Patel, K.D. Whitney, S. Janumpalli, A. Tenner, and J.O. McNamara Glutamate receptor GluR3 antibodies and death of cortical cells Neuron 20 1998 153 163
12. K. Jin, M. Minami, J.Q. Lan, X.O. Mao, S. Batteur, R.P. Simon, and D.A. Greenberg Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat Proc. Natl. Acad. Sci. U. S. A. 98 2001 4710 4715
13. I.A. Klioueva, E.L. van Luijtelaar, N.E. Chepurnova, and S.A. Chepurnov PTZ-induced seizures in rats: effects of age and strain Physiol. Behav. 72 2001 421 426
14. E. Koustova, Y. Sei, L. Fossom, M.L. Wei, P.N. Usherwood, N.B. Keele, M.A. Rogawski, and A.S. Basile LP-BM5 virus-infected mice produce activating autoantibodies to the AMPA receptor J. Clin. Invest. 107 2001 737 744
15. M. Levite, and A. Hermelin Autoimmunity to the glutamate receptor in mice-A model for Rasmussen's encephalitis? J. Autoimmun. 13 1999 73 82
16. M. Levite, I.A. Fleidervish, A. Schwarz, D. Pelled, and A.H. Futerman Autoantibodies to the glutamate receptor kill neurons via activation of the receptor ion channel J. Autoimmun. 13 1999 61 72
17. W. Loscher Animal models of epilepsy for the development of antiepileptogenic and disease-modifying drugs. A comparison of the pharmacology of kindling and post-status epilepticus models of temporal lobe epilepsy Epilepsy Res. 50 2002 105 123
18. R. Mantegazza, P. Bernasconi, F. Baggi, R. Spreafico, F. Ragona, C. Antozzi, G. Bernardi, and T. Granata Antibodies against GluR3 peptides are not specific for Rasmussen's encephalitis but are also present in epilepsy patients with severe, early onset disease and intractable seizures J. Neuroimmunol. 131 2002 179 185
19. M. Pekny, and M. Pekna Astrocyte intermediate filaments in CNS pathologies and regeneration J. Pathol. 204 2004 428 437
20. M.S. Rao, and A.K. Shetty Efficacy of doublecortin as a marker to analyse the absolute number and dendritic growth of newly generated neurons in the adult dentate gyrus Eur. J. Neurosci. 19 2004 234 246
21. S.W. Rogers, P.I. Andrews, L.C. Gahring, T. Whisenand, K. Cauley, B. Crain, T.E. Hughes, S.F. Heinemann, and J.O. McNamara Autoantibodies to glutamate receptor GluR3 in Rasmussen's encephalitis Science 265 1994 648 651
22. R.E. Twyman, L.C. Gahring, J. Spiess, and S.W. Rogers Glutamate receptor antibodies activate a subset of receptors and reveal an agonist binding site Neuron 14 1995 755 762
23. K.D. Whitney, and J.O. McNamara GluR3 autoantibodies destroy neural cells in a complement-dependent manner modulated by complement regulatory proteins J. Neurosci. 20 2000 7307 7316
24. H. Wiendl, C.G. Bien, P. Bernasconi, B. Fleckenstein, C.E. Elger, J. Dichgans, R. Mantegazza, and A. Melms GluR3 antibodies: prevalence in focal epilepsy but no specificity for Rasmussen's encephalitis Neurology 57 2001 1511 1514
25. H.K. Wolf, R. Buslei, R. Schmidt-Kastner, P.K. Schmidt-Kastner, T. Pietsch, O.D. Wiestler, and I. Blumcke NeuN: a useful neuronal marker for diagnostic histopathology J. Histochem. Cytochem. 44 1996 1167 1171
26. Z.Q. Xiong, and J.O. McNamara Fleeting activation of ionotropic glutamate receptors sensitizes cortical neurons to complement attack Neuron 36 2002 363 374
27. H. Yamamoto, T. Yamano, S. Niijima, J. Kohyama, and H. Yamanouchi Spontaneous improvement of intractable epileptic seizures following acute viral infections Brain Dev. 26 2004 377 379