Cognitive deficits following anti-NMDA receptor encephalitis

Journal of Neurology, Neurosurgery and Psychiatry

Volumn 83, Issue 2, 2012, Pages 195-198

  Finke, Carsten ^a   Kopp, Ute A ^a   Prüss, Harald ^a   Dalmau, Josep ^b   Wandinger, Klaus Peter ^c,d   Ploner, Christoph J ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c Institute of Experimental Immunology   (Germany)

^d UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CORTICOSTEROID; IMMUNOGLOBULIN; METHOTREXATE; METHYLPREDNISOLONE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR ANTIBODY; PREDNISOLONE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNE ENCEPHALITIS; CLINICAL ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE SEVERITY; ENCEPHALITIS; EXECUTIVE FUNCTION; FEMALE; HUMAN; IMMUNOTHERAPY; MALE; MEMORY DISORDER; MENTAL PERFORMANCE; NEUROPSYCHOLOGICAL TEST; PRIORITY JOURNAL; THERAPY DELAY;

ADULT; ANTI-N-METHYL-D-ASPARTATE RECEPTOR ENCEPHALITIS; AUTOANTIBODIES; AUTOIMMUNE DISEASES; BRAIN; COGNITION DISORDERS; COLOR PERCEPTION; FEMALE; HIPPOCAMPUS; HUMANS; IMMUNOTHERAPY; LEARNING DISORDERS; MAGNETIC RESONANCE IMAGING; MALE; MEMORY DISORDERS; NEUROPSYCHOLOGICAL TESTS; PSYCHOMOTOR PERFORMANCE; RECEPTORS, N-METHYL-D-ASPARTATE; YOUNG ADULT;

EID: 84855607331     PISSN: 00223050     EISSN: 1468330X     Source Type: Journal    
DOI: 10.1136/jnnp-2011-300411     Document Type: Article

References (12)

1. Dalmau J, Gleichman AJ, Hughes EG, et al. Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol 2008;7:1091-8.
2. Irani SR, Bera K, Waters P, et al. N-methyl-D-aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both sexes. Brain 2010;133:1655-67.
3. Dalmau J, Lancaster E, Martinez-Hernandez E, et al. Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis. Lancet Neurol 2011;10:63-74.
4. Finke C, Braun M, Ostendorf F, et al. The human hippocampal formation mediates short-term memory of colour-location associations. Neuropsychologia 2008;46:614-23. (Pubitemid 351186570)
5. Braun M, Finke C, Ostendorf F, et al. Reorganization of associative memory in humans with long-standing hippocampal damage. Brain 2008;131:2742-50.
6. Prüss H, Dalmau J, Harms L, et al. Retrospective analysis of NMDA receptor antibodies in encephalitis of unknown origin. Neurology 2010;75:1735-9.
7. Wandinger K, Saschenbrecker S, Stoecker W, et al. Anti-NMDA-receptor encephalitis: a severe, multistage, treatable disorder presenting with psychosis. J Neuroimmunol 2011;231:86-91.
8. Flanagan EP, McKeon A, Lennon VA, et al. Autoimmune dementia: clinical course and predictors of immunotherapy response. Mayo Clin Proc 2010;85:881-97.
9. Morris RG, Anderson E, Lynch GS, et al. Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5. Nature 1986;319:774-6. (Pubitemid 16145031)
10. Krystal JH, Bennett A, Abi-Saab D, et al. Dissociation of ketamine effects on rule acquisition and rule implementation: possible relevance to NMDA receptor contributions to executive cognitive functions. Biol Psychiatry 2000;47:137-43. (Pubitemid 30069737)
11. Tsien JZ, Huerta PT, Tonegawa S. The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. Cell 1996;87:1327-38. (Pubitemid 27010115)
12. Nakazawa K, Quirk MC, Chitwood RA, et al. Requirement for hippocampal CA3 NMDA receptors in associative memory recall. Science 2002;297:211-18. (Pubitemid 34761276)