Neurological sequelae of 2009 influenza A (H1N1) in children: A case series observed during a pandemic

Pediatric Critical Care Medicine

Volumn 11, Issue 2, 2010, Pages 179-184

  Baltagi, Sirine A ^a   Shoykhet, Michael ^a   Felmet, Kathryn ^a   Kochanek, Patrick M ^a   Bell, Michael J ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Children; Encephalopathy encephalitis; H1N1; Influenza A; Neurologic outcome

Indexed keywords

ACICLOVIR; ADRENALIN; ANTIBIOTIC AGENT; CEFTRIAXONE; FOSPHENYTOIN SODIUM; HYDROCORTISONE; IMMUNOGLOBULIN; METHYLPREDNISOLONE SODIUM SUCCINATE; OSELTAMIVIR; VANCOMYCIN;

ARTICLE; ARTIFICIAL VENTILATION; CASE REPORT; CHILD; COMMON COLD; CONSCIOUSNESS DISORDER; DIAGNOSTIC IMAGING; DISEASE COURSE; ELECTROENCEPHALOGRAM; FEMALE; FEVER; HOSPITAL ADMISSION; HOSPITAL DISCHARGE; HUMAN; INFLUENZA; INFLUENZA VIRUS A H1N1; INTENSIVE CARE UNIT; MALE; MEDICAL RECORD REVIEW; MENTAL HEALTH; NEUROLOGIC DISEASE; NEUROLOGICAL COMPLICATION; PANDEMIC; PRESCHOOL CHILD; PRIORITY JOURNAL; RESPIRATORY FAILURE; SCHOOL CHILD; SEIZURE; SURVIVAL; TERTIARY HEALTH CARE; THROAT CULTURE; UNITED STATES; WORLD HEALTH ORGANIZATION;

EID: 77949472285     PISSN: 15297535     EISSN: None     Source Type: Journal    
DOI: 10.1097/PCC.0b013e3181cf4652     Document Type: Article

References (32)

1. Louie JK, Acosta M, Winter K, et al: Factors associated with death or hospitalization due to pandemic 2009 influenza A (H1N1) infection in California. JAMA 2009; 302: 1896-1902
2. Kumar A, Zarychanski R, Pinto R, et al: Critically ill patients with 2009 influenza A (H1N1) infection in Canada. JAMA 2009; 302: 1872-1879
3. Maricich SM, Neul JL, Lotze TE, et al: Neurologic complications associated with influenza A in children during the 2003-2004 influenza season in Houston, Texas. Pediatrics 2004; 114:e626-e633
4. Morishima T, Togashi T, Yokota S, et al: Encephalitis and encephalopathy associated with an influenza epidemic in Japan. Clin Infect Dis 2002; 35:512-517
5. Ryan MM, Procopis PG, Ouvrier RA: Influenza A encephalitis with movement disorder. Pediatr Neurol 1999; 21:669-673
6. Togashi T, Matsuzono Y, Narita M, et al: Influenza-associated acute encephalopathy in Japanese children in 1994-2002. Virus Res 2004; 103:75-78
7. Centers for disease Control and Prevention (CDC): Neurologic complications associated with novel influenza A (H1N1) virus infection in children-Dallas, Texas, May 2009. MMWR Morb Mortal Wkly Rep 2009; 58: 773-778
8. Belser JA, Wadford DA, Xu J, et al: Ocular infection of mice with influenza A (H7) viruses: A site of primary replication and spread to the respiratory tract. J Virol 2009; 83:7075-7084
9. Majde JA, Bohnet SG, Ellis GA, et al: Detection of mouse-adapted human influenza virus in the olfactory bulbs of mice within hours after intranasal infection. J Neurovirol 2007; 13:399-409
10. Togashi T, Matsuzono Y, Anakura M, et al: [Acute encephalitis and encephalopathy at the height of influenza in childhood.] Nippon Rinsho 1997; 55:2699-2705
11. Gambotto A, Barratt-Boyes SM, de Jong MD, et al: Human infection with highly pathogenic H5N1 influenza virus. Lancet 2008; 371:1464-1475
12. Jang H, Boltz D, Sturm-Ramirez K, et al: Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration. Proc Natl Acad Sci U S A 2009; 106: 14063-14068
13. Nakai Y, Itoh M, Mizuguchi M, et al: Apoptosis and microglial activation in influenza encephalopathy. Acta Neuropathol 2003; 105: 233-239
14. Wang G, Zhang J, Li W, et al: Apoptosis and proinflammatory cytokine responses of primary mouse microglia and astrocytes induced by human H1N1 and avian H5N1 influenza viruses. Cell Mol Immunol 2008; 5:113-120
15. Ichiyama T, Morishima T, Kajimoto M, et al: Matrix metalloproteinase-9 and tissue inhibitors of metalloproteinases 1 in influenzaassociated encephalopathy. Pediatr Infect Dis J 2007; 26:542-544
16. Soldo I, Duvnjak M, Lisnjić D, et al: Encephalitis or encephalopathy during an influenza-A epidemic. Coll Antropol 2003; 27(Suppl 1): 19-22
17. Amin R, Ford-Jones E, Richardson SE, et al: Acute childhood encephalitis and encephalopathy associated with influenza: A prospective 11-year review. Pediatr Infect Dis J 2008; 27:390-395
18. Friedman MJ, Attia MW: Clinical predictors of influenza in children. Arch Pediatr Adolesc Med 2004; 158:391-394
19. Peltola V, Reunanen T, Ziegler T, et al: Accuracy of clinical diagnosis of influenza in outpatient children. Clin Infect Dis 2005; 41: 1198-1200
20. Wada T, Morishima T, Okumura A, et al: Differences in clinical manifestations of influenza- associated encephalopathy by age. Microbiol Immunol 2009; 53:83-88
21. Fujimoto S, Kobayashi M, Uemura O, et al: PCR on cerebrospinal fluid to show influenzaassociated acute encephalopathy or encephalitis. Lancet 1998; 352:873-875
22. Kirton A, Busche K, Ross C, et al: Acute necrotizing encephalopathy in caucasian children: Two cases and review of the literature. J Child Neurol 2005; 20:527-532
23. Mizuguchi M: Acute necrotizing encephalopathy of childhood: A novel form of acute encephalopathy prevalent in Japan and Taiwan. Brain Dev 1997; 19:81-92
24. Okumura A, Abe S, Kidokoro H, et al: Acute necrotizing encephalopathy: A comparison between influenza and non-influenza cases. Microbiol Immunol 2009; 53:277-280
25. Yoshikawa H, Watanabe T, Abe T, et al: Clinical diversity in acute necrotizing encephalopathy. J Child Neurol 1999; 14: 249-255
26. Protheroe SM, Mellor DH: Imaging in influenza A encephalitis. Arch Dis Child 1991; 66:702-705
27. Dalmau J, Gleichman AJ, Hughes EG, et al: Anti-NMDA-receptor encephalitis: Case series and analysis of the effects of antibodies. Lancet Neurol 2008; 7:1091-1098
28. Florance NR, Davis RL, Lam C, et al: Anti-Nmethyl- D-aspartate receptor (NMDAR) encephalitis in children and adolescents. Ann Neurol 2009; 66:11-18
29. Gable MS, Gavali S, Radner A, et al: Anti- NMDA receptor encephalitis: Report of ten cases and comparison with viral encephalitis. Eur J Clin Microbiol Infect Dis 2009 August 29. [Epub ahead of print]
30. Modoni A, Masciullo M, Spinelli P, et al: Successful treatment of acute autoimmune limbic encephalitis with negative VGKC and NMDAR antibodies. Cogn Behav Neurol 2009; 22:63-66
31. Musallam B, Matoth I, Wolf DG, et al: Steroids for deteriorating herpes simplex virus encephalitis. Pediatr Neurol 2007; 37: 229-232
32. Troedson C, Gill D, Dale RC: Emergence of acute necrotising encephalopathy in Australia. J Paediatr Child Health 2008; 44: 599-601